MP2K2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MP2K2_MOUSE
• UniProt AC: Q63932
• Protein Name: Dual specificity mitogen-activated protein kinase kinase 2
• Gene Name: Map2k2
• Organism: Mus musculus (Mouse).
• Sequence Length: 401
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . Membrane localization is probably regulated by its interaction with KSR1.
• Protein Description: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases..
• Protein Sequence: MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLARRKPV -------CCCCCCCC	6.27	-
13	Phosphorylation	KPVLPALTINPTIAE CCCCCEEEECCCCCC	22.33	25619855
17	Phosphorylation	PALTINPTIAEGPSP CEEEECCCCCCCCCC	28.47	25619855
23	Phosphorylation	PTIAEGPSPTSEGAS CCCCCCCCCCCCCCC	52.22	27087446
25	Phosphorylation	IAEGPSPTSEGASEA CCCCCCCCCCCCCHH	43.69	25619855
26	Phosphorylation	AEGPSPTSEGASEAN CCCCCCCCCCCCHHC	37.10	25619855
30	Phosphorylation	SPTSEGASEANLVDL CCCCCCCCHHCHHHH	48.36	25619855
76	Phosphorylation	DDDFERISELGAGNG CCCHHHHHHCCCCCC	32.75	27180971
87	Phosphorylation	AGNGGVVTKARHRPS CCCCCEEECCCCCCC	19.31	27180971
88	Malonylation	GNGGVVTKARHRPSG CCCCEEECCCCCCCC	31.64	26320211
88	Ubiquitination	GNGGVVTKARHRPSG CCCCEEECCCCCCCC	31.64	-
196	Ubiquitination	QIMHRDVKPSNILVN CCCCCCCCHHHEEEC	47.20	22790023
216	Phosphorylation	KLCDFGVSGQLIDSM EECCCCCCHHHHHHH	22.62	15358159
222	Phosphorylation	VSGQLIDSMANSFVG CCHHHHHHHHHHCCC	16.89	22322096
222	Acetylation	VSGQLIDSMANSFVG CCHHHHHHHHHHCCC	16.89	-
226	Acetylation	LIDSMANSFVGTRSY HHHHHHHHCCCCCCC	16.27	-
226	Phosphorylation	LIDSMANSFVGTRSY HHHHHHHHCCCCCCC	16.27	22322096
230	Phosphorylation	MANSFVGTRSYMSPE HHHHCCCCCCCCCHH	15.90	26643407
235	Phosphorylation	VGTRSYMSPERLQGT CCCCCCCCHHHHCCC	18.51	22942356
278	Phosphorylation	DAKELEASFGRPVVD CHHHHHHHHCCCEEC	20.89	25777480
293	Phosphorylation	GADGEPHSVSPRPRP CCCCCCCCCCCCCCC	34.70	21082442
295	Phosphorylation	DGEPHSVSPRPRPPG CCCCCCCCCCCCCCC	20.43	26824392
306	Phosphorylation	RPPGRPISVGHGMDS CCCCCCCEECCCCCC	25.40	26824392
313	Phosphorylation	SVGHGMDSRPAMAIF EECCCCCCCHHHHHH	31.13	23737553
362	Ubiquitination	PAERADLKLLMNHAF HHHHHHHHHHHHHCC	39.87	22790023
394	Phosphorylation	TLRLKQPSTPTRTAV HHCCCCCCCCCCCCC	44.52	27742792
395	Phosphorylation	LRLKQPSTPTRTAV- HCCCCCCCCCCCCC-	35.05	26824392
397	Phosphorylation	LKQPSTPTRTAV--- CCCCCCCCCCCC---	40.52	27742792
399	Phosphorylation	QPSTPTRTAV----- CCCCCCCCCC-----	33.96	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
222	S	Phosphorylation	Kinase	RAF	-	Uniprot
226	S	Phosphorylation	Kinase	RAF	-	Uniprot
395	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
397	T	Phosphorylation	Kinase	CDK5	Q00535	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MP2K2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MP2K2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MP2K2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.