dbPTM

KRA32_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KRA32_HUMAN
UniProt AC	Q9BYR7
Protein Name	Keratin-associated protein 3-2
Gene Name	KRTAP3-2
Organism	Homo sapiens (Human).
Sequence Length	98
Subcellular Localization
Protein Description	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins..
Protein Sequence	MDCCASRSCSVPTGPATTICSSDKSCRCGVCLPSTCPHTVWLLEPICCDNCPPPCHIPQPCVPTCFLLNSCQPTPGLETLNLTTFTQPCCEPCLPRGC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
21	Phosphorylation	GPATTICSSDKSCRC CCCEEEECCCCCCCC	37.41	-
22	Phosphorylation	PATTICSSDKSCRCG CCEEEECCCCCCCCC	44.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KRA32_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KRA32_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KRA32_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRA32_HUMAN	KRTAP3-2	physical	25416956
KRA92_HUMAN	KRTAP9-2	physical	25416956
DHRS1_HUMAN	DHRS1	physical	25416956
TBC16_HUMAN	TBC1D16	physical	25416956
LCE4A_HUMAN	LCE4A	physical	25416956
CE060_HUMAN	C5orf60	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
LCE1B_HUMAN	LCE1B	physical	25416956
LCE2A_HUMAN	LCE2A	physical	25416956
LCE3C_HUMAN	LCE3C	physical	25416956
LCE3E_HUMAN	LCE3E	physical	25416956
KR122_HUMAN	KRTAP12-2	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR261_HUMAN	KRTAP26-1	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KRA32_HUMAN

Related Literatures of Post-Translational Modification