RRP12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRP12_HUMAN
• UniProt AC: Q5JTH9
• Protein Name: RRP12-like protein
• Gene Name: RRP12
• Organism: Homo sapiens (Human).
• Sequence Length: 1297
• Subcellular Localization: Nucleus, nucleolus . Nucleus membrane ; Single-pass membrane protein .
• Protein Sequence: MGRSGKLPSGVSAKLKRWKKGHSSDSNPAICRHRQAARSRFFSRPSGRSDLTVDAVKLHNELQSGSLRLGKSEAPETPMEEEAELVLTEKSSGTFLSGLSDCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVESPESLAAVAYLLNLVLKRVPSPVLIKKFSDTSKAFMDIMSAQASSGSTSVLRWVLSCLATLLRKQDLEAWGYPVTLQVYHGLLSFTVHPKPKIRKAAQHGVCSVLKGSEFMFEKAPAHHPAAISTAKFCIQEIEKSGGSKEATTTLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLSHVLVTACAMQAFHSLFHARPGLSTLSAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHINLVRLQWDLGLGHLPRFFGTAVTCLLSPHSQVLTAATQSLKEILKECVAPHMADIGSVTSSASGPAQSVAKMFRAVEEGLTYKFHAAWSSVLQLLCVFFEACGRQAHPVMRKCLQSLCDLRLSPHFPHTAALDQAVGAAVTSMGPEVVLQAVPLEIDGSEETLDFPRSWLLPVIRDHVQETRLGFFTTYFLPLANTLKSKAMDLAQAGSTVESKIYDTLQWQMWTLLPGFCTRPTDVAISFKGLARTLGMAISERPDLRVTVCQALRTLITKGCQAEADRAEVSRFAKNFLPILFNLYGQPVAAGDTPAPRRAVLETIRTYLTITDTQLVNSLLEKASEKVLDPASSDFTRLSVLDLVVALAPCADEAAISKLYSTIRPYLESKAHGVQKKAYRVLEEVCASPQGPGALFVQSHLEDLKKTLLDSLRSTSSPAKRPRLKCLLHIVRKLSAEHKEFITALIPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGSNQEEALQCYLVLIYPGLVGAVTMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVTVMDVAHLAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELVKRLLPEEYHRVLVNIRKAEARAKRHRALSQAAVEEEEEEEEEEEPAQGKGDSIEEILADSEDEEDNEEEERSRGKEQRKLARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGRKKDHGFKVSADGRLIIREEADGNKMEEEEGAKGEDEEMADPMEDVIIRNKKHQKLKHQKEAEEEELEIPPQYQAGGSGIHRPVAKKAMPGAEYKAKKAKGDVKKKGRPDPYAYIPLNRSKLNRRKKMKLQGQFKGLVKAARRGSQVGHKNRRKDRRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGRSGKLPSGV ----CCCCCCCCCCH	51.66	20068231
6	Acetylation	--MGRSGKLPSGVSA --CCCCCCCCCCHHH	59.48	25953088
6	Ubiquitination	--MGRSGKLPSGVSA --CCCCCCCCCCHHH	59.48	-
9	Phosphorylation	GRSGKLPSGVSAKLK CCCCCCCCCHHHHHH	63.36	20068231
12	Phosphorylation	GKLPSGVSAKLKRWK CCCCCCHHHHHHHHH	24.18	20068231
14	Acetylation	LPSGVSAKLKRWKKG CCCCHHHHHHHHHCC	47.22	23954790
14	Ubiquitination	LPSGVSAKLKRWKKG CCCCHHHHHHHHHCC	47.22	-
23	Phosphorylation	KRWKKGHSSDSNPAI HHHHCCCCCCCCHHH	44.50	26434776
24	Phosphorylation	RWKKGHSSDSNPAIC HHHCCCCCCCCHHHH	39.11	26434776
26	Phosphorylation	KKGHSSDSNPAICRH HCCCCCCCCHHHHHH	46.81	26434776
