| UniProt ID | RNF31_HUMAN | |
|---|---|---|
| UniProt AC | Q96EP0 | |
| Protein Name | E3 ubiquitin-protein ligase RNF31 | |
| Gene Name | RNF31 {ECO:0000312|HGNC:HGNC:16031} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1072 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. [PubMed: 17006537] | |
| Protein Sequence | MPGEEEERAFLVAREELASALRRDSGQAFSLEQLRPLLASSLPLAARYLQLDAARLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRGVKFNNPVFRSTVDAVQGGRDVLRLYGYTEEQPDGLSFPEGQEEPDEHQVATVTLEVLLLRTELSLLLQNTHPRQQALEQLLEDKVEDDMLQLSEFDPLLREIAPGPLTTPSVPGSTPGPCFLCGSAPGTLHCPSCKQALCPACDHLFHGHPSRAHHLRQTLPGVLQGTHLSPSLPASAQPRPQSTSLLALGDSSLSSPNPASAHLPWHCAACAMLNEPWAVLCVACDRPRGCKGLGLGTEGPQGTGGLEPDLARGRWACQSCTFENEAAAVLCSICERPRLAQPPSLVVDSRDAGICLQPLQQGDALLASAQSQVWYCIHCTFCNSSPGWVCVMCNRTSSPIPAQHAPRPYASSLEKGPPKPGPPRRLSAPLPSSCGDPEKQRQDKMREEGLQLVSMIREGEAAGACPEEIFSALQYSGTEVPLQWLRSELPYVLEMVAELAGQQDPGLGAFSCQEARRAWLDRHGNLDEAVEECVRTRRRKVQELQSLGFGPEEGSLQALFQHGGDVSRALTELQRQRLEPFRQRLWDSGPEPTPSWDGPDKQSLVRRLLAVYALPSWGRAELALSLLQETPRNYELGDVVEAVRHSQDRAFLRRLLAQECAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHITDMVCPACGRPDLTDDTQLLSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRMNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPAGARAVPGGGCRVIEQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRRRK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | VAREELASALRRDSG HHHHHHHHHHHCCCC | 40.22 | 26434776 | |
| 81 | Ubiquitination | TALNILEKYGRNLLS HHHHHHHHHCCCCCC | 49.95 | - | |
| 88 | Phosphorylation | KYGRNLLSPQRPRYW HHCCCCCCCCCCCCC | 23.35 | 24719451 | |
| 99 | Ubiquitination | PRYWRGVKFNNPVFR CCCCCCCCCCCHHHH | 45.24 | 21890473 | |
| 99 | Ubiquitination | PRYWRGVKFNNPVFR CCCCCCCCCCCHHHH | 45.24 | 27667366 | |
| 99 (in isoform 1) | Ubiquitination | - | 45.24 | 21890473 | |
| 179 | Ubiquitination | QALEQLLEDKVEDDM HHHHHHHHHHCHHCH | 65.46 | 23000965 | |
| 179 (in isoform 3) | Ubiquitination | - | 65.46 | 21890473 | |
| 225 (in isoform 2) | Ubiquitination | - | 40.40 | 21906983 | |
| 226 (in isoform 2) | Ubiquitination | - | 16.57 | 21906983 | |
| 257 | Phosphorylation | RAHHLRQTLPGVLQG HHHHHHHHCCCCCCC | 28.61 | 23312004 | |
| 265 | Phosphorylation | LPGVLQGTHLSPSLP CCCCCCCCCCCCCCC | 13.49 | 23312004 | |
| 268 | Phosphorylation | VLQGTHLSPSLPASA CCCCCCCCCCCCCCC | 12.58 | 28188228 | |
| 270 | Phosphorylation | QGTHLSPSLPASAQP CCCCCCCCCCCCCCC | 43.54 | 25849741 | |
