AF17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AF17_HUMAN
• UniProt AC: P55198
• Protein Name: Protein AF-17
• Gene Name: MLLT6
• Organism: Homo sapiens (Human).
• Sequence Length: 1093
• Subcellular Localization: Nucleus .
• Protein Sequence: MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGGAGGGGGSMGGGGSGFISGRRSRSASPSTQQEKHPTHHERGQKKSRKDKERLKQKHKKRPESPPSILTPPVVPTADKVSSSASSSSHHEASTQETSESSRESKGKKSSSHSLSHKGKKLSSGKGVSSFTSASSSSSSSSSSSGGPFQPAVSSLQSSPDFSAFPKLEQPEEDKYSKPTAPAPSAPPSPSAPEPPKADLFEQKVVFSGFGPIMRFSTTTSSSGRARAPSPGDYKSPHVTGSGASAGTHKRMPALSATPVPADETPETGLKEKKHKASKRSRHGPGRPKGSRNKEGTGGPAAPSLPSAQLAGFTATAASPFSGGSLVSSGLGGLSSRTFGPSGSLPSLSLESPLLGAGIYTSNKDPISHSGGMLRAVCSTPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSASISTTQVFSLAGSTFSLPSTHIFGTPMGAVNPLLSQAESSHTEPDLEDCSFRCRGTSPQESLSSMSPISSLPALFDQTASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQILSLTAKKERLQILNVQLSVPFPALPAALPAANGPVPGPYGLPPQAGSSDSLSTSKSPPGKSSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGAPAPLPPQPQNGLGRAPGAAGLGAMPMAEGLLGGLAGSGGLPLNGLLGGLNGAAAPNPASLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQQIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAPSLGNNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLSGAEGSGGGPKGGTADKGASANQEKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
130	Phosphorylation	CEEQGRESKAASGAC EHHHCCCCCHHCCCC	26.66	-
134	Phosphorylation	GRESKAASGACMTCN CCCCCHHCCCCCCCC	31.61	-
183	Ubiquitination	YCKYHFSKMKTSRHS CCHHEECCCCCCCCC	43.39	29967540
186	Phosphorylation	YHFSKMKTSRHSSGG HEECCCCCCCCCCCC	27.74	22210691
187	Phosphorylation	HFSKMKTSRHSSGGG EECCCCCCCCCCCCC	23.60	28555341
190	Phosphorylation	KMKTSRHSSGGGGGG CCCCCCCCCCCCCCC	29.57	27251789
191	Phosphorylation	MKTSRHSSGGGGGGA CCCCCCCCCCCCCCC	35.02	30108239
204	Phosphorylation	GAGGGGGSMGGGGSG CCCCCCCCCCCCCCC	19.96	30108239
210	Phosphorylation	GSMGGGGSGFISGRR CCCCCCCCCCCCCCC	33.53	22210691
214	Phosphorylation	GGGSGFISGRRSRSA CCCCCCCCCCCCCCC	24.80	27251789
218	Phosphorylation	GFISGRRSRSASPST CCCCCCCCCCCCCCC	29.26	20363803
220	Phosphorylation	ISGRRSRSASPSTQQ CCCCCCCCCCCCCCH	34.05	28176443
222	Phosphorylation	GRRSRSASPSTQQEK CCCCCCCCCCCCHHC	22.19	28176443
224	Phosphorylation	RSRSASPSTQQEKHP CCCCCCCCCCHHCCC	36.03	28985074
225	O-linked_Glycosylation	SRSASPSTQQEKHPT CCCCCCCCCHHCCCC	37.34	30059200
225	Phosphorylation	SRSASPSTQQEKHPT CCCCCCCCCHHCCCC	37.34	30242111
232	Phosphorylation	TQQEKHPTHHERGQK CCHHCCCCHHHHCHH	35.27	23312004
258	Phosphorylation	KHKKRPESPPSILTP HHHHCCCCCCCCCCC	44.80	29255136
261	Phosphorylation	KRPESPPSILTPPVV HCCCCCCCCCCCCCC	33.35	30266825
264	Phosphorylation	ESPPSILTPPVVPTA CCCCCCCCCCCCCCC	24.71	23927012
270	Phosphorylation	LTPPVVPTADKVSSS CCCCCCCCCCHHCCC	35.56	23403867