39	Phosphorylation	RHRQAARSRFFSRPS HHHHHHHHHHCCCCC	28.81	28555341
46	Phosphorylation	SRFFSRPSGRSDLTV HHHCCCCCCCCCCEE	45.81	20860994
49	Phosphorylation	FSRPSGRSDLTVDAV CCCCCCCCCCEEEHH	40.26	19060867
52	Phosphorylation	PSGRSDLTVDAVKLH CCCCCCCEEEHHHHH	22.72	21815630
57	2-Hydroxyisobutyrylation	DLTVDAVKLHNELQS CCEEEHHHHHHHHHH	45.83	-
57	Acetylation	DLTVDAVKLHNELQS CCEEEHHHHHHHHHH	45.83	26051181
57	Ubiquitination	DLTVDAVKLHNELQS CCEEEHHHHHHHHHH	45.83	-
64	Phosphorylation	KLHNELQSGSLRLGK HHHHHHHHCCCEECC	42.87	30266825
66	Phosphorylation	HNELQSGSLRLGKSE HHHHHHCCCEECCCC	18.63	30266825
71	Acetylation	SGSLRLGKSEAPETP HCCCEECCCCCCCCC	50.11	26051181
71	Sumoylation	SGSLRLGKSEAPETP HCCCEECCCCCCCCC	50.11	25114211
71	Ubiquitination	SGSLRLGKSEAPETP HCCCEECCCCCCCCC	50.11	21906983
71 (in isoform 1)	Ubiquitination	-	50.11	21906983
71 (in isoform 2)	Ubiquitination	-	50.11	21906983
72	Phosphorylation	GSLRLGKSEAPETPM CCCEECCCCCCCCCC	36.87	25159151
77	Phosphorylation	GKSEAPETPMEEEAE CCCCCCCCCCHHHCE	27.20	25159151
88	Phosphorylation	EEAELVLTEKSSGTF HHCEEEEEECCCCCC	33.61	19664994
91	Phosphorylation	ELVLTEKSSGTFLSG EEEEEECCCCCCCCC	27.97	29743597
92	Phosphorylation	LVLTEKSSGTFLSGL EEEEECCCCCCCCCC	53.58	29743597
94	Phosphorylation	LTEKSSGTFLSGLSD EEECCCCCCCCCCCC	24.29	25159151
97	Phosphorylation	KSSGTFLSGLSDCTN CCCCCCCCCCCCCCC	33.23	25159151
100	Phosphorylation	GTFLSGLSDCTNVTF CCCCCCCCCCCCCCH	33.88	18691976
103	Phosphorylation	LSGLSDCTNVTFSKV CCCCCCCCCCCHHHH	37.40	25159151
106	Phosphorylation	LSDCTNVTFSKVQRF CCCCCCCCHHHHHHH	25.02	25159151
109	Acetylation	CTNVTFSKVQRFWES CCCCCHHHHHHHHHC	37.89	26051181
109	Ubiquitination	CTNVTFSKVQRFWES CCCCCHHHHHHHHHC	37.89	-
116	Phosphorylation	KVQRFWESNSAAHKE HHHHHHHCCHHHHHH	27.04	27732954
118	Phosphorylation	QRFWESNSAAHKEIC HHHHHCCHHHHHHHH	35.79	25159151
132	Phosphorylation	CAVLAAVTEVIRSQG HHHHHHHHHHHHHCC	21.58	21601212
137	Phosphorylation	AVTEVIRSQGGKETE HHHHHHHHCCCCCCC	23.27	21601212
180	Phosphorylation	LVLKRVPSPVLIKKF HHHHCCCCCCEEEEC	25.45	27499020
185	2-Hydroxyisobutyrylation	VPSPVLIKKFSDTSK CCCCCEEEECCCCCH	43.54	-
185	Ubiquitination	VPSPVLIKKFSDTSK CCCCCEEEECCCCCH	43.54	-
191	Phosphorylation	IKKFSDTSKAFMDIM EEECCCCCHHHHHHH	27.29	22210691
199	Phosphorylation	KAFMDIMSAQASSGS HHHHHHHHHHCCCCC	19.98	25072903
203	Phosphorylation	DIMSAQASSGSTSVL HHHHHHCCCCCHHHH	24.13	25072903
