RGS12_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS12_RAT
• UniProt AC: O08774
• Protein Name: Regulator of G-protein signaling 12
• Gene Name: Rgs12
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1387
• Subcellular Localization: Nucleus . Cytoplasm . Cell projection, dendrite . Cell junction, synapse .
• Protein Description: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form..
• Protein Sequence: MYRAGEPGKRQSGPAPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAINEINVKKASHEDVVKLIGKCSGVLRMVISEGSSHVEPSSSDEEGGLCEGKGWLRPKLDSKALGINRAERVVEEVQSGGIFNMIFESPSLCASGSEPLKLKQRSLSESAALRLDVGQDSLCTPHPSMLSKEEISKVINDDSVFTVGLDNHDDFGLDASILNVAMVVGYLGSIELPSTSSNLEHDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDCVQLVTDRAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGCLAQEDEGALRTSCHVFMVDPDLFHHKIHQGIARRFGFACTADPDTSGCLEFPASSLPVLQFISVLYRDMGELIEGVRARAFLDGDADAHQNNSTSSNSDSGIGNFNQEEKSNRVLVVDLGGGSSRHGQGSSPGWESVSGRGSQPWSAPWNGTFCHDSEAGSPLETSPNTDRFWDLTKHSGPVFHMEVPPATLRSSIPPSKRGATGSSCGFNQRWLPVHVLQEWQCGHASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFAQAPLSTQKRDWSRKAFGMQNLFGPHRNVRKTKEDKKSSKLGRGVALAQTSQRTSARRSFGRSRRFSLTRSLDDLESATVSDGELTGADLKDCISNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVEGRTLPDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRKGAFFSWSRSRSTGRSQKKKDHGDHAHDALHANGGLCRRESQGSVSSAGSLDLSEACRTSALERDKAAKHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQDSSILATRDLRLGKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRLSGEKEPLDLGAPISSLDGQRVILEERDPSRGKVSTEKQKGAPVKQSSAVNSSPRNHSAMGEERTLGKSNSIKIRGENGKSARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLVLPEFLRLPPGSSELALSSPPPVKGFSKRAVTSHGQEGAVQTEESYSDSPATSPASAQSPCSAYSPGSAHSPGSAHSPGSAHSTPGPPGTAQPGEKPTKPSCISTVQEGTTQAWRRLSPELEAGGIQTVEEEQVADLTLMGEGDISSPNSTLLPPPPLPQDTPGPTRPGTSRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Acetylation	YRAGEPGKRQSGPAP CCCCCCCCCCCCCCC	58.96	72626085
12	Phosphorylation	GEPGKRQSGPAPPRV CCCCCCCCCCCCCCE	51.26	25403869
98	Phosphorylation	RMVISEGSSHVEPSS EHHHCCCCCCCCCCC	17.14	27097102
99	Phosphorylation	MVISEGSSHVEPSSS HHHCCCCCCCCCCCC	42.27	27097102
104	Phosphorylation	GSSHVEPSSSDEEGG CCCCCCCCCCCCCCC	29.03	27097102
105	Phosphorylation	SSHVEPSSSDEEGGL CCCCCCCCCCCCCCC	53.15	27097102
106	Phosphorylation	SHVEPSSSDEEGGLC CCCCCCCCCCCCCCC	54.07	27097102
169	Phosphorylation	PLKLKQRSLSESAAL CCCCCCCCCCHHHHH	33.48	28432305
171	Phosphorylation	KLKQRSLSESAALRL CCCCCCCCHHHHHHC	30.65	27097102
173	Phosphorylation	KQRSLSESAALRLDV CCCCCCHHHHHHCCC	18.57	28432305
194	Phosphorylation	TPHPSMLSKEEISKV CCCHHHCCHHHHHHH	29.40	-
453	Phosphorylation	SSRHGQGSSPGWESV CCCCCCCCCCCCCCC	26.02	27097102
454	Phosphorylation	SRHGQGSSPGWESVS CCCCCCCCCCCCCCC	33.97	27097102
459	Phosphorylation	GSSPGWESVSGRGSQ CCCCCCCCCCCCCCC	18.31	27097102
524	Methylation	SSIPPSKRGATGSSC CCCCCHHCCCCCCCC	44.29	-
529	Phosphorylation	SKRGATGSSCGFNQR HHCCCCCCCCCCCCC	20.35	27097102
530	Phosphorylation	KRGATGSSCGFNQRW HCCCCCCCCCCCCCC	21.43	27097102
