STXB1_HUMAN - dbPTM
STXB1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STXB1_HUMAN
UniProt AC P61764
Protein Name Syntaxin-binding protein 1
Gene Name STXBP1
Organism Homo sapiens (Human).
Sequence Length 594
Subcellular Localization Cytoplasm, cytosol . Membrane
Peripheral membrane protein.
Protein Description May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions..
Protein Sequence MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Ubiquitination-MAPIGLKAVVGEKI
-CCCCCCHHHHCHHH		33.6430230243
7 (in isoform 2)Ubiquitination-33.64-
13UbiquitinationLKAVVGEKIMHDVIK
CHHHHCHHHHHHHHH		39.1332015554
13 (in isoform 2)Ubiquitination-39.13-
13AcetylationLKAVVGEKIMHDVIK
CHHHHCHHHHHHHHH		39.1325953088
20AcetylationKIMHDVIKKVKKKGE
HHHHHHHHHHHHCCC		51.9025953088
38SulfoxidationLVVDQLSMRMLSSCC
EEEEHHHHHHHHHHH		3.8721406390
48PhosphorylationLSSCCKMTDIMTEGI
HHHHHHCHHHHHCCE		14.1028122231
52PhosphorylationCKMTDIMTEGITIVE
HHCHHHHHCCEEEEE		31.2428122231
56PhosphorylationDIMTEGITIVEDINK
HHHHCCEEEEECHHH		29.8128122231
70PhosphorylationKRREPLPSLEAVYLI
HCCCCCCCCEEEEEE		46.6623312004
75PhosphorylationLPSLEAVYLITPSEK
CCCCEEEEEECCCHH		10.2323312004
78UbiquitinationLEAVYLITPSEKSVH
CEEEEEECCCHHHHH		20.4033845483
84UbiquitinationITPSEKSVHSLISDF
ECCCHHHHHHHHHCC		5.4230230243
89PhosphorylationKSVHSLISDFKDPPT
HHHHHHHHCCCCCCC		42.1425332170
92UbiquitinationHSLISDFKDPPTAKY
HHHHHCCCCCCCCCC		74.4532015554
98UbiquitinationFKDPPTAKYRAAHVF
CCCCCCCCCEEEEEE		37.4330230243
106UbiquitinationYRAAHVFFTDSCPDA
CEEEEEEECCCCHHH		7.8430230243
107PhosphorylationRAAHVFFTDSCPDAL
EEEEEEECCCCHHHH		18.6221082442
120UbiquitinationALFNELVKSRAAKVI
HHHHHHHHHHHHHHH		47.0130230243
145PhosphorylationLPYESQVYSLDSADS
ECCCCCCEECCCCHH		8.90-
170UbiquitinationQMKNPILERLAEQIA
HCCCHHHHHHHHHHH		46.5030230243
181UbiquitinationEQIATLCATLKEYPA
HHHHHHHHHHHHCCC		21.0530230243
182UbiquitinationQIATLCATLKEYPAV
HHHHHHHHHHHCCCC		37.0530230243
184UbiquitinationATLCATLKEYPAVRY
HHHHHHHHHCCCCEE		51.3430230243
193UbiquitinationYPAVRYRGEYKDNAL
CCCCEECCCCCCCHH		33.3830230243
196UbiquitinationVRYRGEYKDNALLAQ
CEECCCCCCCHHHHH		39.9630230243
199UbiquitinationRGEYKDNALLAQLIQ
CCCCCCCHHHHHHHH		17.6830230243
208UbiquitinationLAQLIQDKLDAYKAD
HHHHHHHHHHHHHCC		31.7121906983
208 (in isoform 1)Ubiquitination-31.7121906983
208 (in isoform 2)Ubiquitination-31.7121906983
210UbiquitinationQLIQDKLDAYKADDP
HHHHHHHHHHHCCCC		54.3030230243
211UbiquitinationLIQDKLDAYKADDPT
HHHHHHHHHHCCCCC		20.4030230243
213UbiquitinationQDKLDAYKADDPTMG
HHHHHHHHCCCCCCC		47.2430230243
222UbiquitinationDDPTMGEGPDKARSQ
CCCCCCCCCHHHHHH		29.9430230243
225UbiquitinationTMGEGPDKARSQLLI
CCCCCCHHHHHHEEE		49.1630230243
272UbiquitinationKYETSGIGEARVKEV
EEECCCCCCEEEEEE		26.4932142685
280UbiquitinationEARVKEVLLDEDDDL
CEEEEEEEECCCCCE		5.3830230243
291UbiquitinationDDDLWIALRHKHIAE
CCCEEHHHHCHHHHH		4.3130230243
294UbiquitinationLWIALRHKHIAEVSQ
EEHHHHCHHHHHHCH		30.2132142685
296UbiquitinationIALRHKHIAEVSQEV
HHHHCHHHHHHCHHH		4.1132142685
