dbPTM

TAU_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TAU_HUMAN
UniProt AC	P10636
Protein Name	Microtubule-associated protein tau
Gene Name	MAPT
Organism	Homo sapiens (Human).
Sequence Length	758
Subcellular Localization	Cytoplasm, cytosol . Cell membrane Peripheral membrane protein Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Cytoplasm . Cell projection, dendrite . Mostly found in the axons of neurons, in the cytosol and in association wi
Protein Description	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization..
Protein Sequence	MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEPRQEFE ------CCCCHHHHE	35.19	1512244
17	Phosphorylation	VMEDHAGTYGLGDRK ECCCCCCCCCCCCCC	18.39	29978859
18	Nitration	MEDHAGTYGLGDRKD CCCCCCCCCCCCCCC	14.94	-
18	Phosphorylation	MEDHAGTYGLGDRKD CCCCCCCCCCCCCCC	14.94	29978859
19 (in isoform 3)	Phosphorylation	-	24.03	24076635
29	Phosphorylation	DRKDQGGYTMHQDQE CCCCCCCCCCEECCC	14.02	28796482
29 (in isoform 3)	Phosphorylation	-	14.02	12387894
30	Phosphorylation	RKDQGGYTMHQDQEG CCCCCCCCCEECCCC	16.08	28796482
37 (in isoform 3)	Phosphorylation	-	37.17	17287340
39	Phosphorylation	HQDQEGDTDAGLKES EECCCCCCCCCCCCC	38.31	30624053
41 (in isoform 3)	Phosphorylation	-	27.58	17287340
43 (in isoform 3)	Phosphorylation	-	6.28	16674116
44	Methylation	GDTDAGLKESPLQTP CCCCCCCCCCCCCCC	56.05	-
46	Phosphorylation	TDAGLKESPLQTPTE CCCCCCCCCCCCCCC	29.35	30278072
50	Phosphorylation	LKESPLQTPTEDGSE CCCCCCCCCCCCCCC	39.60	30278072
52	Phosphorylation	ESPLQTPTEDGSEEP CCCCCCCCCCCCCCC	50.53	25307156
53 (in isoform 2)	Phosphorylation	-	62.67	27732954
53 (in isoform 6)	Phosphorylation	-	62.67	27732954
55 (in isoform 2)	Phosphorylation	-	30.63	25849741
55 (in isoform 3)	Phosphorylation	-	30.63	-
55 (in isoform 6)	Phosphorylation	-	30.63	25849741
56	Phosphorylation	QTPTEDGSEEPGSET CCCCCCCCCCCCCCC	51.62	27050516
59 (in isoform 3)	Phosphorylation	-	47.78	25849741
61	Phosphorylation	DGSEEPGSETSDAKS CCCCCCCCCCCCCCC	48.71	28985074
63	Phosphorylation	SEEPGSETSDAKSTP CCCCCCCCCCCCCCC	33.34	24076635
64	Phosphorylation	EEPGSETSDAKSTPT CCCCCCCCCCCCCCC	31.36	24076635
65 (in isoform 2)	Phosphorylation	-	66.49	27050516
65 (in isoform 6)	Phosphorylation	-	66.49	27050516
68	Phosphorylation	SETSDAKSTPTAEDV CCCCCCCCCCCHHHC	41.14	25307156
68 (in isoform 4)	Phosphorylation	-	41.14	25159151
68 (in isoform 7)	Phosphorylation	-	41.14	25159151
69	Phosphorylation	ETSDAKSTPTAEDVT CCCCCCCCCCHHHCC	24.77	22798277
69 (in isoform 4)	Phosphorylation	-	24.77	25159151
69 (in isoform 7)	Phosphorylation	-	24.77	25159151
71	Phosphorylation	SDAKSTPTAEDVTAP CCCCCCCCHHHCCCC	42.65	28985074
71 (in isoform 4)	Phosphorylation	-	42.65	25307156
71 (in isoform 7)	Phosphorylation	-	42.65	25307156
73 (in isoform 2)	Phosphorylation	-	56.33	17287340
73 (in isoform 6)	Phosphorylation	-	56.33	17287340
77 (in isoform 2)	Phosphorylation	-	8.69	17287340
77 (in isoform 6)	Phosphorylation	-	8.69	17287340
79 (in isoform 2)	Phosphorylation	-	7.61	16674116
79 (in isoform 6)	Phosphorylation	-	7.61	16674116
82 (in isoform 4)	Phosphorylation	-	50.18	28450419
82 (in isoform 7)	Phosphorylation	-	50.18	28450419
84 (in isoform 4)	Phosphorylation	-	13.97	25849741
84 (in isoform 7)	Phosphorylation	-	13.97	25849741
87	Glycation	VDEGAPGKQAAAQPH CCCCCCCCCCCCCCC	35.39	-
87	N-linked_Glycosylation	VDEGAPGKQAAAQPH CCCCCCCCCCCCCCC	35.39	9326300
91 (in isoform 2)	Phosphorylation	-	26.84	-
91 (in isoform 6)	Phosphorylation	-	26.84	-
94 (in isoform 4)	Phosphorylation	-	24.85	28450419
94 (in isoform 7)	Phosphorylation	-	24.85	28450419
95	Phosphorylation	QAAAQPHTEIPEGTT CCCCCCCCCCCCCCC	42.15	9614189
95 (in isoform 2)	Phosphorylation	-	42.15	25849741
95 (in isoform 6)	Phosphorylation	-	42.15	25849741
101	Phosphorylation	HTEIPEGTTAEEAGI CCCCCCCCCHHHCCC	22.59	-
102	Phosphorylation	TEIPEGTTAEEAGIG CCCCCCCCHHHCCCC	42.82	-
102 (in isoform 4)	Phosphorylation	-	42.82	17287340
102 (in isoform 7)	Phosphorylation	-	42.82	17287340
106 (in isoform 4)	Phosphorylation	-	13.35	17287340
106 (in isoform 7)	Phosphorylation	-	13.35	17287340
108 (in isoform 4)	Phosphorylation	-	6.10	16674116
108 (in isoform 7)	Phosphorylation	-	6.10	16674116
111	Phosphorylation	EEAGIGDTPSLEDEA HHCCCCCCCCHHHHH	15.01	-
111 (in isoform 5)	Phosphorylation	-	15.01	27732954
111 (in isoform 8)	Phosphorylation	-	15.01	27732954
113	Phosphorylation	AGIGDTPSLEDEAAG CCCCCCCCHHHHHCC	46.62	28985074
113 (in isoform 5)	Phosphorylation	-	46.62	27732954
113 (in isoform 8)	Phosphorylation	-	46.62	27732954
120 (in isoform 4)	Phosphorylation	-	23.89	-
120 (in isoform 7)	Phosphorylation	-	23.89	-
123	Phosphorylation	DEAAGHVTQEPESGK HHHCCCCCCCCCCCC	22.88	18510355
123 (in isoform 5)	Phosphorylation	-	22.88	27050516
123 (in isoform 8)	O-linked_Glycosylation	-	22.88	15249677
123 (in isoform 8)	Phosphorylation	-	22.88	27050516
124 (in isoform 4)	Phosphorylation	-	64.26	25849741
124 (in isoform 7)	Phosphorylation	-	64.26	25849741
131 (in isoform 5)	Phosphorylation	-	6.48	17287340
131 (in isoform 8)	Phosphorylation	-	6.48	17287340
135 (in isoform 5)	Phosphorylation	-	15.14	17287340
135 (in isoform 8)	Phosphorylation	-	15.14	17287340
137 (in isoform 5)	Phosphorylation	-	9.97	16674116
137 (in isoform 8)	Phosphorylation	-	9.97	16674116
148 (in isoform 8)	Acetylation	-	35.17	-
149 (in isoform 5)	Phosphorylation	-	2.17	-
149 (in isoform 8)	Phosphorylation	-	2.17	-
150 (in isoform 8)	Acetylation	-	2.34	-
153 (in isoform 5)	Phosphorylation	-	1.86	25849741
153 (in isoform 8)	Phosphorylation	-	1.86	25849741
163 (in isoform 8)	Acetylation	-	29.31	-
167	Phosphorylation	PEGPREATRQPSGTG CCCCCCCCCCCCCCC	25.69	26699800
169 (in isoform 3)	Phosphorylation	-	31.96	25849741
171	Phosphorylation	REATRQPSGTGPEDT CCCCCCCCCCCCCCC	40.42	26699800
173	Phosphorylation	ATRQPSGTGPEDTEG CCCCCCCCCCCCCCC	54.63	9199504
174 (in isoform 8)	Acetylation	-	27.42	-
180 (in isoform 8)	Acetylation	-	40.29	-
185 (in isoform 8)	O-linked_Glycosylation	-	27.00	15249677
190 (in isoform 8)	Acetylation	-	24.40	-
191 (in isoform 8)	O-linked_Glycosylation	-	36.47	15249677
199 (in isoform 8)	O-linked_Glycosylation	-	64.02	15249677
202 (in isoform 8)	O-linked_Glycosylation	-	58.52	15249677
205 (in isoform 2)	Phosphorylation	-	36.82	25849741
205 (in isoform 8)	O-linked_Glycosylation	-	36.82	15249677
208 (in isoform 8)	O-linked_Glycosylation	-	28.28	15249677
212 (in isoform 8)	O-linked_Glycosylation	-	53.12	15249677
214	Phosphorylation	GGKERPGSKEEVDED CCCCCCCCHHHCCCC	39.31	12435421
214 (in isoform 8)	O-linked_Glycosylation	-	39.31	15249677
217 (in isoform 8)	O-linked_Glycosylation	-	60.03	15249677
227	Phosphorylation	EDRDVDESSPQDSPP CCCCCCCCCCCCCCC	42.74	25849741
228	Phosphorylation	DRDVDESSPQDSPPS CCCCCCCCCCCCCCC	25.24	25849741
232	Phosphorylation	DESSPQDSPPSKASP CCCCCCCCCCCCCCC	33.20	25849741
234 (in isoform 4)	Phosphorylation	-	53.03	25849741
234 (in isoform 8)	Acetylation	-	53.03	-
235	Phosphorylation	SPQDSPPSKASPAQD CCCCCCCCCCCCCCC	44.21	20068231
237 (in isoform 8)	Phosphorylation	-	25.69	8999860
238	Phosphorylation	DSPPSKASPAQDGRP CCCCCCCCCCCCCCC	25.22	20068231
238 (in isoform 8)	O-linked_Glycosylation	-	25.22	15249677
240 (in isoform 8)	Acetylation	-	20.01	-
248	Phosphorylation	QDGRPPQTAAREATS CCCCCCCCHHHHHCC	28.23	24114839
