ZMYM6_HUMAN - dbPTM
ZMYM6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZMYM6_HUMAN
UniProt AC O95789
Protein Name Zinc finger MYM-type protein 6
Gene Name ZMYM6
Organism Homo sapiens (Human).
Sequence Length 1325
Subcellular Localization Nucleus .
Protein Description Plays a role in the regulation of cell morphology and cytoskeletal organization..
Protein Sequence MKEPLDGECGKAVVPQQELLDKIKEEPDNAQEYGCVQQPKTQESKLKIGGVSSVNERPIAQQLNPGFQLSFASSGPSVLLPSVPAVAIKVFCSGCKKMLYKGQTAYHKTGSTQLFCSTRCITRHSSPACLPPPPKKTCTNCSKDILNPKDVITTRFENSYPSKDFCSQSCLSSYELKKKPVVTIYTKSISTKCSMCQKNADTRFEVKYQNVVHGLCSDACFSKFHSTNNLTMNCCENCGSYCYSSSGPCQSQKVFSSTSVTAYKQNSAQIPPYALGKSLRPSAEMIETTNDSGKTELFCSINCLSAYRVKTVTSSGVQVSCHSCKTSAIPQYHLAMSNGTIYSFCSSSCVVAFQNVFSKPKGTNSSAVPLSQGQVVVSPPSSRSAVSIGGGNTSAVSPSSIRGSAAASLQPLAEQSQQVALTHTVVKLKCQHCNHLFATKPELLFYKGKMFLFCGKNCSDEYKKKNKVVAMCDYCKLQKIIKETVRFSGVDKPFCSEVCKFLSARDFGERWGNYCKMCSYCSQTSPNLVENRLEGKLEEFCCEDCMSKFTVLFYQMAKCDGCKRQGKLSESIKWRGNIKHFCNLFCVLEFCHQQIMNDCLPQNKVNISKAKTAVTELPSARTDTTPVITSVMSLAKIPATLSTGNTNSVLKGAVTKEAAKIIQDESTQEDAMKFPSSQSSQPSRLLKNKGISCKPVTQTKATSCKPHTQHKECQTDLPMPNEKNDAELDSPPSKKKRLGFFQTYDTEYLKVGFIICPGSKESSPRPQCVICGEILSSENMKPANLSHHLKTKHSELENKPVDFFEQKSLEMECQNSSLKKCLLVEKSLVKASYLIAFQTAASKKPFSIAEELIKPYLVEMCSEVLGSSAGDKMKTIPLSNVTIQHRIDELSADIEDQLIQKVRESKWFALQIDESSEISNITLLLCYIRFIDYDCRDVKEELLFCIEMPTQITGFEIFELINKYIDSKSLNWKHCVGLCTDGAASMTGRYSGLKAKIQEVAMNTAAFTHCFIHRERLVAEKLSPCLHKILLQSAQILSFIKSNALNSRMLTILCEEMGSEHVSLPLHAEVRWISRGRMLKRLFELRHEIEIFLSQKHSDLAKYFHDEEWVGKLAYLSDIFSLINELNLSLQGTLTTFFNLCNKIDVFKRKLKMWLKRTQENDYDMFPSFSEFSNSSGLNMTDITRIIFEHLEGLSQVFSDCFPPEQDLRSGNLWIIHPFMNHQNNNLTDFEEEKLTELSSDLGLQALFKSVSVTQFWINAKTSYPELHERAMKFLLPFSTVYLCDAAFSALTESKQKNLLGSGPALRLAVTSLIPRIEKLVKEKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24SumoylationQELLDKIKEEPDNAQ
HHHHHHHHHCCCCHH		62.86-
33PhosphorylationEPDNAQEYGCVQQPK
CCCCHHHHCCCCCCC		12.0727642862
43 (in isoform 5)Phosphorylation-55.8825056879
104PhosphorylationKMLYKGQTAYHKTGS
HHHHCCCCEEECCCC		37.5429083192
106PhosphorylationLYKGQTAYHKTGSTQ
HHCCCCEEECCCCCE		13.7729083192
109PhosphorylationGQTAYHKTGSTQLFC
CCCEEECCCCCEEEE		24.0529083192
111PhosphorylationTAYHKTGSTQLFCST
CEEECCCCCEEEEEC		20.4329083192
112PhosphorylationAYHKTGSTQLFCSTR
EEECCCCCEEEEECC		30.5429083192
