DHRS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHRS1_HUMAN
• UniProt AC: Q96LJ7
• Protein Name: Dehydrogenase/reductase SDR family member 1
• Gene Name: DHRS1
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Protein Sequence: MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLRVPKWIIALYTSKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAPMNGQV ------CCCCCCCCE	21.92	22814378
13	Phosphorylation	NGQVCVVTGASRGIG CCCEEEEECCCCCCC	13.46	24043423
16	Phosphorylation	VCVVTGASRGIGRGI EEEEECCCCCCCHHH	32.17	24043423
21	Methylation	GASRGIGRGIALQLC CCCCCCCHHHHHHHH	31.27	-
29	Ubiquitination	GIALQLCKAGATVYI HHHHHHHHCCCEEEE	59.45	21906983
73	Phosphorylation	SQESEVRSLFEQVDR CCHHHHHHHHHHHCH	42.45	20873877
106	Ubiquitination	TILNTRNKAFWETPA HHHHCCCCCCCCCCH	41.49	21906983
133	Phosphorylation	GHYFCSVYGARLMVP CEEEHHHCCCEEEEE	6.70	21253578
172	Ubiquitination	VGKAACDKLAADCAH CCHHHHHHHHHHHHH	39.65	29967540
187	Phosphorylation	ELRRHGVSCVSLWPG HHHHCCCCHHHCCCC	17.25	20068231
190	Phosphorylation	RHGVSCVSLWPGIVQ HCCCCHHHCCCCHHH	29.10	20068231
198	Phosphorylation	LWPGIVQTELLKEHM CCCCHHHHHHHHHHH	20.08	20068231
202	Ubiquitination	IVQTELLKEHMAKEE HHHHHHHHHHHCHHH	59.19	29967540
207	Ubiquitination	LLKEHMAKEEVLQDP HHHHHHCHHHHHCCH	47.00	29967540
217	Ubiquitination	VLQDPVLKQFKSAFS HHCCHHHHHHHHHHC	54.65	23000965
220	Ubiquitination	DPVLKQFKSAFSSAE CHHHHHHHHHHCCCC	38.08	23000965
221	Phosphorylation	PVLKQFKSAFSSAET HHHHHHHHHHCCCCC	35.52	23312004
224	Phosphorylation	KQFKSAFSSAETTEL HHHHHHHCCCCCCCC	28.49	23312004
225	Phosphorylation	QFKSAFSSAETTELS HHHHHHCCCCCCCCC	24.54	23312004
228	Phosphorylation	SAFSSAETTELSGKC HHHCCCCCCCCCCCE	25.86	23312004
229	Phosphorylation	AFSSAETTELSGKCV HHCCCCCCCCCCCEE	26.83	23312004
247	Phosphorylation	ATDPNILSLSGKVLP ECCCCEECCCCCCCC	19.38	-
249	Phosphorylation	DPNILSLSGKVLPSC CCCEECCCCCCCCCC	32.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHRS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHRS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHRS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.