VPS16_HUMAN - dbPTM
VPS16_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS16_HUMAN
UniProt AC Q9H269
Protein Name Vacuolar protein sorting-associated protein 16 homolog
Gene Name VPS16
Organism Homo sapiens (Human).
Sequence Length 839
Subcellular Localization Late endosome membrane
Peripheral membrane protein
Cytoplasmic side . Lysosome membrane
Peripheral membrane protein
Cytoplasmic side . Early endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Cytoplasmic vesicle, autophagosome . Coloca
Protein Description Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. [PubMed: 11382755]
Protein Sequence MDCYTANWNPLGDSAFYRKYELYSMDWDLKEELRDCLVAAAPYGGPIALLRNPWRKEKAASVRPVLDIYSASGMPLASLLWKSGPVVSLGWSAEEELLCVQEDGAVLVYGLHGDFRRHFSMGNEVLQNRVLDARIFHTEFGSGVAILTGAHRFTLSANVGDLKLRRMPEVPGLQSAPSCWTVLCQDRVAHILLAVGPDLYLLDHAACSAVTPPGLAPGVSSFLQMAVSFTYRHLALFTDTGYIWMGTASLKEKLCEFNCNIRAPPKQMVWCSRPRSKERAVVVAWERRLMVVGDAPESIQFVLDEDSYLVPELDGVRIFSRSTHEFLHEVPAASEEIFKIASMAPGALLLEAQKEYEKESQKADEYLREIQELGQLTQAVQQCIEAAGHEHQPDMQKSLLRAASFGKCFLDRFPPDSFVHMCQDLRVLNAVRDYHIGIPLTYSQYKQLTIQVLLDRLVLRRLYPLAIQICEYLRLPEVQGVSRILAHWACYKVQQKDVSDEDVARAINQKLGDTPGVSYSDIAARAYGCGRTELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQFCKHQELETLKDLYNQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAAKATEDQMRLLRLQRRLEDELGGQFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPDKRLWWLKLTALADLEDWEELEKFSKSKKSPIGYLPFVEICMKQHNKYEAKKYASRVGPEQKVKALLLVGDVAQAADVAIEHRNEAELSLVLSHCTGATDGATADKIQRARAQAQKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Nitrated tyrosine----MDCYTANWNPL
----CCCEECCCCCC		12.48-
4Nitration----MDCYTANWNPL
----CCCEECCCCCC		12.48-
30UbiquitinationYSMDWDLKEELRDCL
ECCCCCHHHHHHHHH		46.8232015554
58UbiquitinationRNPWRKEKAASVRPV
CCHHHHHHCCCCCCC		52.89-
78PhosphorylationASGMPLASLLWKSGP
CCCCCHHHHHHHCCC		31.5126422651
163UbiquitinationSANVGDLKLRRMPEV
EECCCCCEECCCCCC		44.6923000965
163 (in isoform 2)Ubiquitination-44.6921890473
163 (in isoform 1)Ubiquitination-44.6921890473
253UbiquitinationGTASLKEKLCEFNCN
EEHHHHHHHHHCCCC		57.7729967540
343SulfoxidationEIFKIASMAPGALLL
HHHHHHHCCHHHHHH		3.7421406390
348UbiquitinationASMAPGALLLEAQKE
HHCCHHHHHHHHHHH		7.5122817900
352 (in isoform 2)Ubiquitination-26.2221890473
352UbiquitinationPGALLLEAQKEYEKE
HHHHHHHHHHHHHHH		26.2233845483
354UbiquitinationALLLEAQKEYEKESQ
HHHHHHHHHHHHHHH		70.1229967540
358UbiquitinationEAQKEYEKESQKADE
HHHHHHHHHHHHHHH		62.8622817900
362 (in isoform 1)Ubiquitination-68.0621890473
362UbiquitinationEYEKESQKADEYLRE
HHHHHHHHHHHHHHH		68.0621906983