254 (in isoform 8)	Acetylation	-	23.57	-
257 (in isoform 8)	Acetylation	-	37.83	-
259 (in isoform 8)	Acetylation	-	4.32	-
262 (in isoform 8)	O-linked_Glycosylation	-	49.77	15249677
262 (in isoform 8)	Phosphorylation	-	49.77	8999860
263 (in isoform 5)	Phosphorylation	-	30.80	25849741
263 (in isoform 8)	O-linked_Glycosylation	-	30.80	15249677
267 (in isoform 8)	Acetylation	-	5.44	-
274 (in isoform 8)	Acetylation	-	42.21	-
280 (in isoform 8)	Acetylation	-	24.41	-
281 (in isoform 8)	Acetylation	-	31.99	-
285 (in isoform 8)	Phosphorylation	-	77.05	8999860
290 (in isoform 8)	Acetylation	-	28.32	-
298 (in isoform 8)	Acetylation	-	40.49	-
305 (in isoform 8)	Phosphorylation	-	5.07	8999860
311 (in isoform 8)	Acetylation	-	10.15	-
317 (in isoform 8)	Acetylation	-	35.12	-
318	Phosphorylation	VQKEQAHSEEHLGRA CCHHHCCCHHHHHCC	47.93	26437602
321 (in isoform 8)	Acetylation	-	29.54	-
331 (in isoform 8)	Acetylation	-	47.48	-
341	Phosphorylation	GPEARGPSLGEDTKE CCCCCCCCCCCCCCC	52.40	26437602
352 (in isoform 8)	Phosphorylation	-	52.58	8999860
353 (in isoform 8)	Acetylation	-	69.61	-
355	Phosphorylation	EADLPEPSEKQPAAA CCCCCCCCCCCCCCC	56.62	12387894
369	Phosphorylation	APRGKPVSRVPQLKA CCCCCCCCCCCHHHH	35.77	29978859
369 (in isoform 8)	Acetylation	-	35.77	-
370 (in isoform 8)	Acetylation	-	44.35	-
382	Phosphorylation	KARMVSKSKDGTGSD HHHEECCCCCCCCCC	28.59	-
383	Glycation	ARMVSKSKDGTGSDD HHEECCCCCCCCCCC	65.01	-
383	N-linked_Glycosylation	ARMVSKSKDGTGSDD HHEECCCCCCCCCCC	65.01	9326300
383 (in isoform 8)	Acetylation	-	65.01	-
385 (in isoform 8)	Acetylation	-	35.39	-
386	Phosphorylation	VSKSKDGTGSDDKKA ECCCCCCCCCCCHHC	43.58	17287340
388	Phosphorylation	KSKDGTGSDDKKAKT CCCCCCCCCCHHCCC	42.34	-
395 (in isoform 8)	Acetylation	-	39.94	-
396	Phosphorylation	DDKKAKTSTRSSAKT CCHHCCCCCHHHHHH	22.55	9565682
396 (in isoform 8)	O-linked_Glycosylation	-	22.55	15249677
400	O-linked_Glycosylation	AKTSTRSSAKTLKNR CCCCCHHHHHHHCCC	30.41	15249677
400	Phosphorylation	AKTSTRSSAKTLKNR CCCCCHHHHHHHCCC	30.41	19413330
403	Phosphorylation	STRSSAKTLKNRPCL CCHHHHHHHCCCCCC	42.56	20068231
404 (in isoform 8)	O-linked_Glycosylation	-	4.57	15249677
411	Phosphorylation	LKNRPCLSPKHPTPG HCCCCCCCCCCCCCC	38.32	29116813
412 (in isoform 8)	O-linked_Glycosylation	-	26.48	15249677
413 (in isoform 8)	O-linked_Glycosylation	-	59.86	15249677
416	Phosphorylation	CLSPKHPTPGSSDPL CCCCCCCCCCCCCCC	39.75	26552605
419	Phosphorylation	PKHPTPGSSDPLIQP CCCCCCCCCCCCCCC	32.54	26552605
420	Phosphorylation	KHPTPGSSDPLIQPS CCCCCCCCCCCCCCC	49.52	26552605
422 (in isoform 8)	O-linked_Glycosylation	-	33.05	15249677
427	Phosphorylation	SDPLIQPSSPAVCPE CCCCCCCCCCCCCCC	32.36	28450419
428	Phosphorylation	DPLIQPSSPAVCPEP CCCCCCCCCCCCCCC	24.46	30278072
437	Phosphorylation	AVCPEPPSSPKYVSS CCCCCCCCCCCCEEC	70.73	30278072
438	Phosphorylation	VCPEPPSSPKYVSSV CCCCCCCCCCCEECC	31.05	30278072
447	Phosphorylation	KYVSSVTSRTGSSGA CCEECCEECCCCCCC	26.20	29116813
449	Phosphorylation	VSSVTSRTGSSGAKE EECCEECCCCCCCCE	40.98	-
451	Phosphorylation	SVTSRTGSSGAKEMK CCEECCCCCCCCEEE	25.61	-
466	Phosphorylation	LKGADGKTKIATPRG EECCCCCCEECCCCC	32.96	-
467	Acetylation	KGADGKTKIATPRGA ECCCCCCEECCCCCC	33.55	20869593
467	Glycation	KGADGKTKIATPRGA ECCCCCCEECCCCCC	33.55	-
467	N-linked_Glycosylation	KGADGKTKIATPRGA ECCCCCCEECCCCCC	33.55	9326300
470	Phosphorylation	DGKTKIATPRGAAPP CCCCEECCCCCCCCC	19.59	25849741
472	Methylation	KTKIATPRGAAPPGQ CCEECCCCCCCCCCC	42.92	-
480	"N6,N6-dimethyllysine"	GAAPPGQKGQANATR CCCCCCCCCCCCCCC	59.93	-
480	Acetylation	GAAPPGQKGQANATR CCCCCCCCCCCCCCC	59.93	20869593
480	Glycation	GAAPPGQKGQANATR CCCCCCCCCCCCCCC	59.93	-
480	Methylation	GAAPPGQKGQANATR CCCCCCCCCCCCCCC	59.93	-
480	N-linked_Glycosylation	GAAPPGQKGQANATR CCCCCCCCCCCCCCC	59.93	9326300
484	Deamidated asparagine	PGQKGQANATRIPAK CCCCCCCCCCCCCCC	33.68	-
484	Deamidation	PGQKGQANATRIPAK CCCCCCCCCCCCCCC	33.68	1512244
486	Phosphorylation	QKGQANATRIPAKTP CCCCCCCCCCCCCCC	29.01	23532336
491	Acetylation	NATRIPAKTPPAPKT CCCCCCCCCCCCCCC	57.10	20869593
491	Glycation	NATRIPAKTPPAPKT CCCCCCCCCCCCCCC	57.10	-
491	N-linked_Glycosylation	NATRIPAKTPPAPKT CCCCCCCCCCCCCCC	57.10	9326300
492	Phosphorylation	ATRIPAKTPPAPKTP CCCCCCCCCCCCCCC	36.29	25159151
497	Acetylation	AKTPPAPKTPPSSGE CCCCCCCCCCCCCCC	75.63	20869593
498	Phosphorylation	KTPPAPKTPPSSGEP CCCCCCCCCCCCCCC	39.10	30266825
501	Phosphorylation	PAPKTPPSSGEPPKS CCCCCCCCCCCCCCC	52.78	30266825
502	Phosphorylation	APKTPPSSGEPPKSG CCCCCCCCCCCCCCC	53.61	30266825
507	Acetylation	PSSGEPPKSGDRSGY CCCCCCCCCCCCCCC	77.20	20869593
508	Phosphorylation	SSGEPPKSGDRSGYS CCCCCCCCCCCCCCC	52.26	29116813
512	Phosphorylation	PPKSGDRSGYSSPGS CCCCCCCCCCCCCCC	46.99	21945579
514	Phosphorylation	KSGDRSGYSSPGSPG CCCCCCCCCCCCCCC	13.76	21945579
515	Phosphorylation	SGDRSGYSSPGSPGT CCCCCCCCCCCCCCC	33.31	21945579
516	Phosphorylation	GDRSGYSSPGSPGTP CCCCCCCCCCCCCCC	25.46	25159151
519	Phosphorylation	SGYSSPGSPGTPGSR CCCCCCCCCCCCCCC	24.44	25159151
522	Phosphorylation	SSPGSPGTPGSRSRT CCCCCCCCCCCCCCC	28.06	23927012
525	O-linked_Glycosylation	GSPGTPGSRSRTPSL CCCCCCCCCCCCCCC	28.43	15249677
525	Phosphorylation	GSPGTPGSRSRTPSL CCCCCCCCCCCCCCC	28.43	21945579
527	Phosphorylation	PGTPGSRSRTPSLPT CCCCCCCCCCCCCCC	42.05	25159151
529	Phosphorylation	TPGSRSRTPSLPTPP CCCCCCCCCCCCCCC	20.62	25159151
531	Phosphorylation	GSRSRTPSLPTPPTR CCCCCCCCCCCCCCC	46.50	25159151
534	Phosphorylation	SRTPSLPTPPTREPK CCCCCCCCCCCCCCC	47.39	9199504
537	Phosphorylation	PSLPTPPTREPKKVA CCCCCCCCCCCCEEE	49.20	25159151
542	Acetylation	PPTREPKKVAVVRTP CCCCCCCEEEEEECC	46.25	-
542	Glycation	PPTREPKKVAVVRTP CCCCCCCEEEEEECC	46.25	-
542	N-linked_Glycosylation	PPTREPKKVAVVRTP CCCCCCCEEEEEECC	46.25	9326300
548	Phosphorylation	KKVAVVRTPPKSPSS CEEEEEECCCCCCCH	32.12	20201521
551	Acetylation	AVVRTPPKSPSSAKS EEEECCCCCCCHHHH	75.98	20869593
551	Glycation	AVVRTPPKSPSSAKS EEEECCCCCCCHHHH	75.98	-
551	N-linked_Glycosylation	AVVRTPPKSPSSAKS EEEECCCCCCCHHHH	75.98	9326300
552	Phosphorylation	VVRTPPKSPSSAKSR EEECCCCCCCHHHHH	35.47	20201521
554	Phosphorylation	RTPPKSPSSAKSRLQ ECCCCCCCHHHHHHH	50.44	30278072
555	O-linked_Glycosylation	TPPKSPSSAKSRLQT CCCCCCCHHHHHHHC	43.00	15249677
555	Phosphorylation	TPPKSPSSAKSRLQT CCCCCCCHHHHHHHC	43.00	30278072
557	Acetylation	PKSPSSAKSRLQTAP CCCCCHHHHHHHCCC	37.75	21427723
558	Phosphorylation	KSPSSAKSRLQTAPV CCCCHHHHHHHCCCC	37.63	20068231
562	Phosphorylation	SAKSRLQTAPVPMPD HHHHHHHCCCCCCCC	37.20	27251275
567	Sulfoxidation	LQTAPVPMPDLKNVK HHCCCCCCCCHHCCH	4.03	21406390
571	Acetylation	PVPMPDLKNVKSKIG CCCCCCHHCCHHHCC	68.05	20869593
571	Ubiquitination	PVPMPDLKNVKSKIG CCCCCCHHCCHHHCC	68.05	16443603
574	Acetylation	MPDLKNVKSKIGSTE CCCHHCCHHHCCCCC	56.26	20869593
575	Phosphorylation	PDLKNVKSKIGSTEN CCHHCCHHHCCCCCC	25.81	12714590
576	Acetylation	DLKNVKSKIGSTENL CHHCCHHHCCCCCCC	45.42	20869593
576	Glycation	DLKNVKSKIGSTENL CHHCCHHHCCCCCCC	45.42	-
576	Methylation	DLKNVKSKIGSTENL CHHCCHHHCCCCCCC	45.42	-
576	N-linked_Glycosylation	DLKNVKSKIGSTENL CHHCCHHHCCCCCCC	45.42	9326300
579	Phosphorylation	NVKSKIGSTENLKHQ CCHHHCCCCCCCCCC	35.70	30266825
580	Phosphorylation	VKSKIGSTENLKHQP CHHHCCCCCCCCCCC	24.55	30266825
584	Acetylation	IGSTENLKHQPGGGK CCCCCCCCCCCCCCC	52.34	20869593
591	Acetylation	KHQPGGGKVQIINKK CCCCCCCCEEEECCE	33.95	20869593