| 274 | Phosphorylation | LSPSLPASAQPRPQS CCCCCCCCCCCCCCC | 26.04 | 23312004 | |
| 281 | Phosphorylation | SAQPRPQSTSLLALG CCCCCCCCCCEEEEC | 23.73 | 28787133 | |
| 290 | Phosphorylation | SLLALGDSSLSSPNP CEEEECCCCCCCCCC | 31.23 | 28787133 | |
| 303 | Ubiquitination | NPASAHLPWHCAACA CCCCCCCCHHHHHHH | 14.65 | 21890473 | |
| 303 (in isoform 3) | Ubiquitination | - | 14.65 | 21890473 | |
| 307 | Ubiquitination | AHLPWHCAACAMLNE CCCCHHHHHHHHHCC | 7.84 | 21890473 | |
| 307 (in isoform 3) | Ubiquitination | - | 7.84 | 21890473 | |
| 315 | Phosphorylation | ACAMLNEPWAVLCVA HHHHHCCCEEEEEHH | 24.21 | 32142685 | |
| 327 | Ubiquitination | CVACDRPRGCKGLGL EHHCCCCCCCCCCCC | 65.13 | 27667366 | |
| 330 | Ubiquitination | CDRPRGCKGLGLGTE CCCCCCCCCCCCCCC | 61.05 | 21890473 | |
| 330 | Ubiquitination | CDRPRGCKGLGLGTE CCCCCCCCCCCCCCC | 61.05 | 23000965 | |
| 330 (in isoform 1) | Ubiquitination | - | 61.05 | 21890473 | |
| 358 | Phosphorylation | RGRWACQSCTFENEA CCCEECCCCCCCHHH | 18.27 | 27251275 | |
| 383 | Phosphorylation | PRLAQPPSLVVDSRD CCCCCCCCEEEECCC | 40.24 | 29255136 | |
| 388 | Phosphorylation | PPSLVVDSRDAGICL CCCEEEECCCCCCCC | 22.05 | 29255136 | |
| 428 | Ubiquitination | CNSSPGWVCVMCNRT CCCCCCEEEEEECCC | 1.87 | 22817900 | |
| 428 (in isoform 3) | Ubiquitination | - | 1.87 | 21890473 | |
| 435 | Phosphorylation | VCVMCNRTSSPIPAQ EEEEECCCCCCCCCC | 21.40 | 23403867 | |
| 436 | Phosphorylation | CVMCNRTSSPIPAQH EEEECCCCCCCCCCC | 30.77 | 21712546 | |
| 437 | Phosphorylation | VMCNRTSSPIPAQHA EEECCCCCCCCCCCC | 26.66 | 23401153 | |
| 448 | Phosphorylation | AQHAPRPYASSLEKG CCCCCCCCHHHCCCC | 22.01 | 23403867 | |
| 450 | Phosphorylation | HAPRPYASSLEKGPP CCCCCCHHHCCCCCC | 29.61 | 23403867 | |
| 451 | Phosphorylation | APRPYASSLEKGPPK CCCCCHHHCCCCCCC | 32.16 | 23403867 | |
| 454 | Ubiquitination | PYASSLEKGPPKPGP CCHHHCCCCCCCCCC | 80.26 | 21890473 | |
| 454 | Ubiquitination | PYASSLEKGPPKPGP CCHHHCCCCCCCCCC | 80.26 | 27667366 | |
| 454 (in isoform 1) | Ubiquitination | - | 80.26 | 21890473 | |
| 458 | Ubiquitination | SLEKGPPKPGPPRRL HCCCCCCCCCCCCCC | 66.78 | 21890473 | |
| 458 | Ubiquitination | SLEKGPPKPGPPRRL HCCCCCCCCCCCCCC | 66.78 | 27667366 | |
| 458 (in isoform 1) | Ubiquitination | - | 66.78 | 21890473 | |
| 466 | Phosphorylation | PGPPRRLSAPLPSSC CCCCCCCCCCCCCCC | 26.48 | 28189684 | |