204	Phosphorylation	IMSAQASSGSTSVLR HHHHHCCCCCHHHHH	39.52	22210691
206	Phosphorylation	SAQASSGSTSVLRWV HHHCCCCCHHHHHHH	21.32	25072903
207	Phosphorylation	AQASSGSTSVLRWVL HHCCCCCHHHHHHHH	26.78	25072903
208	Phosphorylation	QASSGSTSVLRWVLS HCCCCCHHHHHHHHH	22.35	25072903
212 (in isoform 2)	Ubiquitination	-	7.40	21906983
219	Phosphorylation	WVLSCLATLLRKQDL HHHHHHHHHHHHCCH	17.24	24260401
231	Phosphorylation	QDLEAWGYPVTLQVY CCHHHHCCCEEEEEE	5.48	24043423
234	Phosphorylation	EAWGYPVTLQVYHGL HHHCCCEEEEEEEHH	13.63	24043423
238	Phosphorylation	YPVTLQVYHGLLSFT CCEEEEEEEHHHCCC	4.17	24043423
243	Phosphorylation	QVYHGLLSFTVHPKP EEEEHHHCCCCCCCH	24.74	24043423
245	Phosphorylation	YHGLLSFTVHPKPKI EEHHHCCCCCCCHHH	17.96	24043423
254	Ubiquitination	HPKPKIRKAAQHGVC CCCHHHHHHHHHCCH	52.09	-
262	Phosphorylation	AAQHGVCSVLKGSEF HHHHCCHHHHCCCHH	28.25	-
265	Acetylation	HGVCSVLKGSEFMFE HCCHHHHCCCHHHHC	59.23	25953088
265	Ubiquitination	HGVCSVLKGSEFMFE HCCHHHHCCCHHHHC	59.23	-
273	Acetylation	GSEFMFEKAPAHHPA CCHHHHCCCCCCCHH	48.70	25953088
273	Ubiquitination	GSEFMFEKAPAHHPA CCHHHHCCCCCCCHH	48.70	21906983
273 (in isoform 1)	Ubiquitination	-	48.70	21906983
286	Acetylation	PAAISTAKFCIQEIE HHHHHHHHHHHHHHH	40.64	25953088
286	Ubiquitination	PAAISTAKFCIQEIE HHHHHHHHHHHHHHH	40.64	-
288	Glutathionylation	AISTAKFCIQEIEKS HHHHHHHHHHHHHHC	2.86	22555962
294	2-Hydroxyisobutyrylation	FCIQEIEKSGGSKEA HHHHHHHHCCCCHHH	61.12	-
294	Acetylation	FCIQEIEKSGGSKEA HHHHHHHHCCCCHHH	61.12	26051181
294	Ubiquitination	FCIQEIEKSGGSKEA HHHHHHHHCCCCHHH	61.12	-
299	Acetylation	IEKSGGSKEATTTLH HHHCCCCHHHHHHHH	55.43	26051181
309	Phosphorylation	TTTLHMLTLLKDLLP HHHHHHHHHHHHHHC	23.59	18767875
317	S-nitrosocysteine	LLKDLLPCFPEGLVK HHHHHHCCCCHHHHH	10.04	-
317	S-nitrosylation	LLKDLLPCFPEGLVK HHHHHHCCCCHHHHH	10.04	19483679
325	Phosphorylation	FPEGLVKSCSETLLR CCHHHHHHHHHHHHH	18.52	20860994
327	Phosphorylation	EGLVKSCSETLLRVM HHHHHHHHHHHHHHH	40.48	20860994
329	Phosphorylation	LVKSCSETLLRVMTL HHHHHHHHHHHHHHH	18.13	20860994
396	Ubiquitination	AWLKVMEKAHINLVR HHHHHHHHHCCCEEE	27.46	-
444	Acetylation	QSLKEILKECVAPHM HHHHHHHHHHCCHHH	55.52	26051181
444	Ubiquitination	QSLKEILKECVAPHM HHHHHHHHHHCCHHH	55.52	-
458	Phosphorylation	MADIGSVTSSASGPA HHCCCCCCCCCCCCH	20.75	25599653
459	Phosphorylation	ADIGSVTSSASGPAQ HCCCCCCCCCCCCHH	23.04	28348404
460	Phosphorylation	DIGSVTSSASGPAQS CCCCCCCCCCCCHHH	19.65	25159151
