dbPTM

GULP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GULP1_HUMAN
UniProt AC	Q9UBP9
Protein Name	PTB domain-containing engulfment adapter protein 1
Gene Name	GULP1
Organism	Homo sapiens (Human).
Sequence Length	304
Subcellular Localization	Cytoplasm . May associate with the cytoplasmic side of the plasma membrane and early endosomes.
Protein Description	May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6..
Protein Sequence	MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	FSRKKDKTWMHTPEA CCCCCCCCCCCCHHH	37.85	27251275
16	Phosphorylation	KDKTWMHTPEALSKH CCCCCCCCHHHHHHC	13.50	21712546
35	Phosphorylation	NAKFLGSTEVEQPKG CCEECCCCCCCCCCC	42.10	18491316
41	Ubiquitination	STEVEQPKGTEVVRD CCCCCCCCCCHHHHH	77.49	29967540
43	Phosphorylation	EVEQPKGTEVVRDAV CCCCCCCCHHHHHHH	31.56	-
55	Ubiquitination	DAVRKLKFARHIKKS HHHHHHHHHHHHHHC	11.93	29967540
61	Acetylation	KFARHIKKSEGQKIP HHHHHHHHCCCCCCC	53.81	7306327
61	Ubiquitination	KFARHIKKSEGQKIP HHHHHHHHCCCCCCC	53.81	29967540
68	Ubiquitination	KSEGQKIPKVELQIS HCCCCCCCCEEEEEE	41.49	29967540
77	Phosphorylation	VELQISIYGVKILEP EEEEEEEEEEEECCC	14.74	19702290
83	Ubiquitination	IYGVKILEPKTKEVQ EEEEEECCCCCCHHH	48.50	29967540
86	Phosphorylation	VKILEPKTKEVQHNC EEECCCCCCHHHHCC	43.06	24719451
155	Phosphorylation	AYRKFLESGGKDVET HHHHHHHCCCCCHHH	55.80	-
155	O-linked_Glycosylation	AYRKFLESGGKDVET HHHHHHHCCCCCHHH	55.80	30379171
158	Ubiquitination	KFLESGGKDVETRKQ HHHHCCCCCHHHHHH	63.23	29967540
162	Phosphorylation	SGGKDVETRKQIAGL CCCCCHHHHHHHHHH	42.91	-
164	Ubiquitination	GKDVETRKQIAGLQK CCCHHHHHHHHHHHH	54.17	29967540
171	Ubiquitination	KQIAGLQKRIQDLET HHHHHHHHHHHHHHH	57.41	29967540
178	Phosphorylation	KRIQDLETENMELKN HHHHHHHHHCHHHHH	39.70	23403867
186	Ubiquitination	ENMELKNKVQDLENQ HCHHHHHHHHHHHHH	39.42	29967540
197	Phosphorylation	LENQLRITQVSAPPA HHHHHHHEEECCCCC	19.24	23186163
200	Phosphorylation	QLRITQVSAPPAGSM HHHHEEECCCCCCCC	25.82	29514088
206	Phosphorylation	VSAPPAGSMTPKSPS ECCCCCCCCCCCCCC	22.91	25850435
208	Phosphorylation	APPAGSMTPKSPSTD CCCCCCCCCCCCCCC	29.30	25690035
211	Phosphorylation	AGSMTPKSPSTDIFD CCCCCCCCCCCCCCC	25.86	21712546
213	Phosphorylation	SMTPKSPSTDIFDMI CCCCCCCCCCCCCCC	45.89	21712546
214	Phosphorylation	MTPKSPSTDIFDMIP CCCCCCCCCCCCCCC	36.18	29632367
223	Phosphorylation	IFDMIPFSPISHQSS CCCCCCCCCCCCCCC	18.90	26055452
226	Phosphorylation	MIPFSPISHQSSMPT CCCCCCCCCCCCCCC	20.89	22199227
229	Phosphorylation	FSPISHQSSMPTRNG CCCCCCCCCCCCCCC	24.15	22199227
230	Phosphorylation	SPISHQSSMPTRNGT CCCCCCCCCCCCCCC	23.39	20068231
233	Phosphorylation	SHQSSMPTRNGTQPP CCCCCCCCCCCCCCC	28.29	20068231
237	Phosphorylation	SMPTRNGTQPPPVPS CCCCCCCCCCCCCCC	41.26	-
244	Phosphorylation	TQPPPVPSRSTEIKR CCCCCCCCCCCCCCH	38.81	28555341
247	Phosphorylation	PPVPSRSTEIKRDLF CCCCCCCCCCCHHHC	40.39	-
289	Phosphorylation	EGFKMGLTLEGTVFC HHHCCCCEEEEEEEE	19.62	22210691
302	Phosphorylation	FCLDPLDSRC----- EEECCCCCCC-----	43.14	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GULP1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GULP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GULP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SMC2_HUMAN	SMC2	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GULP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213 AND SER-223, ANDMASS SPECTROMETRY.	18220336 [Abstract]