366 (in isoform 2)Ubiquitination-16.1721890473
366UbiquitinationESQKADEYLREIQEL
HHHHHHHHHHHHHHH		16.1727667366
393UbiquitinationAAGHEHQPDMQKSLL
HCCCCCCHHHHHHHH		40.7322817900
393 (in isoform 2)Ubiquitination-40.7321890473
397UbiquitinationEHQPDMQKSLLRAAS
CCCHHHHHHHHHHHH		36.1129967540
398PhosphorylationHQPDMQKSLLRAASF
CCHHHHHHHHHHHHC		18.7524719451
410UbiquitinationASFGKCFLDRFPPDS
HHCCCHHHHCCCCCH		6.9132015554
412UbiquitinationFGKCFLDRFPPDSFV
CCCHHHHCCCCCHHH		48.3924816145
465UbiquitinationVLRRLYPLAIQICEY
HHHHHHHHHHHHHHH		4.0729967540
473UbiquitinationAIQICEYLRLPEVQG
HHHHHHHHCCCCCCC		1.8029967540
492UbiquitinationLAHWACYKVQQKDVS
HHHHHHHHCCCCCCC		33.1922817900
496 (in isoform 1)Ubiquitination-42.9021890473
496UbiquitinationACYKVQQKDVSDEDV
HHHHCCCCCCCHHHH		42.9021906983
510UbiquitinationVARAINQKLGDTPGV
HHHHHHHHHCCCCCC		50.3721906983
510 (in isoform 1)Ubiquitination-50.3721890473
516 (in isoform 2)Ubiquitination-24.09-
516UbiquitinationQKLGDTPGVSYSDIA
HHHCCCCCCCHHHHH		24.0922505724
518UbiquitinationLGDTPGVSYSDIAAR
HCCCCCCCHHHHHHH		25.4927667366
519PhosphorylationGDTPGVSYSDIAARA
CCCCCCCHHHHHHHH		14.1427642862
524UbiquitinationVSYSDIAARAYGCGR
CCHHHHHHHHHCCCC		9.2922817900
524 (in isoform 2)Ubiquitination-9.2921890473
537UbiquitinationGRTELAIKLLEYEPR
CCHHHHHHHHHCCCC		41.2221906983
537 (in isoform 1)Ubiquitination-41.2221890473
545O-linked_GlycosylationLLEYEPRSGEQVPLL
HHHCCCCCCCCCCHH		58.3529351928
554UbiquitinationEQVPLLLKMKRSKLA
CCCCHHHHHHHHHHH		42.2032015554
556UbiquitinationVPLLLKMKRSKLALS
CCHHHHHHHHHHHHH		52.5124816145
559AcetylationLLKMKRSKLALSKAI
HHHHHHHHHHHHHHH		41.6425953088
592SulfoxidationLNRGDFFMTLRNQPM
CCCCCCEEEECCCHH		3.3121406390
601UbiquitinationLRNQPMALSLYRQFC
ECCCHHHHHHHHHHH		2.7029967540
602PhosphorylationRNQPMALSLYRQFCK
CCCHHHHHHHHHHHH		17.5128857561
604PhosphorylationQPMALSLYRQFCKHQ
CHHHHHHHHHHHHHH		10.05-
609UbiquitinationSLYRQFCKHQELETL
HHHHHHHHHHHHHHH		50.0029967540
617UbiquitinationHQELETLKDLYNQDD
HHHHHHHHHHHCCCC		53.7829967540
621UbiquitinationETLKDLYNQDDNHQE
HHHHHHHCCCCCCCC		46.2132015554
630UbiquitinationDDNHQELGSFHIRAS
CCCCCCCCCEEHHHH		27.7529967540
631PhosphorylationDNHQELGSFHIRASY
CCCCCCCCEEHHHHH		26.6927080861
640UbiquitinationHIRASYAAEERIEGR
EHHHHHHHHHHHHHH		15.7929967540
660UbiquitinationTAADAFYKAKNEFAA
HHHHHHHHHHHHHHH		46.5622505724
662UbiquitinationADAFYKAKNEFAAKA
HHHHHHHHHHHHHHC		53.5127667366
668 (in isoform 1)Ubiquitination-53.0321890473
668UbiquitinationAKNEFAAKATEDQMR
HHHHHHHHCCHHHHH		53.0322817900
684UbiquitinationLRLQRRLEDELGGQF
HHHHHHHHHHHCCCE		47.8629967540
