dbPTM

TPR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TPR_HUMAN
UniProt AC	P12270
Protein Name	Nucleoprotein TPR
Gene Name	TPR
Organism	Homo sapiens (Human).
Sequence Length	2363
Subcellular Localization	Nucleus . Nucleus membrane Peripheral membrane protein Nucleoplasmic side . Nucleus envelope . Nucleus, nuclear pore complex . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Nucleus membrane Peripheral membrane
Protein Description	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export. [PubMed: 22253824 and 11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally]
Protein Sequence	MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDLGPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQRIQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAAPVTVFTESTTSDASEHASQSVPMVTTSTGTLSTTNETATGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGVSHAMGGRGGINRGNIN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVLQQVL ------CHHHHHHHH	19.99	22223895
16	2-Hydroxyisobutyrylation	LERTELNKLPKSVQN HHHHHHHHCCHHHHH	77.96	-
16	Acetylation	LERTELNKLPKSVQN HHHHHHHHCCHHHHH	77.96	25953088
27	Acetylation	SVQNKLEKFLADQQS HHHHHHHHHHHHCHH	56.99	26051181
27	Ubiquitination	SVQNKLEKFLADQQS HHHHHHHHHHHHCHH	56.99	29967540
34	Phosphorylation	KFLADQQSEIDGLKG HHHHHCHHHHCCCCC	30.77	-
40	Acetylation	QSEIDGLKGRHEKFK HHHHCCCCCCCCCCC	60.47	26051181
40	Ubiquitination	QSEIDGLKGRHEKFK HHHHCCCCCCCCCCC	60.47	21906983
45	Ubiquitination	GLKGRHEKFKVESEQ CCCCCCCCCCCCCHH	44.34	22817900
47	Acetylation	KGRHEKFKVESEQQY CCCCCCCCCCCHHHH	57.04	26051181
54	Phosphorylation	KVESEQQYFEIEKRL CCCCHHHHHHHHHHH	11.68	27642862
59	Acetylation	QQYFEIEKRLSHSQE HHHHHHHHHHCCCHH	65.39	26051181
59	Ubiquitination	QQYFEIEKRLSHSQE HHHHHHHHHHCCCHH	65.39	21906983
62	Phosphorylation	FEIEKRLSHSQERLV HHHHHHHCCCHHHHH	25.73	20068231
64	Phosphorylation	IEKRLSHSQERLVNE HHHHHCCCHHHHHHH	30.29	28102081
84	Acetylation	SLRLELEKLNNQLKA HHHHHHHHHHHHHHH	69.96	25953088
90	Ubiquitination	EKLNNQLKALTEKNK HHHHHHHHHHHHHHH	31.42	29967540
95	Acetylation	QLKALTEKNKELEIA HHHHHHHHHHHHHHH	68.99	25953088
97	2-Hydroxyisobutyrylation	KALTEKNKELEIAQD HHHHHHHHHHHHHHH	74.80	-
97	Acetylation	KALTEKNKELEIAQD HHHHHHHHHHHHHHH	74.80	26051181
97	Ubiquitination	KALTEKNKELEIAQD HHHHHHHHHHHHHHH	74.80	24816145
105	Methylation	ELEIAQDRNIAIQSQ HHHHHHHCCHHHHHH	25.11	115918829
111	Phosphorylation	DRNIAIQSQFTRTKE HCCHHHHHHCCCCHH	22.58	30622161
114	Phosphorylation	IAIQSQFTRTKEELE HHHHHHCCCCHHHHH	29.77	30622161
116	Phosphorylation	IQSQFTRTKEELEAE HHHHCCCCHHHHHHH	39.49	30622161
117	Acetylation	QSQFTRTKEELEAEK HHHCCCCHHHHHHHH	45.99	26051181
117	Methylation	QSQFTRTKEELEAEK HHHCCCCHHHHHHHH	45.99	23644510
124	Acetylation	KEELEAEKRDLIRTN HHHHHHHHHHHHHHC	59.25	26051181
124	Methylation	KEELEAEKRDLIRTN HHHHHHHHHHHHHHC	59.25	23644510
124	Ubiquitination	KEELEAEKRDLIRTN HHHHHHHHHHHHHHC	59.25	24816145
135	Phosphorylation	IRTNERLSQELEYLT HHHCHHHHHHHHHHH	28.03	20068231
140	Phosphorylation	RLSQELEYLTEDVKR HHHHHHHHHHHHHHH	31.39	20068231
142	Phosphorylation	SQELEYLTEDVKRLN HHHHHHHHHHHHHHH	29.27	20068231
146	Acetylation	EYLTEDVKRLNEKLK HHHHHHHHHHHHHHH	64.59	26051181
146	Ubiquitination	EYLTEDVKRLNEKLK HHHHHHHHHHHHHHH	64.59	32015554
159	2-Hydroxyisobutyrylation	LKESNTTKGELQLKL HHHCCCCCCHHEEHH	48.64	-
172	Phosphorylation	KLDELQASDVSVKYR HHHHHHHCCCHHHHH	26.11	21712546
177	2-Hydroxyisobutyrylation	QASDVSVKYREKRLE HHCCCHHHHHHHHHH	30.96	-
177	Acetylation	QASDVSVKYREKRLE HHCCCHHHHHHHHHH	30.96	26051181
177	Ubiquitination	QASDVSVKYREKRLE HHCCCHHHHHHHHHH	30.96	21906983
181	Ubiquitination	VSVKYREKRLEQEKE CHHHHHHHHHHHHHH	53.97	22817900
187	2-Hydroxyisobutyrylation	EKRLEQEKELLHSQN HHHHHHHHHHHHCCC	54.05	-
187	Acetylation	EKRLEQEKELLHSQN HHHHHHHHHHHHCCC	54.05	26051181
187	Ubiquitination	EKRLEQEKELLHSQN HHHHHHHHHHHHCCC	54.05	29967540
202	2-Hydroxyisobutyrylation	TWLNTELKTKTDELL HHHCHHHCCCHHHHH	41.57	-
203	Phosphorylation	WLNTELKTKTDELLA HHCHHHCCCHHHHHH	52.37	24719451
204	Ubiquitination	LNTELKTKTDELLAL HCHHHCCCHHHHHHH	53.01	29967540
215	2-Hydroxyisobutyrylation	LLALGREKGNEILEL HHHHCHHHCHHHHEE	66.72	-
215	Ubiquitination	LLALGREKGNEILEL HHHHCHHHCHHHHEE	66.72	29967540
223	Ubiquitination	GNEILELKCNLENKK CHHHHEEECCCCCHH	16.23	24816145
229	Acetylation	LKCNLENKKEEVSRL EECCCCCHHHHHHHH	52.79	26051181
244	Acetylation	EEQMNGLKTSNEHLQ HHHHCCCCCCHHHHH	51.83	25953088
252	Acetylation	TSNEHLQKHVEDLLT CCHHHHHHHHHHHHH	56.85	19608861
252	Ubiquitination	TSNEHLQKHVEDLLT CCHHHHHHHHHHHHH	56.85	29967540
260	2-Hydroxyisobutyrylation	HVEDLLTKLKEAKEQ HHHHHHHHHHHHHHH	58.49	-
260	Acetylation	HVEDLLTKLKEAKEQ HHHHHHHHHHHHHHH	58.49	25953088
260	Ubiquitination	HVEDLLTKLKEAKEQ HHHHHHHHHHHHHHH	58.49	29967540
262	Acetylation	EDLLTKLKEAKEQQA HHHHHHHHHHHHHHH	58.12	11920931
265	Acetylation	LTKLKEAKEQQASME HHHHHHHHHHHHHHH	58.09	26051181
270	Phosphorylation	EAKEQQASMEEKFHN HHHHHHHHHHHHHHH	23.53	20068231
284	Acetylation	NELNAHIKLSNLYKS HHHHHHHHHHHHHHH	35.68	25953088
