MAGI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGI1_HUMAN
• UniProt AC: Q96QZ7
• Protein Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
• Gene Name: MAGI1
• Organism: Homo sapiens (Human).
• Sequence Length: 1491
• Subcellular Localization: Cell junction, tight junction . Cell membrane ; Peripheral membrane protein . Localizes to epithelial cells tight junctions.
• Protein Description: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity)..
• Protein Sequence: MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQDAGRSSRHPPEQRRRPYKECSTDLSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
124	Phosphorylation	NQRFQKGSPDHELQQ HHHHHCCCCCHHHHH	33.90	28985074
145	Phosphorylation	YRHAVPCTTRSPREG HHHCCCCCCCCCCCC	21.12	29449344
146	Phosphorylation	RHAVPCTTRSPREGE HHCCCCCCCCCCCCC	35.55	26091039
146 (in isoform 2)	Phosphorylation	-	35.55	27251275
148	Phosphorylation	AVPCTTRSPREGEVP CCCCCCCCCCCCCCC	26.64	23312004
159	Phosphorylation	GEVPGVDYNFLTVKE CCCCCCCCCEEEHHH	12.86	23312004
163	Phosphorylation	GVDYNFLTVKEFLDL CCCCCEEEHHHHHCH	25.95	23312004
209	Phosphorylation	ITTDALHSLQSGSKQ EEHHHHHHHHCCCCC	29.02	29116813
212	Phosphorylation	DALHSLQSGSKQSTP HHHHHHHCCCCCCCC	50.78	29514088
214	Phosphorylation	LHSLQSGSKQSTPKR HHHHHCCCCCCCCCC	32.54	27050516
214 (in isoform 2)	Phosphorylation	-	32.54	27251275
224	Phosphorylation	STPKRTKSYNDMQNA CCCCCCCCHHHHHHC	28.67	24275569
327	Phosphorylation	DHNTKTTSWLDPRCL ECCCCEECCCCHHHC	30.76	28857561
357	Phosphorylation	VHTEELDSELELPAG CCHHHCCCCEECCCC	57.62	24275569
373	Phosphorylation	EKIEDPVYGIYYVDH EECCCCCEEEEEEEC	11.82	27273156
373 (in isoform 2)	Phosphorylation	-	11.82	27251275
373 (in isoform 5)	Phosphorylation	-	11.82	27642862
376	Phosphorylation	EDPVYGIYYVDHINR CCCCEEEEEEECCCC	7.96	28152594
376 (in isoform 5)	Phosphorylation	-	7.96	27642862
377	Phosphorylation	DPVYGIYYVDHINRK CCCEEEEEEECCCCC	9.47	28152594
377 (in isoform 5)	Phosphorylation	-	9.47	27642862
385	Phosphorylation	VDHINRKTQYENPVL EECCCCCCCCCCHHH	32.90	28796482
387	Phosphorylation	HINRKTQYENPVLEA CCCCCCCCCCHHHHH	23.94	28796482
387 (in isoform 5)	Phosphorylation	-	23.94	27642862
464	Phosphorylation	PFFTRNPSELKGKFI CCCCCCHHHHCCEEE	60.14	28857561
464 (in isoform 2)	Phosphorylation	-	60.14	27251275
500	Phosphorylation	DEFLQIKSLVLDGPA CCCEEEEEEEEECCC	25.91	27050516
500 (in isoform 2)	Phosphorylation	-	25.91	27251275
512	Acetylation	GPAALDGKMETGDVI CCCHHCCCCCCCCEE	32.98	30590253
588	Phosphorylation	IIVNGQETYDSPASH EEECCEEECCCCCCC	25.41	22199227
