CFA36_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CFA36_HUMAN
• UniProt AC: Q96G28
• Protein Name: Cilia- and flagella-associated protein 36 {ECO:0000312|HGNC:HGNC:30540}
• Gene Name: CFAP36
• Organism: Homo sapiens (Human).
• Sequence Length: 342
• Subcellular Localization: Nucleus . Cytoplasm . Cell projection, cilium, flagellum .
• Protein Description: May act as an effector for ARL3..
• Protein Sequence: MAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACTSPLAKTHTSQAILQPVLAAEDFTIFKAMMVQKNIEMQLQAIRIIQERNGVLPDCLTDGSDVVSDLEHEEMKILREVLRKSKEEYDQEEERKRKKQLSEAKTEEPTVHSSEAAIMNNSQGDGEHFAHPPSEVKMHFANQSIEPLGRKVERSETSSLPQKDLKIPGLEHASIEGPIANLSVLGTEELRQREHYLKQKRDKLMSMRKDMRTKQIQNMEQKGKPTGEVEEMTEKPEMTAEEKQTLLKRRLLAEKLKEEVINK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	EEDEVEWVVESIAGF CHHHHHHHHHHHHHH		24816145
36	Ubiquitination	ILDFVEQKCEVFDDE HHHHHHHHCCCCCCH		-
45	Ubiquitination	EVFDDEEESKLTYTE CCCCCHHHHCCCHHH		24816145
47	Ubiquitination	FDDEEESKLTYTEIH CCCHHHHCCCHHHHH		21963094
49	Phosphorylation	DEEESKLTYTEIHQE CHHHHCCCHHHHHHH		26074081
50	Phosphorylation	EEESKLTYTEIHQEY HHHHCCCHHHHHHHH		26074081
51	Phosphorylation	EESKLTYTEIHQEYK HHHCCCHHHHHHHHH		26074081
58	Ubiquitination	TEIHQEYKELVEKLL HHHHHHHHHHHHHHH		23000965
63 (in isoform 1)	Ubiquitination	-		21890473
63	Ubiquitination	EYKELVEKLLEGYLK HHHHHHHHHHHHHHH		23000965
70	Ubiquitination	KLLEGYLKEIGINED HHHHHHHHHHCCCHH		21963094
83	Ubiquitination	EDQFQEACTSPLAKT HHHHHHHHCCCCHHC		23000965
84	Phosphorylation	DQFQEACTSPLAKTH HHHHHHHCCCCHHCC		25159151
85	Phosphorylation	QFQEACTSPLAKTHT HHHHHHCCCCHHCCC		25159151
88	Ubiquitination	EACTSPLAKTHTSQA HHHCCCCHHCCCCHH		23000965
89	Ubiquitination	ACTSPLAKTHTSQAI HHCCCCHHCCCCHHH		21963094
90	Phosphorylation	CTSPLAKTHTSQAIL HCCCCHHCCCCHHHH		26074081
92	Phosphorylation	SPLAKTHTSQAILQP CCCHHCCCCHHHHHH		26074081
93	Phosphorylation	PLAKTHTSQAILQPV CCHHCCCCHHHHHHH		26074081
95 (in isoform 2)	Ubiquitination	-		-
95	Ubiquitination	AKTHTSQAILQPVLA HHCCCCHHHHHHHHH		21963094
110	Ubiquitination	AEDFTIFKAMMVQKN CCCCHHHHHHHHHCC		23000965
114 (in isoform 2)	Ubiquitination	-		-
114	Ubiquitination	TIFKAMMVQKNIEMQ HHHHHHHHHCCHHHH		21963094
116	Ubiquitination	FKAMMVQKNIEMQLQ HHHHHHHCCHHHHHH		23000965
116 (in isoform 1)	Ubiquitination	-		21890473
124	Ubiquitination	NIEMQLQAIRIIQER CHHHHHHHHHHHHHH		23000965