284	Ubiquitination	NELNAHIKLSNLYKS HHHHHHHHHHHHHHH	35.68	23503661
290	Acetylation	IKLSNLYKSAADDSE HHHHHHHHHHCCCHH	36.46	26051181
290	Ubiquitination	IKLSNLYKSAADDSE HHHHHHHHHHCCCHH	36.46	21906983
299	2-Hydroxyisobutyrylation	AADDSEAKSNELTRA HCCCHHHHHHHHHHH	50.16	-
299	Ubiquitination	AADDSEAKSNELTRA HCCCHHHHHHHHHHH	50.16	21906983
312	2-Hydroxyisobutyrylation	RAVEELHKLLKEAGE HHHHHHHHHHHHHHH	69.05	-
312	Acetylation	RAVEELHKLLKEAGE HHHHHHHHHHHHHHH	69.05	19608861
312	Ubiquitination	RAVEELHKLLKEAGE HHHHHHHHHHHHHHH	69.05	21890473
312	Ubiquitination	RAVEELHKLLKEAGE HHHHHHHHHHHHHHH	69.05	21890473
312	Ubiquitination	RAVEELHKLLKEAGE HHHHHHHHHHHHHHH	69.05	21890473
315	Acetylation	EELHKLLKEAGEANK HHHHHHHHHHHHHHH	56.82	25953088
315	Ubiquitination	EELHKLLKEAGEANK HHHHHHHHHHHHHHH	56.82	21906983
322	2-Hydroxyisobutyrylation	KEAGEANKAIQDHLL HHHHHHHHHHHHHHH	54.65	-
322	Ubiquitination	KEAGEANKAIQDHLL HHHHHHHHHHHHHHH	54.65	32015554
335	Acetylation	LLEVEQSKDQMEKEM HHHHHHCHHHHHHHH	52.23	26051181
335	Ubiquitination	LLEVEQSKDQMEKEM HHHHHHCHHHHHHHH	52.23	-
340	Acetylation	QSKDQMEKEMLEKIG HCHHHHHHHHHHHHH	42.98	23236377
345	2-Hydroxyisobutyrylation	MEKEMLEKIGRLEKE HHHHHHHHHHHHHHH	46.64	-
345	Acetylation	MEKEMLEKIGRLEKE HHHHHHHHHHHHHHH	46.64	19608861
345	Ubiquitination	MEKEMLEKIGRLEKE HHHHHHHHHHHHHHH	46.64	32015554
351	Acetylation	EKIGRLEKELENAND HHHHHHHHHHHCHHH	72.66	23236377
351	Ubiquitination	EKIGRLEKELENAND HHHHHHHHHHHCHHH	72.66	21906983
351	Ubiquitination	EKIGRLEKELENAND HHHHHHHHHHHCHHH	72.66	21890473
351	Ubiquitination	EKIGRLEKELENAND HHHHHHHHHHHCHHH	72.66	21890473
361	Phosphorylation	ENANDLLSATKRKGA HCHHHHHHHHHHCCC	40.98	21815630
363	Phosphorylation	ANDLLSATKRKGAIL HHHHHHHHHHCCCCC	28.18	21815630
364	2-Hydroxyisobutyrylation	NDLLSATKRKGAILS HHHHHHHHHCCCCCC	52.40	-
364	Acetylation	NDLLSATKRKGAILS HHHHHHHHHCCCCCC	52.40	25953088
364	Ubiquitination	NDLLSATKRKGAILS HHHHHHHHHCCCCCC	52.40	23000965
364	Ubiquitination	NDLLSATKRKGAILS HHHHHHHHHCCCCCC	52.40	21890473
364	Ubiquitination	NDLLSATKRKGAILS HHHHHHHHHCCCCCC	52.40	21890473
366	Ubiquitination	LLSATKRKGAILSEE HHHHHHHCCCCCCHH	55.01	23000965
371	Phosphorylation	KRKGAILSEEELAAM HHCCCCCCHHHHHCC	36.53	28176443
379	Phosphorylation	EEELAAMSPTAAAVA HHHHHCCCHHHHHHH	17.86	29255136
381	Phosphorylation	ELAAMSPTAAAVAKI HHHCCCHHHHHHHHH	22.94	29255136
387	Ubiquitination	PTAAAVAKIVKPGMK HHHHHHHHHHCCCCC	41.24	32015554
390	Ubiquitination	AAVAKIVKPGMKLTE HHHHHHHCCCCCHHH	39.05	33845483
394	Ubiquitination	KIVKPGMKLTELYNA HHHCCCCCHHHHHHH	59.16	29967540
413	Acetylation	QDQLLLEKLENKRIN HHHHHHHHHHHHHHH	62.16	22361417
413	Ubiquitination	QDQLLLEKLENKRIN HHHHHHHHHHHHHHH	62.16	32015554
417	Acetylation	LLEKLENKRINKYLD HHHHHHHHHHHHHHH	45.33	26051181
417	Ubiquitination	LLEKLENKRINKYLD HHHHHHHHHHHHHHH	45.33	23000965
421	Acetylation	LENKRINKYLDEIVK HHHHHHHHHHHHHHH	44.83	25953088
421	Ubiquitination	LENKRINKYLDEIVK HHHHHHHHHHHHHHH	44.83	23000965
421	Ubiquitination	LENKRINKYLDEIVK HHHHHHHHHHHHHHH	44.83	21890473
421	Ubiquitination	LENKRINKYLDEIVK HHHHHHHHHHHHHHH	44.83	21890473
428	Acetylation	KYLDEIVKEVEAKAP HHHHHHHHHHHHHCH	62.80	19608861
428	Ubiquitination	KYLDEIVKEVEAKAP HHHHHHHHHHHHHCH	62.80	32015554
433	2-Hydroxyisobutyrylation	IVKEVEAKAPILKRQ HHHHHHHHCHHHHHH	40.98	-
433	Acetylation	IVKEVEAKAPILKRQ HHHHHHHHCHHHHHH	40.98	26822725
433	Ubiquitination	IVKEVEAKAPILKRQ HHHHHHHHCHHHHHH	40.98	21906983
438	Ubiquitination	EAKAPILKRQREEYE HHHCHHHHHHHHHHH	47.40	22817900
449	Acetylation	EEYERAQKAVASLSV HHHHHHHHHHHHHHH	43.79	23954790
449	Ubiquitination	EEYERAQKAVASLSV HHHHHHHHHHHHHHH	43.79	32015554
453	Phosphorylation	RAQKAVASLSVKLEQ HHHHHHHHHHHHHHH	17.99	24719451
457	Acetylation	AVASLSVKLEQAMKE HHHHHHHHHHHHHHH	42.82	19608861
457	Ubiquitination	AVASLSVKLEQAMKE HHHHHHHHHHHHHHH	42.82	23503661
463	Acetylation	VKLEQAMKEIQRLQE HHHHHHHHHHHHHHH	55.47	26051181
463	Ubiquitination	VKLEQAMKEIQRLQE HHHHHHHHHHHHHHH	55.47	21906983
472	Phosphorylation	IQRLQEDTDKANKQS HHHHHHHHHHHHHHH	38.35	29978859
474	Ubiquitination	RLQEDTDKANKQSSV HHHHHHHHHHHHHHH	56.82	22817900
477	Acetylation	EDTDKANKQSSVLER HHHHHHHHHHHHHHH	57.31	23749302
477	Ubiquitination	EDTDKANKQSSVLER HHHHHHHHHHHHHHH	57.31	21906983
494	2-Hydroxyisobutyrylation	RRMEIQVKDLSQQIR CCEEEEHHHHHHHHH	36.25	-
494	Acetylation	RRMEIQVKDLSQQIR CCEEEEHHHHHHHHH	36.25	27452117
494	Ubiquitination	RRMEIQVKDLSQQIR CCEEEEHHHHHHHHH	36.25	23000965
494	Ubiquitination	RRMEIQVKDLSQQIR CCEEEEHHHHHHHHH	36.25	21890473
494	Ubiquitination	RRMEIQVKDLSQQIR CCEEEEHHHHHHHHH	36.25	21890473
497	Phosphorylation	EIQVKDLSQQIRVLL EEEHHHHHHHHHHHH	30.12	-
505	Sulfoxidation	QQIRVLLMELEEARG HHHHHHHHHHHHHHC	4.89	21406390
522	Phosphorylation	VIRDEEVSSADISSS CCCCCCCCCCCCCCC	24.08	30266825
523	Phosphorylation	IRDEEVSSADISSSS CCCCCCCCCCCCCCH	34.83	30266825
527	Phosphorylation	EVSSADISSSSEVIS CCCCCCCCCCHHHHH	25.39	17081983
528	Phosphorylation	VSSADISSSSEVISQ CCCCCCCCCHHHHHH	37.91	17081983
529	Phosphorylation	SSADISSSSEVISQH CCCCCCCCHHHHHHH	24.59	17081983
