KR412_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KR412_HUMAN
• UniProt AC: Q9BQ66
• Protein Name: Keratin-associated protein 4-12
• Gene Name: KRTAP4-12
• Organism: Homo sapiens (Human).
• Sequence Length: 201
• Protein Description: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins..
• Protein Sequence: MVNSCCGSVCSDQGCGLENCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCISSSCCPSCCESSCCRPCCCLRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	CQTTCCRTTCCRPSC HCCCCCCCCCCCCCE	15.40	-
34	Phosphorylation	QTTCCRTTCCRPSCC CCCCCCCCCCCCCEE	7.11	-
73	Phosphorylation	CQTTCCRTTCCRPSC CCCEECCCCCCCCCE	15.40	-
74	Phosphorylation	QTTCCRTTCCRPSCC CCEECCCCCCCCCEE	7.11	-
113	Phosphorylation	CQTTCCRTTCCRPSC CCCEECCCCCCCCCE	15.40	-
114	Phosphorylation	QTTCCRTTCCRPSCC CCEECCCCCCCCCEE	7.11	-
184	Phosphorylation	HTTCYRPTCVISTCP CCCCCCCCEEEECCC	15.48	20068231
188	Phosphorylation	YRPTCVISTCPRPLC CCCCEEEECCCCCEE	11.98	20068231
189	Phosphorylation	RPTCVISTCPRPLCC CCCEEEECCCCCEEE	18.53	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KR412_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KR412_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KR412_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CJ062_HUMAN	C10orf62	physical	16189514
ZN764_HUMAN	ZNF764	physical	16189514
CBX2_HUMAN	CBX2	physical	16189514
KR412_HUMAN	KRTAP4-12	physical	16189514
CC116_HUMAN	CCDC116	physical	16189514
CC185_HUMAN	CCDC185	physical	16189514
ZN439_HUMAN	ZNF439	physical	16189514
ZN417_HUMAN	ZNF417	physical	16189514
LNX1_HUMAN	LNX1	physical	16189514
BEX2_HUMAN	BEX2	physical	16189514
FA76B_HUMAN	FAM76B	physical	16189514
KRA32_HUMAN	KRTAP3-2	physical	16189514
ZN440_HUMAN	ZNF440	physical	16189514
CTSR1_HUMAN	CATSPER1	physical	16189514
LIGO1_HUMAN	LINGO1	physical	16189514
KR412_HUMAN	KRTAP4-12	physical	25416956
KRA92_HUMAN	KRTAP9-2	physical	25416956
CTSR1_HUMAN	CATSPER1	physical	25416956
TBC16_HUMAN	TBC1D16	physical	25416956
SPTA3_HUMAN	SPATA3	physical	25416956
LCE4A_HUMAN	LCE4A	physical	25416956
LCE1B_HUMAN	LCE1B	physical	25416956
LCE2D_HUMAN	LCE2D	physical	25416956
LCE3E_HUMAN	LCE3E	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
KR261_HUMAN	KRTAP26-1	physical	25416956
KRA56_HUMAN	KRTAP5-6	physical	25416956
IGSF8_HUMAN	IGSF8	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.