ZN440_HUMAN - dbPTM
ZN440_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN440_HUMAN
UniProt AC Q8IYI8
Protein Name Zinc finger protein 440
Gene Name ZNF440
Organism Homo sapiens (Human).
Sequence Length 595
Subcellular Localization Nucleus .
Protein Description May be involved in transcriptional regulation..
Protein Sequence MDPVAFKDVAVNFTQEEWALLDISQRKLYREVMLETFRNLTSLGKRWKDQNIEYEHQNPRRNFRSLIEEKVNEIKDDSHCGETFTPVPDDRLNFQEKKASPEVKSCESFVCGEVGLGNSSFNMNIRGDIGHKAYEYQEYGPKPCKCQQPKKAFRYRPSFRTQERDHTGEKPNACKVCGKTFISHSSVRRHMVMHSGDGPYKCKFCGKAFHCLRLYLIHERIHTGEKPCECKQCGKSFSYSATHRIHKRTHTGEKPYEYQECGKAFHSPRSYRRHERIHMGEKAYQCKECGKAFTCPRYVRIHERTHSRKNLYECKQCGKALSSLTSFQTHVRLHSGERPYECKICGKDFCSVNSFQRHEKIHSGEKPYKCKQCGKAFPHSSSLRYHERTHTGEKPYECKQCGKAFRSASHLRVHGRTHTGEKPYECKECGKAFRYVNNLQSHERTQTHIRIHSGERRYKCKICGKGFYCPKSFQRHEKTHTGEKLYECKQRSVVPSVVPVPFDIMKGLTLERSPINASNVGKPSELCQSFECMVGLTLKRNPMSVSNDGKPSDLPHTFEYVVGHTMERSPMHVRNVGNPSDLPRTFEFMKGHKHT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationDISQRKLYREVMLET
HHHHHHHHHHHHHHH		14.0429496907
36PhosphorylationYREVMLETFRNLTSL
HHHHHHHHHHHHHHH		24.7529496907
48UbiquitinationTSLGKRWKDQNIEYE
HHHHHHHHHCCCCCC		54.17-
54PhosphorylationWKDQNIEYEHQNPRR
HHHCCCCCCCCCCCC		18.21-
65PhosphorylationNPRRNFRSLIEEKVN
CCCCCHHHHHHHHHH		29.5721815630
70UbiquitinationFRSLIEEKVNEIKDD
HHHHHHHHHHHCCCC		37.25-
97UbiquitinationDRLNFQEKKASPEVK
CCCCCCHHCCCCCCC		42.74-
139PhosphorylationKAYEYQEYGPKPCKC
CCEECHHHCCCCCCC		24.17-
195PhosphorylationRRHMVMHSGDGPYKC
HHHEEEECCCCCCCC		22.0828555341
240PhosphorylationCGKSFSYSATHRIHK
CCCCEEEECEEEEEC		26.03-
242PhosphorylationKSFSYSATHRIHKRT
CCEEEECEEEEECCC		13.02-
249PhosphorylationTHRIHKRTHTGEKPY
EEEEECCCCCCCCCC		28.70-
251PhosphorylationRIHKRTHTGEKPYEY
EEECCCCCCCCCCCH		46.56-
254UbiquitinationKRTHTGEKPYEYQEC
CCCCCCCCCCCHHHH		55.0029967540
267PhosphorylationECGKAFHSPRSYRRH
HHHHHCCCCHHHHCC		18.63-
270PhosphorylationKAFHSPRSYRRHERI
HHCCCCHHHHCCCCC		26.78-
271PhosphorylationAFHSPRSYRRHERIH
HCCCCHHHHCCCCCC		16.97-
272UbiquitinationFHSPRSYRRHERIHM
CCCCHHHHCCCCCCC		34.4222505724
300UbiquitinationFTCPRYVRIHERTHS
CCCCCCEEHHCCCCC		18.6622505724
312PhosphorylationTHSRKNLYECKQCGK
CCCCCCHHHHHHHHH		28.7728842319
335PhosphorylationQTHVRLHSGERPYEC
CCCCEECCCCCCEEE		47.1125159151
363PhosphorylationQRHEKIHSGEKPYKC
CCCCCCCCCCCCCCC		52.7129496963
385PhosphorylationPHSSSLRYHERTHTG
CCCCCCCEECCCCCC		17.2129083192
389PhosphorylationSLRYHERTHTGEKPY
CCCEECCCCCCCCCC		22.3229396449
391PhosphorylationRYHERTHTGEKPYEC
CEECCCCCCCCCCCC		46.5629496963
394UbiquitinationERTHTGEKPYECKQC
CCCCCCCCCCCCCHH		55.00-
396PhosphorylationTHTGEKPYECKQCGK
CCCCCCCCCCCHHHH		45.0529083192
399SumoylationGEKPYECKQCGKAFR
CCCCCCCCHHHHHHH		36.36-
399SumoylationGEKPYECKQCGKAFR
CCCCCCCCHHHHHHH		36.36-
417PhosphorylationHLRVHGRTHTGEKPY
CEEEECCCCCCCCCE		28.5129396449
419PhosphorylationRVHGRTHTGEKPYEC
EEECCCCCCCCCEEC		46.5629496963
422UbiquitinationGRTHTGEKPYECKEC
CCCCCCCCCEECCHH		55.00-
427SumoylationGEKPYECKECGKAFR
CCCCEECCHHHHHHH		44.06-
427UbiquitinationGEKPYECKECGKAFR
CCCCEECCHHHHHHH		44.06-
427SumoylationGEKPYECKECGKAFR
CCCCEECCHHHHHHH		44.06-
461AcetylationGERRYKCKICGKGFY
CCCEEEEEECCCEEE		36.567978681
484UbiquitinationEKTHTGEKLYECKQR
CCCCCCCCHHHHHHC		58.68-
506UbiquitinationPVPFDIMKGLTLERS
CCCCCCCCCCCEECC		51.61-
513PhosphorylationKGLTLERSPINASNV
CCCCEECCCCCHHHC		22.2825159151
544PhosphorylationTLKRNPMSVSNDGKP
EECCCCCCCCCCCCC		24.5328348404
546PhosphorylationKRNPMSVSNDGKPSD
CCCCCCCCCCCCCCC		23.1528348404
552PhosphorylationVSNDGKPSDLPHTFE
CCCCCCCCCCCCCEE		56.0928348404
557PhosphorylationKPSDLPHTFEYVVGH
CCCCCCCCEEHHCCC		19.0728348404
560PhosphorylationDLPHTFEYVVGHTME
CCCCCEEHHCCCCCC		9.0328348404
565PhosphorylationFEYVVGHTMERSPMH
EEHHCCCCCCCCCCE		18.1328348404
569PhosphorylationVGHTMERSPMHVRNV
CCCCCCCCCCEEECC		17.1728348404
580PhosphorylationVRNVGNPSDLPRTFE
EECCCCHHHCCCHHH		56.6428348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN440_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN440_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN440_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KR109_HUMANKRTAP10-9physical
25416956
KR101_HUMANKRTAP10-1physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
CCDB1_HUMANCCNDBP1physical
21516116
MDFI_HUMANMDFIphysical
21516116
TRAF1_HUMANTRAF1physical
21516116
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN440_HUMAN

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Related Literatures of Post-Translational Modification

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