530	Phosphorylation	SADISSSSEVISQHL CCCCCCCHHHHHHHH	37.52	17081983
534	Phosphorylation	SSSSEVISQHLVSYR CCCHHHHHHHHHHHC	19.40	27732954
539	Phosphorylation	VISQHLVSYRNIEEL HHHHHHHHHCCHHHH	25.41	27080861
540	Phosphorylation	ISQHLVSYRNIEELQ HHHHHHHHCCHHHHH	10.53	27080861
572	Phosphorylation	EREEQETTSSKITEL HHHHHHCCHHHHHHH	30.19	-
575	Acetylation	EQETTSSKITELQLK HHHCCHHHHHHHHHH	54.11	25953088
575	Ubiquitination	EQETTSSKITELQLK HHHCCHHHHHHHHHH	54.11	21906983
575	Ubiquitination	EQETTSSKITELQLK HHHCCHHHHHHHHHH	54.11	21890473
575	Ubiquitination	EQETTSSKITELQLK HHHCCHHHHHHHHHH	54.11	21890473
577	Phosphorylation	ETTSSKITELQLKLE HCCHHHHHHHHHHHH	34.09	20860994
582	Ubiquitination	KITELQLKLESALTE HHHHHHHHHHHHHHH	36.93	21906983
585	Phosphorylation	ELQLKLESALTELEQ HHHHHHHHHHHHHHH	38.73	20860994
588	Phosphorylation	LKLESALTELEQLRK HHHHHHHHHHHHHHH	37.94	-
606	Phosphorylation	HQMQLVDSIVRQRDM HHHHHHHHHHHHHHH	18.59	28555341
622	Phosphorylation	RILLSQTTGVAIPLH HHHHCCCCCCEEECC	23.25	23186163
631	Phosphorylation	VAIPLHASSLDDVSL CEEECCCCCCCCCCC	22.23	29255136
632	Phosphorylation	AIPLHASSLDDVSLA EEECCCCCCCCCCCC	36.28	29255136
637	Phosphorylation	ASSLDDVSLASTPKR CCCCCCCCCCCCCCC	25.80	29255136
640	Phosphorylation	LDDVSLASTPKRPST CCCCCCCCCCCCCCC	51.00	29255136
641	Phosphorylation	DDVSLASTPKRPSTS CCCCCCCCCCCCCCC	27.50	29255136
646	Phosphorylation	ASTPKRPSTSQTVST CCCCCCCCCCCCCCC	44.73	30266825
647	Phosphorylation	STPKRPSTSQTVSTP CCCCCCCCCCCCCCC	27.77	30266825
648	Phosphorylation	TPKRPSTSQTVSTPA CCCCCCCCCCCCCCC	28.35	30266825
650	Phosphorylation	KRPSTSQTVSTPAPV CCCCCCCCCCCCCCC	19.05	30266825
652	Phosphorylation	PSTSQTVSTPAPVPV CCCCCCCCCCCCCCC	31.87	30266825
653	Phosphorylation	STSQTVSTPAPVPVI CCCCCCCCCCCCCCC	21.09	30266825
662	Phosphorylation	APVPVIESTEAIEAK CCCCCCCCCHHHHHH	22.03	30266825
663	Phosphorylation	PVPVIESTEAIEAKA CCCCCCCCHHHHHHH	19.35	30266825
669	2-Hydroxyisobutyrylation	STEAIEAKAALKQLQ CCHHHHHHHHHHHHH	22.77	-
669	Ubiquitination	STEAIEAKAALKQLQ CCHHHHHHHHHHHHH	22.77	32015554
673	Ubiquitination	IEAKAALKQLQEIFE HHHHHHHHHHHHHHH	44.21	21906983
673	Ubiquitination	IEAKAALKQLQEIFE HHHHHHHHHHHHHHH	44.21	21890473
673	Ubiquitination	IEAKAALKQLQEIFE HHHHHHHHHHHHHHH	44.21	21890473
682	Phosphorylation	LQEIFENYKKEKAEN HHHHHHHHHHHHHHC	19.08	-
686	Acetylation	FENYKKEKAENEKIQ HHHHHHHHHHCHHHC	70.63	26051181
686	Ubiquitination	FENYKKEKAENEKIQ HHHHHHHHHHCHHHC	70.63	22817900
691	Ubiquitination	KEKAENEKIQNEQLE HHHHHCHHHCHHHHH	62.26	21906983
699	Acetylation	IQNEQLEKLQEQVTD HCHHHHHHHHHHHHH	65.15	25953088
699	Ubiquitination	IQNEQLEKLQEQVTD HCHHHHHHHHHHHHH	65.15	21906983
705	Phosphorylation	EKLQEQVTDLRSQNT HHHHHHHHHHHHCCH	29.07	29759185
708	Methylation	QEQVTDLRSQNTKIS HHHHHHHHHCCHHHH	38.72	115918857
709	Phosphorylation	EQVTDLRSQNTKIST HHHHHHHHCCHHHHH	34.77	29759185
713	Acetylation	DLRSQNTKISTQLDF HHHHCCHHHHHHHHH	42.06	19608861
713	Ubiquitination	DLRSQNTKISTQLDF HHHHCCHHHHHHHHH	42.06	22817900
715	Phosphorylation	RSQNTKISTQLDFAS HHCCHHHHHHHHHHH	16.20	29759185
716	Phosphorylation	SQNTKISTQLDFASK HCCHHHHHHHHHHHH	36.30	29759185
722	Phosphorylation	STQLDFASKRYEMLQ HHHHHHHHHHHHHHH	20.05	29759185
723	2-Hydroxyisobutyrylation	TQLDFASKRYEMLQD HHHHHHHHHHHHHHH	56.41	-
723	Acetylation	TQLDFASKRYEMLQD HHHHHHHHHHHHHHH	56.41	19608861
723	Ubiquitination	TQLDFASKRYEMLQD HHHHHHHHHHHHHHH	56.41	22817900
723	Ubiquitination	TQLDFASKRYEMLQD HHHHHHHHHHHHHHH	56.41	21890473
723	Ubiquitination	TQLDFASKRYEMLQD HHHHHHHHHHHHHHH	56.41	21890473
725	Phosphorylation	LDFASKRYEMLQDNV HHHHHHHHHHHHHHH	14.93	21712546
735	Phosphorylation	LQDNVEGYRREITSL HHHHHHHHHHHHHHH	7.93	23663014
740	Phosphorylation	EGYRREITSLHERNQ HHHHHHHHHHHHHHH	22.08	20068231
741	Phosphorylation	GYRREITSLHERNQK HHHHHHHHHHHHHHH	33.13	20068231
748	Acetylation	SLHERNQKLTATTQK HHHHHHHHCCCHHHH	51.89	19608861
750	Phosphorylation	HERNQKLTATTQKQE HHHHHHCCCHHHHHH	29.06	-
753	Phosphorylation	NQKLTATTQKQEQII HHHCCCHHHHHHHHH	31.16	-
755	2-Hydroxyisobutyrylation	KLTATTQKQEQIINT HCCCHHHHHHHHHHH	54.43	-
755	Acetylation	KLTATTQKQEQIINT HCCCHHHHHHHHHHH	54.43	19608861
755	Ubiquitination	KLTATTQKQEQIINT HCCCHHHHHHHHHHH	54.43	21906983
764	Phosphorylation	EQIINTMTQDLRGAN HHHHHHHHHHHCCCC	19.52	-
768	Methylation	NTMTQDLRGANEKLA HHHHHHHCCCCHHHH	50.93	115918861
773	2-Hydroxyisobutyrylation	DLRGANEKLAVAEVR HHCCCCHHHHHHHHH	41.37	-
773	Acetylation	DLRGANEKLAVAEVR HHCCCCHHHHHHHHH	41.37	26051181
773	Ubiquitination	DLRGANEKLAVAEVR HHCCCCHHHHHHHHH	41.37	32015554
792	Acetylation	KKEKEMLKLSEVRLS HHHHHHHHHHHHHHH	48.97	30582747
792	Ubiquitination	KKEKEMLKLSEVRLS HHHHHHHHHHHHHHH	48.97	24816145
799	Phosphorylation	KLSEVRLSQQRESLL HHHHHHHHHHHHHHH	17.44	23312004
804	Phosphorylation	RLSQQRESLLAEQRG HHHHHHHHHHHHHHH	30.76	23312004
821	Phosphorylation	LLLTNLQTIQGILER HHHHHHHHHHHHHHC	20.59	28348404
829	Phosphorylation	IQGILERSETETKQR HHHHHHCCHHHHHHH	39.22	28348404
831	Phosphorylation	GILERSETETKQRLS HHHHCCHHHHHHHHH	50.64	28348404
