dbPTM

IL8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IL8_HUMAN
UniProt AC	P10145
Protein Name	Interleukin-8
Gene Name	CXCL8
Organism	Homo sapiens (Human).
Sequence Length	99
Subcellular Localization	Secreted.
Protein Description	IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively..
Protein Sequence	MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Citrullination	CEGAVLPRSAKELRC HCCCCCCCCHHHHHC	45.12	-
27	Citrullination	CEGAVLPRSAKELRC HCCCCCCCCHHHHHC	45.12	19608678
40	Nitration	RCQCIKTYSKPFHPK HCHHHHCCCCCCCHH	15.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IL8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
27	R	Citrullination		18710930
Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IL8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDC1_HUMAN	SDC1	physical	12902511
IL8_HUMAN	CXCL8	physical	8077676
IL8_HUMAN	CXCL8	physical	2184886
EP300_HUMAN	EP300	physical	11940655
PMGT1_HUMAN	POMGNT1	physical	21988832
SGTA_HUMAN	SGTA	physical	21988832
IL8_HUMAN	CXCL8	physical	20047188

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IL8_HUMAN

Related Literatures of Post-Translational Modification