275	Phosphorylation	VPTADKVSSSASSSS CCCCCHHCCCCCCCC	25.06	28450419
276	Phosphorylation	PTADKVSSSASSSSH CCCCHHCCCCCCCCC	32.67	28450419
277	Phosphorylation	TADKVSSSASSSSHH CCCHHCCCCCCCCCC	25.35	28450419
279	Phosphorylation	DKVSSSASSSSHHEA CHHCCCCCCCCCCCC	32.47	28450419
280	Phosphorylation	KVSSSASSSSHHEAS HHCCCCCCCCCCCCH	35.26	28450419
281	Phosphorylation	VSSSASSSSHHEAST HCCCCCCCCCCCCHH	31.06	28450419
282	Phosphorylation	SSSASSSSHHEASTQ CCCCCCCCCCCCHHH	30.70	28450419
287	Phosphorylation	SSSHHEASTQETSES CCCCCCCHHHHCCHH	27.86	23312004
288	Phosphorylation	SSHHEASTQETSESS CCCCCCHHHHCCHHH	37.16	23312004
291	Phosphorylation	HEASTQETSESSRES CCCHHHHCCHHHHHC	28.16	23312004
292	Phosphorylation	EASTQETSESSRESK CCHHHHCCHHHHHCC	34.43	23312004
294	Phosphorylation	STQETSESSRESKGK HHHHCCHHHHHCCCC	34.17	23312004
295	Phosphorylation	TQETSESSRESKGKK HHHCCHHHHHCCCCC	35.70	23312004
298	Phosphorylation	TSESSRESKGKKSSS CCHHHHHCCCCCCCC	45.67	-
303	Phosphorylation	RESKGKKSSSHSLSH HHCCCCCCCCCCCCC	40.33	-
329	Phosphorylation	SSFTSASSSSSSSSS CCCEECCCCCCCCCC	33.68	27251275
330	Phosphorylation	SFTSASSSSSSSSSS CCEECCCCCCCCCCC	31.57	27251275
331	Phosphorylation	FTSASSSSSSSSSSS CEECCCCCCCCCCCC	35.87	27251275
332	Phosphorylation	TSASSSSSSSSSSSG EECCCCCCCCCCCCC	35.87	27251275
333	Phosphorylation	SASSSSSSSSSSSGG ECCCCCCCCCCCCCC	35.87	27251275
334	Phosphorylation	ASSSSSSSSSSSGGP CCCCCCCCCCCCCCC	35.87	27251275
335	Phosphorylation	SSSSSSSSSSSGGPF CCCCCCCCCCCCCCC	35.87	27251275
336	Phosphorylation	SSSSSSSSSSGGPFQ CCCCCCCCCCCCCCC	30.39	27251275
337	Phosphorylation	SSSSSSSSSGGPFQP CCCCCCCCCCCCCCC	34.64	27251275
338	Phosphorylation	SSSSSSSSGGPFQPA CCCCCCCCCCCCCCH	50.12	27251275
347	Phosphorylation	GPFQPAVSSLQSSPD CCCCCHHHHCCCCCC	27.69	27251275
348	Phosphorylation	PFQPAVSSLQSSPDF CCCCHHHHCCCCCCC	24.67	27251275
351	Phosphorylation	PAVSSLQSSPDFSAF CHHHHCCCCCCCCCC	49.48	27251275
352	Phosphorylation	AVSSLQSSPDFSAFP HHHHCCCCCCCCCCC	18.61	27251275
369	Phosphorylation	EQPEEDKYSKPTAPA CCCCCCCCCCCCCCC	33.96	26356563
370	Phosphorylation	QPEEDKYSKPTAPAP CCCCCCCCCCCCCCC	37.59	26356563
373	Phosphorylation	EDKYSKPTAPAPSAP CCCCCCCCCCCCCCC	49.35	23663014
378	Phosphorylation	KPTAPAPSAPPSPSA CCCCCCCCCCCCCCC	56.36	29255136
382	Phosphorylation	PAPSAPPSPSAPEPP CCCCCCCCCCCCCCC	30.35	29255136
384	Phosphorylation	PSAPPSPSAPEPPKA CCCCCCCCCCCCCCC	61.87	29255136
401	O-linked_Glycosylation	FEQKVVFSGFGPIMR HCCEEEEECCCCEEE	22.92	30059200
412	O-linked_Glycosylation	PIMRFSTTTSSSGRA CEEEEEECCCCCCCC	24.39	30059200
414	O-linked_Glycosylation	MRFSTTTSSSGRARA EEEEECCCCCCCCCC	22.03	30059200
416	O-linked_Glycosylation	FSTTTSSSGRARAPS EEECCCCCCCCCCCC	31.87	30059200