833	Phosphorylation	LERSETETKQRLSSQ HHCCHHHHHHHHHHH	39.64	27251275
834	Ubiquitination	ERSETETKQRLSSQI HCCHHHHHHHHHHHH	27.47	-
838	Phosphorylation	TETKQRLSSQIEKLE HHHHHHHHHHHHHHH	23.53	21406692
839	Phosphorylation	ETKQRLSSQIEKLEH HHHHHHHHHHHHHHH	39.51	21406692
843	Acetylation	RLSSQIEKLEHEISH HHHHHHHHHHHHHHH	61.88	26051181
843	Ubiquitination	RLSSQIEKLEHEISH HHHHHHHHHHHHHHH	61.88	23503661
852	2-Hydroxyisobutyrylation	EHEISHLKKKLENEV HHHHHHHHHHHHHHH	42.30	-
852	Acetylation	EHEISHLKKKLENEV HHHHHHHHHHHHHHH	42.30	25953088
852	Ubiquitination	EHEISHLKKKLENEV HHHHHHHHHHHHHHH	42.30	23503661
853	Acetylation	HEISHLKKKLENEVE HHHHHHHHHHHHHHH	69.79	25953088
853	Ubiquitination	HEISHLKKKLENEVE HHHHHHHHHHHHHHH	69.79	23503661
854	Acetylation	EISHLKKKLENEVEQ HHHHHHHHHHHHHHH	60.49	23749302
854	Ubiquitination	EISHLKKKLENEVEQ HHHHHHHHHHHHHHH	60.49	23503661
877	2-Hydroxyisobutyrylation	DVQLLDTKRQLDTET HHHHCCCCCCCCCCC	37.50	-
877	Ubiquitination	DVQLLDTKRQLDTET HHHHCCCCCCCCCCC	37.50	21906983
895	Ubiquitination	LNTKELLKNAQKEIA CCHHHHHHHHHHHHH	63.96	-
899	Malonylation	ELLKNAQKEIATLKQ HHHHHHHHHHHHHHH	48.99	26320211
899	Ubiquitination	ELLKNAQKEIATLKQ HHHHHHHHHHHHHHH	48.99	33845483
903	Phosphorylation	NAQKEIATLKQHLSN HHHHHHHHHHHHHHC	39.90	29978859
905	2-Hydroxyisobutyrylation	QKEIATLKQHLSNME HHHHHHHHHHHHCCC	31.17	-
905	Ubiquitination	QKEIATLKQHLSNME HHHHHHHHHHHHCCC	31.17	32015554
909	Phosphorylation	ATLKQHLSNMEVQVA HHHHHHHHCCCCCHH	31.82	29978859
917	Phosphorylation	NMEVQVASQSSQRTG CCCCCHHCCCCCCCC	31.57	29214152
919	Phosphorylation	EVQVASQSSQRTGKG CCCHHCCCCCCCCCC	26.41	29978859
920	Phosphorylation	VQVASQSSQRTGKGQ CCHHCCCCCCCCCCC	18.95	17525332
923	Phosphorylation	ASQSSQRTGKGQPSN HCCCCCCCCCCCCCC	35.29	24719451
925	Acetylation	QSSQRTGKGQPSNKE CCCCCCCCCCCCCHH	54.48	26051181
925	Ubiquitination	QSSQRTGKGQPSNKE CCCCCCCCCCCCCHH	54.48	32015554
929	Phosphorylation	RTGKGQPSNKEDVDD CCCCCCCCCHHHHHH	53.28	24719451
931	Acetylation	GKGQPSNKEDVDDLV CCCCCCCHHHHHHHH	60.68	26051181
931	Ubiquitination	GKGQPSNKEDVDDLV CCCCCCCHHHHHHHH	60.68	32015554
944	Phosphorylation	LVSQLRQTEEQVNDL HHHHHHHHHHHHHHH	34.75	29052541
952	Acetylation	EEQVNDLKERLKTST HHHHHHHHHHHHHCC	43.59	26822725
952	Ubiquitination	EEQVNDLKERLKTST HHHHHHHHHHHHHCC	43.59	21906983
956	Ubiquitination	NDLKERLKTSTSNVE HHHHHHHHHCCCCHH	46.80	29901268
957	Phosphorylation	DLKERLKTSTSNVEQ HHHHHHHHCCCCHHH	41.66	28270605
958	Phosphorylation	LKERLKTSTSNVEQY HHHHHHHCCCCHHHH	28.40	28270605
959	Phosphorylation	KERLKTSTSNVEQYQ HHHHHHCCCCHHHHH	29.56	28270605
960	Phosphorylation	ERLKTSTSNVEQYQA HHHHHCCCCHHHHHH	38.35	28270605
965	Phosphorylation	STSNVEQYQAMVTSL CCCCHHHHHHHHHHH	5.68	22817900
970	Phosphorylation	EQYQAMVTSLEESLN HHHHHHHHHHHHHHC	17.95	28270605
971	Phosphorylation	QYQAMVTSLEESLNK HHHHHHHHHHHHHCH	23.52	28270605
975	Phosphorylation	MVTSLEESLNKEKQV HHHHHHHHHCHHHHH	28.06	28270605
978	Acetylation	SLEESLNKEKQVTEE HHHHHHCHHHHHHHH	72.14	26051181
978	Ubiquitination	SLEESLNKEKQVTEE HHHHHHCHHHHHHHH	72.14	29967540
995	Acetylation	KNIEVRLKESAEFQT HHHHHHHHHCHHHHH	38.77	26051181
995	Ubiquitination	KNIEVRLKESAEFQT HHHHHHHHHCHHHHH	38.77	33845483
1006	2-Hydroxyisobutyrylation	EFQTQLEKKLMEVEK HHHHHHHHHHHHHHH	60.85	-
1007	2-Hydroxyisobutyrylation	FQTQLEKKLMEVEKE HHHHHHHHHHHHHHH	43.63	-
1037	2-Hydroxyisobutyrylation	EQQLSELKKTLSSVQ HHHHHHHHHHHHHHH	39.39	-
1037	Acetylation	EQQLSELKKTLSSVQ HHHHHHHHHHHHHHH	39.39	26051181
1037	Ubiquitination	EQQLSELKKTLSSVQ HHHHHHHHHHHHHHH	39.39	22817900
1038	Ubiquitination	QQLSELKKTLSSVQN HHHHHHHHHHHHHHH	68.28	22817900
1038	Ubiquitination	QQLSELKKTLSSVQN HHHHHHHHHHHHHHH	68.28	21890473
1038	Ubiquitination	QQLSELKKTLSSVQN HHHHHHHHHHHHHHH	68.28	21890473
1039	Phosphorylation	QLSELKKTLSSVQNE HHHHHHHHHHHHHHH	30.22	21712546
1041	Phosphorylation	SELKKTLSSVQNEVQ HHHHHHHHHHHHHHH	33.42	21712546
1042	Phosphorylation	ELKKTLSSVQNEVQE HHHHHHHHHHHHHHH	30.73	21712546
1073	Acetylation	RDCQEQAKIAVEAQN HHHHHHHHHHHHHCH	30.78	26051181
1081	Acetylation	IAVEAQNKYERELML HHHHHCHHHHHHHHH	36.09	26051181
1081	Ubiquitination	IAVEAQNKYERELML HHHHHCHHHHHHHHH	36.09	32015554
1082	Phosphorylation	AVEAQNKYERELMLH HHHHCHHHHHHHHHH	27.98	28152594
1087	Sulfoxidation	NKYERELMLHAADVE HHHHHHHHHHHHHHH	1.90	21406390
1100	Acetylation	VEALQAAKEQVSKMA HHHHHHHHHHHHHHH	52.25	26051181
1100	Ubiquitination	VEALQAAKEQVSKMA HHHHHHHHHHHHHHH	52.25	32015554
1105	"N6,N6-dimethyllysine"	AAKEQVSKMASVRQH HHHHHHHHHHHHHHH	39.36	-
1105	Acetylation	AAKEQVSKMASVRQH HHHHHHHHHHHHHHH	39.36	25953088
1105	Methylation	AAKEQVSKMASVRQH HHHHHHHHHHHHHHH	39.36	-
1105	Ubiquitination	AAKEQVSKMASVRQH HHHHHHHHHHHHHHH	39.36	29967540
1108	Phosphorylation	EQVSKMASVRQHLEE HHHHHHHHHHHHHHH	17.84	24719451
1119	Acetylation	HLEETTQKAESQLLE HHHHHHHHHHHHHHH	52.62	26051181
1119	Ubiquitination	HLEETTQKAESQLLE HHHHHHHHHHHHHHH	52.62	29967540
1128	Acetylation	ESQLLECKASWEERE HHHHHHHHHCHHHHH	35.76	25953088
1128	Ubiquitination	ESQLLECKASWEERE HHHHHHHHHCHHHHH	35.76	32015554
1139	Acetylation	EERERMLKDEVSKCV HHHHHHHHHHHHHHH	42.36	26051181
