dbPTM

TSR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TSR1_HUMAN
UniProt AC	Q2NL82
Protein Name	Pre-rRNA-processing protein TSR1 homolog
Gene Name	TSR1
Organism	Homo sapiens (Human).
Sequence Length	804
Subcellular Localization	Nucleus, nucleolus.
Protein Description	Required during maturation of the 40S ribosomal subunit in the nucleolus..
Protein Sequence	MAAHRPGPLKQQNKAHKGGRHRGRGSAQRDGKGRLALKTLSKKVRKELSRVDQRHRASQLRKQKKEAVLAEKRQLGGKDGPPHQVLVVPLHSRISLPEAMQLLQDRDTGTVHLNELGNTQNFMLLCPRLKHRWFFTSARPGDLHVVLDMAKVADTILFLLDPLEGWDSTGDYCLSCLFAQGLPTYTLAVQGISGLPLKKQIDTRKKLSKAVEKRFPHDKLLLLDTQQEAGMLLRQLANQKQQHLAFRDRRAYLFAHAVDFVPSEENNLVGTLKISGYVRGQTLNVNRLLHIVGYGDFQMKQIDAPGDPFPLNPRGIKPQKDPDMAMEICATDAVDDMEEGLKVLMKADPGRQESLQAEVIPDPMEGEQTWPTEEELSEAKDFLKESSKVVKKVPKGTSSYQAEWILDGGSQSGGEGDEYEYDDMEHEDFMEEESQDESSEEEEEYETMTIGESVHDDLYDKKVDEEAEAKMLEKYKQERLEEMFPDEVDTPRDVAARIRFQKYRGLKSFRTSPWDPKENLPQDYARIFQFQNFTNTRKSIFKEVEEKEVEGAEVGWYVTLHVSEVPVSVVECFRQGTPLIAFSLLPHEQKMSVLNMVVRRDPGNTEPVKAKEELIFHCGFRRFRASPLFSQHTAADKHKLQRFLTADMALVATVYAPITFPPASVLLFKQKSNGMHSLIATGHLMSVDPDRMVIKRVVLSGHPFKIFTKMAVVRYMFFNREDVLWFKPVELRTKWGRRGHIKEPLGTHGHMKCSFDGKLKSQDTVLMNLYKRVFPKWTYDPYVPEPVPWLKSEISSTVPQGGME

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Ubiquitination	GSAQRDGKGRLALKT CCCCCCCCCHHHHHH	45.18	23000965
32	Acetylation	GSAQRDGKGRLALKT CCCCCCCCCHHHHHH	45.18	19829891
38	Acetylation	GKGRLALKTLSKKVR CCCHHHHHHHHHHHH	41.64	25953088
38	Ubiquitination	GKGRLALKTLSKKVR CCCHHHHHHHHHHHH	41.64	23000965
39	Phosphorylation	KGRLALKTLSKKVRK CCHHHHHHHHHHHHH	36.79	20873877
41	Phosphorylation	RLALKTLSKKVRKEL HHHHHHHHHHHHHHH	35.34	20873877
42	Ubiquitination	LALKTLSKKVRKELS HHHHHHHHHHHHHHH	59.40	23000965
42	Methylation	LALKTLSKKVRKELS HHHHHHHHHHHHHHH	59.40	116252813
43	Ubiquitination	ALKTLSKKVRKELSR HHHHHHHHHHHHHHH	43.85	23000965
58	Phosphorylation	VDQRHRASQLRKQKK HHHHHHHHHHHHHHH	29.69	29449344
62	Ubiquitination	HRASQLRKQKKEAVL HHHHHHHHHHHHHHH	75.06	24816145
72	2-Hydroxyisobutyrylation	KEAVLAEKRQLGGKD HHHHHHHHHHHCCCC	39.58	-
72	Acetylation	KEAVLAEKRQLGGKD HHHHHHHHHHHCCCC	39.58	23749302
72	Ubiquitination	KEAVLAEKRQLGGKD HHHHHHHHHHHCCCC	39.58	33845483
95	Phosphorylation	VPLHSRISLPEAMQL EECCCCCCHHHHHHH	36.44	27174698
108	Phosphorylation	QLLQDRDTGTVHLNE HHHHCCCCCEEEHHH	35.33	27174698
110	Phosphorylation	LQDRDTGTVHLNELG HHCCCCCEEEHHHCC	13.57	27174698
119	Phosphorylation	HLNELGNTQNFMLLC EHHHCCCCCEEEEEC	24.08	27174698
205	Ubiquitination	KKQIDTRKKLSKAVE HHHHHHHHHHHHHHH	61.22	24816145
219	Ubiquitination	EKRFPHDKLLLLDTQ HHHCCCCCEEEEEHH	37.69	21963094
231	Sulfoxidation	DTQQEAGMLLRQLAN EHHHHHHHHHHHHHH	4.03	21406390
