| UniProt ID | EFC4B_HUMAN | |
|---|---|---|
| UniProt AC | Q9BSW2 | |
| Protein Name | EF-hand calcium-binding domain-containing protein 4B | |
| Gene Name | CRACR2A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 395 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.. | |
| Protein Sequence | MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRCVGGHWPVLRAPPRSLGSEGPV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | APDGRVVSRPQRLGQ CCCCCEECCCCCCCC | 35.07 | 26074081 | |
| 19 | Phosphorylation | PQRLGQGSGQGPKGS CCCCCCCCCCCCCCC | 21.76 | 26074081 | |
| 26 | Phosphorylation | SGQGPKGSGACLHPL CCCCCCCCCCCCCCC | 29.37 | 26657352 | |
| 35 | Phosphorylation | ACLHPLDSLEQKETQ CCCCCCCHHCCHHHH | 41.30 | 26657352 | |
| 41 | Phosphorylation | DSLEQKETQEQTSGQ CHHCCHHHHCCCCHH | 44.43 | 28348404 | |
| 51 | Sulfoxidation | QTSGQLVMLRKAQEF CCCHHEEHHHHHHHH | 3.99 | 21406390 | |
| 54 | Ubiquitination | GQLVMLRKAQEFFQT HHEEHHHHHHHHHHH | 50.92 | 29967540 | |
| 67 | Ubiquitination | QTCDAEGKGFIARKD HHCCCCCCCEEEHHH | 42.00 | 29967540 | |
| 141 | Phosphorylation | QRHEEKVYLSRGDED HHHHHHHHCCCCCCC | 15.27 | 29978859 | |
| 143 | Phosphorylation | HEEKVYLSRGDEDLG HHHHHHCCCCCCCCC | 19.27 | 29978859 | |
| 152 | Sulfoxidation | GDEDLGDMGEDEEAQ CCCCCCCCCCCHHHH | 6.34 | 21406390 | |
| 171 | Ubiquitination | MDRLGAQKVLEDESD HHHHCCHHHHCCHHH | 48.53 | 29967540 | |
| 237 | Phosphorylation | DEEIQHLYEEMEQQI HHHHHHHHHHHHHHH | 14.02 | 28796482 | |
| 263 | Phosphorylation | TERFQARSQELEQKL HHHHHHHHHHHHHHH | 30.90 | 29255136 | |
| 269 | Ubiquitination | RSQELEQKLLCKEQE HHHHHHHHHHCCHHH | 33.77 | 29967540 | |
| 292 | Phosphorylation | KRLEGQCTALHHDKH HHHHHHHHHHCCCCC | 25.11 | - | |
| 301 | Phosphorylation | LHHDKHETKAENTKL HCCCCCCHHHCCCHH | 34.96 | - | |
| 309 | Ubiquitination | KAENTKLKLTNQELA HHCCCHHHCCHHHHH | 55.62 | 29967540 | |
| 311 | Phosphorylation | ENTKLKLTNQELARE CCCHHHCCHHHHHHH | 33.01 | - | |
| 322 | Phosphorylation | LARELERTSWELQDA HHHHHHHHHHHHHHH | 28.90 | 27690223 | |
| 323 | Phosphorylation | ARELERTSWELQDAQ HHHHHHHHHHHHHHH | 25.44 | 27690223 | |
| 342 | Ubiquitination | SLQQEACKLHQEKEM HHHHHHHHHHHHHHH | 56.93 | 29967540 | |
| 355 | Phosphorylation | EMEVYRVTESLQREK HHHHHHHHHHHHHHH | 15.74 | 24719451 | |
| 357 | Phosphorylation | EVYRVTESLQREKAG HHHHHHHHHHHHHCH | 22.04 | 23403867 | |
| 388 | O-linked_Glycosylation | VLRAPPRSLGSEGPV HHCCCCCCCCCCCCC | 42.74 | 30379171 | |
| 391 | O-linked_Glycosylation | APPRSLGSEGPV--- CCCCCCCCCCCC--- | 44.68 | 30379171 | |
| 391 | Phosphorylation | APPRSLGSEGPV--- CCCCCCCCCCCC--- | 44.68 | 22210691 | |
| 397 (in isoform 2) | Phosphorylation | - | 29978859 | ||
| 400 (in isoform 2) | Phosphorylation | - | 28634120 | ||
| 403 (in isoform 2) | Phosphorylation | - | 29978859 | ||
| 408 (in isoform 2) | Phosphorylation | - | 28102081 | ||
| 410 (in isoform 2) | Phosphorylation | - | 26853621 | ||
| 414 | Ubiquitination | -------------------------- -------------------------- | 29967540 | ||
| 415 (in isoform 2) | Phosphorylation | - | - | ||
| 424 (in isoform 2) | Phosphorylation | - | 30266825 | ||
| 426 (in isoform 2) | Phosphorylation | - | 30266825 | ||
| 439 (in isoform 2) | Phosphorylation | - | 25849741 | ||
| 440 (in isoform 2) | Phosphorylation | - | 25849741 | ||
| 444 (in isoform 2) | Phosphorylation | - | 28450419 | ||
| 446 (in isoform 2) | Phosphorylation | - | 28450419 | ||
| 449 (in isoform 2) | Phosphorylation | - | 28450419 | ||
| 455 (in isoform 2) | Phosphorylation | - | 28634298 | ||
| 464 (in isoform 2) | Phosphorylation | - | 28634298 | ||
| 473 (in isoform 2) | Phosphorylation | - | 30266825 | ||
| 492 (in isoform 2) | Phosphorylation | - | 22210691 | ||
| 495 (in isoform 2) | Phosphorylation | - | 26657352 | ||
| 501 (in isoform 2) | Phosphorylation | - | 25072903 | ||
| 518 (in isoform 2) | Phosphorylation | - | 26657352 | ||
| 520 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 521 (in isoform 2) | Phosphorylation | - | 30266825 | ||
| 529 (in isoform 2) | Ubiquitination | - | - | ||
| 537 (in isoform 2) | Phosphorylation | - | 30108239 | ||
| 538 (in isoform 2) | Phosphorylation | - | 30108239 | ||
| 540 (in isoform 2) | Phosphorylation | - | 30108239 | ||
| 571 (in isoform 2) | Phosphorylation | - | - | ||
| 601 (in isoform 2) | Phosphorylation | - | - | ||
| 607 (in isoform 2) | Phosphorylation | - | - | ||
| 729 | Geranylgeranylation | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | 27016526 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EFC4B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EFC4B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EFC4B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| IF1AX_HUMAN | EIF1AX | physical | 26186194 | |
| MCPH1_HUMAN | MCPH1 | physical | 26186194 | |
| MCPH1_HUMAN | MCPH1 | physical | 28514442 | |
| PLSI_HUMAN | PLS1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