1139	Ubiquitination	EERERMLKDEVSKCV HHHHHHHHHHHHHHH	42.36	24816145
1144	2-Hydroxyisobutyrylation	MLKDEVSKCVCRCED HHHHHHHHHHHHCCC	35.54	-
1144	Acetylation	MLKDEVSKCVCRCED HHHHHHHHHHHHCCC	35.54	25953088
1144	Ubiquitination	MLKDEVSKCVCRCED HHHHHHHHHHHHCCC	35.54	33845483
1154	Acetylation	CRCEDLEKQNRLLHD HHCCCHHHHHHHHHH	61.23	26051181
1165	Acetylation	LLHDQIEKLSDKVVA HHHHHHHHHCHHHHH	55.72	25953088
1165	Ubiquitination	LLHDQIEKLSDKVVA HHHHHHHHHCHHHHH	55.72	29967540
1167	Phosphorylation	HDQIEKLSDKVVASV HHHHHHHCHHHHHHH	46.59	21406692
1169	2-Hydroxyisobutyrylation	QIEKLSDKVVASVKE HHHHHCHHHHHHHHC	34.92	-
1169	Acetylation	QIEKLSDKVVASVKE HHHHHCHHHHHHHHC	34.92	25953088
1169	Ubiquitination	QIEKLSDKVVASVKE HHHHHCHHHHHHHHC	34.92	33845483
1173	Phosphorylation	LSDKVVASVKEGVQG HCHHHHHHHHCCCCC	23.32	21406692
1175	Ubiquitination	DKVVASVKEGVQGPL HHHHHHHHCCCCCCC	46.37	33845483
1185	Phosphorylation	VQGPLNVSLSEEGKS CCCCCCCCCCCCCCC	25.71	19664994
1187	Phosphorylation	GPLNVSLSEEGKSQE CCCCCCCCCCCCCHH	26.54	30266825
1191	Ubiquitination	VSLSEEGKSQEQILE CCCCCCCCCHHHHHH	52.85	29967540
1192	Phosphorylation	SLSEEGKSQEQILEI CCCCCCCCHHHHHHH	50.21	21406692
1207	Ubiquitination	LRFIRREKEIAETRF HHHHHHHHHHHHHHH	53.24	29901268
1241	Phosphorylation	ELQELQDSLNAEREK HHHHHHHHHHHHHHH	15.57	25159151
1248	2-Hydroxyisobutyrylation	SLNAEREKVQVTAKT HHHHHHHHHHHHHHH	44.16	-
1248	Acetylation	SLNAEREKVQVTAKT HHHHHHHHHHHHHHH	44.16	25953088
1248	Ubiquitination	SLNAEREKVQVTAKT HHHHHHHHHHHHHHH	44.16	29967540
1252	Phosphorylation	EREKVQVTAKTMAQH HHHHHHHHHHHHHHH	12.82	20068231
1254	Ubiquitination	EKVQVTAKTMAQHEE HHHHHHHHHHHHHHH	29.48	21906983
1254	Ubiquitination	EKVQVTAKTMAQHEE HHHHHHHHHHHHHHH	29.48	21890473
1254	Ubiquitination	EKVQVTAKTMAQHEE HHHHHHHHHHHHHHH	29.48	21890473
1255	Phosphorylation	KVQVTAKTMAQHEEL HHHHHHHHHHHHHHH	18.44	20068231
1265	Trimethylation	QHEELMKKTETMNVV HHHHHHHHHCHHHHH	37.31	-
1265	Acetylation	QHEELMKKTETMNVV HHHHHHHHHCHHHHH	37.31	20167786
1265	Methylation	QHEELMKKTETMNVV HHHHHHHHHCHHHHH	37.31	-
1266	O-linked_Glycosylation	HEELMKKTETMNVVM HHHHHHHHCHHHHHH	31.04	30059200
1266	Phosphorylation	HEELMKKTETMNVVM HHHHHHHHCHHHHHH	31.04	23401153
1268	Phosphorylation	ELMKKTETMNVVMET HHHHHHCHHHHHHHH	21.19	29978859
1275	Phosphorylation	TMNVVMETNKMLREE HHHHHHHHHHHHHHH	23.26	23401153
1277	Acetylation	NVVMETNKMLREEKE HHHHHHHHHHHHHHH	46.89	20167786
1293	Sulfoxidation	LEQDLQQMQAKVRKL HHHHHHHHHHHHHHH	2.42	21406390
1296	Ubiquitination	DLQQMQAKVRKLELD HHHHHHHHHHHHHHH	26.19	21906983
1296	Ubiquitination	DLQQMQAKVRKLELD HHHHHHHHHHHHHHH	26.19	21890473
1296	Ubiquitination	DLQQMQAKVRKLELD HHHHHHHHHHHHHHH	26.19	21890473
1299	Acetylation	QMQAKVRKLELDILP HHHHHHHHHHHHCCC	49.66	26051181
1299	Ubiquitination	QMQAKVRKLELDILP HHHHHHHHHHHHCCC	49.66	22817900
1317	Acetylation	ANAELSEKSGMLQAE HCHHHHHHHCCHHHH	49.27	19824191
1318	O-linked_Glycosylation	NAELSEKSGMLQAEK CHHHHHHHCCHHHHH	25.94	30059200
1318	Phosphorylation	NAELSEKSGMLQAEK CHHHHHHHCCHHHHH	25.94	29396449
1325	Acetylation	SGMLQAEKKLLEEDV HCCHHHHHHHHHHHH	52.30	12437643
1326	Trimethylation	GMLQAEKKLLEEDVK CCHHHHHHHHHHHHH	50.22	-
1326	Acetylation	GMLQAEKKLLEEDVK CCHHHHHHHHHHHHH	50.22	19824199
1326	Methylation	GMLQAEKKLLEEDVK CCHHHHHHHHHHHHH	50.22	23644510
1333	Acetylation	KLLEEDVKRWKARNQ HHHHHHHHHHHHHHH	65.93	25953088
1333	Malonylation	KLLEEDVKRWKARNQ HHHHHHHHHHHHHHH	65.93	26320211
1344	Phosphorylation	ARNQHLVSQQKDPDT HHHHHHHHCCCCCCH	33.00	28555341
1347	Acetylation	QHLVSQQKDPDTEEY HHHHHCCCCCCHHHH	64.69	26051181
1347	Ubiquitination	QHLVSQQKDPDTEEY HHHHHCCCCCCHHHH	64.69	29967540
1356	Ubiquitination	PDTEEYRKLLSEKEV CCHHHHHHHHHHHHH	53.53	24816145
1359	Phosphorylation	EEYRKLLSEKEVHTK HHHHHHHHHHHHHHH	57.99	24719451
1361	2-Hydroxyisobutyrylation	YRKLLSEKEVHTKRI HHHHHHHHHHHHHHH	62.76	-
1361	Acetylation	YRKLLSEKEVHTKRI HHHHHHHHHHHHHHH	62.76	25953088
1361	Ubiquitination	YRKLLSEKEVHTKRI HHHHHHHHHHHHHHH	62.76	33845483
1385	Phosphorylation	LKAEIARSNASLTNN HHHHHHHCCCCCCCC	27.94	20068231
1388	Phosphorylation	EIARSNASLTNNQNL HHHHCCCCCCCCHHH	39.72	20068231
1390	Phosphorylation	ARSNASLTNNQNLIQ HHCCCCCCCCHHHHH	29.63	20068231
1398	Phosphorylation	NNQNLIQSLKEDLNK CCHHHHHHHHHHHHH	34.12	20068231
1400	Acetylation	QNLIQSLKEDLNKVR HHHHHHHHHHHHHHH	55.20	25953088
1400	Ubiquitination	QNLIQSLKEDLNKVR HHHHHHHHHHHHHHH	55.20	23000965
1400	Ubiquitination	QNLIQSLKEDLNKVR HHHHHHHHHHHHHHH	55.20	21890473
1400	Ubiquitination	QNLIQSLKEDLNKVR HHHHHHHHHHHHHHH	55.20	21890473
1405	Ubiquitination	SLKEDLNKVRTEKET HHHHHHHHHHHHHHH	40.15	23000965
1410	Acetylation	LNKVRTEKETIQKDL HHHHHHHHHHHHHHH	60.59	25953088
1415	Ubiquitination	TEKETIQKDLDAKII HHHHHHHHHHHHHEE	57.31	33845483
1420	2-Hydroxyisobutyrylation	IQKDLDAKIIDIQEK HHHHHHHHEEEHHHH	39.60	-
1420	Acetylation	IQKDLDAKIIDIQEK HHHHHHHHEEEHHHH	39.60	26051181
1420	Ubiquitination	IQKDLDAKIIDIQEK HHHHHHHHEEEHHHH	39.60	32142685
1427	2-Hydroxyisobutyrylation	KIIDIQEKVKTITQV HEEEHHHHHHHHHHH	32.43	-
