dbPTM

MARH7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MARH7_HUMAN
UniProt AC	Q9H992
Protein Name	E3 ubiquitin-protein ligase MARCH7
Gene Name	7-Mar
Organism	Homo sapiens (Human).
Sequence Length	704
Subcellular Localization
Protein Description	E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates..
Protein Sequence	MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWRHSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSYSQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQPGFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSLSHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILPGSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESKPSRI -------CCCCCCCC	13.65	22814378
3	Phosphorylation	-----MESKPSRIPR -----CCCCCCCCCC	48.87	28152594
4	Ubiquitination	----MESKPSRIPRR ----CCCCCCCCCCC	33.43	-
6	Phosphorylation	--MESKPSRIPRRIS --CCCCCCCCCCCCE	46.72	17081983
13	Phosphorylation	SRIPRRISVQPSSSL CCCCCCCEECCCCHH	16.94	29978859
17	Phosphorylation	RRISVQPSSSLSARM CCCEECCCCHHHHHH	18.57	27732954
18	Phosphorylation	RISVQPSSSLSARMM CCEECCCCHHHHHHH	41.82	27732954
19	Phosphorylation	ISVQPSSSLSARMMS CEECCCCHHHHHHHC	30.59	27732954
21	Phosphorylation	VQPSSSLSARMMSGS ECCCCHHHHHHHCCC	18.77	27732954
26	Phosphorylation	SLSARMMSGSRGSSL HHHHHHHCCCCCCCC	25.03	30576142
28	Phosphorylation	SARMMSGSRGSSLND HHHHHCCCCCCCCCC	26.59	30622161
29	Methylation	ARMMSGSRGSSLNDT HHHHCCCCCCCCCCC	53.16	115482579
31	Phosphorylation	MMSGSRGSSLNDTYH HHCCCCCCCCCCCCC	30.46	26434776
32	Phosphorylation	MSGSRGSSLNDTYHS HCCCCCCCCCCCCCC	33.73	28857561
36	Phosphorylation	RGSSLNDTYHSRDSS CCCCCCCCCCCCCCC	23.28	28152594
37	Phosphorylation	GSSLNDTYHSRDSSF CCCCCCCCCCCCCCC	10.72	28152594
39	Phosphorylation	SLNDTYHSRDSSFRL CCCCCCCCCCCCCCC	27.63	28152594
50	Phosphorylation	SFRLDSEYQSTSASA CCCCCCCHHCCCCCC	16.24	30576142
53	Phosphorylation	LDSEYQSTSASASAS CCCCHHCCCCCCCCC	16.88	30576142
55	Ubiquitination	SEYQSTSASASASPF CCHHCCCCCCCCCCC	14.81	-
56	Phosphorylation	EYQSTSASASASPFQ CHHCCCCCCCCCCCC	23.64	30576142
93	Ubiquitination	DHDSKRPKLSCTNCT CCCCCCCCCCCCCCC	58.00	-
102	Phosphorylation	SCTNCTTSAGRNVGN CCCCCCCCCCCCCCC	15.57	-
127	Phosphorylation	RHSQVPRSSSMVLGS CCCCCCCHHHHHHHH	22.24	28857561
128	Phosphorylation	HSQVPRSSSMVLGSF CCCCCCHHHHHHHHH	24.59	28857561
129	Phosphorylation	SQVPRSSSMVLGSFG CCCCCHHHHHHHHHH	17.73	28857561
134	Phosphorylation	SSSMVLGSFGTDLMR HHHHHHHHHHHHHHH	19.15	24719451
137	Phosphorylation	MVLGSFGTDLMRERR HHHHHHHHHHHHHHH	24.77	24719451
150	Phosphorylation	RRDLERRTDSSISNL HHHHHHHCCCHHHHH	46.59	23312004
152	Phosphorylation	DLERRTDSSISNLMD HHHHHCCCHHHHHHH	29.03	23312004
153	Phosphorylation	LERRTDSSISNLMDY HHHHCCCHHHHHHHH	32.61	23312004
