ESRP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ESRP2_HUMAN
• UniProt AC: Q9H6T0
• Protein Name: Epithelial splicing regulatory protein 2
• Gene Name: ESRP2
• Organism: Homo sapiens (Human).
• Sequence Length: 727
• Subcellular Localization: Nucleus .
• Protein Description: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2..
• Protein Sequence: MTPPPPPPPPPGPDPAADPAADPCPWPGSLVVLFGATAGALGRDLGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSTQCREASGLSADSLARAEPLDKVLQQFSQLVNGDVALLGGGPYMLCTDGQQLLRQVLHPEASRKNLVLPDMFFSFYDLRREFHMQHPSTCPARDLTVATMAQGLGLETDATEDDFGVWEVKTMVAVILHLLKEPSSQLFSKPEVIKQKYETGPCSDSTVPCPYSSKADVVDSETVVRARGLPWQSSDQDVARFFKGLNVARGGVALCLNAQGRRNGEALIRFVDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGTSLEVARFLSREDQVILRLRGLPFSAGPTDVLGFLGPECPVTGGTEGLLFVRHPDGRPTGDAFALFACEELAQAALRRHKGMLGKRYIELFRSTAAEVQQVLNRYASGPLLPTLTAPLLPIPFPLAPGTGRDCVRLRGLPYTATIEDILSFLGEAAADIRPHGVHMVLNQQGRPSGDAFIQMTSAERALAAAQRCHKKVMKERYVEVVPCSTEEMSRVLMGGTLGRSGMSPPPCKLPCLSPPTYTTFQATPTLIPTETAALYPSSALLPAARVPAAPTPVAYYPGPATQLYLNYTAYYPSPPVSPTTVGYLTTPTAALASAPTSVLSQSGALVRMQGVPYTAGMKDLLSVFQAYQLPADDYTSLMPVGDPPRTVLQAPKEWVCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTPPPPPPP ------CCCCCCCCC	44.49	29496963
83	Phosphorylation	RAEAAALSTQCREAS HHHHHHHHHHHHHHC	16.23	-
113	Ubiquitination	VLQQFSQLVNGDVAL HHHHHHHHHCCCEEE	2.90	21963094
142	Ubiquitination	LLRQVLHPEASRKNL HHHHHHCHHHHHCCC	34.39	21963094
179	Phosphorylation	TCPARDLTVATMAQG CCCHHHCHHHHHHCC	16.63	-
182	Phosphorylation	ARDLTVATMAQGLGL HHHCHHHHHHCCCCC	14.54	-
223	Phosphorylation	EPSSQLFSKPEVIKQ CCHHHHCCCHHHHHH	56.76	24719451
224	Ubiquitination	PSSQLFSKPEVIKQK CHHHHCCCHHHHHHH	37.55	29967540
229	Ubiquitination	FSKPEVIKQKYETGP CCCHHHHHHHHCCCC	46.01	29967540
232 (in isoform 2)	Phosphorylation	-	19.07	20068231
234 (in isoform 2)	Phosphorylation	-	43.25	20068231
238 (in isoform 2)	Phosphorylation	-	37.42	20068231
239	Ubiquitination	YETGPCSDSTVPCPY HCCCCCCCCCCCCCC	55.85	21963094
245 (in isoform 2)	Phosphorylation	-	26.43	20068231
245	Phosphorylation	SDSTVPCPYSSKADV CCCCCCCCCCCCCCE	26.43	20068231
247	Phosphorylation	STVPCPYSSKADVVD CCCCCCCCCCCCEEC	15.54	20068231
247 (in isoform 2)	Phosphorylation	-	15.54	20068231
255	Phosphorylation	SKADVVDSETVVRAR CCCCEECCHHHHHHC	24.45	20068231
257	Phosphorylation	ADVVDSETVVRARGL CCEECCHHHHHHCCC	28.40	20068231
267	Ubiquitination	RARGLPWQSSDQDVA HHCCCCCCCCHHHHH	30.99	21963094
268	Ubiquitination	ARGLPWQSSDQDVAR HCCCCCCCCHHHHHH	31.82	21963094