126	Ubiquitination	EMQLQAIRIIQERNG HHHHHHHHHHHHHCC		23000965
129	Ubiquitination	LQAIRIIQERNGVLP HHHHHHHHHHCCCCC		21890473
135	Ubiquitination	IQERNGVLPDCLTDG HHHHCCCCCCCCCCC		23000965
135 (in isoform 2)	Ubiquitination	-		-
140	Ubiquitination	GVLPDCLTDGSDVVS CCCCCCCCCCCCCCC		23000965
141	Ubiquitination	VLPDCLTDGSDVVSD CCCCCCCCCCCCCCC		23000965
147	Phosphorylation	TDGSDVVSDLEHEEM CCCCCCCCCCCHHHH		-
148	Ubiquitination	DGSDVVSDLEHEEMK CCCCCCCCCCHHHHH		23503661
150	Ubiquitination	SDVVSDLEHEEMKIL CCCCCCCCHHHHHHH		21963094
155	Ubiquitination	DLEHEEMKILREVLR CCCHHHHHHHHHHHH		21963094
157	Ubiquitination	EHEEMKILREVLRKS CHHHHHHHHHHHHHC		23000965
159	Ubiquitination	EEMKILREVLRKSKE HHHHHHHHHHHHCHH		23000965
162	Ubiquitination	KILREVLRKSKEEYD HHHHHHHHHCHHHHH		21890473
165	Ubiquitination	REVLRKSKEEYDQEE HHHHHHCHHHHHHHH		24816145
168	Ubiquitination	LRKSKEEYDQEEERK HHHCHHHHHHHHHHH		23000965
168	Phosphorylation	LRKSKEEYDQEEERK HHHCHHHHHHHHHHH		-
173	Ubiquitination	EEYDQEEERKRKKQL HHHHHHHHHHHHHHH		23000965
174	Ubiquitination	EYDQEEERKRKKQLS HHHHHHHHHHHHHHH		27667366
180	Ubiquitination	ERKRKKQLSEAKTEE HHHHHHHHHHHCCCC		21963094
180 (in isoform 2)	Ubiquitination	-		-
181	Ubiquitination	RKRKKQLSEAKTEEP HHHHHHHHHHCCCCC		21890473
183	Ubiquitination	RKKQLSEAKTEEPTV HHHHHHHHCCCCCCC		21963094
185	Phosphorylation	KQLSEAKTEEPTVHS HHHHHHCCCCCCCCH		23186163
189	Phosphorylation	EAKTEEPTVHSSEAA HHCCCCCCCCHHHHH		23186163
190	Ubiquitination	AKTEEPTVHSSEAAI HCCCCCCCCHHHHHH		24816145
192	Phosphorylation	TEEPTVHSSEAAIMN CCCCCCCHHHHHHCC		23186163
193	Phosphorylation	EEPTVHSSEAAIMNN CCCCCCHHHHHHCCC		24043423
201	Phosphorylation	EAAIMNNSQGDGEHF HHHHCCCCCCCCCCC		17525332
207	Ubiquitination	NSQGDGEHFAHPPSE CCCCCCCCCCCCCHH		27667366
213	Phosphorylation	EHFAHPPSEVKMHFA CCCCCCCHHHHHHCC		29978859
214	Ubiquitination	HFAHPPSEVKMHFAN CCCCCCHHHHHHCCC		21890473
216	Ubiquitination	AHPPSEVKMHFANQS CCCCHHHHHHCCCCC		29967540
223	Phosphorylation	KMHFANQSIEPLGRK HHHCCCCCCCCCCCC		28857561
241	Ubiquitination	SETSSLPQKDLKIPG CCCCCCCHHHCCCCC		29967540
253	Phosphorylation	IPGLEHASIEGPIAN CCCCCCCCEECCCCC		28348404
277	Ubiquitination	RQREHYLKQKRDKLM HHHHHHHHHHHHHHH		23000965
277	Methylation	RQREHYLKQKRDKLM HHHHHHHHHHHHHHH		-
279	Ubiquitination	REHYLKQKRDKLMSM HHHHHHHHHHHHHHH		23000965
282	Ubiquitination	YLKQKRDKLMSMRKD HHHHHHHHHHHHHHH		23000965
282 (in isoform 1)	Ubiquitination	-		21890473
