dbPTM

MYO5B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYO5B_HUMAN
UniProt AC	Q9ULV0
Protein Name	Unconventional myosin-Vb
Gene Name	MYO5B
Organism	Homo sapiens (Human).
Sequence Length	1848
Subcellular Localization	Cytoplasm .
Protein Description	May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis..
Protein Sequence	MSVGELYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQERNDPQQLLLDAKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1 (in isoform 3)	Acetylation	-	34.12	22814378
2	Phosphorylation	------MSVGELYSQ ------CCHHHHHHH	50.57	27251275
169	Ubiquitination	SGESGAGKTVSAKYA ECCCCCCCCHHHHHH	45.26	-
170	Phosphorylation	GESGAGKTVSAKYAM CCCCCCCCHHHHHHH	20.83	20068231
172	Phosphorylation	SGAGKTVSAKYAMRY CCCCCCHHHHHHHHH	25.03	20068231
175	Phosphorylation	GKTVSAKYAMRYFAT CCCHHHHHHHHHHHC	12.83	30177828
179	Phosphorylation	SAKYAMRYFATVGGS HHHHHHHHHHCCCCC	5.63	30177828
182	Phosphorylation	YAMRYFATVGGSASE HHHHHHHCCCCCCCC	15.13	30177828
186	Phosphorylation	YFATVGGSASETNIE HHHCCCCCCCCCCHH	23.77	30177828
188	Phosphorylation	ATVGGSASETNIEEK HCCCCCCCCCCHHHH	46.80	30177828
190	Phosphorylation	VGGSASETNIEEKVL CCCCCCCCCHHHHHH	38.71	30177828
199	Phosphorylation	IEEKVLASSPIMEAI HHHHHHHCCHHHHHH	32.27	21406692
200	Phosphorylation	EEKVLASSPIMEAIG HHHHHHCCHHHHHHC	16.91	21406692
211	Phosphorylation	EAIGNAKTTRNDNSS HHHCCCCCCCCCCCC	28.69	20068231
212	Phosphorylation	AIGNAKTTRNDNSSR HHCCCCCCCCCCCCC	27.11	20068231
217	Phosphorylation	KTTRNDNSSRFGKYI CCCCCCCCCCCEEEE	26.25	29514088
218	Phosphorylation	TTRNDNSSRFGKYIQ CCCCCCCCCCEEEEE	37.57	29514088
222	Acetylation	DNSSRFGKYIQIGFD CCCCCCEEEEEEECC	36.15	22424773
241	Phosphorylation	IIGANMRTYLLEKSR EECCCHHHHHHHHCE	14.04	29083192
242	Phosphorylation	IGANMRTYLLEKSRV ECCCHHHHHHHHCEE	10.02	29083192
246	Ubiquitination	MRTYLLEKSRVVFQA HHHHHHHHCEEEEEC	43.46	-
247	Phosphorylation	RTYLLEKSRVVFQAD HHHHHHHCEEEEECC	22.41	29083192
313	Phosphorylation	EKTRQAFTLLGVKES HHHHHHHHHHCCCHH	24.88	24719451
324	Phosphorylation	VKESHQMSIFKIIAS CCHHHHHHHHHHHHH	20.50	24719451
383	Phosphorylation	LCHRKLVTTSETYVK HHCCCCCCCCHHHHH	34.73	-
478	Phosphorylation	FKLEQEEYMKEQIPW HHHHHHHHHHHHCCC	16.85	30177828
544	Phosphorylation	HFQKPRMSNTAFIIV CCCCCCCCCCEEEEE	32.10	21406692
546	Phosphorylation	QKPRMSNTAFIIVHF CCCCCCCCEEEEEEE	18.68	21406692
559	Phosphorylation	HFADKVEYLSDGFLE EEHHHHHHCCCCHHH	17.94	22817900
561	Phosphorylation	ADKVEYLSDGFLEKN HHHHHHCCCCHHHHC	34.48	20068231
602	Phosphorylation	DKDPVPATTPGKGSS CCCCCCCCCCCCCCC	27.70	27050516
603	Phosphorylation	KDPVPATTPGKGSSS CCCCCCCCCCCCCCC	31.95	29496963
608	Phosphorylation	ATTPGKGSSSKISVR CCCCCCCCCCCEEEC	34.62	21712546
