CSKP_HUMAN - dbPTM
CSKP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CSKP_HUMAN
UniProt AC O14936
Protein Name Peripheral plasma membrane protein CASK
Gene Name CASK
Organism Homo sapiens (Human).
Sequence Length 926
Subcellular Localization Nucleus. Cytoplasm. Cell membrane
Peripheral membrane protein.
Protein Description Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1..
Protein Sequence MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41UbiquitinationTGQQFAVKIVDVAKF
CCCEEEEEEEEHHHH		33.32-
49PhosphorylationIVDVAKFTSSPGLST
EEEHHHHCCCCCCCH		27.8222199227
50PhosphorylationVDVAKFTSSPGLSTE
EEHHHHCCCCCCCHH		37.3522199227
51PhosphorylationDVAKFTSSPGLSTED
EHHHHCCCCCCCHHH		21.6725159151
55PhosphorylationFTSSPGLSTEDLKRE
HCCCCCCCHHHHHHH		35.3527050516
56PhosphorylationTSSPGLSTEDLKREA
CCCCCCCHHHHHHHH		38.2627050516
60UbiquitinationGLSTEDLKREASICH
CCCHHHHHHHHHHHH		61.5921906983
60 (in isoform 1)Ubiquitination-61.5921890473
60 (in isoform 2)Ubiquitination-61.5921890473
60 (in isoform 3)Ubiquitination-61.5921890473
60 (in isoform 4)Ubiquitination-61.5921890473
60 (in isoform 6)Ubiquitination-61.5921890473
64PhosphorylationEDLKREASICHMLKH
HHHHHHHHHHHHHCC		22.4628348404
151PhosphorylationPHCVLLASKENSAPV
CCEEEEEECCCCCCE		40.2418423203
155PhosphorylationLLASKENSAPVKLGG
EEEECCCCCCEEECC		34.7318423203
182PhosphorylationVAGGRVGTPHFMAPE
CCCCCCCCCCCCCCH		15.6723312004
185 (in isoform 5)Phosphorylation-4.7429514088
186 (in isoform 5)Phosphorylation-5.7429514088
188 (in isoform 5)Phosphorylation-24.1130266825
190 (in isoform 5)Phosphorylation-6.3130266825
191 (in isoform 5)Phosphorylation-4.6330266825
192 (in isoform 5)Phosphorylation-57.1130266825
198 (in isoform 5)Phosphorylation-35.7022167270
199 (in isoform 5)Phosphorylation-24.1522167270
200 (in isoform 5)Phosphorylation-12.0522167270
257 (in isoform 5)Ubiquitination-2.6721890473
268PhosphorylationPAERITVYEALNHPW
HHHHEEHHHHHCCHH		6.1927642862
282PhosphorylationWLKERDRYAYKIHLP
HHHHCCCEEEEECCC		20.69-
313PhosphorylationGAVLAAVSSHKFNSF
HHHHHHHHHCCHHHC		23.2330266825
314PhosphorylationAVLAAVSSHKFNSFY
HHHHHHHHCCHHHCC		24.8925849741
319PhosphorylationVSSHKFNSFYGDPPE
HHHCCHHHCCCCCHH		23.9924275569
319 (in isoform 3)Phosphorylation-23.9928387310
336 (in isoform 3)Phosphorylation-48.0927251275
337 (in isoform 3)Phosphorylation-28.0027251275
338 (in isoform 3)Phosphorylation-35.6227251275
342 (in isoform 3)Phosphorylation-16.6027251275
347 (in isoform 3)Phosphorylation-5.2827251275
348PhosphorylationLAAERAVSQVLDSLE
HHHHHHHHHHHHCHH		17.3727732954
353PhosphorylationAVSQVLDSLEEIHAL
HHHHHHHCHHHHHHH		33.2527732954
355 (in isoform 3)Phosphorylation-59.8828348404
358 (in isoform 3)Phosphorylation-20.2627251275
361PhosphorylationLEEIHALTDCSEKDL
HHHHHHHHCCCHHHH		35.4227732954
364PhosphorylationIHALTDCSEKDLDFL
HHHHHCCCHHHHHHH		50.9527732954
387PhosphorylationLHTLLDLYDKINTKS
HHHHHHHHHHHCCCC		18.17-
394PhosphorylationYDKINTKSSPQIRNP
HHHHCCCCCCCCCCC		45.2520068231
395PhosphorylationDKINTKSSPQIRNPP
HHHCCCCCCCCCCCC		23.5230576142
417 (in isoform 5)Ubiquitination-15.7521890473
453PhosphorylationVVAHEVYSDEALRVT
CEEEEECCCCCCCCC		33.8626074081
460PhosphorylationSDEALRVTPPPTSPY
CCCCCCCCCCCCCCC		24.5226074081
464PhosphorylationLRVTPPPTSPYLNGD
CCCCCCCCCCCCCCC		48.3726074081