1427	Acetylation	KIIDIQEKVKTITQV HEEEHHHHHHHHHHH	32.43	23749302
1427	Ubiquitination	KIIDIQEKVKTITQV HEEEHHHHHHHHHHH	32.43	29967540
1429	Ubiquitination	IDIQEKVKTITQVKK EEHHHHHHHHHHHHH	45.32	29967540
1435	2-Hydroxyisobutyrylation	VKTITQVKKIGRRYK HHHHHHHHHHCHHHH	28.93	-
1435	Acetylation	VKTITQVKKIGRRYK HHHHHHHHHHCHHHH	28.93	25953088
1435	Ubiquitination	VKTITQVKKIGRRYK HHHHHHHHHHCHHHH	28.93	27667366
1441	Phosphorylation	VKKIGRRYKTQYEEL HHHHCHHHHHHHHHH	19.61	-
1442	2-Hydroxyisobutyrylation	KKIGRRYKTQYEELK HHHCHHHHHHHHHHH	27.60	-
1445	Phosphorylation	GRRYKTQYEELKAQQ CHHHHHHHHHHHHHH	19.32	-
1449	Ubiquitination	KTQYEELKAQQDKVM HHHHHHHHHHHCHHH	47.64	21906983
1454	Ubiquitination	ELKAQQDKVMETSAQ HHHHHHCHHHHHHHC	38.86	22817900
1458	Phosphorylation	QQDKVMETSAQSSGD HHCHHHHHHHCCCCC	15.97	20068231
1459	Phosphorylation	QDKVMETSAQSSGDH HCHHHHHHHCCCCCH	15.82	25159151
1462	Phosphorylation	VMETSAQSSGDHQEQ HHHHHHCCCCCHHHH	35.68	25159151
1463	Phosphorylation	METSAQSSGDHQEQH HHHHHCCCCCHHHHH	35.84	30576142
1472	Phosphorylation	DHQEQHVSVQEMQEL CHHHHHCCHHHHHHH	18.89	23186163
1480	Acetylation	VQEMQELKETLNQAE HHHHHHHHHHHHHHH	48.15	26051181
1480	Ubiquitination	VQEMQELKETLNQAE HHHHHHHHHHHHHHH	48.15	32015554
1489	Ubiquitination	TLNQAETKSKSLESQ HHHHHHHHHHHHHHH	47.60	22817900
1490	Phosphorylation	LNQAETKSKSLESQV HHHHHHHHHHHHHHH	34.59	-
1491	Ubiquitination	NQAETKSKSLESQVE HHHHHHHHHHHHHHH	61.69	21906983
1491	Ubiquitination	NQAETKSKSLESQVE HHHHHHHHHHHHHHH	61.69	21890473
1491	Ubiquitination	NQAETKSKSLESQVE HHHHHHHHHHHHHHH	61.69	21890473
1492	Phosphorylation	QAETKSKSLESQVEN HHHHHHHHHHHHHHH	44.45	21601212
1495	Phosphorylation	TKSKSLESQVENLQK HHHHHHHHHHHHHHH	44.83	21712546
1502	Ubiquitination	SQVENLQKTLSEKET HHHHHHHHHHCHHHH	55.38	29967540
1503	Phosphorylation	QVENLQKTLSEKETE HHHHHHHHHCHHHHH	23.66	-
1505	Phosphorylation	ENLQKTLSEKETEAR HHHHHHHCHHHHHHH	52.43	-
1507	Ubiquitination	LQKTLSEKETEARNL HHHHHCHHHHHHHHH	67.57	29901268
1509	Phosphorylation	KTLSEKETEARNLQE HHHCHHHHHHHHHHH	46.11	21601212
1518	Phosphorylation	ARNLQEQTVQLQSEL HHHHHHHHHHHHHHH	14.96	30242111
1523	Phosphorylation	EQTVQLQSELSRLRQ HHHHHHHHHHHHHHH	49.44	30242111
1526	Phosphorylation	VQLQSELSRLRQDLQ HHHHHHHHHHHHHHH	25.80	30242111
1535	Methylation	LRQDLQDRTTQEEQL HHHHHHHHHHHHHHH	27.06	115918833
1547	Phosphorylation	EQLRQQITEKEEKTR HHHHHHHHHHHHHHH	36.34	28842319
1549	Acetylation	LRQQITEKEEKTRKA HHHHHHHHHHHHHHH	63.62	23749302
1549	Ubiquitination	LRQQITEKEEKTRKA HHHHHHHHHHHHHHH	63.62	24816145
1552	Acetylation	QITEKEEKTRKAIVA HHHHHHHHHHHHHHH	55.51	23749302
1561	2-Hydroxyisobutyrylation	RKAIVAAKSKIAHLA HHHHHHHHHHHHHHH	42.41	-
1561	Acetylation	RKAIVAAKSKIAHLA HHHHHHHHHHHHHHH	42.41	25953088
1563	Malonylation	AIVAAKSKIAHLAGV HHHHHHHHHHHHHCC	43.11	26320211
1563	Ubiquitination	AIVAAKSKIAHLAGV HHHHHHHHHHHHHCC	43.11	29967540
1571	2-Hydroxyisobutyrylation	IAHLAGVKDQLTKEN HHHHHCCHHHHHHHH	38.55	-
1571	Acetylation	IAHLAGVKDQLTKEN HHHHHCCHHHHHHHH	38.55	26051181
1571	Ubiquitination	IAHLAGVKDQLTKEN HHHHHCCHHHHHHHH	38.55	29967540
1575	Phosphorylation	AGVKDQLTKENEELK HCCHHHHHHHHHHHH	30.58	28634298
1576	Ubiquitination	GVKDQLTKENEELKQ CCHHHHHHHHHHHHH	68.11	33845483
1592	Acetylation	NGALDQQKDELDVRI CCCHHHHHHHHHHHH	47.76	26051181
1592	Ubiquitination	NGALDQQKDELDVRI CCCHHHHHHHHHHHH	47.76	24816145
1600	Phosphorylation	DELDVRITALKSQYE HHHHHHHHHHHHHHH	18.51	28555341
1603	2-Hydroxyisobutyrylation	DVRITALKSQYEGRI HHHHHHHHHHHHHHH	32.80	-
1603	Acetylation	DVRITALKSQYEGRI HHHHHHHHHHHHHHH	32.80	25953088
1603	Malonylation	DVRITALKSQYEGRI HHHHHHHHHHHHHHH	32.80	26320211
1603	Methylation	DVRITALKSQYEGRI HHHHHHHHHHHHHHH	32.80	115979617
1603	Ubiquitination	DVRITALKSQYEGRI HHHHHHHHHHHHHHH	32.80	33845483
1604	Phosphorylation	VRITALKSQYEGRIS HHHHHHHHHHHHHHH	38.55	20860994
1611	Phosphorylation	SQYEGRISRLERELR HHHHHHHHHHHHHHH	29.47	28348404
1637	Ubiquitination	EPQEPSNKVPEQQRQ CCCCCCCCCCHHHHC	64.60	21906983
1648	Acetylation	QQRQITLKTTPASGE HHHCEEEECCCCCCC	41.52	25953088
1648	Ubiquitination	QQRQITLKTTPASGE HHHCEEEECCCCCCC	41.52	27667366
1649	Phosphorylation	QRQITLKTTPASGER HHCEEEECCCCCCCC	40.92	29396449
1650	Phosphorylation	RQITLKTTPASGERG HCEEEECCCCCCCCC	18.44	29396449
1653	Phosphorylation	TLKTTPASGERGIAS EEECCCCCCCCCCCC	42.25	29396449
1656	Methylation	TTPASGERGIASTSD CCCCCCCCCCCCCCC	45.39	115918837
1660	O-linked_Glycosylation	SGERGIASTSDPPTA CCCCCCCCCCCCCCC	26.90	30059200
1660	Phosphorylation	SGERGIASTSDPPTA CCCCCCCCCCCCCCC	26.90	25159151
1661	Phosphorylation	GERGIASTSDPPTAN CCCCCCCCCCCCCCC	28.29	25159151
1662	Phosphorylation	ERGIASTSDPPTANI CCCCCCCCCCCCCCC	45.70	25159151
1666	Phosphorylation	ASTSDPPTANIKPTP CCCCCCCCCCCCCCC	37.41	30266825
1670	Acetylation	DPPTANIKPTPVVST CCCCCCCCCCCCCCC	42.52	23236377
1670	Ubiquitination	DPPTANIKPTPVVST CCCCCCCCCCCCCCC	42.52	23000965
1672	O-linked_Glycosylation	PTANIKPTPVVSTPS CCCCCCCCCCCCCCC	24.58	30059200
1672	Phosphorylation	PTANIKPTPVVSTPS CCCCCCCCCCCCCCC	24.58	30266825
1676	O-linked_Glycosylation	IKPTPVVSTPSKVTA CCCCCCCCCCCHHHH	34.53	32574038