609	Phosphorylation	TTPGKGSSSKISVRS CCCCCCCCCCEEECC	44.30	21712546
610	Phosphorylation	TPGKGSSSKISVRSA CCCCCCCCCEEECCC	35.39	21712546
613	Phosphorylation	KGSSSKISVRSARPP CCCCCCEEECCCCCC	18.40	24719451
650	Phosphorylation	LMETLNATTPHYVRC HHHHHCCCCCCEEEE	39.52	-
694	Phosphorylation	IRISAAGYPSRWAYH EEHHCCCCCCCHHHH	8.03	17053785
727	Phosphorylation	DKKAICRSVLENLIK CHHHHHHHHHHHHCC	27.00	27251275
744	Phosphorylation	DKFQFGRTKIFFRAG CCCCCCCEEEEEECC	28.95	-
755	Phosphorylation	FRAGQVAYLEKLRAD EECCHHHHHHHHCCC	19.28	-
865	Phosphorylation	VLMEHKATTIQKHVR HHHHHHCHHHHHHHH	29.27	26270265
866	Phosphorylation	LMEHKATTIQKHVRG HHHHHCHHHHHHHHH	26.69	26270265
912	Phosphorylation	ALRIEARSAEHLKRL HHHHHHHCHHHHHHC	45.09	-
943	Phosphorylation	EQNKEFKTLSEQLSV HCHHHHHHHHHHHHC	40.62	-
945	Phosphorylation	NKEFKTLSEQLSVTT HHHHHHHHHHHHCEE	28.64	-
949	Phosphorylation	KTLSEQLSVTTSTYT HHHHHHHHCEECEEH	19.67	27251275
956	Phosphorylation	SVTTSTYTMEVERLK HCEECEEHHHHHHHH	13.62	-
969	Phosphorylation	LKKELVHYQQSPGED HHHHHCCCCCCCCCC	10.77	20068231
972	Phosphorylation	ELVHYQQSPGEDTSL HHCCCCCCCCCCCHH	21.24	20068231
977	Phosphorylation	QQSPGEDTSLRLQEE CCCCCCCCHHHHHHH	25.92	20068231
978	Phosphorylation	QSPGEDTSLRLQEEV CCCCCCCHHHHHHHH	24.66	20068231
987	Phosphorylation	RLQEEVESLRTELQR HHHHHHHHHHHHHHH	28.47	29978859
990	Phosphorylation	EEVESLRTELQRAHS HHHHHHHHHHHHHHH	46.47	29978859
1072	Ubiquitination	SRYQNLVKEYSQLEQ HHHHHHHHHHHHHHH	54.85	-
1102	Phosphorylation	PGHRRNPSNQSSLES CCCCCCCCCCCCCCC	51.56	26657352
1105	Phosphorylation	RRNPSNQSSLESDSN CCCCCCCCCCCCCCC	40.93	26657352
1106	Phosphorylation	RNPSNQSSLESDSNY CCCCCCCCCCCCCCC	26.79	26657352
1109	Phosphorylation	SNQSSLESDSNYPSI CCCCCCCCCCCCCCC	52.19	23090842
1111	Phosphorylation	QSSLESDSNYPSIST CCCCCCCCCCCCCCH	47.76	26657352
1113	Phosphorylation	SLESDSNYPSISTSE CCCCCCCCCCCCHHH	11.43	23090842
1115	Phosphorylation	ESDSNYPSISTSEIG CCCCCCCCCCHHHCC	20.86	26657352
1117	Phosphorylation	DSNYPSISTSEIGDT CCCCCCCCHHHCCCH	30.16	26657352
1118	Phosphorylation	SNYPSISTSEIGDTE CCCCCCCHHHCCCHH	28.80	23090842
1119	Phosphorylation	NYPSISTSEIGDTED CCCCCCHHHCCCHHH	22.04	23090842
1124	Phosphorylation	STSEIGDTEDALQQV CHHHCCCHHHHHHHH	30.47	23090842
1197	Phosphorylation	DPNADLAYNSLKRQE CCCCHHHHHHHHHHH	16.75	21406692
1199	Phosphorylation	NADLAYNSLKRQELE CCHHHHHHHHHHHHH	23.69	24719451
1207	Phosphorylation	LKRQELESENKKLKN HHHHHHHHHHHHHHH	60.12	16097034
1228	Phosphorylation	KAVADQATQNNSSHG HHHHHHHHHCCCCCC	26.62	28348404
1232	Phosphorylation	DQATQNNSSHGSPDS HHHHHCCCCCCCHHH	31.12	28348404
1233	Phosphorylation	QATQNNSSHGSPDSY HHHHCCCCCCCHHHH	33.71	28348404
1236	Phosphorylation	QNNSSHGSPDSYSLL HCCCCCCCHHHHHHH	21.80	28348404