596	Deamidated asparagine	GGKVQIINKKLDLSN CCCEEEECCEECHHH	36.72	-
596	Deamidation	GGKVQIINKKLDLSN CCCEEEECCEECHHH	36.72	1512244
597	Acetylation	GKVQIINKKLDLSNV CCEEEECCEECHHHH	44.28	20869593
597	Glycation	GKVQIINKKLDLSNV CCEEEECCEECHHHH	44.28	-
597	N-linked_Glycosylation	GKVQIINKKLDLSNV CCEEEECCEECHHHH	44.28	9326300
598	Acetylation	KVQIINKKLDLSNVQ CEEEECCEECHHHHH	42.62	20869593
598	Glycation	KVQIINKKLDLSNVQ CEEEECCEECHHHHH	42.62	-
598	N-linked_Glycosylation	KVQIINKKLDLSNVQ CEEEECCEECHHHHH	42.62	9326300
602	Phosphorylation	INKKLDLSNVQSKCG ECCEECHHHHHHHCC	34.32	25159151
606	Phosphorylation	LDLSNVQSKCGSKDN ECHHHHHHHCCCCCC	26.15	19060867
607	Acetylation	DLSNVQSKCGSKDNI CHHHHHHHCCCCCCC	26.06	20869593
610	Phosphorylation	NVQSKCGSKDNIKHV HHHHHCCCCCCCEEC	46.43	7706316
611	Methylation	VQSKCGSKDNIKHVP HHHHCCCCCCCEECC	39.83	-
615	Acetylation	CGSKDNIKHVPGGGS CCCCCCCEECCCCCC	44.82	20869593
622	Phosphorylation	KHVPGGGSVQIVYKP EECCCCCCEEEEEEC	17.70	25307156
627	Phosphorylation	GGSVQIVYKPVDLSK CCCEEEEEECCCHHH	15.94	29978859
628	"N6,N6-dimethyllysine"	GSVQIVYKPVDLSKV CCEEEEEECCCHHHH	27.89	-
628	Acetylation	GSVQIVYKPVDLSKV CCEEEEEECCCHHHH	27.89	23954790
628	Methylation	GSVQIVYKPVDLSKV CCEEEEEECCCHHHH	27.89	-
628	Ubiquitination	GSVQIVYKPVDLSKV CCEEEEEECCCHHHH	27.89	16443603
633	Phosphorylation	VYKPVDLSKVTSKCG EEECCCHHHHHHCCC	22.18	30622161
634	Acetylation	YKPVDLSKVTSKCGS EECCCHHHHHHCCCC	57.75	20869593
636	Phosphorylation	PVDLSKVTSKCGSLG CCCHHHHHHCCCCCC	26.63	-
637	Phosphorylation	VDLSKVTSKCGSLGN CCHHHHHHCCCCCCC	29.01	9199504
638	Acetylation	DLSKVTSKCGSLGNI CHHHHHHCCCCCCCC	33.00	20869593
641	Phosphorylation	KVTSKCGSLGNIHHK HHHHCCCCCCCCCCC	42.44	7931292
648	Acetylation	SLGNIHHKPGGGQVE CCCCCCCCCCCCCEE	31.06	20869593
657	Sumoylation	GGGQVEVKSEKLDFK CCCCEEEEEEECCHH	39.12	-
658	Phosphorylation	GGQVEVKSEKLDFKD CCCEEEEEEECCHHH	45.18	-
660	Acetylation	QVEVKSEKLDFKDRV CEEEEEEECCHHHHH	61.52	-
664	Acetylation	KSEKLDFKDRVQSKI EEEECCHHHHHHHHH	44.27	-
664	Glycation	KSEKLDFKDRVQSKI EEEECCHHHHHHHHH	44.27	-
664	N-linked_Glycosylation	KSEKLDFKDRVQSKI EEEECCHHHHHHHHH	44.27	9326300
666	Methylation	EKLDFKDRVQSKIGS EECCHHHHHHHHHCC	29.03	-
669	Phosphorylation	DFKDRVQSKIGSLDN CHHHHHHHHHCCCCC	24.31	11104762
670	Acetylation	FKDRVQSKIGSLDNI HHHHHHHHHCCCCCC	33.71	20869593
670	Glycation	FKDRVQSKIGSLDNI HHHHHHHHHCCCCCC	33.71	-
670	N-linked_Glycosylation	FKDRVQSKIGSLDNI HHHHHHHHHCCCCCC	33.71	9326300
670	Ubiquitination	FKDRVQSKIGSLDNI HHHHHHHHHCCCCCC	33.71	16443603
673	Phosphorylation	RVQSKIGSLDNITHV HHHHHHCCCCCCEEC	35.70	25159151
678	Phosphorylation	IGSLDNITHVPGGGN HCCCCCCEECCCCCC	24.07	26330541
686	Acetylation	HVPGGGNKKIETHKL ECCCCCCCCCEEEEC	59.40	25953088
686	Glycation	HVPGGGNKKIETHKL ECCCCCCCCCEEEEC	59.40	-
686	N-linked_Glycosylation	HVPGGGNKKIETHKL ECCCCCCCCCEEEEC	59.40	9326300
687	Acetylation	VPGGGNKKIETHKLT CCCCCCCCCEEEECC	50.18	20869593
690	Phosphorylation	GGNKKIETHKLTFRE CCCCCCEEEECCHHH	27.99	12387894
694	Phosphorylation	KIETHKLTFRENAKA CCEEEECCHHHHCCC	26.00	28857561
700	Acetylation	LTFRENAKAKTDHGA CCHHHHCCCCCCCCC	63.10	20869593
702	Acetylation	FRENAKAKTDHGAEI HHHHCCCCCCCCCEE	54.50	20869593
703	Phosphorylation	RENAKAKTDHGAEIV HHHCCCCCCCCCEEE	37.78	30278072
711	Phosphorylation	DHGAEIVYKSPVVSG CCCCEEEEECCCCCC	16.06	21945579
712	Acetylation	HGAEIVYKSPVVSGD CCCEEEEECCCCCCC	37.07	20869593
713	Phosphorylation	GAEIVYKSPVVSGDT CCEEEEECCCCCCCC	12.77	29255136
717	O-linked_Glycosylation	VYKSPVVSGDTSPRH EEECCCCCCCCCCCH	31.05	15249677
717	Phosphorylation	VYKSPVVSGDTSPRH EEECCCCCCCCCCCH	31.05	29255136
720	Phosphorylation	SPVVSGDTSPRHLSN CCCCCCCCCCCHHCC	44.12	29255136
721	Phosphorylation	PVVSGDTSPRHLSNV CCCCCCCCCCHHCCC	25.36	29255136
726	Phosphorylation	DTSPRHLSNVSSTGS CCCCCHHCCCCCCCC	29.12	30278072
729	Phosphorylation	PRHLSNVSSTGSIDM CCHHCCCCCCCCCCC	26.83	30278072
730	Phosphorylation	RHLSNVSSTGSIDMV CHHCCCCCCCCCCCC	32.29	30278072
731	Phosphorylation	HLSNVSSTGSIDMVD HHCCCCCCCCCCCCC	27.69	30278072
733	Phosphorylation	SNVSSTGSIDMVDSP CCCCCCCCCCCCCCH	18.59	30278072
739	Phosphorylation	GSIDMVDSPQLATLA CCCCCCCCHHHHHHH	11.79	25159151
744	Phosphorylation	VDSPQLATLADEVSA CCCHHHHHHHHHHHH	30.94	15365985
750	Phosphorylation	ATLADEVSASLAKQG HHHHHHHHHHHHHCC	15.30	27732954
752	Phosphorylation	LADEVSASLAKQGL- HHHHHHHHHHHCCC-	22.73	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
18	Y	Phosphorylation	Kinase	FYN	P06241	Uniprot
18	Y	Phosphorylation	Kinase	FYN	P06241	PSP
18	Y	Phosphorylation	Kinase	SYK	P43405	PSP
18	Y	Phosphorylation	Kinase	SYK	P43405	GPS
18	Y	Phosphorylation	Kinase	SRC	P12931	PSP
39	T	Phosphorylation	Kinase	CSNK2A1	P68399	GPS
46	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
46	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
46	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
50	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
50	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
50	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
50	T	Phosphorylation	Kinase	MAPK11	Q15759	GPS
50	T	Phosphorylation	Kinase	MAPK12	P53778	GPS
50	T	Phosphorylation	Kinase	MAPK13	O15264	GPS
50	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
69	T	Phosphorylation	Kinase	MAPK11	Q15759	GPS
69	T	Phosphorylation	Kinase	MAPK12	P53778	GPS
69	T	Phosphorylation	Kinase	MAPK13	O15264	GPS
69	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
111	T	Phosphorylation	Kinase	MAPK11	Q15759	GPS
111	T	Phosphorylation	Kinase	MAPK12	P53778	GPS
149	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
153	T	Phosphorylation	Kinase	CDK1	P06493	PSP
153	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
153	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
153	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
153	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
153	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
153	T	Phosphorylation	Kinase	MAPK11	Q15759	GPS
153	T	Phosphorylation	Kinase	MAPK12	P53778	GPS
153	T	Phosphorylation	Kinase	MAPK13	O15264	GPS
153	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
156	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
169	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
173	T	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
173	T	Phosphorylation	Kinase	CAMK2A	P11275	PSP
173	T	Phosphorylation	Kinase	PRKCA	P05696	GPS
175	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
175	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
175	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
177	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
177	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
177	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
181	T	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
181	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
181	T	Phosphorylation	Kinase	CDK5	P49615	PSP
181	T	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
181	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
181	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
181	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
181	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
181	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
181	T	Phosphorylation	Kinase	MAPK9	P45984	GPS
181	T	Phosphorylation	Kinase	MAPK11	Q15759	GPS
