IF1AX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF1AX_HUMAN
• UniProt AC: P47813
• Protein Name: Eukaryotic translation initiation factor 1A, X-chromosomal
• Gene Name: EIF1AX
• Organism: Homo sapiens (Human).
• Sequence Length: 144
• Protein Description: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits..
• Protein Sequence: MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MPKNKGKGGK -----CCCCCCCCCC	70.73	69689
5	Acetylation	---MPKNKGKGGKNR ---CCCCCCCCCCCC	69.03	69691
7	Ubiquitination	-MPKNKGKGGKNRRR -CCCCCCCCCCCCCC	67.13	24816145
7	Acetylation	-MPKNKGKGGKNRRR -CCCCCCCCCCCCCC	67.13	69693
10	Acetylation	KNKGKGGKNRRRGKN CCCCCCCCCCCCCCC	56.82	7673865
23	Ubiquitination	KNENESEKRELVFKE CCCCHHHHHEEEEEC	61.52	33845483
29	Ubiquitination	EKRELVFKEDGQEYA HHHEEEEECCHHHHH	47.63	32015554
35	Phosphorylation	FKEDGQEYAQVIKML EECCHHHHHHHHHHH	8.41	-
40	Ubiquitination	QEYAQVIKMLGNGRL HHHHHHHHHHCCCCE	29.26	21890473
50	Sulfoxidation	GNGRLEAMCFDGVKR CCCCEEEEEECHHHH	1.38	21406390
51	Glutathionylation	NGRLEAMCFDGVKRL CCCEEEEEECHHHHH	3.47	22555962
56	Acetylation	AMCFDGVKRLCHIRG EEEECHHHHHHHHHH	45.22	23749302
56	Ubiquitination	AMCFDGVKRLCHIRG EEEECHHHHHHHHHH	45.22	22817900
73	Phosphorylation	RKKVWINTSDIILVG CCCEEEECCCEEEEE	20.74	21815630
74	Phosphorylation	KKVWINTSDIILVGL CCEEEECCCEEEEEC	23.48	21815630
82	Methylation	DIILVGLRDYQDNKA CEEEEECCCCCCCCC	34.36	-
84	Phosphorylation	ILVGLRDYQDNKADV EEEECCCCCCCCCCE	16.01	28152594
88	Malonylation	LRDYQDNKADVILKY CCCCCCCCCCEEEEE	55.01	26320211
88	Ubiquitination	LRDYQDNKADVILKY CCCCCCCCCCEEEEE	55.01	23000965
88	Acetylation	LRDYQDNKADVILKY CCCCCCCCCCEEEEE	55.01	8665785
94	Sumoylation	NKADVILKYNADEAR CCCCEEEEECHHHHH	25.90	-
94	Ubiquitination	NKADVILKYNADEAR CCCCEEEEECHHHHH	25.90	23000965
95	Phosphorylation	KADVILKYNADEARS CCCEEEEECHHHHHH	16.49	-
102	Phosphorylation	YNADEARSLKAYGEL ECHHHHHHHHHHCCC	41.07	25849741
104	Neddylation	ADEARSLKAYGELPE HHHHHHHHHHCCCCC	40.59	32015554
104	Ubiquitination	ADEARSLKAYGELPE HHHHHHHHHHCCCCC	40.59	21906983
104	Malonylation	ADEARSLKAYGELPE HHHHHHHHHHCCCCC	40.59	26320211
106	Phosphorylation	EARSLKAYGELPEHA HHHHHHHHCCCCCCC	15.00	28152594
106	Nitration	EARSLKAYGELPEHA HHHHHHHHCCCCCCC	15.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF1AX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF1AX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF1AX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IPO13_HUMAN	IPO13	physical	11447110
A4_HUMAN	APP	physical	21832049
PUR8_HUMAN	ADSL	physical	22863883

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.