dbPTM

TRAF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRAF1_HUMAN
UniProt AC	Q13077
Protein Name	TNF receptor-associated factor 1
Gene Name	TRAF1
Organism	Homo sapiens (Human).
Sequence Length	416
Subcellular Localization
Protein Description	Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2..
Protein Sequence	MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALCCAGCLSENPRNGEDQICPKCRGEDLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASSSGSSPR -----CCCCCCCCCC	24.60	30108239
4	Phosphorylation	----MASSSGSSPRP ----CCCCCCCCCCC	29.22	30108239
5	Phosphorylation	---MASSSGSSPRPA ---CCCCCCCCCCCC	39.95	28450419
7	Phosphorylation	-MASSSGSSPRPAPD -CCCCCCCCCCCCCC	38.83	30108239
8	Phosphorylation	MASSSGSSPRPAPDE CCCCCCCCCCCCCCC	28.58	29507054
43	Phosphorylation	LCCAGCLSENPRNGE EEECCCCCCCCCCCC	39.13	30108239
61	Ubiquitination	CPKCRGEDLQSISPG CCCCCCCCCCCCCCC	53.48	22817900
63	Ubiquitination	KCRGEDLQSISPGSR CCCCCCCCCCCCCCC	51.55	22817900
64	Phosphorylation	CRGEDLQSISPGSRL CCCCCCCCCCCCCCC	32.12	28450419
66	Phosphorylation	GEDLQSISPGSRLRT CCCCCCCCCCCCCCC	28.58	30266825
69	Phosphorylation	LQSISPGSRLRTQEK CCCCCCCCCCCCCHH	31.37	30266825
71	Ubiquitination	SISPGSRLRTQEKAH CCCCCCCCCCCHHHC	8.12	22817900
96	Phosphorylation	PFAGVGCSFKGSPQS CCCCCCCCCCCCCCC	24.86	30108239
100	Phosphorylation	VGCSFKGSPQSVQEH CCCCCCCCCCCHHEE	21.98	30108239
103	Phosphorylation	SFKGSPQSVQEHEVT CCCCCCCCHHEEECC	29.20	30108239
110	Phosphorylation	SVQEHEVTSQTSHLN CHHEEECCCHHHHHH	16.48	30108239
111	Phosphorylation	VQEHEVTSQTSHLNL HHEEECCCHHHHHHH	36.31	30108239
113	Phosphorylation	EHEVTSQTSHLNLLL EEECCCHHHHHHHHH	20.20	30108239
114	Phosphorylation	HEVTSQTSHLNLLLG EECCCHHHHHHHHHH	20.52	30108239
124	Ubiquitination	NLLLGFMKQWKARLG HHHHHHHHHHHHHHC	51.23	22817900
127	Ubiquitination	LGFMKQWKARLGCGL HHHHHHHHHHHCCCC	22.57	22817900
146	Phosphorylation	MALEQNLSDLQLQAA CCHHHCHHHHHHHHH	43.77	-
170	Phosphorylation	DCYRAPCSESQEELA EEEECCCCCCHHHHH	38.94	30108239
172	Phosphorylation	YRAPCSESQEELALQ EECCCCCCHHHHHHH	26.97	30108239
183	Ubiquitination	LALQHFMKEKLLAEL HHHHHHHHHHHHHHH	51.24	22817900
185	Ubiquitination	LQHFMKEKLLAELEG HHHHHHHHHHHHHHH	43.19	22817900
193	Ubiquitination	LLAELEGKLRVFENI HHHHHHHHHHHHHHH	24.60	22817900
275	Ubiquitination	TFLWKITNVTRRCHE EEEEEEECHHHHHHH	36.31	25015289
310	Phosphorylation	YKLCLRLYLNGDGTG CEEEEEEEECCCCCC	7.53	-
316	Phosphorylation	LYLNGDGTGKRTHLS EEECCCCCCCCCEEE	44.24	-
320	Phosphorylation	GDGTGKRTHLSLFIV CCCCCCCCEEEEEEE	30.56	22210691
323	Phosphorylation	TGKRTHLSLFIVIMR CCCCCEEEEEEEEEC	17.40	22210691
