FCSD2_HUMAN - dbPTM
FCSD2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FCSD2_HUMAN
UniProt AC O94868
Protein Name F-BAR and double SH3 domains protein 2
Gene Name FCHSD2
Organism Homo sapiens (Human).
Sequence Length 740
Subcellular Localization
Protein Description
Protein Sequence MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYDQPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPPPTQNHRRPAEKIEDVEITLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59UbiquitinationEYAQGMQKLASQYLK
HHHHHHHHHHHHHHH		36.8129967540
66UbiquitinationKLASQYLKRDWPGVK
HHHHHHHHCCCCCCC		43.29-
94PhosphorylationWKSFLEGTMQVAQSR
HHHHHHHHHHHHHHH		8.6123401153
108PhosphorylationRMNICENYKNFISEP
HHHHHHHHHHHHCCH		5.7523401153
113PhosphorylationENYKNFISEPARTVR
HHHHHHHCCHHHHHH		33.1326270265
123UbiquitinationARTVRSLKEQQLKRC
HHHHHHHHHHHHHHH		55.51-
146UbiquitinationTELQETVKDLAKGKK
HHHHHHHHHHHHCCH		55.2129967540
175PhosphorylationKADIEAKSKLSLFQS
HHCHHHHHHHHHHHH		45.9720068231
178PhosphorylationIEAKSKLSLFQSRIS
HHHHHHHHHHHHHHH		30.7620068231
182PhosphorylationSKLSLFQSRISLQKA
HHHHHHHHHHHHHHH		25.0129514088
185PhosphorylationSLFQSRISLQKASVK
HHHHHHHHHHHHHHH		24.5224719451
190PhosphorylationRISLQKASVKLKARR
HHHHHHHHHHHHHHH		27.1628450419
198PhosphorylationVKLKARRSECNSKAT
HHHHHHHHHHHCCHH		40.73-
226PhosphorylationNAHQDRYYQTDLVNI
HHCCCCCCHHHHHHH		13.0621659604
276UbiquitinationFLLENSSKVVRDYNL
HHHHCCCHHHHCCCE		44.57-
326UbiquitinationTEEHSLNKEARKWAT
CCHHHCCHHHHHHHH		59.03-
333PhosphorylationKEARKWATRVAREHK
HHHHHHHHHHHHHHC		25.26-
345UbiquitinationEHKNIVHQQRVLNDL
HHCCHHHHHHHHHHH		23.1424816145
349UbiquitinationIVHQQRVLNDLECHG
HHHHHHHHHHHHHHC		4.4924816145
370UbiquitinationSRAELEQKIDEAREN
HHHHHHHHHHHHHHH		42.6324816145
436PhosphorylationTSNGTLHSLNADTER
CCCCEEECCCCCCCC		26.8227080861
460PhosphorylationMDVFDDSSSSPSGTL
CCCCCCCCCCCCCCC		41.6627732954
461PhosphorylationDVFDDSSSSPSGTLR
CCCCCCCCCCCCCCC		50.6627732954
462PhosphorylationVFDDSSSSPSGTLRN
CCCCCCCCCCCCCCC		25.6527732954
464PhosphorylationDDSSSSPSGTLRNYP
CCCCCCCCCCCCCCC		46.4927732954
466PhosphorylationSSSSPSGTLRNYPLT
CCCCCCCCCCCCCEE		27.2127732954
491 (in isoform 3)Phosphorylation-48.3322210691
493 (in isoform 3)Phosphorylation-20.0622210691
498 (in isoform 3)Phosphorylation-5.1922210691
529PhosphorylationEKYLQFPTSNSLLSM
HHHCCCCCCHHHHHH		41.6628348404
530PhosphorylationKYLQFPTSNSLLSML
HHCCCCCCHHHHHHH		25.3428348404
532PhosphorylationLQFPTSNSLLSMLQS
CCCCCCHHHHHHHHH		30.3828464451
628PhosphorylationSVLVEELSASENGDT
HHHHHHHHCCCCCCC		32.7828348404
630PhosphorylationLVEELSASENGDTPW
HHHHHHCCCCCCCCC		28.3728348404
644PhosphorylationWMREIQISPSPKPHA