633	Methylation	KKSSKLGRGVALAQT HHHCCCCHHHHHHHH	47.01	-
640	Phosphorylation	RGVALAQTSQRTSAR HHHHHHHHCCHHHHH	22.63	27097102
641	Phosphorylation	GVALAQTSQRTSARR HHHHHHHCCHHHHHH	12.94	27097102
657	Phosphorylation	FGRSRRFSLTRSLDD HCCHHHHEEECCHHH	27.33	22673903
661	Phosphorylation	RRFSLTRSLDDLESA HHHEEECCHHHHHHC	30.80	27097102
667	Phosphorylation	RSLDDLESATVSDGE CCHHHHHHCCCCCCC	36.22	27097102
669	Phosphorylation	LDDLESATVSDGELT HHHHHHCCCCCCCCC	29.80	27097102
671	Phosphorylation	DLESATVSDGELTGA HHHHCCCCCCCCCCC	35.23	27097102
676	Phosphorylation	TVSDGELTGADLKDC CCCCCCCCCCCHHHH	26.48	27097102
685	Phosphorylation	ADLKDCISNNSLSSN CCHHHHHHCCCCCCC	35.97	27097102
688	Phosphorylation	KDCISNNSLSSNASL HHHHHCCCCCCCCCC	33.60	27097102
690	Phosphorylation	CISNNSLSSNASLPS HHHCCCCCCCCCCCC	22.74	27097102
691	Phosphorylation	ISNNSLSSNASLPSV HHCCCCCCCCCCCCH	41.53	27097102
694	Phosphorylation	NSLSSNASLPSVQSC CCCCCCCCCCCHHHH	45.09	27097102
715	Phosphorylation	RVASWAVSFERLLQD HHHHHHHCHHHHHCC	17.40	27097102
849	Phosphorylation	PDSQQVPSSPASKHS CCHHCCCCCCHHHCC	50.53	27097102
850	Phosphorylation	DSQQVPSSPASKHSI CHHCCCCCCHHHCCC	20.58	27097102
853	Phosphorylation	QVPSSPASKHSISSD CCCCCCHHHCCCCCC	33.99	27097102
856	Phosphorylation	SSPASKHSISSDHSN CCCHHHCCCCCCCCC	28.09	27097102
858	Phosphorylation	PASKHSISSDHSNVS CHHHCCCCCCCCCCC	32.50	27097102
859	Phosphorylation	ASKHSISSDHSNVST HHHCCCCCCCCCCCC	37.36	27097102
862	Phosphorylation	HSISSDHSNVSTPKK CCCCCCCCCCCCCCC	43.87	27097102
865	Phosphorylation	SSDHSNVSTPKKLSG CCCCCCCCCCCCCCC	43.15	27097102
866	Phosphorylation	SDHSNVSTPKKLSGK CCCCCCCCCCCCCCC	34.54	27097102
879	Phosphorylation	GKSKSGRSLNEDVGE CCCCCCCCCCCCCCC	38.79	25403869
909	Phosphorylation	RSRSTGRSQKKKDHG CCCCCCCCHHCCCCC	47.93	25403869
934	Phosphorylation	GGLCRRESQGSVSSA CCCCCCCCCCCCCCC	37.72	27097102
937	Phosphorylation	CRRESQGSVSSAGSL CCCCCCCCCCCCCCC	15.93	27097102
939	Phosphorylation	RESQGSVSSAGSLDL CCCCCCCCCCCCCCH	19.03	27097102
940	Phosphorylation	ESQGSVSSAGSLDLS CCCCCCCCCCCCCHH	34.20	27097102
943	Phosphorylation	GSVSSAGSLDLSEAC CCCCCCCCCCHHHHH	20.58	27097102
947	Phosphorylation	SAGSLDLSEACRTSA CCCCCCHHHHHHHHH	23.86	27097102
1170	Phosphorylation	RLSKREESIAKIGKK CHHHHHHHHHHHCHH	24.08	25403869
1226	Phosphorylation	FLRLPPGSSELALSS HHCCCCCCCHHHCCC	26.81	27097102
1227	Phosphorylation	LRLPPGSSELALSSP HCCCCCCCHHHCCCC	42.41	27097102
1232	Phosphorylation	GSSELALSSPPPVKG CCCHHHCCCCCCCCC	34.88	27097102
1233	Phosphorylation	SSELALSSPPPVKGF CCHHHCCCCCCCCCC	42.13	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGS12_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGS12_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS12_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CXCR2_HUMAN	CXCR2	physical	9651375
ARAF_RAT	Araf	physical	17380122
RASH_RAT	Hras	physical	17380122
RASN_RAT	Nras	physical	17380122
MP2K2_RAT	Map2k2	physical	17380122
DLGP3_MOUSE	Dlgap3	physical	17380122
MP2K2_MOUSE	Map2k2	physical	17380122

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.