| UniProt ID | STX3_HUMAN | |
|---|---|---|
| UniProt AC | Q13277 | |
| Protein Name | Syntaxin-3 | |
| Gene Name | STX3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 289 | |
| Subcellular Localization |
Membrane Single-pass type IV membrane protein . |
|
| Protein Description | Potentially involved in docking of synaptic vesicles at presynaptic active zones.. | |
| Protein Sequence | MKDRLEQLKAKQLTQDDDTDAVEIAIDNTAFMDEFFSEIEETRLNIDKISEHVEEAKKLYSIILSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLKSMEKHIEEDEVRSSADLRIRKSQHSVLSRKFVEVMTKYNEAQVDFRERSKGRIQRQLEITGKKTTDEELEEMLESGNPAIFTSGIIDSQISKQALSEIEGRHKDIVRLESSIKELHDMFMDIAMLVENQGEMLDNIELNVMHTVDHVEKARDETKKAVKYQSQARKKLIIIIVLVVVLLGILALIIGLSVGLN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Ubiquitination | KDRLEQLKAKQLTQD HHHHHHHHHHHCCCC | 53.91 | - | |
| 14 | Phosphorylation | QLKAKQLTQDDDTDA HHHHHHCCCCCCCCC | 27.71 | - | |
| 60 | Phosphorylation | VEEAKKLYSIILSAP HHHHHHHHHHHHCCC | 13.50 | 25219547 | |
| 61 | Phosphorylation | EEAKKLYSIILSAPI HHHHHHHHHHHCCCC | 17.37 | 25219547 | |
| 65 | Phosphorylation | KLYSIILSAPIPEPK HHHHHHHCCCCCCCC | 22.91 | 25219547 | |
| 73 | Phosphorylation | APIPEPKTKDDLEQL CCCCCCCCHHHHHHH | 50.88 | 25219547 | |
| 100 | Ubiquitination | NKLKSMEKHIEEDEV HHHHHHHHHHCHHHH | 41.04 | 21906983 | |
| 100 (in isoform 1) | Ubiquitination | - | 41.04 | 21906983 | |
| 100 (in isoform 2) | Ubiquitination | - | 41.04 | 21906983 | |
| 109 | Phosphorylation | IEEDEVRSSADLRIR HCHHHHHHHHHHHHH | 34.75 | 23312004 | |
| 110 | Phosphorylation | EEDEVRSSADLRIRK CHHHHHHHHHHHHHH | 18.42 | 23312004 | |
| 117 | Acetylation | SADLRIRKSQHSVLS HHHHHHHHHHHHHHH | 52.69 | 21339330 | |
| 117 | Ubiquitination | SADLRIRKSQHSVLS HHHHHHHHHHHHHHH | 52.69 | - | |
| 118 | Phosphorylation | ADLRIRKSQHSVLSR HHHHHHHHHHHHHHH | 24.23 | 30576142 | |
| 124 | Phosphorylation | KSQHSVLSRKFVEVM HHHHHHHHHHHHHHH | 31.13 | 30576142 | |
| 126 | Ubiquitination | QHSVLSRKFVEVMTK HHHHHHHHHHHHHHH | 50.84 | - | |
| 159 | Ubiquitination | QLEITGKKTTDEELE HHHHCCCCCCHHHHH | 58.98 | 2190698 | |
| 159 (in isoform 2) | Ubiquitination | - | 58.98 | 21906983 | |
| 159 (in isoform 1) | Ubiquitination | - | 58.98 | 21906983 | |
| 188 | Ubiquitination | IIDSQISKQALSEIE HCCHHHHHHHHHHCC | 41.02 | - | |
| 192 | Phosphorylation | QISKQALSEIEGRHK HHHHHHHHHCCCCHH | 39.27 | - | |
| 206 | Phosphorylation | KDIVRLESSIKELHD HHHHHHHHHHHHHHH | 41.79 | 22496350 | |
| 207 | Phosphorylation | DIVRLESSIKELHDM HHHHHHHHHHHHHHH | 28.45 | 25159151 | |
| 256 | Phosphorylation | ETKKAVKYQSQARKK HHHHHHHHHHHHHHH | 13.54 | 21406692 | |
| 258 | Phosphorylation | KKAVKYQSQARKKLI HHHHHHHHHHHHHHH | 23.79 | 21406692 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of STX3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of STX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STX3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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