| UniProt ID | CREB5_HUMAN | |
|---|---|---|
| UniProt AC | Q02930 | |
| Protein Name | Cyclic AMP-responsive element-binding protein 5 | |
| Gene Name | CREB5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 508 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Binds to the cAMP response element and activates transcription.. | |
| Protein Sequence | MIYEESKMNLEQERPFVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKTDNMLSDQTPTPTRFLKNCEEVGLFSELDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSARLPNHDTNVVIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLNPIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MIYEESKMNL -----CCCHHHCCCH | 16.61 | - | |
| 50 | Sumoylation | TLKFPSIKTDNMLSD EEECCCCCCCCCCCC | 54.91 | 28112733 | |
| 56 | Phosphorylation | IKTDNMLSDQTPTPT CCCCCCCCCCCCCCC | 19.53 | 29978859 | |
| 59 | Phosphorylation | DNMLSDQTPTPTRFL CCCCCCCCCCCCHHH | 33.83 | 25159151 | |
| 61 | Phosphorylation | MLSDQTPTPTRFLKN CCCCCCCCCCHHHHC | 40.45 | 25159151 | |
| 63 | Phosphorylation | SDQTPTPTRFLKNCE CCCCCCCCHHHHCHH | 36.21 | 22496350 | |
| 100 | Phosphorylation | ESSKRNISMHNAVGG HHHHHCCCCHHHHCC | 19.96 | 24043423 | |
| 110 | Phosphorylation | NAVGGAMTGPGTHQL HHHCCCCCCCCCCCC | 39.42 | 24043423 | |
| 114 | Phosphorylation | GAMTGPGTHQLSSAR CCCCCCCCCCCCCCC | 15.02 | 24043423 | |
| 118 | Phosphorylation | GPGTHQLSSARLPNH CCCCCCCCCCCCCCC | 18.51 | 24043423 | |
| 119 | Phosphorylation | PGTHQLSSARLPNHD CCCCCCCCCCCCCCC | 26.46 | 24043423 | |
| 137 | Phosphorylation | VIQQAMPSPQSSSVI EEEECCCCCCCCCCE | 23.61 | 21712546 | |
| 140 | Phosphorylation | QAMPSPQSSSVITQA ECCCCCCCCCCEEEC | 28.15 | 20068231 | |
| 141 | Phosphorylation | AMPSPQSSSVITQAP CCCCCCCCCCEEECC | 24.31 | 22496350 | |
| 142 | Phosphorylation | MPSPQSSSVITQAPS CCCCCCCCCEEECCC | 23.84 | 20068231 | |
| 145 | Phosphorylation | PQSSSVITQAPSTNR CCCCCCEEECCCCCC | 19.27 | 27732954 | |
| 149 | Phosphorylation | SVITQAPSTNRQIGP CCEEECCCCCCCCCC | 41.13 | 27732954 | |
| 150 | Phosphorylation | VITQAPSTNRQIGPV CEEECCCCCCCCCCC | 33.10 | 27732954 | |
| 172 | Methylation | LHLHNRQRQPMPASM HHHHHCCCCCCCCCC | 39.06 | - | |
| 178 | Phosphorylation | QRQPMPASMPGTLPN CCCCCCCCCCCCCCC | 21.46 | 23532336 | |
| 182 | Phosphorylation | MPASMPGTLPNPTMP CCCCCCCCCCCCCCC | 32.92 | 22210691 | |
| 187 | Phosphorylation | PGTLPNPTMPGSSAV CCCCCCCCCCCCCEE | 42.51 | 22210691 | |
| 191 | Phosphorylation | PNPTMPGSSAVLMPM CCCCCCCCCEEEEEC | 14.84 | 22210691 | |
| 192 | Phosphorylation | NPTMPGSSAVLMPME CCCCCCCCEEEEECC | 28.45 | 22210691 | |
| 206 | Phosphorylation | ERQMSVNSSIMGMQG CHHHCCCHHHCCCCC | 21.05 | 24719451 | |
| 248 | Phosphorylation | THHPAAMSNGNMNTM HCCHHHHHCCCHHHH | 36.54 | 20363803 | |
| 254 | Phosphorylation | MSNGNMNTMGHMMEM HHCCCHHHHHHHHHH | 17.48 | 20363803 | |
| 293 | Ubiquitination | PHHPYPHQHQHPAHH CCCCCCCCCCCCCCC | 33.17 | 21890473 | |
| 293 | Ubiquitination | PHHPYPHQHQHPAHH CCCCCCCCCCCCCCC | 33.17 | 21890473 | |
| 293 (in isoform 4) | Ubiquitination | - | 33.17 | 21890473 | |
| 353 | Phosphorylation | ATQQMQPTQTIQPPQ CCCCCCCCCCCCCCC | 22.81 | - | |
| 355 | Phosphorylation | QQMQPTQTIQPPQPT CCCCCCCCCCCCCCC | 24.86 | - | |
| 362 | Phosphorylation | TIQPPQPTGGRRRRV CCCCCCCCCCCCCCC | 47.20 | - | |
| 399 | Ubiquitination | CRQKRKVWVMSLEKK HHHHHHEEEEEHHHH | 5.32 | 21890473 | |
| 399 (in isoform 3) | Ubiquitination | - | 5.32 | 21890473 | |
| 422 | Phosphorylation | MQLQNEVSMLKNEVA HHHHHHHHHHHHHHH | 16.54 | 23532336 | |
| 425 | Ubiquitination | QNEVSMLKNEVAQLK HHHHHHHHHHHHHHH | 42.28 | 21890473 | |
| 425 (in isoform 2) | Ubiquitination | - | 42.28 | 21890473 | |
| 425 | Ubiquitination | QNEVSMLKNEVAQLK HHHHHHHHHHHHHHH | 42.28 | 21890473 | |
| 432 | Ubiquitination | KNEVAQLKQLLLTHK HHHHHHHHHHHHHCC | 27.16 | 21890473 | |
| 432 | Ubiquitination | KNEVAQLKQLLLTHK HHHHHHHHHHHHHCC | 27.16 | 23000965 | |
| 432 (in isoform 1) | Ubiquitination | - | 27.16 | 21890473 | |
| 432 (in isoform 2) | Ubiquitination | - | 27.16 | 21890473 | |
| 461 | Ubiquitination | LSPESSPPASPVPAC CCCCCCCCCCCCCCC | 47.52 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CREB5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CREB5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CREB5_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