| 471 | Phosphorylation | RLSAPLPSSCGDPEK CCCCCCCCCCCCHHH | 46.04 | 23927012 | |
| 472 | Phosphorylation | LSAPLPSSCGDPEKQ CCCCCCCCCCCHHHH | 21.85 | 23927012 | |
| 478 | Ubiquitination | SSCGDPEKQRQDKMR CCCCCHHHHHHHHHH | 57.05 | 27667366 | |
| 483 | Ubiquitination | PEKQRQDKMREEGLQ HHHHHHHHHHHHHHH | 31.36 | - | |
| 489 | Ubiquitination | DKMREEGLQLVSMIR HHHHHHHHHHHHHHH | 3.94 | 21890473 | |
| 489 (in isoform 2) | Ubiquitination | - | 3.94 | 21906983 | |
| 489 (in isoform 3) | Ubiquitination | - | 3.94 | 21890473 | |
| 493 | Phosphorylation | EEGLQLVSMIREGEA HHHHHHHHHHHCCCC | 19.65 | 27251275 | |
| 579 | Ubiquitination | CVRTRRRKVQELQSL HHHHHHHHHHHHHHC | 46.59 | 21906983 | |
| 579 (in isoform 1) | Ubiquitination | - | 46.59 | 21890473 | |
| 632 | Phosphorylation | WDSGPEPTPSWDGPD HHCCCCCCCCCCCCC | 28.43 | - | |
| 632 | Ubiquitination | WDSGPEPTPSWDGPD HHCCCCCCCCCCCCC | 28.43 | 22817900 | |
| 632 (in isoform 3) | Ubiquitination | - | 28.43 | 21890473 | |
| 633 | Ubiquitination | DSGPEPTPSWDGPDK HCCCCCCCCCCCCCH | 44.10 | 22817900 | |
| 633 (in isoform 3) | Ubiquitination | - | 44.10 | 21890473 | |
| 634 | Phosphorylation | SGPEPTPSWDGPDKQ CCCCCCCCCCCCCHH | 40.03 | 27251275 | |
| 640 | Ubiquitination | PSWDGPDKQSLVRRL CCCCCCCHHHHHHHH | 44.94 | 21890473 | |
| 640 | Ubiquitination | PSWDGPDKQSLVRRL CCCCCCCHHHHHHHH | 44.94 | 21963094 | |
| 640 (in isoform 1) | Ubiquitination | - | 44.94 | 21890473 | |
| 642 | Phosphorylation | WDGPDKQSLVRRLLA CCCCCHHHHHHHHHH | 34.27 | 24719451 | |
| 651 | Phosphorylation | VRRLLAVYALPSWGR HHHHHHHHHCCCCCH | 9.23 | 27642862 | |
| 655 | Phosphorylation | LAVYALPSWGRAELA HHHHHCCCCCHHHHH | 42.91 | 28857561 | |
| 664 | Phosphorylation | GRAELALSLLQETPR CHHHHHHHHHHHCCC | 22.79 | 30108239 | |
| 669 | Phosphorylation | ALSLLQETPRNYELG HHHHHHHCCCCCCCH | 18.00 | 30108239 | |
| 685 | Phosphorylation | VVEAVRHSQDRAFLR HHHHHHHHHHHHHHH | 24.18 | 28555341 | |
| 697 | Ubiquitination | FLRRLLAQECAVCGW HHHHHHHHHHHHHCC | 46.39 | 29967540 | |
| 715 | Phosphorylation | HNRMQALTSCECTIC CCHHHHHHHCEEEEC | 34.05 | 27251275 | |
| 716 | Phosphorylation | NRMQALTSCECTICP CHHHHHHHCEEEECH | 14.58 | 27251275 | |
| 735 | Ubiquitination | QHFTIALKEKHITDM HHEEEEECHHHCCCC | 56.55 | - | |
| 759 | Ubiquitination | LTDDTQLLSYFSTLD CCCCHHHHHHHHHHC | 2.54 | 29967540 | |
| 783 | Ubiquitination | DAYALFHKKLTEGVL CHHHHHHCCCCCCCC | 41.99 | 21906983 | |