305UbiquitinationEVSQEVTRSLKDFSS
HHCHHHHHHHHHCCC		45.2132142685
306PhosphorylationVSQEVTRSLKDFSSS
HCHHHHHHHHHCCCC		30.3312519779
308UbiquitinationQEVTRSLKDFSSSKR
HHHHHHHHHCCCCCC		58.9532142685
313PhosphorylationSLKDFSSSKRMNTGE
HHHHCCCCCCCCCCC		24.0812519779
314UbiquitinationLKDFSSSKRMNTGEK
HHHCCCCCCCCCCCC		58.5824816145
314 (in isoform 2)Ubiquitination-58.58-
314AcetylationLKDFSSSKRMNTGEK
HHHCCCCCCCCCCCC		58.5825953088
318UbiquitinationSSSKRMNTGEKTTMR
CCCCCCCCCCCCCHH		37.0632142685
321TrimethylationKRMNTGEKTTMRDLS
CCCCCCCCCCHHHHH		51.11-
321MethylationKRMNTGEKTTMRDLS
CCCCCCCCCCHHHHH		51.1123644510
321UbiquitinationKRMNTGEKTTMRDLS
CCCCCCCCCCHHHHH		51.1129967540
321 (in isoform 2)Ubiquitination-51.11-
321AcetylationKRMNTGEKTTMRDLS
CCCCCCCCCCHHHHH		51.1125953088
322PhosphorylationRMNTGEKTTMRDLSQ
CCCCCCCCCHHHHHH		22.8629083192
323O-linked_GlycosylationMNTGEKTTMRDLSQM
CCCCCCCCHHHHHHH		22.6730379171
323PhosphorylationMNTGEKTTMRDLSQM
CCCCCCCCHHHHHHH		22.6729083192
328UbiquitinationKTTMRDLSQMLKKMP
CCCHHHHHHHHHHCH		20.1730230243
328PhosphorylationKTTMRDLSQMLKKMP
CCCHHHHHHHHHHCH		20.1729083192
329UbiquitinationTTMRDLSQMLKKMPQ
CCHHHHHHHHHHCHH		48.8232142685
332UbiquitinationRDLSQMLKKMPQYQK
HHHHHHHHHCHHHHH		41.5032142685
332AcetylationRDLSQMLKKMPQYQK
HHHHHHHHHCHHHHH		41.5025953088
333UbiquitinationDLSQMLKKMPQYQKE
HHHHHHHHCHHHHHH		52.4229967540
333 (in isoform 2)Ubiquitination-52.42-
337PhosphorylationMLKKMPQYQKELSKY
HHHHCHHHHHHHHHH		18.71-
339UbiquitinationKKMPQYQKELSKYST
HHCHHHHHHHHHHHH		56.54-
339 (in isoform 2)Ubiquitination-56.54-
344PhosphorylationYQKELSKYSTHLHLA
HHHHHHHHHHHHHHH		18.5422210691
345PhosphorylationQKELSKYSTHLHLAE
HHHHHHHHHHHHHHH		17.0622210691
346PhosphorylationKELSKYSTHLHLAED
HHHHHHHHHHHHHHH		25.9321082442
350UbiquitinationKYSTHLHLAEDCMKH
HHHHHHHHHHHHHHH		7.6030230243
361UbiquitinationCMKHYQGTVDKLCRV
HHHHCCCHHHHHHHH		15.2530230243
361PhosphorylationCMKHYQGTVDKLCRV
HHHHCCCHHHHHHHH		15.2522210691
364UbiquitinationHYQGTVDKLCRVEQD
HCCCHHHHHHHHHHH		45.1930230243
364 (in isoform 2)Ubiquitination-45.19-
374SulfoxidationRVEQDLAMGTDAEGE
HHHHHHCCCCCCCCC		8.4721406390
376PhosphorylationEQDLAMGTDAEGEKI
HHHHCCCCCCCCCCC		20.96-
382UbiquitinationGTDAEGEKIKDPMRA
CCCCCCCCCCCHHHH		66.9529967540
382MalonylationGTDAEGEKIKDPMRA
CCCCCCCCCCCHHHH		66.9526320211
384UbiquitinationDAEGEKIKDPMRAIV
CCCCCCCCCHHHHHH		67.8424816145
400PhosphorylationILLDANVSTYDKIRI
HHHCCCCCHHHHHHH		22.5127732954
401PhosphorylationLLDANVSTYDKIRII
HHCCCCCHHHHHHHH		31.3027732954
402PhosphorylationLDANVSTYDKIRIIL
HCCCCCHHHHHHHHH		14.0327732954
454PhosphorylationGVPIVTDSTLRRRSK
CCCEECHHHHHHCCC		21.7021406692
455PhosphorylationVPIVTDSTLRRRSKP
CCEECHHHHHHCCCH		27.3921406692
461UbiquitinationSTLRRRSKPERKERI
HHHHHCCCHHHHHHH		49.4333845483
471PhosphorylationRKERISEQTYQLSRW
HHHHHHHHHHHHHCC		38.4232142685
472PhosphorylationKERISEQTYQLSRWT
HHHHHHHHHHHHCCC		14.8021945579
473PhosphorylationERISEQTYQLSRWTP
HHHHHHHHHHHCCCH		13.7221945579
476PhosphorylationSEQTYQLSRWTPIIK
HHHHHHHHCCCHHHH		15.39-