395	Phosphorylation	FPLSKLQSPKHAYVK EEHHHCCCCCCEEEC	46.48	26091039
397	Ubiquitination	LSKLQSPKHAYVKDD HHHCCCCCCEEECCC	46.22	25015289

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF31	Q96EP0	PMID:25996949
-	K	Ubiquitination	E3 ubiquitin ligase	BIRC2	Q13490	PMID:15468071
-	K	Ubiquitination	E3 ubiquitin ligase	BIRC3	Q13489	PMID:15468071

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRAF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRAF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF2_HUMAN	TRAF2	physical	14743216
SRC_HUMAN	SRC	physical	10635328
CFLAR_HUMAN	CFLAR	physical	9208847
M3K5_HUMAN	MAP3K5	physical	9774977
RIPK2_HUMAN	RIPK2	physical	9705938
TANK_HUMAN	TANK	physical	8710854
CFLAR_HUMAN	CFLAR	physical	10837247
TNR17_HUMAN	TNFRSF17	physical	10903733
TNAP3_HUMAN	TNFAIP3	physical	9928991
RIPK1_HUMAN	RIPK1	physical	8612133
TRADD_HUMAN	TRADD	physical	8565075
BIRC2_HUMAN	BIRC2	physical	8943045
BIRC2_HUMAN	BIRC2	physical	21903422
DBLOH_HUMAN	DIABLO	physical	21903422
HOIL1_HUMAN	RBCK1	physical	21903422
RNF31_HUMAN	RNF31	physical	21903422
TRAF2_HUMAN	TRAF2	physical	21903422
SRC_HUMAN	SRC	physical	15707590
SH3K1_HUMAN	SH3KBP1	physical	15707590
TRAF2_HUMAN	TRAF2	physical	10544141
TNR1B_HUMAN	TNFRSF1B	physical	7859281
TRAF2_HUMAN	TRAF2	physical	15383523
TCAM1_HUMAN	TICAM1	physical	16323247
TRAF2_HUMAN	TRAF2	physical	9500555
M3K14_HUMAN	MAP3K14	physical	9275204
TRAF2_HUMAN	TRAF2	physical	14557256
TR19L_HUMAN	RELT	physical	11313261
TR13C_HUMAN	TNFRSF13C	physical	19698991
TRAF3_HUMAN	TRAF3	physical	9718306
TRAF2_HUMAN	TRAF2	physical	9718306
TRAF1_HUMAN	TRAF1	physical	9718306
TRADD_HUMAN	TRADD	physical	19287455
TNR1A_HUMAN	TNFRSF1A	physical	19287455
TRAF2_HUMAN	TRAF2	physical	19287455
RIPK1_HUMAN	RIPK1	physical	19287455
IKKA_HUMAN	CHUK	physical	19287455
TNR9_HUMAN	TNFRSF9	physical	15941918
TNR4_HUMAN	TNFRSF4	physical	15941918
TRAF1_HUMAN	TRAF1	physical	8069916
TRAF2_HUMAN	TRAF2	physical	8069916
NF2IP_HUMAN	NFATC2IP	physical	11435475
ZMY11_HUMAN	ZMYND11	physical	20138174
UBE2O_HUMAN	UBE2O	physical	23381138
TNR1B_HUMAN	TNFRSF1B	physical	18429822
M3K14_HUMAN	MAP3K14	physical	23543740
TRAF6_HUMAN	TRAF6	physical	21988832
TRAF1_HUMAN	TRAF1	physical	25416956
TRAF6_HUMAN	TRAF6	physical	25416956
ZNF20_HUMAN	ZNF20	physical	25416956
ZN124_HUMAN	ZNF124	physical	25416956
TCL1A_HUMAN	TCL1A	physical	25416956
AK17A_HUMAN	AKAP17A	physical	25416956
RIPK1_HUMAN	RIPK1	physical	25416956
CFLAR_HUMAN	CFLAR	physical	25416956