589	Phosphorylation	IVNGQETYDSPASHS EECCEEECCCCCCCC	17.42	22199227
591	Phosphorylation	NGQETYDSPASHSSK CCEEECCCCCCCCCC	16.38	22199227
594	Phosphorylation	ETYDSPASHSSKTGK EECCCCCCCCCCCCC	27.56	22199227
596	Phosphorylation	YDSPASHSSKTGKVN CCCCCCCCCCCCCCC	30.91	22199227
597	Phosphorylation	DSPASHSSKTGKVNG CCCCCCCCCCCCCCC	28.90	22199227
611	Phosphorylation	GMKDARPSSPADVAS CCCCCCCCCHHHHHC	43.32	29116813
612	Phosphorylation	MKDARPSSPADVASN CCCCCCCCHHHHHCC	27.13	25849741
612 (in isoform 2)	Phosphorylation	-	27.13	27251275
618	Phosphorylation	SSPADVASNSSHGYP CCHHHHHCCCCCCCC	36.77	29116813
620	Phosphorylation	PADVASNSSHGYPND HHHHHCCCCCCCCCC	22.63	21406692
621	Phosphorylation	ADVASNSSHGYPNDT HHHHCCCCCCCCCCC	25.78	24275569
624	Phosphorylation	ASNSSHGYPNDTVSL HCCCCCCCCCCCCCH	8.08	30576142
628	Phosphorylation	SHGYPNDTVSLASSI CCCCCCCCCCHHHHH	20.73	21406692
630	Phosphorylation	GYPNDTVSLASSIAT CCCCCCCCHHHHHHC	21.95	21406692
633	Phosphorylation	NDTVSLASSIATQPE CCCCCHHHHHHCCCC	27.80	21406692
634	Phosphorylation	DTVSLASSIATQPEL CCCCHHHHHHCCCCE	15.61	21406692
637	Phosphorylation	SLASSIATQPELITV CHHHHHHCCCCEEEE	42.88	27251275
643	Phosphorylation	ATQPELITVHIVKGP HCCCCEEEEEEEECC	20.75	27251275
656	Phosphorylation	GPMGFGFTIADSPGG CCCCCCEEEECCCCC	18.68	21964256
660	Phosphorylation	FGFTIADSPGGGGQR CCEEEECCCCCCCHH	19.20	21964256
681	Acetylation	SPRCRGLKEGDLIVE CCCCCCCCCCCEEEE	63.58	7462179
691	Acetylation	DLIVEVNKKNVQALT CEEEEECHHHCEEEE	51.40	7462191
691	Ubiquitination	DLIVEVNKKNVQALT CEEEEECHHHCEEEE	51.40	29967540
698	Phosphorylation	KKNVQALTHNQVVDM HHHCEEEECCCEEEE	23.07	22210691
711	Acetylation	DMLVECPKGSEVTLL EEEEECCCCCEEEEE	83.30	30590247
730	Phosphorylation	GLPVPKKSPKSQPLE CCCCCCCCCCCCCCC	43.62	23403867
730 (in isoform 2)	Phosphorylation	-	43.62	24719451
733	Phosphorylation	VPKKSPKSQPLERKD CCCCCCCCCCCCCCC	40.18	21406692
741	Phosphorylation	QPLERKDSQNSSQHS CCCCCCCCCCCCCCC	34.01	21082442
741 (in isoform 2)	Phosphorylation	-	34.01	27251275
744	Phosphorylation	ERKDSQNSSQHSVSS CCCCCCCCCCCCHHH	24.60	22496350
744 (in isoform 2)	Phosphorylation	-	24.60	27251275
745	Phosphorylation	RKDSQNSSQHSVSSH CCCCCCCCCCCHHHC	39.19	22496350
745 (in isoform 2)	Phosphorylation	-	39.19	27251275
748	Phosphorylation	SQNSSQHSVSSHRSL CCCCCCCCHHHCHHC	18.96	21406692
750	Phosphorylation	NSSQHSVSSHRSLHT CCCCCCHHHCHHCEE	24.36	21406692
751	Phosphorylation	SSQHSVSSHRSLHTA CCCCCHHHCHHCEEC	22.29	21406692
754	Phosphorylation	HSVSSHRSLHTASPS CCHHHCHHCEECCCC	21.05	29116813
757	Phosphorylation	SSHRSLHTASPSHST HHCHHCEECCCCCCC	33.84	21406692