416	Phosphorylation	FSTTTSSSGRARAPS EEECCCCCCCCCCCC	31.87	-
423	Phosphorylation	SGRARAPSPGDYKSP CCCCCCCCCCCCCCC	40.30	30266825
427	Phosphorylation	RAPSPGDYKSPHVTG CCCCCCCCCCCCCCC	21.20	30266825
429	Phosphorylation	PSPGDYKSPHVTGSG CCCCCCCCCCCCCCC	17.63	23403867
433	O-linked_Glycosylation	DYKSPHVTGSGASAG CCCCCCCCCCCCCCC	23.69	30059200
433	Phosphorylation	DYKSPHVTGSGASAG CCCCCCCCCCCCCCC	23.69	23403867
435	Phosphorylation	KSPHVTGSGASAGTH CCCCCCCCCCCCCCC	23.09	25159151
438	O-linked_Glycosylation	HVTGSGASAGTHKRM CCCCCCCCCCCCCCC	30.65	30059200
438	Phosphorylation	HVTGSGASAGTHKRM CCCCCCCCCCCCCCC	30.65	25159151
441	Phosphorylation	GSGASAGTHKRMPAL CCCCCCCCCCCCCCC	24.76	23403867
443	Acetylation	GASAGTHKRMPALSA CCCCCCCCCCCCCCC	50.67	25953088
449	Phosphorylation	HKRMPALSATPVPAD CCCCCCCCCCCCCCC	32.00	29255136
451	Phosphorylation	RMPALSATPVPADET CCCCCCCCCCCCCCC	22.80	29255136
458	Phosphorylation	TPVPADETPETGLKE CCCCCCCCCCCCCHH	27.29	29255136
461	Phosphorylation	PADETPETGLKEKKH CCCCCCCCCCHHHHH	49.36	29255136
507	O-linked_Glycosylation	SAQLAGFTATAASPF HHHHCCCEEEECCCC	23.37	30059200
509	Phosphorylation	QLAGFTATAASPFSG HHCCCEEEECCCCCC	21.50	25332170
512	O-linked_Glycosylation	GFTATAASPFSGGSL CCEEEECCCCCCCCC	24.82	30059200
521	Phosphorylation	FSGGSLVSSGLGGLS CCCCCCCCCCCCCCC	24.79	25332170
522	Phosphorylation	SGGSLVSSGLGGLSS CCCCCCCCCCCCCCC	30.47	25332170
531	O-linked_Glycosylation	LGGLSSRTFGPSGSL CCCCCCCCCCCCCCC	34.59	30059200
535	O-linked_Glycosylation	SSRTFGPSGSLPSLS CCCCCCCCCCCCCCC	41.20	30059200
537	O-linked_Glycosylation	RTFGPSGSLPSLSLE CCCCCCCCCCCCCCC	41.25	30059200
540	O-linked_Glycosylation	GPSGSLPSLSLESPL CCCCCCCCCCCCCCC	35.56	30059200
542	O-linked_Glycosylation	SGSLPSLSLESPLLG CCCCCCCCCCCCCCC	34.13	30059200
545	O-linked_Glycosylation	LPSLSLESPLLGAGI CCCCCCCCCCCCCEE	26.58	30059200
554	O-linked_Glycosylation	LLGAGIYTSNKDPIS CCCCEEECCCCCCCC	24.73	30059200
555	O-linked_Glycosylation	LGAGIYTSNKDPISH CCCEEECCCCCCCCC	25.55	30059200
561	O-linked_Glycosylation	TSNKDPISHSGGMLR CCCCCCCCCCCCCHH	19.59	30059200
563	O-linked_Glycosylation	NKDPISHSGGMLRAV CCCCCCCCCCCHHHH	30.19	30059200
563	Phosphorylation	NKDPISHSGGMLRAV CCCCCCCCCCCHHHH	30.19	25159151
572	Phosphorylation	GMLRAVCSTPLSSSL CCHHHHHCCCCCHHH	26.85	26074081
573	Phosphorylation	MLRAVCSTPLSSSLL CHHHHHCCCCCHHHC	24.11	26074081
576	Phosphorylation	AVCSTPLSSSLLGPP HHHCCCCCHHHCCCC	21.05	26074081
577	Phosphorylation	VCSTPLSSSLLGPPG HHCCCCCHHHCCCCC	32.46	26074081
578	Phosphorylation	CSTPLSSSLLGPPGT HCCCCCHHHCCCCCC	25.00	26074081
585	Phosphorylation	SLLGPPGTSALPRLS HHCCCCCCCCCCCCC	19.32	26074081
586	Phosphorylation	LLGPPGTSALPRLSR HCCCCCCCCCCCCCC	33.45	24719451
590	Methylation	PGTSALPRLSRSPFT CCCCCCCCCCCCCCC	46.26	115385923