LATS1_HUMAN	LATS1	physical	25416956
NGAP_HUMAN	RASAL2	physical	25416956
NUP58_HUMAN	NUPL1	physical	25416956
JOS1_HUMAN	JOSD1	physical	25416956
TSSC4_HUMAN	TSSC4	physical	25416956
NEBL_HUMAN	NEBL	physical	25416956
GLRX3_HUMAN	GLRX3	physical	25416956
MARE2_HUMAN	MAPRE2	physical	25416956
PRDM7_HUMAN	PRDM7	physical	25416956
SNW1_HUMAN	SNW1	physical	25416956
ASPP1_HUMAN	PPP1R13B	physical	25416956
SIK3_HUMAN	SIK3	physical	25416956
HEY2_HUMAN	HEY2	physical	25416956
ZFY26_HUMAN	ZFYVE26	physical	25416956
CHSP1_HUMAN	CARHSP1	physical	25416956
GORS2_HUMAN	GORASP2	physical	25416956
A1CF_HUMAN	A1CF	physical	25416956
MYEF2_HUMAN	MYEF2	physical	25416956
PF21A_HUMAN	PHF21A	physical	25416956
WAC_HUMAN	WAC	physical	25416956
SPG21_HUMAN	SPG21	physical	25416956
POP5_HUMAN	POP5	physical	25416956
ZN581_HUMAN	ZNF581	physical	25416956
NB5R2_HUMAN	CYB5R2	physical	25416956
CCHCR_HUMAN	CCHCR1	physical	25416956
QRIC1_HUMAN	QRICH1	physical	25416956
MIC19_HUMAN	CHCHD3	physical	25416956
CA109_HUMAN	C1orf109	physical	25416956
CN105_HUMAN	C14orf105	physical	25416956
FA86C_HUMAN	FAM86C1	physical	25416956
RBM41_HUMAN	RBM41	physical	25416956
RYDEN_HUMAN	C19orf66	physical	25416956
TRPV6_HUMAN	TRPV6	physical	25416956
SKT_HUMAN	KIAA1217	physical	25416956
P66B_HUMAN	GATAD2B	physical	25416956
Z512B_HUMAN	ZNF512B	physical	25416956
NUFP2_HUMAN	NUFIP2	physical	25416956
CC146_HUMAN	CCDC146	physical	25416956
DMRT3_HUMAN	DMRT3	physical	25416956
MET17_HUMAN	METTL17	physical	25416956
DPTOR_HUMAN	DEPTOR	physical	25416956
SCNM1_HUMAN	SCNM1	physical	25416956
ZFY21_HUMAN	ZFYVE21	physical	25416956
ARSJ_HUMAN	ARSJ	physical	25416956
ZC21C_HUMAN	ZC2HC1C	physical	25416956
DOK3_HUMAN	DOK3	physical	25416956
FXL18_HUMAN	FBXL18	physical	25416956
THAP7_HUMAN	THAP7	physical	25416956
CDCA3_HUMAN	CDCA3	physical	25416956
RASF5_HUMAN	RASSF5	physical	25416956
PKHN1_HUMAN	PLEKHN1	physical	25416956
F161A_HUMAN	FAM161A	physical	25416956
BEX2_HUMAN	BEX2	physical	25416956
ZN587_HUMAN	ZNF587	physical	25416956
FBF1_HUMAN	FBF1	physical	25416956
CC120_HUMAN	CCDC120	physical	25416956
CE030_HUMAN	C5orf30	physical	25416956
ZN502_HUMAN	ZNF502	physical	25416956
SYCE1_HUMAN	SYCE1	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
TBC16_HUMAN	TBC1D16	physical	25416956
ZN440_HUMAN	ZNF440	physical	25416956
CA216_HUMAN	C1orf216	physical	25416956
RBM45_HUMAN	RBM45	physical	25416956
ZN572_HUMAN	ZNF572	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
C2CD6_HUMAN	ALS2CR11	physical	25416956
S2548_HUMAN	SLC25A48	physical	25416956
ZN564_HUMAN	ZNF564	physical	25416956