181	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
181	T	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
184	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
184	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
191	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
195	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
195	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
195	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
195	S	Phosphorylation	Kinase	MAPK12	P53778	GPS
195	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
195	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
197	Y	Phosphorylation	Kinase	ABL2	P42684	GPS
197	Y	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
198	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
198	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
198	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
198	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
198	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
199	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
199	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
199	S	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
199	S	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
199	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
199	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
199	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
199	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
199	S	Phosphorylation	Kinase	MAPK11	Q15759	GPS
199	S	Phosphorylation	Kinase	MAPK12	P53778	GPS
199	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
199	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
199	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
199	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
202	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
202	S	Phosphorylation	Kinase	CDK1	P06493	PSP
202	S	Phosphorylation	Kinase	CDK2	P24941	PSP
202	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
202	S	Phosphorylation	Kinase	CDK5	P49615	PSP
202	S	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
202	S	Phosphorylation	Kinase	DYRK1A	Q61214	PSP
202	S	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
202	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
202	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
202	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
202	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
202	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
202	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
202	S	Phosphorylation	Kinase	MAPK9	P45984	GPS
202	S	Phosphorylation	Kinase	MAPK11	Q15759	GPS
202	S	Phosphorylation	Kinase	MAPK12	P53778	GPS
202	S	Phosphorylation	Kinase	MAPK13	O15264	GPS
202	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
202	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
202	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
202	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
205	T	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
205	T	Phosphorylation	Kinase	CDK1	P06493	PSP
205	T	Phosphorylation	Kinase	CDK2	P24941	PSP
205	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
205	T	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
205	T	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
205	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
205	T	Phosphorylation	Kinase	PRKACA	P00517	GPS
205	T	Phosphorylation	Kinase	CSNK1D	P48730	GPS
205	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
205	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
205	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
205	T	Phosphorylation	Kinase	MAPK11	Q15759	GPS
205	T	Phosphorylation	Kinase	MAPK12	P53778	GPS
205	T	Phosphorylation	Kinase	MAPK13	O15264	GPS
205	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
205	T	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
205	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
208	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
210	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
212	T	Phosphorylation	Kinase	AKT1	P31749	GPS
212	T	Phosphorylation	Kinase	CDK1	P06493	PSP
212	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
212	T	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
212	T	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
212	T	Phosphorylation	Kinase	DYRK2	Q92630	PSP
212	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
212	T	Phosphorylation	Kinase	RPS6KB1	P23443	GPS
212	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
212	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
212	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
212	T	Phosphorylation	Kinase	MAPK9	P45984	GPS
212	T	Phosphorylation	Kinase	MAPK11	Q15759	GPS
212	T	Phosphorylation	Kinase	MAPK12	P53778	GPS
212	T	Phosphorylation	Kinase	MAPK13	O15264	GPS
212	T	Phosphorylation	Kinase	P70-SUBFAMILY	-	GPS
214	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
214	S	Phosphorylation	Kinase	AKT1	P31749	GPS
214	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
214	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
214	S	Phosphorylation	Kinase	PKACA	P17612	PSP
214	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
214	S	Phosphorylation	Kinase	RPS6KB1	P23443	GPS
214	S	Phosphorylation	Kinase	PKN1	Q16512	PSP
214	S	Phosphorylation	Kinase	SGK1	O00141	Uniprot
214	S	Phosphorylation	Kinase	SGK1	O00141	PSP
214	S	Phosphorylation	Kinase	SRPK2	P78362	PSP
214	S	Phosphorylation	Kinase	P70-SUBFAMILY	-	GPS
214	S	Phosphorylation	Kinase	PKN-FAMILY	-	GPS
217	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
217	T	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
217	T	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
217	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
217	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
217	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
217	T	Phosphorylation	Kinase	MAPK9	P45984	GPS
217	T	Phosphorylation	Kinase	MAPK11	Q15759	GPS
217	T	Phosphorylation	Kinase	MAPK13	O15264	GPS
217	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
220	T	Phosphorylation	Kinase	MAPK13	O15264	GPS
220	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
231	T	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
231	T	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
231	T	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
231	T	Phosphorylation	Kinase	CDK1	P06493	PSP
231	T	Phosphorylation	Kinase	CDK2	P24941	PSP
231	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
231	T	Phosphorylation	Kinase	CDK5	P49615	PSP
231	T	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
231	T	Phosphorylation	Kinase	GSK3A	P49840	PSP
231	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
231	T	Phosphorylation	Kinase	PRKACA	P00517	GPS
231	T	Phosphorylation	Kinase	CAMK2A	P11275	PSP
231	T	Phosphorylation	Kinase	CAMK2A	P11275	PSP
231	T	Phosphorylation	Kinase	PRKCA	P05696	GPS
231	T	Phosphorylation	Kinase	PRKCA	P05696	GPS
231	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
231	T	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
231	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