702PhosphorylationSLHDTVTTLILGGHN
EHHHHCHHHHCCCCH		13.89-
745UbiquitinationEDWEELEKFSKSKKS
CCHHHHHHHHHCCCC		68.5129967540
750UbiquitinationLEKFSKSKKSPIGYL
HHHHHHCCCCCCCHH		62.09-
765AcetylationPFVEICMKQHNKYEA
HHHHHHHHHCCHHHH		43.9530593363
765UbiquitinationPFVEICMKQHNKYEA
HHHHHHHHHCCHHHH		43.9532015554
774UbiquitinationHNKYEAKKYASRVGP
CCHHHHHHHHHHCCH		53.7729967540
775PhosphorylationNKYEAKKYASRVGPE
CHHHHHHHHHHCCHH		14.76-
777PhosphorylationYEAKKYASRVGPEQK
HHHHHHHHHCCHHHH		25.14-
784UbiquitinationSRVGPEQKVKALLLV
HHCCHHHHHHHHHHH		44.0029967540
7842-HydroxyisobutyrylationSRVGPEQKVKALLLV
HHCCHHHHHHHHHHH		44.00-
828UbiquitinationTDGATADKIQRARAQ
CCCCHHHHHHHHHHH		37.9729967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS16_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS16_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS16_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS18_HUMANVPS18physical
11382755
VPS11_HUMANVPS11physical
11382755
PLK2_RATPlk2physical
16203730
UVRAG_HUMANUVRAGphysical
18552835
VPS18_HUMANVPS18physical
22939629
VPS41_HUMANVPS41physical
22939629
WAPL_HUMANWAPALphysical
22939629
PSB6_HUMANPSMB6physical
26344197
VP33A_HUMANVPS33Aphysical
25783203
VPS18_HUMANVPS18physical
25783203
ACV1B_HUMANACVR1Bphysical
26496610
MTOR_HUMANMTORphysical
26496610
CFAH_HUMANCFHphysical
26496610
FAK1_HUMANPTK2physical
26496610
RS11_HUMANRPS11physical
26496610
PIAS1_HUMANPIAS1physical
26496610
TGFA1_HUMANTGFBRAP1physical
26496610
ATP9A_HUMANATP9Aphysical
26496610
IPO7_HUMANIPO7physical
26496610
VPS8_HUMANVPS8physical
26496610
SYHM_HUMANHARS2physical
26496610
VPS41_HUMANVPS41physical
26496610
RT17_HUMANMRPS17physical
26496610
PR40A_HUMANPRPF40Aphysical
26496610
RIOK2_HUMANRIOK2physical
26496610
VPS11_HUMANVPS11physical
26496610
P33MX_HUMANKIAA1191physical
26496610
VPS18_HUMANVPS18physical
26496610
TTC31_HUMANTTC31physical
26496610
RT15_HUMANMRPS15physical
26496610
VP33A_HUMANVPS33Aphysical
26496610
ESRP2_HUMANESRP2physical
26496610
C1QT6_HUMANC1QTNF6physical
26496610
RM54_HUMANMRPL54physical
26496610
ZN800_HUMANZNF800physical
26496610
VP33A_HUMANVPS33Aphysical
23901104
VPS18_HUMANVPS18physical
23901104
VPS11_HUMANVPS11physical
26463206
VPS41_HUMANVPS41physical
26463206
VP33A_HUMANVPS33Aphysical
26463206
VPS18_HUMANVPS18physical
26463206
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS16_HUMAN

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Related Literatures of Post-Translational Modification

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