CC116_HUMAN	CCDC116	physical	25416956
OLIG3_HUMAN	OLIG3	physical	25416956
MORN3_HUMAN	MORN3	physical	25416956
SRCRL_HUMAN	SSC5D	physical	25416956
RTP5_HUMAN	RTP5	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
KLH38_HUMAN	KLHL38	physical	25416956
ZN662_HUMAN	ZNF662	physical	25416956
TRAF6_HUMAN	TRAF6	physical	21516116
AB17A_HUMAN	ABHD17A	physical	21516116
FBF1_HUMAN	FBF1	physical	21516116
ZN697_HUMAN	ZNF697	physical	21516116
RNF31_HUMAN	RNF31	physical	25996949
TNAP3_HUMAN	TNFAIP3	physical	25996949
UBC_HUMAN	UBC	physical	25996949
TRAF3_HUMAN	TRAF3	physical	25996949
TRAF2_HUMAN	TRAF2	physical	25996949
TBK1_HUMAN	TBK1	physical	25996949
FBX28_HUMAN	FBXO28	physical	25996949
HTRA2_HUMAN	HTRA2	physical	25996949
TANK_HUMAN	TANK	physical	25996949
BIRC2_HUMAN	BIRC2	physical	25996949
GOGA3_HUMAN	GOLGA3	physical	25996949
ECI2_HUMAN	ECI2	physical	25996949
ECH1_HUMAN	ECH1	physical	25996949
BIRC3_HUMAN	BIRC3	physical	25996949
TBB4B_HUMAN	TUBB4B	physical	25996949
PBX1_HUMAN	PBX1	physical	25996949
SKP1_HUMAN	SKP1	physical	25996949
PBX2_HUMAN	PBX2	physical	25996949
APC_HUMAN	APC	physical	25996949
DCAF7_HUMAN	DCAF7	physical	25996949
DBLOH_HUMAN	DIABLO	physical	25996949
OTUD4_HUMAN	OTUD4	physical	25996949
E2AK3_HUMAN	EIF2AK3	physical	25996949
SQSTM_HUMAN	SQSTM1	physical	25996949
HOIL1_HUMAN	RBCK1	physical	25996949
SHRPN_HUMAN	SHARPIN	physical	25996949
TNIP1_HUMAN	TNIP1	physical	25996949
NEMO_HUMAN	IKBKG	physical	25996949
VAV3_HUMAN	VAV3	physical	27507811
NEMO_HUMAN	IKBKG	physical	27893701
TANK_HUMAN	TANK	physical	28514442
TRAF6_HUMAN	TRAF6	physical	28514442
FBX28_HUMAN	FBXO28	physical	28514442
OTUD4_HUMAN	OTUD4	physical	28514442
SNX29_HUMAN	SNX29	physical	28514442
TBK1_HUMAN	TBK1	physical	28514442
OSBL6_HUMAN	OSBPL6	physical	28514442
PKNX1_HUMAN	PKNOX1	physical	28514442
RBCC1_HUMAN	RB1CC1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
HYEP_HUMAN	EPHX1	physical	28514442
PEX13_HUMAN	PEX13	physical	28514442
ECI2_HUMAN	ECI2	physical	28514442
CUL1_HUMAN	CUL1	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442
OSBL3_HUMAN	OSBPL3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRAF1_HUMAN

Related Literatures of Post-Translational Modification

Ubiquitylation
Reference	PubMed
"Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor ofapoptosis 2."; Lee J.S., Hong U.S., Lee T.H., Yoon S.K., Yoon J.B.; Proteomics 4:3376-3382(2004). Cited for: UBIQUITINATION AT LYS-185 AND LYS-193, MASS SPECTROMETRY, ANDMUTAGENESIS OF LYS-185 AND LYS-193.	15468071 [Abstract]