462	Phosphorylation	GSVTSSASGPAQSVA CCCCCCCCCCHHHHH	47.46	25599653
467	Phosphorylation	SASGPAQSVAKMFRA CCCCCHHHHHHHHHH	26.58	27251275
470	Acetylation	GPAQSVAKMFRAVEE CCHHHHHHHHHHHHC	36.09	26051181
511	2-Hydroxyisobutyrylation	QAHPVMRKCLQSLCD CCCHHHHHHHHHHHH	22.62	-
511	Acetylation	QAHPVMRKCLQSLCD CCCHHHHHHHHHHHH	22.62	26051181
511	Malonylation	QAHPVMRKCLQSLCD CCCHHHHHHHHHHHH	22.62	26320211
511	Ubiquitination	QAHPVMRKCLQSLCD CCCHHHHHHHHHHHH	22.62	-
536 (in isoform 2)	Ubiquitination	-	15.72	21906983
538 (in isoform 2)	Ubiquitination	-	10.13	21906983
597	Ubiquitination	LPLANTLKSKAMDLA HHHHHHHHHHHHHHH	48.12	21906983
597 (in isoform 1)	Ubiquitination	-	48.12	21906983
598	Phosphorylation	PLANTLKSKAMDLAQ HHHHHHHHHHHHHHH	28.85	20860994
599	2-Hydroxyisobutyrylation	LANTLKSKAMDLAQA HHHHHHHHHHHHHHC	46.25	-
599	Acetylation	LANTLKSKAMDLAQA HHHHHHHHHHHHHHC	46.25	27452117
599	Ubiquitination	LANTLKSKAMDLAQA HHHHHHHHHHHHHHC	46.25	21906983
599 (in isoform 1)	Ubiquitination	-	46.25	21906983
601	Sulfoxidation	NTLKSKAMDLAQAGS HHHHHHHHHHHHCCC	5.08	21406390
608	Phosphorylation	MDLAQAGSTVESKIY HHHHHCCCCHHHHHH	32.09	20860994
610 (in isoform 2)	Ubiquitination	-	9.29	21906983
626 (in isoform 2)	Ubiquitination	-	2.81	21906983
639	Phosphorylation	RPTDVAISFKGLART CCCCEEEHHHHHHHH	15.92	24719451
646	O-linked_Glycosylation	SFKGLARTLGMAISE HHHHHHHHHCHHHHC	23.27	30379171
646	Phosphorylation	SFKGLARTLGMAISE HHHHHHHHHCHHHHC	23.27	-
652	Phosphorylation	RTLGMAISERPDLRV HHHCHHHHCCCCHHH	20.29	-
671	2-Hydroxyisobutyrylation	ALRTLITKGCQAEAD HHHHHHHCCCHHHHH	51.17	-
671	Acetylation	ALRTLITKGCQAEAD HHHHHHHCCCHHHHH	51.17	26051181
671	Malonylation	ALRTLITKGCQAEAD HHHHHHHCCCHHHHH	51.17	26320211
671	Ubiquitination	ALRTLITKGCQAEAD HHHHHHHCCCHHHHH	51.17	-
671 (in isoform 1)	Ubiquitination	-	51.17	21906983
679	Methylation	GCQAEADRAEVSRFA CCHHHHHHHHHHHHH	39.43	115492917
687	Acetylation	AEVSRFAKNFLPILF HHHHHHHHHHHHHHH	45.58	26051181
687	Ubiquitination	AEVSRFAKNFLPILF HHHHHHHHHHHHHHH	45.58	2190698
687 (in isoform 1)	Ubiquitination	-	45.58	21906983
706	Phosphorylation	QPVAAGDTPAPRRAV CCCCCCCCCCCHHHH	22.04	22199227
716	Phosphorylation	PRRAVLETIRTYLTI CHHHHHHHHHHHCCC	16.17	20068231
731	Phosphorylation	TDTQLVNSLLEKASE CCHHHHHHHHHHHHH	27.18	24719451
735	Ubiquitination	LVNSLLEKASEKVLD HHHHHHHHHHHHCCC	58.12	-
737	Phosphorylation	NSLLEKASEKVLDPA HHHHHHHHHHCCCCC	49.36	26074081