759	Phosphorylation	HRSLHTASPSHSTQV CHHCEECCCCCCCCC	28.26	29116813
761	Phosphorylation	SLHTASPSHSTQVLP HCEECCCCCCCCCCC	27.81	21406692
761 (in isoform 2)	Phosphorylation	-	27.81	27251275
763	Phosphorylation	HTASPSHSTQVLPEF EECCCCCCCCCCCCC	25.52	21406692
764	Phosphorylation	TASPSHSTQVLPEFP ECCCCCCCCCCCCCC	19.78	29116813
781	Phosphorylation	EAQAPDQTDSSGQKK HHCCCCCCCCCCCCC	45.27	21406692
783	Phosphorylation	QAPDQTDSSGQKKPD CCCCCCCCCCCCCCC	39.49	21406692
784	Phosphorylation	APDQTDSSGQKKPDP CCCCCCCCCCCCCCH	48.31	21406692
800	Phosphorylation	KIWAQSRSMYENRPM HHEECCCCHHHCCCC	30.85	22798277
808	Phosphorylation	MYENRPMSPSPASGL HHHCCCCCCCCCCCC	25.55	28985074
866	Phosphorylation	NEPGEPIYIGHIVPL CCCCCCEEEEEEEEC	16.15	19060867
932	Phosphorylation	VVFAVPKTENEVPSP EEEECCCCCCCCCCC	37.66	23312004
938	Phosphorylation	KTENEVPSPASSHHS CCCCCCCCCCCCCCC	37.97	27732954
941	Phosphorylation	NEVPSPASSHHSSNQ CCCCCCCCCCCCCCC	33.32	27732954
942	Phosphorylation	EVPSPASSHHSSNQP CCCCCCCCCCCCCCC	27.59	27732954
945	Phosphorylation	SPASSHHSSNQPASL CCCCCCCCCCCCCCC	26.09	27732954
946	Phosphorylation	PASSHHSSNQPASLT CCCCCCCCCCCCCCC	34.82	27732954
951	Phosphorylation	HSSNQPASLTEEKRT CCCCCCCCCCCCCCC	42.37	27732954
953	Phosphorylation	SNQPASLTEEKRTPQ CCCCCCCCCCCCCCC	39.33	27732954
1042 (in isoform 2)	Phosphorylation	-	4.77	27251275
1071	Phosphorylation	GCSITNKSHSDIVNL CEECCCCCHHHHHHH	30.23	22199227
1073	Phosphorylation	SITNKSHSDIVNLIK ECCCCCHHHHHHHHH	35.80	28348404
1089 (in isoform 2)	Phosphorylation	-	18.54	27251275
1110	Phosphorylation	TNAEKIATITTTHTP CCHHHEEEEEECCCC	23.48	23186163
1112	Phosphorylation	AEKIATITTTHTPSQ HHHEEEEEECCCCCC	22.68	23186163
1113	Phosphorylation	EKIATITTTHTPSQQ HHEEEEEECCCCCCC	16.84	23186163
1114	Phosphorylation	KIATITTTHTPSQQG HEEEEEECCCCCCCC	18.33	23186163
1116	Phosphorylation	ATITTTHTPSQQGTQ EEEEECCCCCCCCCC	23.65	22199227
1118	Phosphorylation	ITTTHTPSQQGTQET EEECCCCCCCCCCCC	35.97	22199227
1122	Phosphorylation	HTPSQQGTQETRNTT CCCCCCCCCCCCCCC	20.92	-
1136 (in isoform 2)	Phosphorylation	-	40.93	24719451
1140 (in isoform 4)	Phosphorylation	-	52.54	-
1144 (in isoform 4)	Phosphorylation	-	15.36	-
1165	Phosphorylation	GAKGFGFSLRGGREY CCCCCCEEECCCCEE	19.96	30266825
1177	Phosphorylation	REYNMDLYVLRLAED CEECCEEEEEEECCC	7.99	20068231
1206	Phosphorylation	ILEINGETTKNMKHS EEEECCEECCCCCHH	44.46	22468782
1207	Phosphorylation	LEINGETTKNMKHSR EEECCEECCCCCHHH	19.00	22468782
1208	Acetylation	EINGETTKNMKHSRA EECCEECCCCCHHHH	63.56	19828479
1211	Acetylation	GETTKNMKHSRAIEL CEECCCCCHHHHHHH	48.07	19828489