285	Phosphorylation	QKRDKLMSMRKDMRT HHHHHHHHHHHHHHH		23909892
288	Ubiquitination	DKLMSMRKDMRTKQI HHHHHHHHHHHHHHH		23000965
292	Phosphorylation	SMRKDMRTKQIQNME HHHHHHHHHHHHHHH		29052541
293 (in isoform 1)	Ubiquitination	-		21890473
293	Ubiquitination	MRKDMRTKQIQNMEQ HHHHHHHHHHHHHHH		23000965
293	Neddylation	MRKDMRTKQIQNMEQ HHHHHHHHHHHHHHH		32015554
301	Ubiquitination	QIQNMEQKGKPTGEV HHHHHHHCCCCCCCH		23503661
302	Ubiquitination	IQNMEQKGKPTGEVE HHHHHHCCCCCCCHH		23000965
303	Ubiquitination	QNMEQKGKPTGEVEE HHHHHCCCCCCCHHH		21963094
303 (in isoform 1)	Ubiquitination	-		21890473
304	Ubiquitination	NMEQKGKPTGEVEEM HHHHCCCCCCCHHHH		23000965
307	Ubiquitination	QKGKPTGEVEEMTEK HCCCCCCCHHHHHCC		21890473
313	Ubiquitination	GEVEEMTEKPEMTAE CCHHHHHCCCCCCHH		23000965
314	Ubiquitination	EVEEMTEKPEMTAEE CHHHHHCCCCCCHHH		29967540
318	Neddylation	MTEKPEMTAEEKQTL HHCCCCCCHHHHHHH		32015554
318	Ubiquitination	MTEKPEMTAEEKQTL HHCCCCCCHHHHHHH		23000965
322	Ubiquitination	PEMTAEEKQTLLKRR CCCCHHHHHHHHHHH		32015554
326	Ubiquitination	AEEKQTLLKRRLLAE HHHHHHHHHHHHHHH		23503661
327	Ubiquitination	EEKQTLLKRRLLAEK HHHHHHHHHHHHHHH		30230243
328 (in isoform 2)	Ubiquitination	-		21890473
328	Ubiquitination	EKQTLLKRRLLAEKL HHHHHHHHHHHHHHH		21963094
334 (in isoform 1)	Ubiquitination	-		21890473
334	Ubiquitination	KRRLLAEKLKEEVIN HHHHHHHHHHHHHHC		33845483
336	Sumoylation	RLLAEKLKEEVINK- HHHHHHHHHHHHCC-		-
336	Ubiquitination	RLLAEKLKEEVINK- HHHHHHHHHHHHCC-		33845483
336	Sumoylation	RLLAEKLKEEVINK- HHHHHHHHHHHHCC-		-
339	Ubiquitination	AEKLKEEVINK---- HHHHHHHHHCC----		29967540
347	Ubiquitination	INK------------ HCC------------		32015554
352 (in isoform 2)	Ubiquitination	-		-
352	Ubiquitination	----------------- -----------------		30230243
359	Ubiquitination	------------------------ ------------------------		33845483
361	Ubiquitination	-------------------------- --------------------------		33845483
361 (in isoform 2)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CFA36_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CFA36_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CFA36_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARL2_HUMAN	ARL2	physical	28514442
OSBL9_HUMAN	OSBPL9	physical	28514442
SNTB2_HUMAN	SNTB2	physical	28514442
BACD3_HUMAN	KCTD10	physical	28514442
BDH2_HUMAN	BDH2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.