231	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
231	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
231	T	Phosphorylation	Kinase	MAPK9	P45984	GPS
231	T	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
231	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
235	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
235	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
235	S	Phosphorylation	Kinase	CDK1	P06493	PSP
235	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
235	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
235	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
235	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
235	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
235	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
235	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
235	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
235	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
235	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
235	S	Phosphorylation	Kinase	MAPK11	Q15759	GPS
235	S	Phosphorylation	Kinase	MAPK12	P53778	GPS
235	S	Phosphorylation	Kinase	MAPK13	O15264	GPS
235	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
235	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
235	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
237	S	Phosphorylation	Kinase	PHK-FAMILY	-	GPS
237	S	Phosphorylation	Kinase	PHK_GROUP	-	PhosphoELM
245	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
258	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
258	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
258	S	Phosphorylation	Kinase	PKCB ISO2	P05771-2	PSP
258	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
258	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
258	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
258	S	Phosphorylation	Kinase	PRKCI	P41743	GPS
258	S	Phosphorylation	Kinase	PRKCQ	Q04759	GPS
258	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
258	S	Phosphorylation	Kinase	PKN1	Q16512	PSP
258	S	Phosphorylation	Kinase	PKN-FAMILY	-	GPS
262	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
262	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
262	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
262	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
262	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
262	S	Phosphorylation	Kinase	EIF2AK2	P19525	GPS
262	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
262	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
262	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
262	S	Phosphorylation	Kinase	PKACA	P17612	PSP
262	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
262	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
262	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
262	S	Phosphorylation	Kinase	RPS6KB1	P23443	GPS
262	S	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
262	S	Phosphorylation	Kinase	MARK1	O08678	PSP
262	S	Phosphorylation	Kinase	MARK2	Q7KZI7	PSP
262	S	Phosphorylation	Kinase	MARK2	O08679	PSP
262	S	Phosphorylation	Kinase	NUAK1	O60285	PSP
262	S	Phosphorylation	Kinase	PHKG1	P00518	PSP
262	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
262	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
262	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
262	S	Phosphorylation	Kinase	P70-SUBFAMILY	-	GPS
262	S	Phosphorylation	Kinase	PHK-FAMILY	-	GPS
262	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
262	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
262	S	Phosphorylation	Kinase	PHK_GROUP	-	PhosphoELM
263	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
267	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
285	S	Phosphorylation	Kinase	PHK-FAMILY	-	GPS
285	S	Phosphorylation	Kinase	PHK_GROUP	-	PhosphoELM
293	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
293	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
293	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
293	S	Phosphorylation	Kinase	PKCB ISO2	P05771-2	PSP
293	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
293	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
293	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
293	S	Phosphorylation	Kinase	PRKCI	P41743	GPS
293	S	Phosphorylation	Kinase	PRKCQ	Q04759	GPS
293	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
293	S	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
293	S	Phosphorylation	Kinase	MARK1	O08678	PSP
293	S	Phosphorylation	Kinase	MARK2	O08679	PSP
305	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
305	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
305	S	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
305	S	Phosphorylation	Kinase	PHK-FAMILY	-	GPS
305	S	Phosphorylation	Kinase	PHK_GROUP	-	PhosphoELM
307	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
307	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
307	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
310	Y	Phosphorylation	Kinase	ABL2	P42684	GPS
315	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
315	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
315	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
316	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
320	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
320	S	Phosphorylation	Kinase	PKACA	P17612	PSP
320	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
320	S	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
320	S	Phosphorylation	Kinase	PKN1	Q16512	PSP
320	S	Phosphorylation	Kinase	PKN-FAMILY	-	GPS
324	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
324	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
324	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
324	S	Phosphorylation	Kinase	PKCB ISO2	P05771-2	PSP
324	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
324	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
324	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
324	S	Phosphorylation	Kinase	PRKCI	P41743	GPS
324	S	Phosphorylation	Kinase	PRKCQ	Q04759	GPS
324	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
324	S	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
324	S	Phosphorylation	Kinase	MARK1	O08678	PSP
324	S	Phosphorylation	Kinase	MARK2	Q7KZI7	PSP
324	S	Phosphorylation	Kinase	MARK2	O08679	PSP
325	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
325	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
338	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
338	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
338	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
346	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
346	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
346	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
352	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
352	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
352	S	Phosphorylation	Kinase	PKCB ISO2	P05771-2	PSP
352	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
352	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
352	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
352	S	Phosphorylation	Kinase	PRKCI	P41743	GPS
352	S	Phosphorylation	Kinase	PRKCQ	Q04759	GPS