739	2-Hydroxyisobutyrylation	LLEKASEKVLDPASS HHHHHHHHCCCCCCC	45.67	-
739	Acetylation	LLEKASEKVLDPASS HHHHHHHHCCCCCCC	45.67	26051181
739	Ubiquitination	LLEKASEKVLDPASS HHHHHHHHCCCCCCC	45.67	-
745	Phosphorylation	EKVLDPASSDFTRLS HHCCCCCCCCCCHHH	35.51	26074081
746	Phosphorylation	KVLDPASSDFTRLSV HCCCCCCCCCCHHHH	38.56	26074081
783	2-Hydroxyisobutyrylation	IRPYLESKAHGVQKK HHHHHHHHCCCCHHH	34.72	-
783	Ubiquitination	IRPYLESKAHGVQKK HHHHHHHHCCCCHHH	34.72	-
801	Phosphorylation	VLEEVCASPQGPGAL HHHHHHCCCCCCCCE	16.78	20873877
818	Acetylation	QSHLEDLKKTLLDSL HHHHHHHHHHHHHHH	56.91	26051181
818	Ubiquitination	QSHLEDLKKTLLDSL HHHHHHHHHHHHHHH	56.91	-
819	Ubiquitination	SHLEDLKKTLLDSLR HHHHHHHHHHHHHHH	52.26	-
820	Phosphorylation	HLEDLKKTLLDSLRS HHHHHHHHHHHHHHC	30.85	30206219
824	Phosphorylation	LKKTLLDSLRSTSSP HHHHHHHHHHCCCCC	26.17	30206219
827	Phosphorylation	TLLDSLRSTSSPAKR HHHHHHHCCCCCCCC	37.62	30206219
828	Phosphorylation	LLDSLRSTSSPAKRP HHHHHHCCCCCCCCH	27.13	30206219
829	Phosphorylation	LDSLRSTSSPAKRPR HHHHHCCCCCCCCHH	35.25	30206219
830	Phosphorylation	DSLRSTSSPAKRPRL HHHHCCCCCCCCHHH	29.03	30206219
838	Ubiquitination	PAKRPRLKCLLHIVR CCCCHHHHHHHHHHH	24.90	-
846	Ubiquitination	CLLHIVRKLSAEHKE HHHHHHHHHCHHHHH	35.58	-
852	Acetylation	RKLSAEHKEFITALI HHHCHHHHHHHHHHH	45.91	26051181
937	Phosphorylation	EFKGLMGTSTVEQLL HCCCCCCCHHHHHHH	13.78	29978859
938	Phosphorylation	FKGLMGTSTVEQLLE CCCCCCCHHHHHHHH	25.40	29978859
939	Phosphorylation	KGLMGTSTVEQLLEN CCCCCCHHHHHHHHH	28.09	29978859
953	Phosphorylation	NVCLLLASRTRDVVK HHHHHHHHCCHHHHH	33.87	29978859
960	2-Hydroxyisobutyrylation	SRTRDVVKSALGFIK HCCHHHHHHHHHHHH	29.84	-
1010	Acetylation	KLRNLFTKFIRKFGF HHHHHHHHHHHHHCH	31.31	26051181
1014	Acetylation	LFTKFIRKFGFELVK HHHHHHHHHCHHHHH	45.05	26051181
1021	Acetylation	KFGFELVKRLLPEEY HHCHHHHHHHCCHHH	50.37	26051181
1049	Phosphorylation	AKRHRALSQAAVEEE HHHHHHHHHHHHHHH	19.45	25159151
1072	Phosphorylation	PAQGKGDSIEEILAD CCCCCCCCHHHHHCC	40.34	22167270
1080	Phosphorylation	IEEILADSEDEEDNE HHHHHCCCCCCCCCH	41.14	29255136
1092	Phosphorylation	DNEEEERSRGKEQRK CCHHHHHHHHHHHHH	48.98	30576142
1105	Phosphorylation	RKLARQRSRAWLKEG HHHHHHHHHHHHHCC	20.29	30624053
1110	Methylation	QRSRAWLKEGGGDEP HHHHHHHHCCCCCCC	43.54	115977399
1110	Ubiquitination	QRSRAWLKEGGGDEP HHHHHHHHCCCCCCC	43.54	-
1124	Ubiquitination	PLNFLDPKVAQRVLA CCCCCCHHHHHHHHH	50.28	-
1132	Phosphorylation	VAQRVLATQPGPGRG HHHHHHHCCCCCCCC	31.00	28555341