483UbiquitinationSRWTPIIKDIMEDTI
HCCCHHHHHHHHHHH		41.7533845483
489PhosphorylationIKDIMEDTIEDKLDT
HHHHHHHHHHHCCCC		16.9821406692
493PhosphorylationMEDTIEDKLDTKHYP
HHHHHHHCCCCCCCC		35.1632142685
494UbiquitinationEDTIEDKLDTKHYPY
HHHHHHCCCCCCCCC		18.2933845483
497UbiquitinationIEDKLDTKHYPYIST
HHHCCCCCCCCCEEE		40.5933845483
497MalonylationIEDKLDTKHYPYIST
HHHCCCCCCCCCEEE		40.5926320211
504PhosphorylationKHYPYISTRSSASFS
CCCCCEEECCCCCCC		25.6332142685
506PhosphorylationYPYISTRSSASFSTT
CCCEEECCCCCCCCC		30.2830266825
507PhosphorylationPYISTRSSASFSTTA
CCEEECCCCCCCCCC		25.3330266825
509PhosphorylationISTRSSASFSTTAVS
EEECCCCCCCCCCCH		22.9830266825
511PhosphorylationTRSSASFSTTAVSAR
ECCCCCCCCCCCHHC		23.5023403867
512PhosphorylationRSSASFSTTAVSARY
CCCCCCCCCCCHHCC		19.4323403867
513PhosphorylationSSASFSTTAVSARYG
CCCCCCCCCCHHCCC		24.7023403867
516PhosphorylationSFSTTAVSARYGHWH
CCCCCCCHHCCCCCC		12.4527134283
531PhosphorylationKNKAPGEYRSGPRLI
CCCCCCCCCCCCEEE		18.92-
574PhosphorylationIGSTHILTPQKLLDT
EECCEECCHHHHHHH		24.0715273248
587UbiquitinationDTLKKLNKTDEEISS
HHHHHHCCCHHHHCC		68.722190698
587 (in isoform 1)Ubiquitination-68.7221906983
588PhosphorylationTLKKLNKTDEEISS-
HHHHHCCCHHHHCC-		47.7923403867
590 (in isoform 2)Phosphorylation-63.5620068231
591 (in isoform 2)Phosphorylation-51.4827732954
593PhosphorylationNKTDEEISS------
CCCHHHHCC------		33.0223403867
594PhosphorylationKTDEEISS-------
CCHHHHCC-------		50.3226033855
594 (in isoform 2)Phosphorylation-50.3220068231
601 (in isoform 2)Phosphorylation-20068231
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STXB1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STXB1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STXB1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDK5_HUMANCDK5physical
12963086
TAU_HUMANMAPTphysical
12963086
TBB2A_HUMANTUBB2Aphysical
12963086
TBA4A_HUMANTUBA4Aphysical
12963086
STX1A_HUMANSTX1Aphysical
12963086
STX2_HUMANSTX2physical
12773094
STX4_HUMANSTX4physical
12773094
APBA1_RATApba1physical
9395480
APBA2_RATApba2physical
9395480
DLG4_RATDlg4physical
9395480
STX5_RATStx5physical
9395480
STX1A_HUMANSTX1Aphysical
12093152
STX1B_HUMANSTX1Bphysical
12093152
A4_HUMANAPPphysical
21832049
STX11_HUMANSTX11physical
25416956
TRI38_HUMANTRIM38physical
25416956
STX19_HUMANSTX19physical
25416956
SYTL4_HUMANSYTL4physical
24700782
STX3_HUMANSTX3physical
24700782
STX2_HUMANSTX2physical
24700782
ARP2_HUMANACTR2physical
26344197
RHG17_HUMANARHGAP17physical
26344197
PSA_HUMANNPEPPSphysical
26344197
PP1R8_HUMANPPP1R8physical
26344197
SHC1_HUMANSHC1physical
26344197
GLYC_HUMANSHMT1physical
26344197
Drug and Disease Associations
Kegg Disease
H00606 Early infantile epileptic encephalopathy; Ohtahara syndrome
OMIM Disease
612164Epileptic encephalopathy, early infantile, 4 (EIEE4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STXB1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-473, AND MASSSPECTROMETRY.

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