593	Methylation	SALPRLSRSPFTSTL CCCCCCCCCCCCCCC	53.60	115385931
661	Phosphorylation	CSFRCRGTSPQESLS CCEECCCCCCHHHHH	20.20	29802988
662	Phosphorylation	SFRCRGTSPQESLSS CEECCCCCCHHHHHH	27.66	29802988
668	Phosphorylation	TSPQESLSSMSPISS CCCHHHHHHCCCHHH	33.02	28348404
669	Phosphorylation	SPQESLSSMSPISSL CCHHHHHHCCCHHHC	28.68	28348404
671	Phosphorylation	QESLSSMSPISSLPA HHHHHHCCCHHHCCH	22.49	28348404
674	Phosphorylation	LSSMSPISSLPALFD HHHCCCHHHCCHHHC	29.25	28348404
675	Phosphorylation	SSMSPISSLPALFDQ HHCCCHHHCCHHHCC	38.81	28348404
683	Phosphorylation	LPALFDQTASAPCGG CCHHHCCCCCCCCCC	25.15	27251275
685	Phosphorylation	ALFDQTASAPCGGGQ HHHCCCCCCCCCCCC	35.81	27251275
724	Ubiquitination	VNIVEMLKALHALQK HCHHHHHHHHHHHHH	47.82	29967540
731	Ubiquitination	KALHALQKENQRLQE HHHHHHHHHHHHHHH	60.53	29967540
744	Phosphorylation	QEQILSLTAKKERLQ HHHHHHHHHHHHHEE	32.81	28555341
746	Ubiquitination	QILSLTAKKERLQIL HHHHHHHHHHHEEEE	50.35	29967540
1084	Acetylation	PKGGTADKGASANQE CCCCCCCCCCCCCCC	54.64	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AF17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AF17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AF17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED15_HUMAN	MED15	physical	16189514
DOT1L_HUMAN	DOT1L	physical	19864429
A4_HUMAN	APP	physical	21832049
UB2G2_HUMAN	UBE2G2	physical	21988832
ITF2_HUMAN	TCF4	physical	25416956
HTF4_HUMAN	TCF12	physical	25416956
ZBT22_HUMAN	ZBTB22	physical	25416956
SPY2_HUMAN	SPRY2	physical	25416956
ENOX2_HUMAN	ENOX2	physical	25416956
UBQL1_HUMAN	UBQLN1	physical	25416956
NSD3_HUMAN	WHSC1L1	physical	25416956
CEP44_HUMAN	CEP44	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
AF10_HUMAN	MLLT10	physical	28514442
DOT1L_HUMAN	DOT1L	physical	28514442
GULP1_HUMAN	GULP1	physical	28514442
ZC3HA_HUMAN	ZC3H10	physical	28514442
CREB5_HUMAN	CREB5	physical	28514442
TRI18_HUMAN	MID1	physical	28514442
EEA1_HUMAN	EEA1	physical	28514442
AF9_HUMAN	MLLT3	physical	28514442
ATF7_HUMAN	ATF7	physical	28514442
JUN_HUMAN	JUN	physical	28514442
SYVC_HUMAN	VARS	physical	28514442
NFM_HUMAN	NEFM	physical	28514442
JUND_HUMAN	JUND	physical	28514442
SYCC_HUMAN	CARS	physical	28514442
CEBPG_HUMAN	CEBPG	physical	28514442
EF1B_HUMAN	EEF1B2	physical	28514442
ATF2_HUMAN	ATF2	physical	28514442
IQEC1_HUMAN	IQSEC1	physical	28514442
RGPD8_HUMAN	RGPD8	physical	28514442
EF1D_HUMAN	EEF1D	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
SGO1_HUMAN	SGOL1	physical	28514442
GCC2_HUMAN	GCC2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, AND MASSSPECTROMETRY.
PubMed: 18187866

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-451, AND MASSSPECTROMETRY.
PubMed: 19690332