352	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
352	S	Phosphorylation	Kinase	PKN1	Q16512	PSP
352	S	Phosphorylation	Kinase	PHK-FAMILY	-	GPS
352	S	Phosphorylation	Kinase	PKN-FAMILY	-	GPS
352	S	Phosphorylation	Kinase	PHK_GROUP	-	PhosphoELM
356	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
356	S	Phosphorylation	Kinase	EIF2AK2	P19525	GPS
356	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
356	S	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
356	S	Phosphorylation	Kinase	MARK1	O08678	PSP
356	S	Phosphorylation	Kinase	MARK2	Q7KZI7	PSP
356	S	Phosphorylation	Kinase	MARK2	O08679	PSP
356	S	Phosphorylation	Kinase	NUAK1	O60285	PSP
356	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
356	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
356	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
356	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
365	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
365	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
365	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
369	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
373	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
373	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
373	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
373	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
394	Y	Phosphorylation	Kinase	ABL2	P42684	GPS
394	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS
396	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
396	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
396	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
396	S	Phosphorylation	Kinase	CDK5	P49615	PSP
396	S	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
396	S	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
396	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
396	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
396	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
396	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
396	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
396	S	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
396	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
396	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
396	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
396	S	Phosphorylation	Kinase	MAPK11	Q15759	GPS
396	S	Phosphorylation	Kinase	MAPK12	P53778	GPS
396	S	Phosphorylation	Kinase	MAPK13	O15264	GPS
396	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
396	S	Phosphorylation	Kinase	TTBK2	Q6IQ55	GPS
400	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
400	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
404	S	Phosphorylation	Kinase	GSK3A	A6QLB8	PSP
404	S	Phosphorylation	Kinase	CDK1	P06493	PSP
404	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
404	S	Phosphorylation	Kinase	CDK5	P49615	PSP
404	S	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
404	S	Phosphorylation	Kinase	DYRK1A	Q61214	PSP
404	S	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
404	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
404	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
404	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
404	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
404	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
404	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
404	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
404	S	Phosphorylation	Kinase	MAPK11	Q15759	GPS
404	S	Phosphorylation	Kinase	MAPK12	P53778	GPS
404	S	Phosphorylation	Kinase	MAPK13	O15264	GPS
404	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
404	S	Phosphorylation	Kinase	TTBK2	Q6IQ55	GPS
404	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
404	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
409	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
409	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
409	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
416	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
416	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
416	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
422	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
422	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
422	S	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
422	S	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
422	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
422	S	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
422	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
422	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
422	S	Phosphorylation	Kinase	MAPK11	Q15759	GPS
422	S	Phosphorylation	Kinase	MAPK12	P53778	GPS
422	S	Phosphorylation	Kinase	MAPK13	O15264	GPS
422	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
422	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
422	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
427	T	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
470	T	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
498	T	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
514	Y	Phosphorylation	Kinase	TTBK1	Q5TCY1	Uniprot
515	S	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
515	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	Uniprot
516	S	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
516	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	Uniprot
519	S	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
519	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	Uniprot
519	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
519	S	Phosphorylation	Kinase	CK1	-	Uniprot
519	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
522	T	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
522	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
522	T	Phosphorylation	Kinase	CK1	-	Uniprot
522	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
529	T	Phosphorylation	Kinase	BRSK1	Q8TDC3	Uniprot
529	T	Phosphorylation	Kinase	BRSK2	Q8IWQ3	Uniprot
529	T	Phosphorylation	Kinase	DYRK2	Q92630	Uniprot
529	T	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
529	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
529	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
531	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
531	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
531	S	Phosphorylation	Kinase	PKA	-	Uniprot
531	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
534	T	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
534	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
534	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
548	T	Phosphorylation	Kinase	GSK3B	P49841	PhosphoELM
548	T	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
548	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
548	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
552	S	Phosphorylation	Kinase	GSK3B	P49841	PhosphoELM
552	S	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
552	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
552	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
554	S	Phosphorylation	Kinase	PHK	-	Uniprot