465PhosphorylationRVTPPPTSPYLNGDS
CCCCCCCCCCCCCCC		19.8126074081
467PhosphorylationTPPPTSPYLNGDSPE
CCCCCCCCCCCCCCC		16.7426471730
472PhosphorylationSPYLNGDSPESANGD
CCCCCCCCCCCCCCC		31.7825921289
475PhosphorylationLNGDSPESANGDMDM
CCCCCCCCCCCCCCH		30.3425921289
529PhosphorylationGMIHRQGTLHVGDEI
CCCCCCCEEECCHHH		12.8328857561
562PhosphorylationMLREMRGSITFKIVP
HHHHHCCCCEEEECC		14.2129514088
564PhosphorylationREMRGSITFKIVPSY
HHHCCCCEEEECCCC		22.1529514088
564 (in isoform 3)Phosphorylation-22.1529514088
565 (in isoform 3)Phosphorylation-4.9129514088
567 (in isoform 3)Phosphorylation-4.8730266825
569 (in isoform 3)Phosphorylation-29.1730266825
570PhosphorylationITFKIVPSYRTQSSS
CEEEECCCCCCCCCC		19.16-
570 (in isoform 3)Phosphorylation-19.1630266825
570 (in isoform 4)Phosphorylation-19.1629514088
571PhosphorylationTFKIVPSYRTQSSSC
EEEECCCCCCCCCCC		16.17-
571 (in isoform 3)Phosphorylation-16.1730266825
571 (in isoform 4)Phosphorylation-16.1729514088
573PhosphorylationKIVPSYRTQSSSCER
EECCCCCCCCCCCCC		25.2727732954
573 (in isoform 4)Phosphorylation-25.2730266825
575PhosphorylationVPSYRTQSSSCERDS
CCCCCCCCCCCCCCC		24.4927732954
575 (in isoform 4)Phosphorylation-24.4930266825
576PhosphorylationPSYRTQSSSCERDSP
CCCCCCCCCCCCCCC		29.2330242111
576 (in isoform 4)Phosphorylation-29.2330266825
577PhosphorylationSYRTQSSSCERDSPS
CCCCCCCCCCCCCCC		25.8325159151
577 (in isoform 3)Phosphorylation-25.8322167270
577 (in isoform 4)Phosphorylation-25.8330266825
578 (in isoform 3)Phosphorylation-5.5522167270
579 (in isoform 3)Phosphorylation-62.5622167270
582PhosphorylationSSSCERDSPSTSRQS
CCCCCCCCCCCCCCC		27.2925159151
583 (in isoform 4)Phosphorylation-46.0122167270
584PhosphorylationSCERDSPSTSRQSPA
CCCCCCCCCCCCCCC		42.8630242111
584 (in isoform 4)Phosphorylation-42.8622167270
585PhosphorylationCERDSPSTSRQSPAN
CCCCCCCCCCCCCCC		31.1730242111
585 (in isoform 4)Phosphorylation-31.1722167270
586PhosphorylationERDSPSTSRQSPANG
CCCCCCCCCCCCCCC		32.4323312004
589PhosphorylationSPSTSRQSPANGHSS
CCCCCCCCCCCCCCC		25.5223090842
595PhosphorylationQSPANGHSSTNNSVS
CCCCCCCCCCCCCCC		40.0123090842
596PhosphorylationSPANGHSSTNNSVSD
CCCCCCCCCCCCCCC		29.4923090842
597PhosphorylationPANGHSSTNNSVSDL
CCCCCCCCCCCCCCC		41.2423090842
600PhosphorylationGHSSTNNSVSDLPST
CCCCCCCCCCCCCCC		25.6823090842
602PhosphorylationSSTNNSVSDLPSTTQ
CCCCCCCCCCCCCCC		33.0023090842
606PhosphorylationNSVSDLPSTTQPKGR
CCCCCCCCCCCCCCC		51.9223090842
607PhosphorylationSVSDLPSTTQPKGRQ
CCCCCCCCCCCCCCE		27.7523090842
608PhosphorylationVSDLPSTTQPKGRQI
CCCCCCCCCCCCCEE		47.4123090842
636 (in isoform 3)Ubiquitination-12.2821890473
650PhosphorylationGDIIQIISKDDHNWW
CCEEEEEECCCCCCH		31.4924719451
653 (in isoform 6)Ubiquitination-40.5321890473
665UbiquitinationQGKLENSKNGTAGLI
HHHEECCCCCCCCCC		71.6121906983
665 (in isoform 1)Ubiquitination-71.6121890473
665 (in isoform 2)Ubiquitination-71.6121890473
665 (in isoform 4)Ubiquitination-71.6121890473
697PhosphorylationTKQEQQASCTWFGKK
CHHHHHHHCCCCCCC		14.0328857561
703MethylationASCTWFGKKKKQYKD
HHCCCCCCCCHHHHH		52.53-
704MethylationSCTWFGKKKKQYKDK
HCCCCCCCCHHHHHH		66.63-
708PhosphorylationFGKKKKQYKDKYLAK
CCCCCHHHHHHHHHH		29.99-
711AcetylationKKKQYKDKYLAKHNA
CCHHHHHHHHHHHCH		37.7025953088
712PhosphorylationKKQYKDKYLAKHNAV
CHHHHHHHHHHHCHH		23.25-