117PhosphorylationGSTQLFCSTRCITRH
CCCEEEEECCCCCCC		16.1429083192
118PhosphorylationSTQLFCSTRCITRHS
CCEEEEECCCCCCCC		30.6429083192
122PhosphorylationFCSTRCITRHSSPAC
EEECCCCCCCCCCCC		26.4229083192
125PhosphorylationTRCITRHSSPACLPP
CCCCCCCCCCCCCCC		34.4223312004
126PhosphorylationRCITRHSSPACLPPP
CCCCCCCCCCCCCCC		15.4723312004
149UbiquitinationSKDILNPKDVITTRF
CCCCCCHHHHEECCC		64.6529967540
167PhosphorylationYPSKDFCSQSCLSSY
CCCCCCCCHHHHCCH		25.73-
173PhosphorylationCSQSCLSSYELKKKP
CCHHHHCCHHCCCCC		15.07-
177UbiquitinationCLSSYELKKKPVVTI
HHCCHHCCCCCCEEE		46.9729967540
183PhosphorylationLKKKPVVTIYTKSIS
CCCCCCEEEEECCCC		14.4329449344
185PhosphorylationKKPVVTIYTKSISTK
CCCCEEEEECCCCCC		9.9629449344
186PhosphorylationKPVVTIYTKSISTKC
CCCEEEEECCCCCCC		17.9229449344
207UbiquitinationADTRFEVKYQNVVHG
CCCCEEEEEHHHHHH		33.6429967540
231PhosphorylationFHSTNNLTMNCCENC
CCCCCCCCCCCCCCC		14.4130576142
245PhosphorylationCGSYCYSSSGPCQSQ
CCCCCCCCCCCCCCC		16.9130576142
251PhosphorylationSSSGPCQSQKVFSST
CCCCCCCCCEEECCC		38.3930576142
256PhosphorylationCQSQKVFSSTSVTAY
CCCCEEECCCCEEEE		35.38-
259PhosphorylationQKVFSSTSVTAYKQN
CEEECCCCEEEECCC		21.30-
277UbiquitinationIPPYALGKSLRPSAE
CCHHHCCCCCCCCHH		47.3629967540
278PhosphorylationPPYALGKSLRPSAEM
CHHHCCCCCCCCHHH		28.01-
282PhosphorylationLGKSLRPSAEMIETT
CCCCCCCCHHHEEEE		30.3519053533
311PhosphorylationLSAYRVKTVTSSGVQ
EEEEEEEEEECCCEE		26.5928787133
313PhosphorylationAYRVKTVTSSGVQVS
EEEEEEEECCCEEEE		23.5428787133
315PhosphorylationRVKTVTSSGVQVSCH
EEEEEECCCEEEEEE		33.3528787133
358PhosphorylationVAFQNVFSKPKGTNS
EEEEHHHCCCCCCCC		43.7124719451
371PhosphorylationNSSAVPLSQGQVVVS
CCCCEECCCCCEEEC		26.6228348404
378PhosphorylationSQGQVVVSPPSSRSA
CCCCEEECCCCCCCC		21.3428985074
393PhosphorylationVSIGGGNTSAVSPSS
EEECCCCCCCCCHHH		22.7222210691
394PhosphorylationSIGGGNTSAVSPSSI
EECCCCCCCCCHHHH		30.5828985074
397PhosphorylationGGNTSAVSPSSIRGS
CCCCCCCCHHHHCCC		20.8425159151
399PhosphorylationNTSAVSPSSIRGSAA
CCCCCCHHHHCCCHH		30.7828450419
400PhosphorylationTSAVSPSSIRGSAAA
CCCCCHHHHCCCHHH		21.4928450419
514PhosphorylationFGERWGNYCKMCSYC
HHHHHHHHHHHHHHC		6.90-
516UbiquitinationERWGNYCKMCSYCSQ
HHHHHHHHHHHHCCC		32.36-
611UbiquitinationKVNISKAKTAVTELP
CCCHHHHHHHHHHCC		40.5329967540
612O-linked_GlycosylationVNISKAKTAVTELPS