575	S	Phosphorylation	Kinase	GSK3B	P49841	PhosphoELM
579	S	Phosphorylation	Kinase	BRSK1	Q8TDC3	Uniprot
579	S	Phosphorylation	Kinase	BRSK2	Q8IWQ3	Uniprot
579	S	Phosphorylation	Kinase	GSK3B	P49841	PhosphoELM
579	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
579	S	Phosphorylation	Kinase	MARK1	Q9P0L2	Uniprot
579	S	Phosphorylation	Kinase	MARK2	Q7KZI7	Uniprot
579	S	Phosphorylation	Kinase	MARK3	P27448	Uniprot
579	S	Phosphorylation	Kinase	MARK4	Q96L34	Uniprot
579	S	Phosphorylation	Kinase	PHK	-	Uniprot
602	S	Phosphorylation	Kinase	PHK	-	Uniprot
622	S	Phosphorylation	Kinase	PHK	-	Uniprot
669	S	Phosphorylation	Kinase	PHK	-	Uniprot
673	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
690	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
690	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
713	S	Phosphorylation	Kinase	GSK3B	P49841	PhosphoELM
713	S	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
713	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
713	S	Phosphorylation	Kinase	CK1	-	Uniprot
713	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
721	S	Phosphorylation	Kinase	GSK3B	P49841	PhosphoELM
721	S	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
721	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
721	S	Phosphorylation	Kinase	CK1	-	Uniprot
721	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
726	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
733	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	Uniprot
733	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
739	S	Phosphorylation	Kinase	PDPK1	O15530	Uniprot
739	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	Uniprot
744	T	Phosphorylation	Kinase	TTBK1	Q5TCY1	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF7	Q9H992	PMID:24905733
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:14962978
-	K	Ubiquitination	E3 ubiquitin ligase	SYVN1	Q86TM6	PMID:17044033
-	K	Ubiquitination	E3 ubiquitin ligase	CRBN	Q96SW2	PMID:30907729

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
214	S	Phosphorylation	16982696
Phosphorylation at Ser-214 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons.
548	S	Phosphorylation	16982696
Phosphorylation at Ser-548 by GSK3B reduces ability to bind and stabilize microtubules.
554	S	Phosphorylation	16443603
Phosphorylated at Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK.
579	S	Phosphorylation	16443603
Phosphorylated at Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK.
579	S	Phosphorylation	16443603
Phosphorylation at Ser-579 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization.
602	S	Phosphorylation	8999860
Phosphorylated at Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK.
606	S	Phosphorylation	16982696
Phosphorylated at Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK.
610	S	Phosphorylation	7706316
Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis.
622	S	Phosphorylation	7706316
Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis.
641	S	Phosphorylation	7706316
Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis.
669	S	Phosphorylation	8999860
Phosphorylated at Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK.
673	S	Phosphorylation	7706316
Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis.
713	S	Glycosylation	16443603
Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively.
713	S	Phosphorylation	16443603
Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively.
713	S	Phosphorylation	16443603
Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces O-GlcNAcylation by a factor of 2 and 4 respectively.
717	S	Glycosylation	19690332
Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively.
717	S	Phosphorylation	19690332
O-GlcNAcylation on Ser-717 decreases the phosphorylation on Ser-721 by about 41.5%.
717	S	Phosphorylation	19690332
Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces O-GlcNAcylation by a factor of 2 and 4 respectively.
717	S	Phosphorylation	19690332
Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively.
717	S	Phosphorylation	19690332
Phosphorylation on Ser-721 is reduced by about 41.5% by GlcNAcylation on Ser-717.
721	S	Glycosylation	9614189
Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively.
721	S	Phosphorylation	9614189
O-GlcNAcylation on Ser-717 decreases the phosphorylation on Ser-721 by about 41.5%.
721	S	Phosphorylation	9614189
Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces O-GlcNAcylation by a factor of 2 and 4 respectively.
721	S	Phosphorylation	9614189
Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively.
721	S	Phosphorylation	9614189
Phosphorylation on Ser-721 is reduced by about 41.5% by GlcNAcylation on Ser-717.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TAU_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYUA_HUMAN	SNCA	physical	10464279
APOE_HUMAN	APOE	physical	8620924
1433Z_HUMAN	YWHAZ	physical	10840038
1433B_HUMAN	YWHAB	physical	10840038
CHIP_HUMAN	STUB1	physical	18292230
PRKN_HUMAN	PARK2	physical	18248624
HSP7C_HUMAN	HSPA8	physical	17954934
BAG1_HUMAN	BAG1	physical	17954934
CHIP_HUMAN	STUB1	physical	15447663
PRKN_HUMAN	PARK2	physical	14962978
HSP74_HUMAN	HSPA4	physical	14962978
CHIP_HUMAN	STUB1	physical	14962978
SIR1_HUMAN	SIRT1	physical	20869593
CHIP_HUMAN	STUB1	physical	20466727
HSP7C_HUMAN	HSPA8	physical	14612456
CHIP_HUMAN	STUB1	physical	14612456
SQSTM_HUMAN	SQSTM1	physical	15953362
PRS7_HUMAN	PSMC2	physical	15953362
CHIP_HUMAN	STUB1	physical	17304350
GSK3B_HUMAN	GSK3B	physical	22965877
NUB1_HUMAN	NUB1	physical	22965877
SYUA_HUMAN	SNCA	physical	21985244
GSK3B_HUMAN	GSK3B	physical	21985244
HSP74_HUMAN	HSPA4	physical	21985244
KSYK_HUMAN	SYK	physical	18070606
SYUA_HUMAN	SNCA	physical	15904919
SYUA_HUMAN	SNCA	physical	17408955
SYUA_HUMAN	SNCA	physical	21127069
CHIP_HUMAN	STUB1	physical	23237806
HSP74_HUMAN	HSPA4	physical	23271055
LIMS1_HUMAN	LIMS1	physical	23554879
CHIP_HUMAN	STUB1	physical	23554879
UBC_HUMAN	UBC	physical	1723470
MARH7_HUMAN	MARCH7	physical	24905733
TBA1B_HUMAN	TUBA1B	physical	24905733
TBB3_HUMAN	TUBB3	physical	24905733
1433Z_HUMAN	YWHAZ	physical	15650334
1433T_HUMAN	YWHAQ	physical	15650334
1433Z_RAT	Ywhaz	physical	19014373
ABL1_HUMAN	ABL1	physical	16014719
DCTN1_HUMAN	DCTN1	physical	17932487
CHIP_HUMAN	STUB1	physical	16275660
TAU_HUMAN	MAPT	physical	9353289
EAA2_HUMAN	SLC1A2	physical	19527721
FKBP4_HUMAN	FKBP4	physical	20133804
KAD2_HUMAN	AK2	physical	26496610
P85A_HUMAN	PIK3R1	physical	19681044
TBA4A_HUMAN	TUBA4A	physical	19681044
AATF_HUMAN	AATF	physical	14697667
NDKB_HUMAN	NME2	physical	28514442
GNA1_HUMAN	GNPNAT1	physical	28514442
DENR_HUMAN	DENR	physical	28514442
SMAD2_HUMAN	SMAD2	physical	24964035

Drug and Disease Associations

Kegg Disease
H00058	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
H00077	Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome
H00078	Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia
OMIM Disease
0000269\|PubMed	Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P-TAU). O-GlcNAcylation is greatly reduced in Alzheimer disease brain cerebral cortex leading to an increase in TAU/MAPT phosphorylations. {ECO
600274
172700	Pick disease of the brain (PIDB)
	Note=Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease.
