MKRN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MKRN3_HUMAN
• UniProt AC: Q13064
• Protein Name: Probable E3 ubiquitin-protein ligase makorin-3
• Gene Name: MKRN3
• Organism: Homo sapiens (Human).
• Sequence Length: 507
• Protein Description: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins..
• Protein Sequence: MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPVAPVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLPVIGSAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSSETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQLVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRFLSLRDELPFSEDQWDLLHYELEEYFNLIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Methylation	PVPAHLRRGGLRPAP CCCHHHHCCCCCCCC	50.30	115386301
73	Methylation	HLRRGGLRPAPASGG HHHCCCCCCCCCCCC	28.71	54557383
85	Phosphorylation	SGGGAWPSPLPSRSS CCCCCCCCCCCCCCC	28.50	20873877
89	Phosphorylation	AWPSPLPSRSSGIWT CCCCCCCCCCCCCCC	53.10	28787133
117	Phosphorylation	KEGENCRYSHDLSGR CCCCCCCCCCCCCCC	16.74	24275569
118	Phosphorylation	EGENCRYSHDLSGRK CCCCCCCCCCCCCCC	7.38	24275569
122	Phosphorylation	CRYSHDLSGRKMATE CCCCCCCCCCCEECC	42.48	24275569
128	Phosphorylation	LSGRKMATEGGVSPP CCCCCEECCCCCCCC	31.50	28348404
133	Phosphorylation	MATEGGVSPPGASAG EECCCCCCCCCCCCC	28.75	28348404
138	Phosphorylation	GVSPPGASAGGGPST CCCCCCCCCCCCCCC	33.10	28348404
144	Phosphorylation	ASAGGGPSTAAHIEP CCCCCCCCCCCCCCC	33.67	28348404
145	Phosphorylation	SAGGGPSTAAHIEPP CCCCCCCCCCCCCCC	30.88	28348404
153	Phosphorylation	AAHIEPPTQEVAEAP CCCCCCCCHHHHHCC	48.34	24275569
233	Ubiquitination	QSSETERKQMAVGSG CCCHHHHHHHHHCCC	37.89	-
295	Ubiquitination	ACIEAHEKDMELSFA HHHHHHHHHHHHHHH	53.13	22817900
319	Phosphorylation	GICMEVVYEKANPND CHHHHHHHHHCCCCC	19.52	22817900
384	Ubiquitination	WVEEEEEKQKLIQQY CCCCHHHHHHHHHHH	56.89	29967540
386	Ubiquitination	EEEEEKQKLIQQYKE CCHHHHHHHHHHHHH	59.64	29967540
392	Ubiquitination	QKLIQQYKEAMSNKA HHHHHHHHHHHCCHH	34.36	29967540
398	Ubiquitination	YKEAMSNKACRYFAE HHHHHCCHHHHHHHC	41.37	29967540
476	Ubiquitination	RLASLLFKRFLSLRD HHHHHHHHHHHHCCC	42.06	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MKRN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MKRN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MKRN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM4_HUMAN	MDM4	physical	22493164
TRI23_HUMAN	TRIM23	physical	22493164
RBX2_HUMAN	RNF7	physical	22493164
PEX10_HUMAN	PEX10	physical	22493164
MKRN3_HUMAN	MKRN3	physical	22493164
MKRN3_HUMAN	MKRN3	physical	25416956
SYFM_HUMAN	FARS2	physical	25416956
PRP31_HUMAN	PRPF31	physical	25416956
RBM41_HUMAN	RBM41	physical	25416956
SOSB2_HUMAN	NABP1	physical	25416956
RT06_HUMAN	MRPS6	physical	25416956
SCNM1_HUMAN	SCNM1	physical	25416956
F124B_HUMAN	FAM124B	physical	25416956
TTC25_HUMAN	TTC25	physical	25416956
F110A_HUMAN	FAM110A	physical	25416956
ENKD1_HUMAN	ENKD1	physical	25416956
TCHP_HUMAN	TCHP	physical	25416956
BEX2_HUMAN	BEX2	physical	25416956
EFC4B_HUMAN	CRACR2A	physical	25416956
ENKD1_HUMAN	ENKD1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615346: Precocious puberty, central 2 (CPPB2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.