1676	Phosphorylation	IKPTPVVSTPSKVTA CCCCCCCCCCCHHHH	34.53	30266825
1677	O-linked_Glycosylation	KPTPVVSTPSKVTAA CCCCCCCCCCHHHHH	21.70	30059200
1677	Phosphorylation	KPTPVVSTPSKVTAA CCCCCCCCCCHHHHH	21.70	30266825
1679	O-linked_Glycosylation	TPVVSTPSKVTAAAM CCCCCCCCHHHHHHH	39.59	30059200
1679	Phosphorylation	TPVVSTPSKVTAAAM CCCCCCCCHHHHHHH	39.59	30266825
1680	Acetylation	PVVSTPSKVTAAAMA CCCCCCCHHHHHHHC	44.82	25953088
1680	Ubiquitination	PVVSTPSKVTAAAMA CCCCCCCHHHHHHHC	44.82	32015554
1682	Phosphorylation	VSTPSKVTAAAMAGN CCCCCHHHHHHHCCC	17.83	23403867
1690	Acetylation	AAAMAGNKSTPRASI HHHHCCCCCCCCCCC	55.58	26051181
1690	Ubiquitination	AAAMAGNKSTPRASI HHHHCCCCCCCCCCC	55.58	21906983
1691	O-linked_Glycosylation	AAMAGNKSTPRASIR HHHCCCCCCCCCCCC	47.87	30059200
1691	Phosphorylation	AAMAGNKSTPRASIR HHHCCCCCCCCCCCC	47.87	25159151
1692	Phosphorylation	AMAGNKSTPRASIRP HHCCCCCCCCCCCCC	20.57	25159151
1696	Phosphorylation	NKSTPRASIRPMVTP CCCCCCCCCCCCCCC	22.02	27251275
1711	Phosphorylation	ATVTNPTTTPTATVM CEECCCCCCCCCEEC	31.84	28348404
1712	Phosphorylation	TVTNPTTTPTATVMP EECCCCCCCCCEECC	22.56	22210691
1714	Phosphorylation	TNPTTTPTATVMPTT CCCCCCCCCEECCCC	32.63	28348404
1716	Phosphorylation	PTTTPTATVMPTTQV CCCCCCCEECCCCCC	21.58	28348404
1725	Phosphorylation	MPTTQVESQEAMQSE CCCCCCCCHHHHHCC	34.17	19007248
1731	Phosphorylation	ESQEAMQSEGPVEHV CCHHHHHCCCCCCCC	31.28	28464451
1743	Phosphorylation	EHVPVFGSTSGSVRS CCCCEECCCCCCCCC	14.13	26074081
1744	Phosphorylation	HVPVFGSTSGSVRST CCCEECCCCCCCCCC	37.17	26074081
1745	Phosphorylation	VPVFGSTSGSVRSTS CCEECCCCCCCCCCC	30.67	26074081
1747	Phosphorylation	VFGSTSGSVRSTSPN EECCCCCCCCCCCCC	17.71	26074081
1750	Phosphorylation	STSGSVRSTSPNVQP CCCCCCCCCCCCCCC	30.95	26074081
1751	Phosphorylation	TSGSVRSTSPNVQPS CCCCCCCCCCCCCCC	37.32	26074081
1752	Phosphorylation	SGSVRSTSPNVQPSI CCCCCCCCCCCCCCC	18.74	26074081
1758	Phosphorylation	TSPNVQPSISQPILT CCCCCCCCCCCCEEE	20.13	26074081
1760	Phosphorylation	PNVQPSISQPILTVQ CCCCCCCCCCEEEEE	33.95	26074081
1803	Phosphorylation	NIVEVVQSSPVERPS CHHHHHHCCCCCCCC	25.62	26074081
1804	O-linked_Glycosylation	IVEVVQSSPVERPST HHHHHHCCCCCCCCC	18.84	30059200
1804	Phosphorylation	IVEVVQSSPVERPST HHHHHHCCCCCCCCC	18.84	26074081
1810	Phosphorylation	SSPVERPSTSTAVFG CCCCCCCCCCEEEEE	41.01	26074081
1811	Phosphorylation	SPVERPSTSTAVFGT CCCCCCCCCEEEEEE	32.55	26074081
1812	Phosphorylation	PVERPSTSTAVFGTV CCCCCCCCEEEEEEE	20.78	26074081
1813	Phosphorylation	VERPSTSTAVFGTVS CCCCCCCEEEEEEEE	27.25	26074081
1818	Phosphorylation	TSTAVFGTVSATPSS CCEEEEEEEECCCCC	10.38	26074081
1820	Phosphorylation	TAVFGTVSATPSSSL EEEEEEEECCCCCCC	26.68	26074081
1822	O-linked_Glycosylation	VFGTVSATPSSSLPK EEEEEECCCCCCCCC	19.05	OGP
1822	Phosphorylation	VFGTVSATPSSSLPK EEEEEECCCCCCCCC	19.05	25850435
1824	Phosphorylation	GTVSATPSSSLPKRT EEEECCCCCCCCCCC	28.36	25850435
1825	Phosphorylation	TVSATPSSSLPKRTR EEECCCCCCCCCCCC	36.78	26074081
1826	Phosphorylation	VSATPSSSLPKRTRE EECCCCCCCCCCCCC	53.69	26074081
1831	Phosphorylation	SSSLPKRTREEEEDS CCCCCCCCCCHHCCC	48.86	28176443
1838	Phosphorylation	TREEEEDSTIEASDQ CCCHHCCCCCCCCCC	34.27	25159151
1839	Phosphorylation	REEEEDSTIEASDQV CCHHCCCCCCCCCCC	34.85	25159151
1843	Phosphorylation	EDSTIEASDQVSDDT CCCCCCCCCCCCCCC	18.78	30266825
1847	Phosphorylation	IEASDQVSDDTVEMP CCCCCCCCCCCCCCC	24.92	30266825
1850	Phosphorylation	SDQVSDDTVEMPLPK CCCCCCCCCCCCCCC	24.29	30266825
1857	Acetylation	TVEMPLPKKLKSVTP CCCCCCCCCCCCCCC	77.68	26051181
1890	Phosphorylation	TQVYNQDSQDSIGEG EEEECCCCCCCCCCC	26.56	22468782
1893	Phosphorylation	YNQDSQDSIGEGVTQ ECCCCCCCCCCCCCC	25.51	22468782
1903	Phosphorylation	EGVTQGDYTPMEDSE CCCCCCCCCCCCCCH	21.40	22817900
2020	Phosphorylation	DPGTETEESMGGGEG CCCCCCCHHCCCCCC	54.14	18669648
2034	Phosphorylation	GNHRAADSQNSGEGN CCCCCCCCCCCCCCC	26.91	17525332
2036	Phosphorylation	HRAADSQNSGEGNTG CCCCCCCCCCCCCCC	56.80	17525332
2037	Phosphorylation	RAADSQNSGEGNTGA CCCCCCCCCCCCCCC	30.50	22167270
2042	Phosphorylation	QNSGEGNTGAAESSF CCCCCCCCCCCCCHH	38.77	22167270
2047	Phosphorylation	GNTGAAESSFSQEVS CCCCCCCCHHHHHHC	31.77	30278072
2048	Phosphorylation	NTGAAESSFSQEVSR CCCCCCCHHHHHHCH	22.03	23927012
2050	Phosphorylation	GAAESSFSQEVSREQ CCCCCHHHHHHCHHH	27.64	17525332
2054	Phosphorylation	SSFSQEVSREQQPSS CHHHHHHCHHHCCCC	29.37	23927012
2060	Phosphorylation	VSREQQPSSASERQA HCHHHCCCCHHHCCC	33.91	29978859
2061	Phosphorylation	SREQQPSSASERQAP CHHHCCCCHHHCCCC	42.36	30619164
2063	O-linked_Glycosylation	EQQPSSASERQAPRA HHCCCCHHHCCCCCC	34.95	30059200
2063	Phosphorylation	EQQPSSASERQAPRA HHCCCCHHHCCCCCC	34.95	29978859
2073	Phosphorylation	QAPRAPQSPRRPPHP CCCCCCCCCCCCCCC	21.22	28355574
2086	Phosphorylation	HPLPPRLTIHAPPQE CCCCCCCEEECCHHH	16.40	26074081
2106	Methylation	QRIQMTRRQSVGRGL CEEECCCHHCCCCCC	24.78	30761405
2108	Phosphorylation	IQMTRRQSVGRGLQL EECCCHHCCCCCCCC	25.40	30576142
2111	Dimethylation	TRRQSVGRGLQLTPG CCHHCCCCCCCCCCC	40.26	-
2111	Methylation	TRRQSVGRGLQLTPG CCHHCCCCCCCCCCC	40.26	24129315