1289	Phosphorylation	EPNINARSSWPNSEK CCCCCCCCCCCCCCC	34.05	28102081
1290	Phosphorylation	PNINARSSWPNSEKH CCCCCCCCCCCCCCC	40.79	26657352
1294	Phosphorylation	ARSSWPNSEKHVDQE CCCCCCCCCCCCCHH	43.90	23312004
1307	Phosphorylation	QEDAIEAYHGVCQTN HHHHHHHHHCHHCCC	6.06	27642862
1333	Phosphorylation	DGELGLAYQGLKQVA CCCHHHHHHHHHHHH	14.25	-
1351	Phosphorylation	EAQLQAQSLEHEEEV HHHHHHHCCCCHHHH	38.45	28348404
1403	Phosphorylation	QQEISRLTNENLDLK HHHHHHHHCCCCCHH	39.10	22985185
1410	Ubiquitination	TNENLDLKELVEKLE HCCCCCHHHHHHHHH	48.98	-
1415	Acetylation	DLKELVEKLEKNERK CHHHHHHHHHHHHHH	55.24	178226381
1446	Phosphorylation	AAQALAQSERKRHEL HHHHHHHHHHHHHHH	33.49	25159151
1447	Phosphorylation	AQALAQSERKRHELN HHHHHHHHHHHHHHH	50.57	18669648
1458	Phosphorylation	HELNRQVTVQRKEKD HHHHHCCEEHHHHHC	11.55	-
1464	Acetylation	VTVQRKEKDFQGMLE CEEHHHHHCCCHHHH	67.87	12650055
1528	Phosphorylation	VHSLLTSTINGIKKV HHHHHHHHHHHHHHH	17.15	-
1546	Phosphorylation	HNDDFEMTSFWLSNT CCCCCHHHHHHHHHH	17.36	-
1547	Phosphorylation	NDDFEMTSFWLSNTC CCCCHHHHHHHHHHH	17.08	-
1551	Phosphorylation	EMTSFWLSNTCRLLH HHHHHHHHHHHHHHH	22.23	-
1642	Phosphorylation	PTGYRKRSSSMADGD CCCCCCCCCCCCCCC	29.78	30278072
1643	Phosphorylation	TGYRKRSSSMADGDN CCCCCCCCCCCCCCC	28.32	30278072
1644	Phosphorylation	GYRKRSSSMADGDNS CCCCCCCCCCCCCCH	21.16	30278072
1651	Phosphorylation	SMADGDNSYCLEAII CCCCCCCHHHHHHHH	23.20	20736484
1714	Phosphorylation	STGMQLRYNISQLEE HHCCHHHCCHHHHHH	25.99	25690035
1717	Phosphorylation	MQLRYNISQLEEWLR CHHHCCHHHHHHHHH	25.69	25690035

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MYO5B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MYO5B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYO5B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFIP2_HUMAN	RAB11FIP2	physical	12393859
RB11A_HUMAN	RAB11A	physical	17507647
RB11B_HUMAN	RAB11B	physical	17507647
RAB25_HUMAN	RAB25	physical	17507647
RAB8A_HUMAN	RAB8A	physical	17507647
RPAC1_HUMAN	POLR1C	physical	21988832
ITF2_HUMAN	TCF4	physical	25416956
AMOL2_HUMAN	AMOTL2	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
RFIP2_HUMAN	RAB11FIP2	physical	16473632
EXOC6_HUMAN	EXOC6	physical	26553929
SYTL4_HUMAN	SYTL4	physical	26553929
RAB3B_HUMAN	RAB3B	physical	26553929
STX3_HUMAN	STX3	physical	26553929
RAB8A_HUMAN	RAB8A	physical	26553929
RB11A_HUMAN	RAB11A	physical	26553929

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
251850	Diarrhea 2, with microvillus atrophy (DIAR2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYO5B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1446, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-694, AND MASSSPECTROMETRY.	17053785 [Abstract]