601104
260540	Parkinson-dementia syndrome (PARDE)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TAU_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Characterization of in vitro glycation sites of tau."; Nacharaju P., Ko L., Yen S.H.; J. Neurochem. 69:1709-1719(1997). Cited for: GLYCATION AT LYS-87; LYS-383; LYS-467; LYS-480; LYS-491; LYS-542;LYS-551; LYS-576; LYS-597; LYS-598; LYS-664; LYS-670 AND LYS-686, ANDLACK OF GLYCATION AT LYS-24; LYS-44; LYS-67; LYS-381; LYS-391;LYS-392; LYS-394; LYS-465; LYS-497; LYS-507; LYS-541; LYS-557;LYS-571; LYS-574; LYS-584; LYS-591; LYS-607; LYS-611; LYS-615;LYS-628; LYS-634; LYS-638; LYS-648; LYS-657; LYS-660; LYS-687;LYS-692; LYS-700; LYS-702; LYS-712 AND LYS-755.	9326300 [Abstract]
O-linked Glycosylation
Reference	PubMed
"Identification of O-GlcNAc sites within peptides of the Tau proteinand their impact on phosphorylation."; Smet-Nocca C., Broncel M., Wieruszeski J.M., Tokarski C., Hanoulle X.,Leroy A., Landrieu I., Rolando C., Lippens G., Hackenberger C.P.; Mol. Biosyst. 7:1420-1429(2011). Cited for: GLYCOSYLATION AT SER-525; SER-555 AND SER-717, PHOSPHORYLATION ATSER-519; SER-713 SER-717 AND SER-721, AND MASS SPECTROMETRY.	21327254 [Abstract]
Phosphorylation
Reference	PubMed
"Identification of O-GlcNAc sites within peptides of the Tau proteinand their impact on phosphorylation."; Smet-Nocca C., Broncel M., Wieruszeski J.M., Tokarski C., Hanoulle X.,Leroy A., Landrieu I., Rolando C., Lippens G., Hackenberger C.P.; Mol. Biosyst. 7:1420-1429(2011). Cited for: GLYCOSYLATION AT SER-525; SER-555 AND SER-717, PHOSPHORYLATION ATSER-519; SER-713 SER-717 AND SER-721, AND MASS SPECTROMETRY.	21327254 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519; SER-713; SER-717;SER-721 AND SER-726, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Reduced O-GlcNAcylation links lower brain glucose metabolism and taupathology in Alzheimer's disease."; Liu F., Shi J., Tanimukai H., Gu J., Gu J., Grundke-Iqbal I.,Iqbal K., Gong C.X.; Brain 132:1820-1832(2009). Cited for: GLYCOSYLATION, PHOSPHORYLATION AT SER-516; SER-519; THR-522; THR-529;SER-531; THR-534; SER-579; SER-713; SER-721 AND SER-739, ANDASSOCIATION WITH ALZHEIMER DISEASE.	19451179 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516; SER-519; THR-522;SER-579; SER-717 AND SER-721, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519; THR-529; THR-534AND SER-721, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-548 AND SER-552, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neuriteformation through microtubule depolymerization by SGK1 and by SGK1phosphorylation of tau."; Yang Y.C., Lin C.H., Lee E.H.; Mol. Cell. Biol. 26:8357-8370(2006). Cited for: PHOSPHORYLATION AT SER-214 BY SGK1, AND INTERACTION WITH SGK1.	16982696 [Abstract]
"Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate,is involved in tau phosphorylation and aggregation."; Sato S., Cerny R.L., Buescher J.L., Ikezu T.; J. Neurochem. 98:1573-1584(2006). Cited for: PHOSPHORYLATION AT TYR-514; SER-515; SER-516; SER-519; SER-733;SER-739 AND THR-744.	16923168 [Abstract]
"Phosphoproteomic analysis of synaptosomes from human cerebralcortex."; DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P.,Pant H.C., Dosemeci A.; J. Proteome Res. 4:306-315(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519; THR-548; SER-673;SER-713; THR-720 AND SER-721, AND MASS SPECTROMETRY.	15822905 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Casein kinase 1 delta phosphorylates tau and disrupts its binding tomicrotubules."; Li G., Yin H., Kuret J.; J. Biol. Chem. 279:15938-15945(2004). Cited for: PHOSPHORYLATION AT SER-519; THR-522; SER-713 AND SER-721 BYCSNK1D/CK1, AND INTERACTION WITH CSNK1D.	14761950 [Abstract]
"The regulatory Ser262 of microtubule-associated protein tau isphosphorylated by phosphorylase kinase."; Paudel H.K.; J. Biol. Chem. 272:1777-1785(1997). Cited for: PHOSPHORYLATION AT SER-554; SER-579; SER-602; SER-606 AND SER-669.	8999860 [Abstract]
"Alzheimer disease-specific conformation of hyperphosphorylated pairedhelical filament-tau is polyubiquitinated through Lys-48, Lys-11, andLys-6 ubiquitin conjugation."; Cripps D., Thomas S.N., Jeng Y., Yang F., Davies P., Yang A.J.; J. Biol. Chem. 281:10825-10838(2006). Cited for: PROTEIN SEQUENCE OF 543-551; 560-574; 576-584 AND 623-634,PHOSPHORYLATION AT SER-531; THR-534; THR-548; SER-552; SER-554;SER-579; SER-713 AND SER-739, UBIQUITINATION AT LYS-571; LYS-628 ANDLYS-670, AND MASS SPECTROMETRY.	16443603 [Abstract]
"Role for DYRK family kinases on regulation of apoptosis."; Yoshida K.; Biochem. Pharmacol. 76:1389-1394(2008). Cited for: PHOSPHORYLATION AT THR-529 BY DYRK2.	18599021 [Abstract]
"Primed phosphorylation of tau at Thr231 by glycogen synthase kinase3beta (GSK3beta) plays a critical role in regulating tau's ability tobind and stabilize microtubules."; Cho J.H., Johnson G.V.; J. Neurochem. 88:349-358(2004). Cited for: PHOSPHORYLATION AT THR-548 BY GSK3B.	14690523 [Abstract]
Ubiquitylation
Reference	PubMed
"Alzheimer disease-specific conformation of hyperphosphorylated pairedhelical filament-tau is polyubiquitinated through Lys-48, Lys-11, andLys-6 ubiquitin conjugation."; Cripps D., Thomas S.N., Jeng Y., Yang F., Davies P., Yang A.J.; J. Biol. Chem. 281:10825-10838(2006). Cited for: PROTEIN SEQUENCE OF 543-551; 560-574; 576-584 AND 623-634,PHOSPHORYLATION AT SER-531; THR-534; THR-548; SER-552; SER-554;SER-579; SER-713 AND SER-739, UBIQUITINATION AT LYS-571; LYS-628 ANDLYS-670, AND MASS SPECTROMETRY.	16443603 [Abstract]

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