NUMBL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUMBL_HUMAN
• UniProt AC: Q9Y6R0
• Protein Name: Numb-like protein
• Gene Name: NUMBL
• Organism: Homo sapiens (Human).
• Sequence Length: 609
• Subcellular Localization: Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS..
• Protein Description: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons..
• Protein Sequence: MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRSAAASG ------CCHHHHHCC	34.64	24505115
4	Phosphorylation	----MSRSAAASGGP ----CCHHHHHCCCC	18.23	23403867
8	Phosphorylation	MSRSAAASGGPRRPE CCHHHHHCCCCCCCH	39.29	28857561
48	Phosphorylation	TMNKLRQSLRRRKPA HHHHHHHHHHHCCCC	19.87	29496963
84	Phosphorylation	TCSFPVRYLGHVEVE CCCCEEEEEEEEEEE	19.78	28188228
96	Sulfoxidation	EVEESRGMHVCEDAV EEEHHCCCCCCHHHH	1.76	30846556
209	Phosphorylation	REKECGVTAAFDASR HHHHHCCCEEEECCC	9.50	-
224	Phosphorylation	TSFAREGSFRLSGGG CCCCCCCCEECCCCC	11.48	25159151
228	Phosphorylation	REGSFRLSGGGRPAE CCCCEECCCCCCCCC	31.00	25159151
251	Phosphorylation	AEAAAAPTVAPGPAQ HHHHCCCCCCCCCCC	25.27	23927012
263	Phosphorylation	PAQPGHVSPTPATTS CCCCCCCCCCCCCCC	19.85	29255136
265	Phosphorylation	QPGHVSPTPATTSPG CCCCCCCCCCCCCCC	20.32	29255136
268	Phosphorylation	HVSPTPATTSPGEKG CCCCCCCCCCCCCCC	29.07	29255136
269	Phosphorylation	VSPTPATTSPGEKGE CCCCCCCCCCCCCCC	34.72	29255136
270	Phosphorylation	SPTPATTSPGEKGEA CCCCCCCCCCCCCCC	26.93	29255136
279	Phosphorylation	GEKGEAGTPVAAGTT CCCCCCCCCCCCCCC	22.95	29255136
285	O-linked_Glycosylation	GTPVAAGTTAAAIPR CCCCCCCCCCCCCCC	14.45	30379171
285	Phosphorylation	GTPVAAGTTAAAIPR CCCCCCCCCCCCCCC	14.45	25002506
286	Phosphorylation	TPVAAGTTAAAIPRR CCCCCCCCCCCCCCC	17.24	25002506
305	Phosphorylation	EQLVRQGSFRGFPAL HHHHHCCCCCCCHHH	11.93	23401153
307	Methylation	LVRQGSFRGFPALSQ HHHCCCCCCCHHHCC	47.76	-
313	Phosphorylation	FRGFPALSQKNSPFK CCCCHHHCCCCCHHH	41.01	30266825
317	Phosphorylation	PALSQKNSPFKRQLS HHHCCCCCHHHHHHH	38.46	29496963
324	Phosphorylation	SPFKRQLSLRLNELP CHHHHHHHHHHHHCC	11.78	25159151
332	Phosphorylation	LRLNELPSTLQRRTD HHHHHCCHHHHHCCC	55.14	25850435
333	Phosphorylation	RLNELPSTLQRRTDF HHHHCCHHHHHCCCC	25.60	23312004
409	Phosphorylation	FQPGHKRTPSEAERW CCCCCCCCHHHHHHH	35.65	25159151
411	Phosphorylation	PGHKRTPSEAERWLE CCCCCCHHHHHHHHH	49.15	28355574
421	Phosphorylation	ERWLEEVSQVAKAQQ HHHHHHHHHHHHHHH	23.40	23403867
594	Phosphorylation	KATVEKPSNPFSGDL CCEEECCCCCCCCCC	69.10	20068231
598	Phosphorylation	EKPSNPFSGDLQKTF ECCCCCCCCCCCHHE	32.43	20068231
604	Phosphorylation	FSGDLQKTFEIEL-- CCCCCCHHEEEEC--	17.34	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUMBL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUMBL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUMBL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAB2_HUMAN	TAB2	physical	18299187
TRAF5_HUMAN	TRAF5	physical	22593207
TMC5_HUMAN	TMC5	physical	21988832
TRAF5_HUMAN	TRAF5	physical	21988832
PSA3_HUMAN	PSMA3	physical	21988832
SIAH1_HUMAN	SIAH1	physical	21988832
TPO_HUMAN	THPO	physical	21988832
TRAF6_HUMAN	TRAF6	physical	21988832
RIPK1_HUMAN	RIPK1	physical	21988832
SPSB3_HUMAN	SPSB3	physical	25416956
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; THR-268 ANDTHR-279, AND MASS SPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 AND SER-411, ANDMASS SPECTROMETRY.
PubMed: 17081983