738MethylationVVKLPAFKRKTLVLL
HCCCCCCCCCEEEEE		55.90-
741PhosphorylationLPAFKRKTLVLLGAH
CCCCCCCEEEEECCC		26.57-
761O-linked_GlycosylationHIKNTLITKHPDRFA
HHHCCEECCCCCCCC		26.8129237092
769PhosphorylationKHPDRFAYPIPHTTR
CCCCCCCCCCCCCCC		10.05-
775PhosphorylationAYPIPHTTRPPKKDE
CCCCCCCCCCCCCCC		37.84-
788PhosphorylationDEENGKNYYFVSHDQ
CCCCCCCEEEECHHH		11.1925884760
789PhosphorylationEENGKNYYFVSHDQM
CCCCCCEEEECHHHH		13.6020736484
792PhosphorylationGKNYYFVSHDQMMQD
CCCEEEECHHHHCCC		16.08-
796 (in isoform 3)Ubiquitination-3.0321890473
808PhosphorylationSNNEYLEYGSHEDAM
CCCCCCCCCCHHHHC		22.7229759185
808 (in isoform 6)Ubiquitination-22.7221890473
818PhosphorylationHEDAMYGTKLETIRK
HHHHCCCCHHHHHHH		18.2429759185
820 (in isoform 2)Ubiquitination-7.6321890473
825UbiquitinationTKLETIRKIHEQGLI
CHHHHHHHHHHCCCE		44.5621890473
825 (in isoform 1)Ubiquitination-44.5621890473
871PhosphorylationPGLNEDESLQRLQKE
CCCCCHHHHHHHHHH		41.9728348404
926PhosphorylationWVPVSWVY-------
CEECCCCC-------		13.43-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
151SPhosphorylationKinaseCASKO14936
PSP
155SPhosphorylationKinaseCASKO14936
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CSKP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CSKP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TSYL2_HUMANTSPYL2physical
15066269
DLG4_HUMANDLG4physical
12151521
DLG1_HUMANDLG1physical
12151521
SDC1_HUMANSDC1physical
9660868
SDC2_HUMANSDC2physical
9660868
41_HUMANEPB41physical
9660868
RP3A_HUMANRPH3Aphysical
11377421
TBR1_HUMANTBR1physical
10749215
DLG1_HUMANDLG1physical
10993877
ARI1_HUMANARIH1physical
21590270
PRKN_HUMANPARK2physical
21590270
I15RA_HUMANIL15RAphysical
21988832
WNT7B_HUMANWNT7Bphysical
21988832
CDK9_HUMANCDK9physical
21988832
P4R3A_HUMANSMEK1physical
21988832
DUS3_HUMANDUSP3physical
21988832
IL18_HUMANIL18physical
21988832
SYMC_HUMANMARSphysical
21988832
AF17_HUMANMLLT6physical
21988832
P2RX7_HUMANP2RX7physical
21988832
PCBP2_HUMANPCBP2physical
21988832
PCM1_HUMANPCM1physical
21988832
GCNT3_HUMANGCNT3physical
21988832
TRI22_HUMANTRIM22physical
21988832
PLK2_HUMANPLK2physical
21988832
ELL2_HUMANELL2physical
21988832
LIN7A_HUMANLIN7Aphysical
25416956
SH24A_HUMANSH2D4Aphysical
25416956
ABLM1_HUMANABLIM1physical
25852190
DLG1_HUMANDLG1physical
25852190
DTNB_HUMANDTNBphysical
25852190
EF2_HUMANEEF2physical
25852190
LIN7C_HUMANLIN7Cphysical
25852190
ARHGQ_HUMANARHGEF26physical
25852190
SNTB2_HUMANSNTB2physical
25852190
Drug and Disease Associations
Kegg Disease
H00577 Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Part
H00894 FG syndrome (FGS); Opitz-Kaveggia syndrome
OMIM Disease
300749Mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH)
300422FG syndrome 4 (FGS4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CSKP_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"CASK functions as a Mg2+-independent neurexin kinase.";
Mukherjee K., Sharma M., Urlaub H., Bourenkov G.P., Jahn R.,Suedhof T.C., Wahl M.C.;
Cell 133:328-339(2008).
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 1-337 IN COMPLEX WITH AMP,COFACTOR, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES,PHOSPHORYLATION OF NRXN1, AND AUTOPHOSPHORYLATION AT SER-151 ANDSER-155.

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