TRI65_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI65_HUMAN
• UniProt AC: Q6PJ69
• Protein Name: Tripartite motif-containing protein 65
• Gene Name: TRIM65
• Organism: Homo sapiens (Human).
• Sequence Length: 517
• Protein Sequence: MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDRCGKACPECREPFPDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVCSVCTVRECRLHERALLDAERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQNSACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFDPVSANRHFYLSRQDQQVKHCRQSRGPGGPGSFELWQVQCAQSFQAGHHYWEVRASDHSVTLGVSYPQLPRCRLGPHTDNIGRGPCSWGLCVQEDSLQAWHNGEAQRLPGVSGRLLGMDLDLASGCLTFYSLEPQTQPLYTFHALFNQPLTPVFWLLEGRTLTLCHQPGAVFPLGPQEEVLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAQLLEEK ------CHHHHHHHH	12.15	22223895
144	Phosphorylation	REAQLRASLEVTQQQ HHHHHHHHHHHHHHH	20.73	22210691
148	Phosphorylation	LRASLEVTQQQATQA HHHHHHHHHHHHHHH	15.98	22210691
153	Phosphorylation	EVTQQQATQAEGQLL HHHHHHHHHHHHHHH	24.79	22210691
167	Phosphorylation	LELRKQSSQIQNSAC HHHHHHCHHHHHHHH	28.89	-
185	Phosphorylation	SWVSGKFSSLLQALE HHHHCHHHHHHHHHH	24.46	-
206	Ubiquitination	LRSIEVAKTQALAQA HHHHHHHHHHHHHHC	46.47	27667366
219	Ubiquitination	QARDEEQRLRVHLEA HCCCHHHHHHHHHHH	27.95	27667366
277	Ubiquitination	DQQLGDLKQLLSRLC CCCHHHHHHHHHHHH	43.57	-
299	Ubiquitination	SHPGAPAKPVDLAPV CCCCCCCCCCCCCCC	44.51	29967540
317	Phosphorylation	GPLAPVPSTVCPLRR CCCCCCCCCCCHHHH	33.43	32142685
325	Ubiquitination	TVCPLRRKLWQNYRN CCCHHHHHHHHHHHC	47.87	21906983
334	Phosphorylation	WQNYRNLTFDPVSAN HHHHHCCCCCCCCCC	29.55	28857561
338	Ubiquitination	RNLTFDPVSANRHFY HCCCCCCCCCCCCEE	10.19	21890473
339	Phosphorylation	NLTFDPVSANRHFYL CCCCCCCCCCCCEEE	25.80	32142685
342	Methylation	FDPVSANRHFYLSRQ CCCCCCCCCEEECHH	22.47	115918961
367	Phosphorylation	RGPGGPGSFELWQVQ CCCCCCCCEEEEEEE	20.77	-
413	Phosphorylation	RCRLGPHTDNIGRGP CCCCCCCCCCCCCCC	33.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRI65_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI65_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI65_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MKRN3_HUMAN	MKRN3	physical	22493164
TNR6A_HUMAN	TNRC6A	physical	24778252

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330