155	Phosphorylation	RRTDSSISNLMDYSH HHCCCHHHHHHHHCC	26.34	23312004
160	Phosphorylation	SISNLMDYSHRSGDF HHHHHHHHCCCCCCC	7.75	27642862
171	Phosphorylation	SGDFTTSSYVQDRVP CCCCCCCHHHHHCCC	27.51	28555341
172	Phosphorylation	GDFTTSSYVQDRVPS CCCCCCHHHHHCCCC	11.25	27642862
179	Phosphorylation	YVQDRVPSYSQGARP HHHHCCCCCCCCCCC	34.26	27642862
214	Phosphorylation	SEHQTILSSRDSRNS CCHHHHHCCHHHHHH	21.34	24719451
215	Phosphorylation	EHQTILSSRDSRNSL CHHHHHCCHHHHHHH	36.34	24719451
218	Phosphorylation	TILSSRDSRNSLRSN HHHCCHHHHHHHHHH	32.05	-
221	Phosphorylation	SSRDSRNSLRSNFSS CCHHHHHHHHHHCCC	24.85	26437602
238	Phosphorylation	SESSRSNTQPGFSYS CHHCCCCCCCCCCCC	37.07	22817900
243	Phosphorylation	SNTQPGFSYSSSRDE CCCCCCCCCCCCCCC	29.98	22817900
245	Phosphorylation	TQPGFSYSSSRDEAP CCCCCCCCCCCCCCC	22.19	22817900
246	Phosphorylation	QPGFSYSSSRDEAPI CCCCCCCCCCCCCCC	22.59	28348404
247	Phosphorylation	PGFSYSSSRDEAPII CCCCCCCCCCCCCCC	37.50	28348404
270	Phosphorylation	SQRPFQESSDNEGRR CCCCCCCCCCCHHHH	32.01	23186163
271	Phosphorylation	QRPFQESSDNEGRRT CCCCCCCCCCHHHHH	43.64	30576142
284	Phosphorylation	RTTRRLLSRIASSMS HHHHHHHHHHHHHHH	26.66	-
288	Phosphorylation	RLLSRIASSMSSTFF HHHHHHHHHHHHHHH	24.97	23917254
289	Phosphorylation	LLSRIASSMSSTFFS HHHHHHHHHHHHHHH	17.42	23186163
296	Phosphorylation	SMSSTFFSRRSSQDS HHHHHHHHCCCCCCC	23.69	29759185
299	Phosphorylation	STFFSRRSSQDSLNT HHHHHCCCCCCCCCC	31.10	26699800
300	Phosphorylation	TFFSRRSSQDSLNTR HHHHCCCCCCCCCCC	35.87	30576142
303	Phosphorylation	SRRSSQDSLNTRSLN HCCCCCCCCCCCCCC	18.84	23312004
314	Phosphorylation	RSLNSENSYVSPRIL CCCCCCCCCCCHHHE	23.90	28796482
315	Phosphorylation	SLNSENSYVSPRILT CCCCCCCCCCHHHEE	19.27	30183078
317	Phosphorylation	NSENSYVSPRILTAS CCCCCCCCHHHEECC	10.54	21712546
324	Phosphorylation	SPRILTASQSRSNVP CHHHEECCCCCCCCC	24.37	-
326	Phosphorylation	RILTASQSRSNVPSA HHEECCCCCCCCCCH	34.87	30576142
358	Phosphorylation	LRRRWGLSSLSHNHS HHHHHCCHHCCCCCC	25.87	26434776
359	Phosphorylation	RRRWGLSSLSHNHSS HHHHCCHHCCCCCCC	38.64	26434776
361	Phosphorylation	RWGLSSLSHNHSSES HHCCHHCCCCCCCCC	24.96	26434776
365	Phosphorylation	SSLSHNHSSESDSEN HHCCCCCCCCCCCCC	40.91	25850435
366	Phosphorylation	SLSHNHSSESDSENF HCCCCCCCCCCCCCC	33.30	30576142
368	Phosphorylation	SHNHSSESDSENFNQ CCCCCCCCCCCCCCC	48.67	25850435
370	Phosphorylation	NHSSESDSENFNQES CCCCCCCCCCCCCCC	43.66	25850435
377	Phosphorylation	SENFNQESEGRNTGP CCCCCCCCCCCCCCH	35.27	24719451
387	Phosphorylation	RNTGPWLSSSLRNRC CCCCHHHCHHHHHCC	17.63	23401153
388	Phosphorylation	NTGPWLSSSLRNRCT CCCHHHCHHHHHCCH	31.08	29978859
389	Phosphorylation	TGPWLSSSLRNRCTP CCHHHCHHHHHCCHH	28.15	29978859
395	Phosphorylation	SSLRNRCTPLFSRRR HHHHHCCHHHHHHHH	21.57	21712546
406	Methylation	SRRRREGRDESSRIP HHHHHCCCCCCCCCC	39.51	24377495
