IPO13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IPO13_HUMAN
• UniProt AC: O94829
• Protein Name: Importin-13
• Gene Name: IPO13
• Organism: Homo sapiens (Human).
• Sequence Length: 963
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13..
• Protein Sequence: MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Ubiquitination	FTVENVEKALHQLYY CCHHHHHHHHHHHHC	52.55	29967540
42	Ubiquitination	YDPNIENKNLAQKWL CCCCCCCCCHHHHHH	40.31	29967540
192	Phosphorylation	YRKGLVRTSLAVECG HHCCCCHHHHHHHHH	22.17	-
193	Phosphorylation	RKGLVRTSLAVECGA HCCCCHHHHHHHHHC	12.08	-
309	Carbamidation	METSHGICRIAVALG CCHHHHHHHHHHHHC	2.81	17322306
433	Phosphorylation	DISDTLMYVYEMLGA ECHHHHHHHHHHHCH	11.73	22817900
632	Phosphorylation	AEEIPNPSNKLAIVH HHHCCCHHHHHHHHH	53.92	22210691
649	Phosphorylation	GLLSNLFTTLDISHH HHHHHHHHHHCCCCC	29.61	22210691
650	Phosphorylation	LLSNLFTTLDISHHE HHHHHHHHHCCCCCC	18.33	22210691
735	Phosphorylation	CEMLGRMYSTIPQAS HHHHHHHHHCCCHHH	10.99	-
833	Phosphorylation	LKFPEAPTVKASCGF HHCCCCCCCHHHCCH	41.51	22964224
878	Phosphorylation	EAIGGQASRSLMDCF HHHCCHHHHHHHHHH	17.95	-
898	Phosphorylation	ALNKHCFSLLSMWIK HHHHHHHHHHHHHHH	33.52	22210691
901	Phosphorylation	KHCFSLLSMWIKEAL HHHHHHHHHHHHHHH	19.84	22210691
915	Phosphorylation	LQPPGFPSARLSPEQ HCCCCCCCCCCCHHH	24.62	25627689
919	Phosphorylation	GFPSARLSPEQKDTF CCCCCCCCHHHHCCH	22.34	22210691
923	Ubiquitination	ARLSPEQKDTFSQQI CCCCHHHHCCHHHHH	58.01	22817900
957	Phosphorylation	LCRGLHGTDYTADY- HHHHCCCCCCCCCC-	18.32	29978859
959	Phosphorylation	RGLHGTDYTADY--- HHCCCCCCCCCC---	12.03	25159151
960	Phosphorylation	GLHGTDYTADY---- HCCCCCCCCCC----	18.83	29978859
963	Phosphorylation	GTDYTADY------- CCCCCCCC-------	20.28	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IPO13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IPO13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IPO13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAX6_HUMAN	PAX6	physical	15143176
RL5_HUMAN	RPL5	physical	11447110
RBM8A_HUMAN	RBM8A	physical	11447110
UBC9_HUMAN	UBE2I	physical	11447110
NUP50_HUMAN	NUP50	physical	11447110
IF1AX_HUMAN	EIF1AX	physical	11447110
MGN_HUMAN	MAGOH	physical	11447110
UBC9_HUMAN	UBE2I	physical	21139563
RAN_HUMAN	RAN	physical	21139563
SYNP2_HUMAN	SYNPO2	physical	17828378
THOC6_HUMAN	THOC6	physical	22939629
XPO4_HUMAN	XPO4	physical	22939629
PWP2_HUMAN	PWP2	physical	22939629
PBX4_HUMAN	PBX4	physical	25416956
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.