PSB10_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSB10_RAT
• UniProt AC: Q4KM35
• Protein Name: Proteasome subunit beta type-10
• Gene Name: Psmb10
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 273
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity)..
• Protein Sequence: MLKQAVEHRGGFSFENCQRNASLEHVLPGLRVPLARKTGTTIAGLVFRDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADTEMTTRMAASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLNGPQLYSVHPHGSYSRLPFTALGSGQDAAVALLEDRFQPNMTLEAAQELLVEAITAGILGDLGSGGSVDACVITAGGAKLQRALSSPIEPVQRAGQYRFAPGTTPVQTQEVRALTLELLEETVQAMEVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLKQAVEH -------CHHHHHHH	10.74	-
13	Phosphorylation	VEHRGGFSFENCQRN HHHCCCCCCCCCCCC	34.62	27097102
22	Phosphorylation	ENCQRNASLEHVLPG CCCCCCCCHHHHCCC	37.53	27097102
101	Acetylation	TTRMAASKMELHALS HHHHHHHHHHHHHHH	31.50	22902405
108	Phosphorylation	KMELHALSTGREPRV HHHHHHHHCCCCCHH	29.60	25575281
109	Phosphorylation	MELHALSTGREPRVA HHHHHHHCCCCCHHH	40.90	25575281
229	Phosphorylation	AKLQRALSSPIEPVQ HHHHHHHCCCCCCCH	32.84	29779826
230	Phosphorylation	KLQRALSSPIEPVQR HHHHHHCCCCCCCHH	30.65	22817900
247	Phosphorylation	QYRFAPGTTPVQTQE CCCCCCCCCCCCCHH	27.20	30181290
248	Phosphorylation	YRFAPGTTPVQTQEV CCCCCCCCCCCCHHH	27.64	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSB10_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSB10_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSB10_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PSB10_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.