240	Ubiquitination	LRQLANQKQQHLAFR HHHHHHHHHHHHHHH	52.30	24816145
277	Phosphorylation	GTLKISGYVRGQTLN EEEEEECEECCEEEE	4.72	-
279	Methylation	LKISGYVRGQTLNVN EEEECEECCEEEEHH	24.02	115919073
329	Glutathionylation	PDMAMEICATDAVDD CCHHHHHHHHHCCCC	1.81	22555962
346	Sumoylation	EGLKVLMKADPGRQE HHHHHHHHCCCCCHH	45.54	-
346	Sumoylation	EGLKVLMKADPGRQE HHHHHHHHCCCCCHH	45.54	-
346	Ubiquitination	EGLKVLMKADPGRQE HHHHHHHHCCCCCHH	45.54	33845483
354	Phosphorylation	ADPGRQESLQAEVIP CCCCCHHHCEEEECC	19.90	27251275
372	Phosphorylation	EGEQTWPTEEELSEA CCCCCCCCHHHHHHH	47.81	30576142
377	Phosphorylation	WPTEEELSEAKDFLK CCCHHHHHHHHHHHH	38.50	24850871
384	Ubiquitination	SEAKDFLKESSKVVK HHHHHHHHHCHHHEE	56.39	33845483
386	Phosphorylation	AKDFLKESSKVVKKV HHHHHHHCHHHEEEC	33.59	25159151
387	Phosphorylation	KDFLKESSKVVKKVP HHHHHHCHHHEEECC	30.48	25627689
412	Phosphorylation	ILDGGSQSGGEGDEY EECCCCCCCCCCCCC	50.92	27362937
447	Phosphorylation	EEEEEYETMTIGESV HHHHHHHHCCCCHHH	20.79	26074081
449	Phosphorylation	EEEYETMTIGESVHD HHHHHHCCCCHHHCH	33.00	26074081
453	Phosphorylation	ETMTIGESVHDDLYD HHCCCCHHHCHHHCC	21.38	26074081
459	Phosphorylation	ESVHDDLYDKKVDEE HHHCHHHCCCCCCHH	32.48	26074081
470	Sumoylation	VDEEAEAKMLEKYKQ CCHHHHHHHHHHHHH	35.21	-
470	Ubiquitination	VDEEAEAKMLEKYKQ CCHHHHHHHHHHHHH	35.21	22817900
470	Sumoylation	VDEEAEAKMLEKYKQ CCHHHHHHHHHHHHH	35.21	-
474	Ubiquitination	AEAKMLEKYKQERLE HHHHHHHHHHHHHHH	54.51	22817900
475	Phosphorylation	EAKMLEKYKQERLEE HHHHHHHHHHHHHHH	14.45	22817900
476	Sumoylation	AKMLEKYKQERLEEM HHHHHHHHHHHHHHH	57.67	-
483	Sulfoxidation	KQERLEEMFPDEVDT HHHHHHHHCCCCCCC	4.28	21406390
490	Phosphorylation	MFPDEVDTPRDVAAR HCCCCCCCHHHHHHH	25.96	21815630
502	Ubiquitination	AARIRFQKYRGLKSF HHHHHHHHHCCCCCC	33.91	-
502	Acetylation	AARIRFQKYRGLKSF HHHHHHHHHCCCCCC	33.91	7664451
508	Phosphorylation	QKYRGLKSFRTSPWD HHHCCCCCCCCCCCC	25.63	26270265
511	Phosphorylation	RGLKSFRTSPWDPKE CCCCCCCCCCCCCCC	36.81	25159151
512	Phosphorylation	GLKSFRTSPWDPKEN CCCCCCCCCCCCCCC	21.53	25159151
517	Ubiquitination	RTSPWDPKENLPQDY CCCCCCCCCCCCHHH	57.68	29967540
517	Acetylation	RTSPWDPKENLPQDY CCCCCCCCCCCCHHH	57.68	26051181
534	Phosphorylation	IFQFQNFTNTRKSIF HHHHHCCCHHCHHHH	43.14	-
539	Phosphorylation	NFTNTRKSIFKEVEE CCCHHCHHHHHHHHH	29.93	24719451
542	Ubiquitination	NTRKSIFKEVEEKEV HHCHHHHHHHHHCCC	60.21	29967540
577	Phosphorylation	VECFRQGTPLIAFSL HHHHHCCCCEEEEEC	13.44	-
605	Phosphorylation	VRRDPGNTEPVKAKE EECCCCCCCCCCCHH	47.80	20068231
609	Ubiquitination	PGNTEPVKAKEELIF CCCCCCCCCHHHEEH	65.54	-
611	Acetylation	NTEPVKAKEELIFHC CCCCCCCHHHEEHHC	46.10	26051181