2116	Phosphorylation	VGRGLQLTPGIGGMQ CCCCCCCCCCCCCCC	13.40	23401153
2132	Methylation	HFFDDEDRTVPSTPT CCCCCCCCCCCCCCE	35.26	115384279
2133	Phosphorylation	FFDDEDRTVPSTPTL CCCCCCCCCCCCCEE	49.44	30266825
2136	Phosphorylation	DEDRTVPSTPTLVVP CCCCCCCCCCEEEEC	42.56	25463755
2137	Phosphorylation	EDRTVPSTPTLVVPH CCCCCCCCCEEEECC	17.77	30266825
2139	Phosphorylation	RTVPSTPTLVVPHRT CCCCCCCEEEECCCC	32.07	27273156
2141	Phosphorylation	VPSTPTLVVPHRTDG CCCCCEEEECCCCCC	7.47	17287340
2146	Phosphorylation	TLVVPHRTDGFAEAI EEEECCCCCCHHHHH	37.12	23927012
2155	Phosphorylation	GFAEAIHSPQVAGVP CHHHHHCCCCCCCCC	15.77	29255136
2163	Methylation	PQVAGVPRFRFGPPE CCCCCCCCCCCCCCC	32.73	24411121
2165	Methylation	VAGVPRFRFGPPEDM CCCCCCCCCCCCCCC	36.57	80702649
2175	Phosphorylation	PPEDMPQTSSSHSDL CCCCCCCCCCCCCHH	25.38	28122231
2176	O-linked_Glycosylation	PEDMPQTSSSHSDLG CCCCCCCCCCCCHHH	25.29	30059200
2176	Phosphorylation	PEDMPQTSSSHSDLG CCCCCCCCCCCCHHH	25.29	28464451
2177	Phosphorylation	EDMPQTSSSHSDLGQ CCCCCCCCCCCHHHH	35.14	27251275
2178	Phosphorylation	DMPQTSSSHSDLGQL CCCCCCCCCCHHHHH	27.12	29496963
2180	Phosphorylation	PQTSSSHSDLGQLAS CCCCCCCCHHHHHHH	36.16	28464451
2187	O-linked_Glycosylation	SDLGQLASQGGLGMY CHHHHHHHCCCCCCC	37.64	30059200
2187	Phosphorylation	SDLGQLASQGGLGMY CHHHHHHHCCCCCCC	37.64	27251275
2194	Phosphorylation	SQGGLGMYETPLFLA HCCCCCCCCCCEEEE	18.17	28796482
2196	Phosphorylation	GGLGMYETPLFLAHE CCCCCCCCCEEEEEC	14.06	28796482
2206	Phosphorylation	FLAHEEESGGRSVPT EEEECHHCCCCCCCC	50.23	26074081
2210	Phosphorylation	EEESGGRSVPTTPLQ CHHCCCCCCCCCCCE	35.41	25137130
2213	Phosphorylation	SGGRSVPTTPLQVAA CCCCCCCCCCCEEEC	38.60	26074081
2214	Phosphorylation	GGRSVPTTPLQVAAP CCCCCCCCCCEEECC	18.87	25137130
2223	Phosphorylation	LQVAAPVTVFTESTT CEEECCEEEEECCCC	14.62	26074081
2327	Methylation	PKPFRRVRLQTTLRQ CCCCCEEHHHHHHHH	21.19	54560259
2330	O-linked_Glycosylation	FRRVRLQTTLRQGVR CCEEHHHHHHHHCCC	32.18	30059200
2330	Phosphorylation	FRRVRLQTTLRQGVR CCEEHHHHHHHHCCC	32.18	26270265
2331	Phosphorylation	RRVRLQTTLRQGVRG CEEHHHHHHHHCCCC	13.64	26270265
2333	Methylation	VRLQTTLRQGVRGRQ EHHHHHHHHCCCCCC	29.16	81453743
2337	Methylation	TTLRQGVRGRQFNRQ HHHHHCCCCCCHHHH	41.21	115918841
2339	Methylation	LRQGVRGRQFNRQRG HHHCCCCCCHHHHHC	27.61	115918845
2343	Asymmetric dimethylarginine	VRGRQFNRQRGVSHA CCCCCHHHHHCCCHH	28.94	-
2343	Methylation	VRGRQFNRQRGVSHA CCCCCHHHHHCCCHH	28.94	54549559
2345	Asymmetric dimethylarginine	GRQFNRQRGVSHAMG CCCHHHHHCCCHHHC	44.22	-
2345	Methylation	GRQFNRQRGVSHAMG CCCHHHHHCCCHHHC	44.22	97770607
2354	Asymmetric dimethylarginine	VSHAMGGRGGINRGN CCHHHCCCCCCCCCC	34.14	-
2354	Methylation	VSHAMGGRGGINRGN CCHHHCCCCCCCCCC	34.14	54549563
2359	Dimethylation	GGRGGINRGNIN--- CCCCCCCCCCCC---	37.30	-
2359	Methylation	GGRGGINRGNIN--- CCCCCCCCCCCC---	37.30	54549111

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2073	S	Phosphorylation	Kinase	CDK1	P06493	PSP
2108	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TPR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TPR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP98_HUMAN	NUP98	physical	12802065
NU107_HUMAN	NUP107	physical	12802065
NU205_HUMAN	NUP205	physical	12802065
NUP93_HUMAN	NUP93	physical	12802065
NU153_HUMAN	NUP153	physical	12802065
NUP98_HUMAN	NUP98	physical	11248057
U2AF2_HUMAN	U2AF2	physical	22939629
U5S1_HUMAN	EFTUD2	physical	22939629
MD1L1_HUMAN	MAD1L1	physical	24581499
ATLA3_HUMAN	ATL3	physical	26344197
EF1D_HUMAN	EEF1D	physical	26344197
GLRX1_HUMAN	GLRX	physical	26344197
NU107_HUMAN	NUP107	physical	26344197
RRP12_HUMAN	RRP12	physical	26344197
SRS11_HUMAN	SRSF11	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197

Drug and Disease Associations

Kegg Disease
H00032	Thyroid cancer
OMIM Disease
188550	Thyroid papillary carcinoma (TPC)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TPR_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-379; THR-381; SER-1185 AND THR-1677, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-252; LYS-312; LYS-345;LYS-428; LYS-457; LYS-713; LYS-723; LYS-748 AND LYS-755, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1185; SER-2050 ANDSER-2155, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-379; THR-381; SER-1185 AND THR-1677, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-379; SER-1185; SER-2048AND SER-2155, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2155, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1725 AND SER-1804, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-920; SER-2034 ANDSER-2050, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-646; SER-1185 ANDSER-2155, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2155, AND MASSSPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1185, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2073 AND SER-2155, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2037, AND MASSSPECTROMETRY.	15302935 [Abstract]