| UniProt ID | THOC6_HUMAN | |
|---|---|---|
| UniProt AC | Q86W42 | |
| Protein Name | THO complex subunit 6 homolog | |
| Gene Name | THOC6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 341 | |
| Subcellular Localization | Nucleus . Nucleus speckle . | |
| Protein Description | Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.. | |
| Protein Sequence | MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 67 | Ubiquitination | EAKEESKKPVVTFQA HHHHHHCCCEEEEEC | 52.93 | 29967540 | |
| 83 (in isoform 2) | Ubiquitination | - | 4.60 | 21890473 | |
| 83 | Ubiquitination | DGPVYSMVSTDRHLL CCCEEEEEECCCCHH | 4.60 | 32015554 | |
| 91 | Phosphorylation | STDRHLLSAGDGEVK ECCCCHHCCCCHHHH | 36.24 | 20860994 | |
| 107 | Ubiquitination | WLWAEMLKKGCKELW HHHHHHHHHHHHHHH | 45.89 | 21890473 | |
| 107 (in isoform 3) | Ubiquitination | - | 45.89 | 21890473 | |
| 107 (in isoform 1) | Ubiquitination | - | 45.89 | 21890473 | |
| 107 | Acetylation | WLWAEMLKKGCKELW HHHHHHHHHHHHHHH | 45.89 | 26051181 | |
| 122 | Phosphorylation | RRQPPYRTSLEVPEI HHCCCCCCCCCCCCC | 31.64 | 28857561 | |
| 123 | Phosphorylation | RQPPYRTSLEVPEIN HCCCCCCCCCCCCCC | 17.34 | 28857561 | |
| 177 (in isoform 2) | Ubiquitination | - | 31.51 | 21890473 | |
| 177 | Ubiquitination | YIHCLALRERSPEVL EEEEEEEECCCHHHH | 31.51 | 33845483 | |
| 180 | Phosphorylation | CLALRERSPEVLSGG EEEEECCCHHHHCCC | 22.21 | 29255136 | |
| 185 | Phosphorylation | ERSPEVLSGGEDGAV CCCHHHHCCCCCCCE | 50.34 | 20068231 | |
| 201 (in isoform 1) | Ubiquitination | - | 58.78 | 21890473 | |
| 201 | Ubiquitination | LWDLRTAKEVQTIEV EEECCCCCEEEEEEE | 58.78 | 22817900 | |
| 201 (in isoform 3) | Ubiquitination | - | 58.78 | 21890473 | |
| 210 | Ubiquitination | VQTIEVYKHEECSRP EEEEEEEECCCCCCC | 50.11 | - | |
| 210 | Acetylation | VQTIEVYKHEECSRP EEEEEEEECCCCCCC | 50.11 | 26051181 | |
| 248 | Phosphorylation | LTLWHLRSSTPTTIF EEEEECCCCCCCEEE | 44.94 | 23312004 | |
| 249 | Phosphorylation | TLWHLRSSTPTTIFP EEEECCCCCCCEEEE | 31.78 | 23312004 | |
| 250 | Phosphorylation | LWHLRSSTPTTIFPI EEECCCCCCCEEEEC | 26.38 | 23312004 | |
| 262 | Ubiquitination | FPIRAPQKHVTFYQD EECCCCCCCEEEEHH | 38.70 | 17623298 | |
| 290 | Ubiquitination | WQLSGELKAQVPGSS EEECCEEEEECCCCC | 32.25 | 17623298 | |
| 330 | Phosphorylation | SCRVDVFTNLGYRAF CCEEEEEECCCEEEE | 29.40 | - | |
| 334 | Phosphorylation | DVFTNLGYRAFSLSF EEEECCCEEEEEECC | 11.26 | - | |
| 338 | Phosphorylation | NLGYRAFSLSF---- CCCEEEEEECC---- | 23.32 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of THOC6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of THOC6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of THOC6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| THOC7_HUMAN | THOC7 | physical | 22939629 | |
| U2AF2_HUMAN | U2AF2 | physical | 22939629 | |
| U5S1_HUMAN | EFTUD2 | physical | 22939629 | |
| U2AF1_HUMAN | U2AF1 | physical | 22939629 | |
| U520_HUMAN | SNRNP200 | physical | 22939629 | |
| ZCHC8_HUMAN | ZCCHC8 | physical | 22939629 | |
| ZC3HF_HUMAN | ZC3H15 | physical | 22939629 | |
| U3IP2_HUMAN | RRP9 | physical | 22939629 | |
| TPR_HUMAN | TPR | physical | 22939629 | |
| UTRO_HUMAN | UTRN | physical | 22939629 | |
| ZN326_HUMAN | ZNF326 | physical | 22939629 | |
| TRI55_HUMAN | TRIM55 | physical | 22939629 | |
| VDAC2_HUMAN | VDAC2 | physical | 22939629 | |
| 2AAA_HUMAN | PPP2R1A | physical | 26344197 | |
| THOC1_HUMAN | THOC1 | physical | 26344197 | |
| THOC7_HUMAN | THOC7 | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 613680 | Beaulieu-Boycott-Innes syndrome (BBIS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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