1215 (in isoform 2)	Phosphorylation	-	11.56	27251275
1236 (in isoform 3)	Phosphorylation	-	38.96	-
1240 (in isoform 3)	Phosphorylation	-	27.38	-
1243	Phosphorylation	SVPEYDPSSDRHGPA CCCCCCCCCCCCCCC	41.81	28348404
1244	Phosphorylation	VPEYDPSSDRHGPAT CCCCCCCCCCCCCCC	44.01	28348404
1270	Phosphorylation	PDRRQHPSLESSYPP CCCCCCCCCCCCCCC	42.52	22964224
1275	Phosphorylation	HPSLESSYPPDLHKS CCCCCCCCCCCCCCC	28.23	22964224
1283	Phosphorylation	PPDLHKSSPHGEKRA CCCCCCCCCCCCCCC	26.22	22964224
1332 (in isoform 2)	Phosphorylation	-	28.94	24719451
1336 (in isoform 2)	Phosphorylation	-	14.52	24719451
1359	Phosphorylation	PEKRREGTRSADNTL HHHHHHCCCCCHHHH	19.39	23403867
1361	Phosphorylation	KRREGTRSADNTLER HHHHCCCCCHHHHHH	39.55	23898821
1362 (in isoform 6)	O-linked_Glycosylation	-	15.69	30379171
1365	Phosphorylation	GTRSADNTLERREKH CCCCCHHHHHHHHHH	30.46	29255136
1379	Phosphorylation	HEKRRDVSPERRRER HHHHCCCCHHHHHHC	25.90	26699800
1387	Phosphorylation	PERRRERSPTRRRDG HHHHHHCCCCCCCCC	26.35	-
1395	Phosphorylation	PTRRRDGSPSRRRRS CCCCCCCCHHHHHHH	24.80	27174698
1397	Phosphorylation	RRRDGSPSRRRRSLE CCCCCCHHHHHHHHH	39.87	27174698
1402	Phosphorylation	SPSRRRRSLERLLEQ CHHHHHHHHHHHHHH	32.54	26437602
1412	Phosphorylation	RLLEQRRSPERRRGG HHHHHHCCHHHHCCC	33.05	9647739
1420	Phosphorylation	PERRRGGSPERRAKS HHHHCCCCHHHHHHH	26.81	26329039
1435	Phosphorylation	TDRRRARSPERRRER HHHHHHHCHHHHHHH	30.08	29414761
1443	Phosphorylation	PERRRERSLDKRNRE HHHHHHHHHHHHCHH	35.85	25137130
1454	Phosphorylation	RNREDRASHREREEA HCHHHHHHHHHHHHH	24.79	-
1458 (in isoform 2)	Phosphorylation	-	47.19	24719451
1461	Phosphorylation	SHREREEANLKQDAG HHHHHHHHHHHHHCC	23.15	19413330
1461 (in isoform 2)	Phosphorylation	-	23.15	24719451
1486	Phosphorylation	RRPYKECSTDLSI-- CCCCCCCCCCCCC--	26.50	29514088
1487	Phosphorylation	RPYKECSTDLSI--- CCCCCCCCCCCC---	53.25	29514088
1490	Phosphorylation	KECSTDLSI------ CCCCCCCCC------	29.12	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_HUMAN	CTNNB1	physical	10772923
FCSD2_HUMAN	FCHSD2	physical	14627983
CADH1_HUMAN	CDH1	physical	10772923
ARHG8_MOUSE	Net1	physical	11350080
SYNPO_HUMAN	SYNPO	physical	12042308
ACTN4_HUMAN	ACTN4	physical	12042308
ATN1_HUMAN	ATN1	physical	9647693
IGSF5_HUMAN	IGSF5	physical	12773569
SYDE1_HUMAN	SYDE1	physical	27173435
CING_HUMAN	CGN	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1490, AND MASSSPECTROMETRY.
PubMed: 19413330

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-376, AND MASSSPECTROMETRY.
PubMed: 19534553