MP2K2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MP2K2_RAT
• UniProt AC: P36506
• Protein Name: Dual specificity mitogen-activated protein kinase kinase 2
• Gene Name: Map2k2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 400
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . Membrane localization is probably regulated by its interaction with KSR1.
• Protein Description: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity)..
• Protein Sequence: MLARRKPVLPALTINPTIAEGPSPTSEGASEAHLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLTNHAFIKRSEGEDVDFAGWLCRTLRLKQPSTPTRTAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLARRKPV -------CCCCCCCC	6.27	-
13	Phosphorylation	KPVLPALTINPTIAE CCCCCEEEECCCCCC	22.33	28689409
17	Phosphorylation	PALTINPTIAEGPSP CEEEECCCCCCCCCC	28.47	23984901
23	Phosphorylation	PTIAEGPSPTSEGAS CCCCCCCCCCCCCCC	52.22	27097102
25	Phosphorylation	IAEGPSPTSEGASEA CCCCCCCCCCCCCHH	43.69	27097102
26	Phosphorylation	AEGPSPTSEGASEAH CCCCCCCCCCCCHHH	37.10	27097102
30	Phosphorylation	SPTSEGASEAHLVDL CCCCCCCCHHHHHHH	46.29	27097102
76	Phosphorylation	DDDFERISELGAGNG CCCHHHHHHCCCCCC	32.75	23984901
196	Ubiquitination	QIMHRDVKPSNILVN CCCCCCCCHHHEEEC	47.20	-
216	Phosphorylation	KLCDFGVSGQLIDSM EECCCCCCHHHHHHH	22.62	22817900
222	Phosphorylation	VSGQLIDSMANSFVG CCHHHHHHHHHHCCC	16.89	17314031
222	Acetylation	VSGQLIDSMANSFVG CCHHHHHHHHHHCCC	16.89	-
226	Phosphorylation	LIDSMANSFVGTRSY HHHHHHHHCCCCCCC	16.27	23712012
230	Phosphorylation	MANSFVGTRSYMSPE HHHHCCCCCCCCCHH	15.90	27097102
233	Phosphorylation	SFVGTRSYMSPERLQ HCCCCCCCCCHHHHC	9.79	26022182
278	Phosphorylation	DAKELEASFGRPVVD CHHHHHHHHCCCEEC	20.89	25575281
293	Phosphorylation	GADGEPHSVSPRPRP CCCCCCCCCCCCCCC	34.70	27097102
295	Phosphorylation	DGEPHSVSPRPRPPG CCCCCCCCCCCCCCC	20.43	27097102
306	Phosphorylation	RPPGRPISGHGMDSR CCCCCCCCCCCCCCH	27.67	27097102
393	Phosphorylation	TLRLKQPSTPTRTAV HHCCCCCCCCCCCCC	44.52	23712012
394	Phosphorylation	LRLKQPSTPTRTAV- HCCCCCCCCCCCCC-	35.05	23712012
396	Phosphorylation	LKQPSTPTRTAV--- CCCCCCCCCCCC---	40.52	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
222	S	Phosphorylation	Kinase	RAF	-	Uniprot
226	S	Phosphorylation	Kinase	RAF	-	Uniprot
295	S	Phosphorylation	Kinase	MAPK3	P21708	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MP2K2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MP2K2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGS12_RAT	Rgs12	physical	17380122
MK01_XENLA	mapk1-a	physical	8026469

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.