CCHHHHHHHHHHCCC		31.0830379171
612PhosphorylationVNISKAKTAVTELPS
CCHHHHHHHHHHCCC		31.0826270265
615O-linked_GlycosylationSKAKTAVTELPSART
HHHHHHHHHCCCCCC		29.3730379171
615PhosphorylationSKAKTAVTELPSART
HHHHHHHHHCCCCCC		29.3726270265
619PhosphorylationTAVTELPSARTDTTP
HHHHHCCCCCCCCCH		42.9026270265
646PhosphorylationATLSTGNTNSVLKGA
CEECCCCCCHHHHHC		30.1622817900
648PhosphorylationLSTGNTNSVLKGAVT
ECCCCCCHHHHHCCC		27.13-
655PhosphorylationSVLKGAVTKEAAKII
HHHHHCCCHHHHHHH		23.7222817900
673AcetylationSTQEDAMKFPSSQSS
CCHHHHHCCCCCCCC		56.717482699
676PhosphorylationEDAMKFPSSQSSQPS
HHHHCCCCCCCCCHH		44.11-
677PhosphorylationDAMKFPSSQSSQPSR
HHHCCCCCCCCCHHH		34.0323403867
679PhosphorylationMKFPSSQSSQPSRLL
HCCCCCCCCCHHHHH		32.65-
680PhosphorylationKFPSSQSSQPSRLLK
CCCCCCCCCHHHHHH		38.1723403867
694AcetylationKNKGISCKPVTQTKA
HCCCCCCCCCCCCCC		35.4125953088
730PhosphorylationKNDAELDSPPSKKKR
CCCCCCCCCCCHHHC		51.8721815630
733PhosphorylationAELDSPPSKKKRLGF
CCCCCCCCHHHCCCE		61.5630576142
759PhosphorylationGFIICPGSKESSPRP
EEEECCCCCCCCCCC		20.5625159151
786PhosphorylationNMKPANLSHHLKTKH
CCCCCCHHHHHHHCC		14.5227251275
794PhosphorylationHHLKTKHSELENKPV
HHHHHCCHHHCCCCC		45.4928555341
799UbiquitinationKHSELENKPVDFFEQ
CCHHHCCCCCCHHHH		36.7229967540
820UbiquitinationCQNSSLKKCLLVEKS
HCCCCHHHHHHHHHH		35.09-
867PhosphorylationMCSEVLGSSAGDKMK
HHHHHHCCCCCCCCC		16.9226074081
868PhosphorylationCSEVLGSSAGDKMKT
HHHHHCCCCCCCCCE		34.1826074081
875PhosphorylationSAGDKMKTIPLSNVT
CCCCCCCEEECCCCC		25.0726074081
879PhosphorylationKMKTIPLSNVTIQHR
CCCEEECCCCCHHHH		24.7326074081
882PhosphorylationTIPLSNVTIQHRIDE
EEECCCCCHHHHHHH		21.1226074081
901UbiquitinationIEDQLIQKVRESKWF
HHHHHHHHHHHHCCE		35.9429967540
1038PhosphorylationLQSAQILSFIKSNAL
HHHHHHHHHHHHHCC		26.9324719451
1239PhosphorylationEEKLTELSSDLGLQA
HHHHHHHCHHHHHHH		18.6424247654
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZMYM6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZMYM6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZMYM6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZMYM6_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZMYM6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646 AND THR-655, ANDMASS SPECTROMETRY.

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