| 783 (in isoform 1) | Ubiquitination | - | 41.99 | 21890473 | |
| 784 | Ubiquitination | AYALFHKKLTEGVLM HHHHHHCCCCCCCCC | 52.66 | 21906983 | |
| 784 (in isoform 1) | Ubiquitination | - | 52.66 | 21890473 | |
| 793 | Ubiquitination | TEGVLMRDPKFLWCA CCCCCCCCCCCEEEE | 36.45 | 29967540 | |
| 837 | Ubiquitination | RQWEEQHRGRSCEDF HHHHHHHCCCCCHHH | 41.75 | 29967540 | |
| 840 | Phosphorylation | EEQHRGRSCEDFQNW HHHHCCCCCHHHHHH | 25.36 | 23312004 | |
| 848 | Ubiquitination | CEDFQNWKRMNDPEY CHHHHHHHHCCCHHH | 49.68 | 29967540 | |
| 863 | Phosphorylation | QAQGLAMYLQENGID HHHHHHHHHHHCCCC | 10.30 | 29083192 | |
| 873 | Ubiquitination | ENGIDCPKCKFSYAL HCCCCCCCCHHHHHH | 57.28 | - | |
| 877 | Phosphorylation | DCPKCKFSYALARGG CCCCCHHHHHHHCCC | 8.59 | 24719451 | |
| 899 | Phosphorylation | QCRHQFCSGCYNAFY HHHCHHHHHHHHHHH | 32.94 | 24247654 | |
| 902 | Phosphorylation | HQFCSGCYNAFYAKN CHHHHHHHHHHHCCC | 17.04 | 27251275 | |
| 905 | Ubiquitination | CSGCYNAFYAKNKCP HHHHHHHHHCCCCCC | 5.62 | 22817900 | |
| 905 (in isoform 3) | Ubiquitination | - | 5.62 | 21890473 | |
| 910 | Ubiquitination | NAFYAKNKCPEPNCR HHHHCCCCCCCCCCC | 50.92 | 29967540 | |
| 944 | Ubiquitination | WTALRLQKLLQDNNV HHHHHHHHHHHCCCC | 56.61 | 29967540 | |
| 952 | Sulfoxidation | LLQDNNVMFNTEPPA HHHCCCCEECCCCCC | 2.03 | 21406390 | |
| 988 | Ubiquitination | LRDEACGKETPAGYA CCCCCCCCCCCCCHH | 59.30 | 29967540 | |
| 1005 | Phosphorylation | CQAHYKEYLVSLINA HHHHHHHHHHHHHHH | 14.30 | 26074081 | |
| 1008 | Phosphorylation | HYKEYLVSLINAHSL HHHHHHHHHHHHHCC | 22.42 | 26074081 | |
| 1014 | Phosphorylation | VSLINAHSLDPATLY HHHHHHHCCCHHHEE | 31.86 | 26074081 | |
| 1019 | Phosphorylation | AHSLDPATLYEVEEL HHCCCHHHEEEHHHH | 34.95 | 26074081 | |
| 1021 | Phosphorylation | SLDPATLYEVEELET CCCHHHEEEHHHHHH | 17.36 | 26074081 | |
| 1056 | Ubiquitination | YQARLLQKLTEEVPL HHHHHHHHHHHCCCC | 58.30 | 22817900 | |
| 1056 (in isoform 1) | Ubiquitination | - | 58.30 | 21890473 | |
| 1066 | Phosphorylation | EEVPLGQSIPRRRK- HCCCCCCCCCCCCC- | 32.53 | 28857561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RNF31_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RNF31_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RNF31_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466, AND MASSSPECTROMETRY. | |
| "Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466, AND MASSSPECTROMETRY. | |