268	Phosphorylation	ARGLPWQSSDQDVAR HCCCCCCCCHHHHHH	31.82	24905233
269	Phosphorylation	RGLPWQSSDQDVARF CCCCCCCCHHHHHHH	24.96	24275569
278	Ubiquitination	QDVARFFKGLNVARG HHHHHHHHCCCCCCC	60.83	-
321	Ubiquitination	ALQRHKHHMGVRYIE HHHHHHHHCCCCEEE	21.35	29967540
326	Phosphorylation	KHHMGVRYIEVYKAT HHHCCCCEEEEEEHH	10.06	-
343	Phosphorylation	EFVKIAGGTSLEVAR HHEECCCCCHHHHHH	11.78	27251275
353	Phosphorylation	LEVARFLSREDQVIL HHHHHHCCCCCCEEE	30.80	28348404
448	Phosphorylation	VQQVLNRYASGPLLP HHHHHHHHCCCCCCC	12.21	26074081
450	Phosphorylation	QVLNRYASGPLLPTL HHHHHHCCCCCCCCC	31.82	26074081
472	Phosphorylation	PFPLAPGTGRDCVRL CCCCCCCCCCCCCHH	28.16	-
518	Phosphorylation	LNQQGRPSGDAFIQM ECCCCCCCCCCEEEC	48.20	20068231
526	Phosphorylation	GDAFIQMTSAERALA CCCEEECHHHHHHHH	14.38	20068231
527	Phosphorylation	DAFIQMTSAERALAA CCEEECHHHHHHHHH	23.84	20068231
547	Phosphorylation	KKVMKERYVEVVPCS HHHHHHCCEEEEECC	11.31	-
555	Phosphorylation	VEVVPCSTEEMSRVL EEEEECCHHHHHHHH	42.56	-
563	Phosphorylation	EEMSRVLMGGTLGRS HHHHHHHCCCCCCCC	4.21	24719451
570	Phosphorylation	MGGTLGRSGMSPPPC CCCCCCCCCCCCCCC	36.73	29396449
573	Phosphorylation	TLGRSGMSPPPCKLP CCCCCCCCCCCCCCC	37.47	30278072
576	Phosphorylation	RSGMSPPPCKLPCLS CCCCCCCCCCCCCCC	31.12	27251275
583	Phosphorylation	PCKLPCLSPPTYTTF CCCCCCCCCCCCCCE	35.23	22210691
586	Phosphorylation	LPCLSPPTYTTFQAT CCCCCCCCCCCEECC	36.56	28348404
587	Phosphorylation	PCLSPPTYTTFQATP CCCCCCCCCCEECCC	15.00	28102081
588	Phosphorylation	CLSPPTYTTFQATPT CCCCCCCCCEECCCC	24.50	28102081
589	Phosphorylation	LSPPTYTTFQATPTL CCCCCCCCEECCCCC	11.88	22210691
593	Phosphorylation	TYTTFQATPTLIPTE CCCCEECCCCCCCCC	13.16	28102081
595	Phosphorylation	TTFQATPTLIPTETA CCEECCCCCCCCCCC	32.72	28102081
599	Phosphorylation	ATPTLIPTETAALYP CCCCCCCCCCCCCCC	38.69	28102081
601	Phosphorylation	PTLIPTETAALYPSS CCCCCCCCCCCCCCC	21.51	28102081
677	Methylation	SQSGALVRMQGVPYT HCCCCEEEECCCCCC	16.74	54558635
683	Phosphorylation	VRMQGVPYTAGMKDL EEECCCCCCCCHHHH	13.55	24043423
684	Phosphorylation	RMQGVPYTAGMKDLL EECCCCCCCCHHHHH	15.63	29970186
706	Phosphorylation	LPADDYTSLMPVGDP CCCCCCCCCCCCCCC	19.21	20068231
716	Phosphorylation	PVGDPPRTVLQAPKE CCCCCCCCEEECCCC	31.20	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ESRP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ESRP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ESRP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUMBL_HUMAN	NUMBL	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.