406	Dimethylation	SRRRREGRDESSRIP HHHHHCCCCCCCCCC	39.51	-
428	Phosphorylation	SHIFRRESNEVVHLE CEEEECCCCCEEEEE	36.16	-
498	Ubiquitination	ALGSNLTDNVMITVD CCCCCCCCCEEEEEE	49.22	-
522	Ubiquitination	DGKSDKTKSAPSRDP CCCCCCCCCCCCCCH	50.81	-
536	Ubiquitination	PERLQKIKESLLLED HHHHHHHHHHHHCCC	48.57	-
538	Phosphorylation	RLQKIKESLLLEDSE HHHHHHHHHHCCCCC	21.22	30624053
544	Phosphorylation	ESLLLEDSEEEEGDL HHHHCCCCCCCCCCH	37.22	19664994
548	Ubiquitination	LEDSEEEEGDLCRIC CCCCCCCCCCHHHHH	62.38	-
553	Ubiquitination	EEEGDLCRICQMAAA CCCCCHHHHHHHHHH	39.76	-
561	Phosphorylation	ICQMAAASSSNLLIE HHHHHHHCCCCEEEE	29.58	28348404
562	Phosphorylation	CQMAAASSSNLLIEP HHHHHHCCCCEEEEE	20.65	28348404
563	Phosphorylation	QMAAASSSNLLIEPC HHHHHCCCCEEEEEC	29.06	28348404
570	Ubiquitination	SNLLIEPCKCTGSLQ CCEEEEECCCCCCCH	3.52	21906983
572	Ubiquitination	LLIEPCKCTGSLQYV EEEEECCCCCCCHHC	7.12	-
585	Ubiquitination	YVHQDCMKKWLQAKI HCCHHHHHHHHHHHH	47.32	-
586	Ubiquitination	VHQDCMKKWLQAKIN CCHHHHHHHHHHHHC	26.67	-
591	Ubiquitination	MKKWLQAKINSGSSL HHHHHHHHHCCCCCC	29.47	-
597	Phosphorylation	AKINSGSSLEAVTTC HHHCCCCCCHHHHHH	33.48	-
608	Ubiquitination	VTTCELCKEKLELNL HHHHHHHHHHHCCCH	71.19	21906983
610	Ubiquitination	TCELCKEKLELNLED HHHHHHHHHCCCHHH	32.53	-
666	Phosphorylation	GNTNEPSTRVRFINL CCCCCCHHHHHHHHH	43.85	24719451
676	Phosphorylation	RFINLARTLQAHMED HHHHHHHHHHHHHHH	20.02	27732954
686	Phosphorylation	AHMEDLETSEDDSEE HHHHHHHCCCCCCCC	44.72	18669648
687	Phosphorylation	HMEDLETSEDDSEED HHHHHHCCCCCCCCC	29.65	18669648
691	Phosphorylation	LETSEDDSEEDGDHN HHCCCCCCCCCCCCC	56.03	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF7	Q9H992	PMID:18410486

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MARH7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MARH7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI65_HUMAN	TRIM65	physical	22493164
UBC_HUMAN	UBC	physical	16868077
UB2D3_HUMAN	UBE2D3	physical	24905733
UBC12_HUMAN	UBE2M	physical	24905733
UBE2N_HUMAN	UBE2N	physical	24905733
UB2D1_HUMAN	UBE2D1	physical	24905733
PP2BA_HUMAN	PPP3CA	physical	24905733
PP2BB_HUMAN	PPP3CB	physical	24905733
MARH7_HUMAN	MARCH7	physical	24905733
UB2D2_HUMAN	UBE2D2	physical	24905733
UB2E1_HUMAN	UBE2E1	physical	24905733
TAU_HUMAN	MAPT	physical	24905733
UBE2K_HUMAN	UBE2K	physical	16868077
NLRP3_HUMAN	NLRP3	physical	25594175
UBE2K_HUMAN	UBE2K	physical	18410486
UBE2N_HUMAN	UBE2N	physical	18410486
USP9X_HUMAN	USP9X	physical	18410486
UBP7_HUMAN	USP7	physical	18410486
IQCB1_HUMAN	IQCB1	physical	28498859

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MARH7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-686; SER-687 ANDSER-691, AND MASS SPECTROMETRY.	18669648 [Abstract]