TF3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF3A_HUMAN
• UniProt AC: Q92664
• Protein Name: Transcription factor IIIA
• Gene Name: GTF3A
• Organism: Homo sapiens (Human).
• Sequence Length: 365
• Subcellular Localization: Nucleus.
• Protein Description: Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes. [PubMed: 24120868 Also binds the transcribed 5S RNA's (By similarity]
• Protein Sequence: MDPPAVVAESVSSLTIADAFIAAGESSAPTPPRPALPRRFICSFPDCSANYSKAWKLDAHLCKHTGERPFVCDYEGCGKAFIRDYHLSRHILTHTGEKPFVCAANGCDQKFNTKSNLKKHFERKHENQQKQYICSFEDCKKTFKKHQQLKIHQCQHTNEPLFKCTQEGCGKHFASPSKLKRHAKAHEGYVCQKGCSFVAKTWTELLKHVRETHKEEILCEVCRKTFKRKDYLKQHMKTHAPERDVCRCPREGCGRTYTTVFNLQSHILSFHEESRPFVCEHAGCGKTFAMKQSLTRHAVVHDPDKKKMKLKVKKSREKRSLASHLSGYIPPKRKQGQGLSLCQNGESPNCVEDKMLSTVAVLTLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	AFIAAGESSAPTPPR HHHHCCCCCCCCCCC	30.77	26074081
27	Phosphorylation	FIAAGESSAPTPPRP HHHCCCCCCCCCCCC	33.68	24719451
30	Phosphorylation	AGESSAPTPPRPALP CCCCCCCCCCCCCCC	45.71	26074081
51	Phosphorylation	FPDCSANYSKAWKLD CCCCCCCHHHHHHCH	15.97	-
52	Phosphorylation	PDCSANYSKAWKLDA CCCCCCHHHHHHCHH	18.72	-
65	Phosphorylation	DAHLCKHTGERPFVC HHHHHHHCCCCCEEE	26.66	28555341
74	Phosphorylation	ERPFVCDYEGCGKAF CCCEEECCCCCCHHH	14.75	-
85	Phosphorylation	GKAFIRDYHLSRHIL CHHHHHHHHHHCCCH	8.53	24719451
93	Phosphorylation	HLSRHILTHTGEKPF HHHCCCHHCCCCCCE	19.45	29214152
95	Phosphorylation	SRHILTHTGEKPFVC HCCCHHCCCCCCEEE	41.63	28555341
114	Ubiquitination	CDQKFNTKSNLKKHF CCCCCCCHHHHHHHH	38.15	29967540
150	Ubiquitination	FKKHQQLKIHQCQHT HHHHHHHEEEECCCC	33.53	29967540
157	Phosphorylation	KIHQCQHTNEPLFKC EEEECCCCCCCCCCC	18.52	28555341
165	Phosphorylation	NEPLFKCTQEGCGKH CCCCCCCCCCCCCCC	30.19	26657352
175	Phosphorylation	GCGKHFASPSKLKRH CCCCCCCCHHHHHHH	28.85	23927012
177	Phosphorylation	GKHFASPSKLKRHAK CCCCCCHHHHHHHHH	48.39	30576142
193	Ubiquitination	HEGYVCQKGCSFVAK CCCCCCCCCCHHHHH	57.68	29967540
227	Acetylation	EVCRKTFKRKDYLKQ HHHHHHHCCHHHHHH	64.86	20167786
233	Acetylation	FKRKDYLKQHMKTHA HCCHHHHHHHHHHCC	31.74	20167786
340	Phosphorylation	RKQGQGLSLCQNGES CCCCCCCCCCCCCCC	33.64	28450419
347	Phosphorylation	SLCQNGESPNCVEDK CCCCCCCCCCHHHHH	23.86	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TF3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF3A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TF3A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347, AND MASSSPECTROMETRY.
PubMed: 19413330