1138	Methylation	ATQPGPGRGRKKDHG HCCCCCCCCCCCCCC	44.89	12019387
1140	Methylation	QPGPGRGRKKDHGFK CCCCCCCCCCCCCEE	41.30	115492923
1142	Methylation	GPGRGRKKDHGFKVS CCCCCCCCCCCEEEC	54.30	116252851
1147	Methylation	RKKDHGFKVSADGRL CCCCCCEEECCCCEE	39.61	115977405
1149	Phosphorylation	KDHGFKVSADGRLII CCCCEEECCCCEEEE	22.64	25159151
1212	Phosphorylation	ELEIPPQYQAGGSGI HCCCCCCCCCCCCCC	13.20	28555341
1217	Phosphorylation	PQYQAGGSGIHRPVA CCCCCCCCCCCCCHH	33.39	28985074
1225	Ubiquitination	GIHRPVAKKAMPGAE CCCCCHHHHCCCCHH	41.10	-
1226	Ubiquitination	IHRPVAKKAMPGAEY CCCCHHHHCCCCHHH	39.93	-
1237	Acetylation	GAEYKAKKAKGDVKK CHHHCHHHCCCCCCC	61.26	11791429
1239	Acetylation	EYKAKKAKGDVKKKG HHCHHHCCCCCCCCC	65.60	9854453
1243	Acetylation	KKAKGDVKKKGRPDP HHCCCCCCCCCCCCC	54.21	11791439
1251	Phosphorylation	KKGRPDPYAYIPLNR CCCCCCCCCCCCCCH	21.29	28442448
1253	Phosphorylation	GRPDPYAYIPLNRSK CCCCCCCCCCCCHHH	9.38	22461510
1268	Ubiquitination	LNRRKKMKLQGQFKG CCHHHHHHHHHHHHH	46.68	-
1284	Phosphorylation	VKAARRGSQVGHKNR HHHHHHCCCCCCCCC	21.63	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1049	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRP12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRP12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP2M1_HUMAN	AP2M1	physical	12421765
BRX1_HUMAN	BRIX1	physical	26344197
DDX24_HUMAN	DDX24	physical	26344197
EIF2A_HUMAN	EIF2A	physical	26344197
IF2P_HUMAN	EIF5B	physical	26344197
H1X_HUMAN	H1FX	physical	26344197
MK67I_HUMAN	NIFK	physical	26344197
NOC2L_HUMAN	NOC2L	physical	26344197
RBM19_HUMAN	RBM19	physical	26344197
RL1D1_HUMAN	RSL1D1	physical	26344197
TSR1_HUMAN	TSR1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; THR-77 AND SER-1080,AND MASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1080, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1049 AND SER-1080, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1072 AND SER-1080, ANDMASS SPECTROMETRY.
PubMed: 18691976

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; THR-52 AND SER-1080,AND MASS SPECTROMETRY.
PubMed: 19007248

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1080, AND MASSSPECTROMETRY.
PubMed: 16565220

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1049, AND MASSSPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1080, AND MASSSPECTROMETRY.
PubMed: 17081983