| UniProt ID | CBY1_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y3M2 | |
| Protein Name | Protein chibby homolog 1 | |
| Gene Name | CBY1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 126 | |
| Subcellular Localization | Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Golgi apparatus. Golgi apparatus, trans-Golgi network . | |
| Protein Description | Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.. | |
| Protein Sequence | MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKRK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MPFFGNTFSPKKTP -CCCCCCCCCCCCCC | 26.35 | 29255136 | |
| 9 | Phosphorylation | PFFGNTFSPKKTPPR CCCCCCCCCCCCCCC | 33.50 | 29255136 | |
| 13 | Phosphorylation | NTFSPKKTPPRKSAS CCCCCCCCCCCCCCC | 44.65 | 28555341 | |
| 18 | Phosphorylation | KKTPPRKSASLSNLH CCCCCCCCCCCCCHH | 25.11 | 30266825 | |
| 20 | Phosphorylation | TPPRKSASLSNLHSL CCCCCCCCCCCHHHC | 39.15 | 30266825 | |
| 22 | Phosphorylation | PRKSASLSNLHSLDR CCCCCCCCCHHHCCC | 34.55 | 30266825 | |
| 26 | Phosphorylation | ASLSNLHSLDRSTRE CCCCCHHHCCCCCCE | 34.82 | 23927012 | |
| 30 | Phosphorylation | NLHSLDRSTREVELG CHHHCCCCCCEEHHH | 31.33 | 22210691 | |
| 31 | Phosphorylation | LHSLDRSTREVELGL HHHCCCCCCEEHHHH | 31.57 | 22210691 | |
| 42 | Phosphorylation | ELGLEYGSPTMNLAG HHHHHCCCCCCCCCC | 19.12 | 28348404 | |
| 44 | Phosphorylation | GLEYGSPTMNLAGQS HHHCCCCCCCCCCCE | 22.01 | 28348404 | |
| 51 | Phosphorylation | TMNLAGQSLKFENGQ CCCCCCCEEEEECCE | 32.39 | 22210691 | |
| 52 | Phosphorylation | MNLAGQSLKFENGQW CCCCCCEEEEECCEE | 5.91 | 19413330 | |
| 61 | Phosphorylation | FENGQWIAETGVSGG EECCEEEHHHCCCCC | 12.82 | - | |
| 63 | Phosphorylation | NGQWIAETGVSGGVD CCEEEHHHCCCCCCC | 33.58 | 22210691 | |
| 66 | Phosphorylation | WIAETGVSGGVDRRE EEHHHCCCCCCCHHH | 31.04 | 28555341 | |
| 69 | Phosphorylation | ETGVSGGVDRREVQR HHCCCCCCCHHHHHH | 6.20 | 27251275 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CBY1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CBY1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND MASSSPECTROMETRY. | |
