CXCR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXCR2_HUMAN
• UniProt AC: P25025
• Protein Name: C-X-C chemokine receptor type 2
• Gene Name: CXCR2
• Organism: Homo sapiens (Human).
• Sequence Length: 360
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2..
• Protein Sequence: MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	N-linked_Glycosylation	WKGEDLSNYSYSSTL HCCCCCCCCCCCCCC	36.75	UniProtKB CARBOHYD
76	Phosphorylation	VMLVILYSRVGRSVT HHHHHHHHCCCCCHH	19.62	24719451
123	Phosphorylation	TFLCKVVSLLKEVNF HHHHHHHHHHHHCCC	30.85	24719451
131	Phosphorylation	LLKEVNFYSGILLLA HHHHCCCCCHHHHHH	10.77	22210691
145	Phosphorylation	ACISVDRYLAIVHAT HHHCHHHHHHHHHHH	8.95	22210691
154	Phosphorylation	AIVHATRTLTQKRYL HHHHHHCCCCCHHHH	29.78	29449344
156	Phosphorylation	VHATRTLTQKRYLVK HHHHCCCCCHHHHHH	31.28	22210691
160	Phosphorylation	RTLTQKRYLVKFICL CCCCCHHHHHHHHHH	23.92	29449344
234	Phosphorylation	MLFCYGFTLRTLFKA HHHHHHHHHHHHHHH	15.80	24719451
336	Phosphorylation	LAIHGLISKDSLPKD HHHCCCCCCCCCCCC	35.14	24719451
339	Phosphorylation	HGLISKDSLPKDSRP CCCCCCCCCCCCCCC	50.75	28450419
344	Phosphorylation	KDSLPKDSRPSFVGS CCCCCCCCCCCCCCC	52.82	23312004
347	Phosphorylation	LPKDSRPSFVGSSSG CCCCCCCCCCCCCCC	31.30	22817900
351	Phosphorylation	SRPSFVGSSSGHTST CCCCCCCCCCCCCCC	18.94	22817900
352	Phosphorylation	RPSFVGSSSGHTSTT CCCCCCCCCCCCCCC	34.12	22817900
353	Phosphorylation	PSFVGSSSGHTSTTL CCCCCCCCCCCCCCC	35.97	22817900
358	Phosphorylation	SSSGHTSTTL----- CCCCCCCCCC-----	33.02	23312004
359	Phosphorylation	SSGHTSTTL------ CCCCCCCCC------	30.18	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXCR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXCR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXCR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFIP2_HUMAN	RAB11FIP2	physical	15004234
MYO5B_HUMAN	MYO5B	physical	15004234
CXCR2_HUMAN	CXCR2	physical	12888558
TF3A_HUMAN	GTF3A	physical	11170396
ARRB1_HUMAN	ARRB1	physical	11170396
IL8_HUMAN	CXCL8	physical	9464567
RGS12_RAT	Rgs12	physical	9651375
F10A1_HUMAN	ST13	physical	11751889

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D08984: Reparixin (USAN/INN)
• D10075: Navarixin (USAN); Navarixin hydrate
• D10332: Elubrixin (USAN)
• D10387: Danirixin (USAN/INN)
• D10420: Elubrixin tosylate (USAN)
• DrugBank
• There are no disease associations of PTM sites.