CEEEEECCCCCCCCC		11.7128355574
646PhosphorylationREIQISPSPKPHASL
EEEECCCCCCCCCCC		38.4725159151
652PhosphorylationPSPKPHASLPPLPLY
CCCCCCCCCCCCCCC		38.0728464451
659PhosphorylationSLPPLPLYDQPPSSP
CCCCCCCCCCCCCCC		15.5925159151
664PhosphorylationPLYDQPPSSPYPSPD
CCCCCCCCCCCCCCC		51.1025159151
665PhosphorylationLYDQPPSSPYPSPDK
CCCCCCCCCCCCCCC		33.9425159151
667PhosphorylationDQPPSSPYPSPDKRS
CCCCCCCCCCCCCCC		20.4923401153
669PhosphorylationPPSSPYPSPDKRSSL
CCCCCCCCCCCCCCC		39.6325159151
674PhosphorylationYPSPDKRSSLYFPRS
CCCCCCCCCCCCCCC		30.3623401153
675PhosphorylationPSPDKRSSLYFPRSP
CCCCCCCCCCCCCCC		30.9930266825
677PhosphorylationPDKRSSLYFPRSPSA
CCCCCCCCCCCCCCC		17.3123403867
681PhosphorylationSSLYFPRSPSANEKS
CCCCCCCCCCCCCCC		24.3623401153
683PhosphorylationLYFPRSPSANEKSLH
CCCCCCCCCCCCCCC		45.0023898821
688PhosphorylationSPSANEKSLHAESPG
CCCCCCCCCCCCCCC		21.1421815630
693PhosphorylationEKSLHAESPGFSQAS
CCCCCCCCCCCCHHC		30.9825159151
697PhosphorylationHAESPGFSQASRHTP
CCCCCCCCHHCCCCC		30.6529396449
700PhosphorylationSPGFSQASRHTPETS
CCCCCHHCCCCCCCC		19.5625159151
703PhosphorylationFSQASRHTPETSYGK
CCHHCCCCCCCCCCC		23.0128985074
706PhosphorylationASRHTPETSYGKLRP
HCCCCCCCCCCCCCC		28.5821712546
707PhosphorylationSRHTPETSYGKLRPV
CCCCCCCCCCCCCCC		30.1726270265
708PhosphorylationRHTPETSYGKLRPVR
CCCCCCCCCCCCCCC		26.2126270265
710AcetylationTPETSYGKLRPVRAA
CCCCCCCCCCCCCCC		32.8425953088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FCSD2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FCSD2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FCSD2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CD158_HUMANCCDC158physical
16189514
CC85B_HUMANCCDC85Bphysical
16189514
MAGI1_HUMANMAGI1physical
14627983
CSKP_HUMANCASKphysical
14627983
TERA_HUMANVCPphysical
18654987
VCIP1_HUMANVCPIP1physical
18654987
GRP78_HUMANHSPA5physical
18654987
SRP72_HUMANSRP72physical
18654987
CFA36_HUMANCFAP36physical
18654987
CB073_HUMANC2orf73physical
18654987
MSL1_HUMANMSL1physical
18654987
TCPB_HUMANCCT2physical
18654987
SH3BG_HUMANSH3BGRphysical
18654987
CHKA_HUMANCHKAphysical
18654987
TLS1_HUMANC9orf78physical
18654987
HS90B_HUMANHSP90AB1physical
18654987
WASP_HUMANWASphysical
21988832
WASL_HUMANWASLphysical
21988832
MTUS2_HUMANMTUS2physical
25416956
ABCF3_HUMANABCF3physical
25416956
FAM9B_HUMANFAM9Bphysical
25416956
FCSD2_HUMANFCHSD2physical
26702831
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FCSD2_HUMAN

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Related Literatures of Post-Translational Modification

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