626	Phosphorylation	GFRRFRASPLFSQHT CCCCCCCCCCCCCCC	20.20	23312004
630	Phosphorylation	FRASPLFSQHTAADK CCCCCCCCCCCCCCH	28.83	23312004
633	Phosphorylation	SPLFSQHTAADKHKL CCCCCCCCCCCHHHH	18.86	23312004
637	Ubiquitination	SQHTAADKHKLQRFL CCCCCCCHHHHHHHH	37.60	-
637	Acetylation	SQHTAADKHKLQRFL CCCCCCCHHHHHHHH	37.60	27452117
705	Acetylation	VLSGHPFKIFTKMAV ECCCCCCHHHHHHHH	41.16	25953088
705	Ubiquitination	VLSGHPFKIFTKMAV ECCCCCCHHHHHHHH	41.16	22817900
709	Ubiquitination	HPFKIFTKMAVVRYM CCCHHHHHHHHHHHH	17.70	21963094
709	Acetylation	HPFKIFTKMAVVRYM CCCHHHHHHHHHHHH	17.70	25953088
727	Ubiquitination	REDVLWFKPVELRTK CCCEEEEEEEEEECC	36.25	-
742	Acetylation	WGRRGHIKEPLGTHG CCCCCCCCCCCCCCC	47.83	7379993
752	Acetylation	LGTHGHMKCSFDGKL CCCCCCCEEECCCCC	22.51	7380003
758	Ubiquitination	MKCSFDGKLKSQDTV CEEECCCCCCCCCCH	55.36	29967540
758	Acetylation	MKCSFDGKLKSQDTV CEEECCCCCCCCCCH	55.36	25953088
760	Ubiquitination	CSFDGKLKSQDTVLM EECCCCCCCCCCHHH	49.94	29967540
760	Sumoylation	CSFDGKLKSQDTVLM EECCCCCCCCCCHHH	49.94	-
760	Sumoylation	CSFDGKLKSQDTVLM EECCCCCCCCCCHHH	49.94	-
771	2-Hydroxyisobutyrylation	TVLMNLYKRVFPKWT CHHHHHHHHHCCCCC	45.30	-
776	Ubiquitination	LYKRVFPKWTYDPYV HHHHHCCCCCCCCCC	40.48	-
776	Sumoylation	LYKRVFPKWTYDPYV HHHHHCCCCCCCCCC	40.48	-
776	Sumoylation	LYKRVFPKWTYDPYV HHHHHCCCCCCCCCC	40.48	-
791	Sumoylation	PEPVPWLKSEISSTV CCCCCCHHHHHCCCC	42.02	-
791	Sumoylation	PEPVPWLKSEISSTV CCCCCCHHHHHCCCC	42.02	-
803	Sulfoxidation	STVPQGGME------ CCCCCCCCC------	7.65	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
490	T	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TSR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TSR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS16_HUMAN	VPS16	physical	22939629
UBAC2_HUMAN	UBAC2	physical	22939629
YES_HUMAN	YES1	physical	22939629
SPB1_HUMAN	FTSJ3	physical	24778252
LN28A_HUMAN	LIN28A	physical	24778252
TRBP2_HUMAN	TARBP2	physical	24778252
ENPL_HUMAN	HSP90B1	physical	26344197
LTV1_HUMAN	LTV1	physical	26344197
RM02_HUMAN	MRPL2	physical	26344197
RPAC1_HUMAN	POLR1C	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
UCRI_HUMAN	UQCRFS1	physical	26344197
BYST_HUMAN	BYSL	physical	28514442
LTV1_HUMAN	LTV1	physical	28514442
RS14_HUMAN	RPS14	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
IMB1_HUMAN	KPNB1	physical	28514442
RS2_HUMAN	RPS2	physical	28514442
PARN_HUMAN	PARN	physical	28514442
RRP12_HUMAN	RRP12	physical	28514442
NU153_HUMAN	NUP153	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TSR1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-475, AND MASSSPECTROMETRY.	17081983 [Abstract]