dbPTM

CAR11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CAR11_HUMAN
UniProt AC	Q9BXL7
Protein Name	Caspase recruitment domain-containing protein 11
Gene Name	CARD11
Organism	Homo sapiens (Human).
Sequence Length	1154
Subcellular Localization	Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts.
Protein Description	Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway..
Protein Sequence	MPGGGPEMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIGEEQRKTIWVDEDQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	GGPEMDDYMETLKDE CCCCHHHHHHHHCCH	7.81	23663014
14	Phosphorylation	EMDDYMETLKDEEDA CHHHHHHHHCCHHHH	23.68	23663014
34	Phosphorylation	ECNRHMLSRYINPAK HCCHHHHHHHCCHHH	18.57	26307563
36	Phosphorylation	NRHMLSRYINPAKLT CHHHHHHHCCHHHCC	11.15	26307563
43	Phosphorylation	YINPAKLTPYLRQCK HCCHHHCCHHHHHCC	14.80	26307563
45	Phosphorylation	NPAKLTPYLRQCKVI CHHHCCHHHHHCCCC	14.85	26307563
68	Phosphorylation	LNAPMLPSKINRAGR HCCCCCHHHHCHHHH	42.05	24719451
69	Ubiquitination	NAPMLPSKINRAGRL CCCCCHHHHCHHHHH	41.90	-
116	Phosphorylation	KEPTRRFSTIVVEEG CCCCCCEEEEEEECC	18.53	16809782
117	Phosphorylation	EPTRRFSTIVVEEGH CCCCCEEEEEEECCC	18.32	27251275
180	Phosphorylation	LLTFQERYYKMKEER HHHHHHHHHHHHHHH	13.49	26074081
181	Phosphorylation	LTFQERYYKMKEERD HHHHHHHHHHHHHHH	15.72	26074081
202	Phosphorylation	VKVKDDNYNLAMRYA EEECCCCHHHHHHHH	20.67	-
208	Phosphorylation	NYNLAMRYAQLSEEK CHHHHHHHHHCCHHH	5.89	23403867
212	Phosphorylation	AMRYAQLSEEKNMAV HHHHHHCCHHHCHHH	31.46	23403867
285	O-linked_Glycosylation	TKNQELQSIIQAGKR HHHHHHHHHHHHCHH	33.99	30379171
433	Phosphorylation	ACIVNLESKLRRLSK HHHHHHHHHHHHHCC	39.91	21060948
439	Phosphorylation	ESKLRRLSKDSNNLD HHHHHHHCCCCCCCC	32.38	21949786
442	Phosphorylation	LRRLSKDSNNLDQSL HHHHCCCCCCCCHHC	31.21	21949786
448	Phosphorylation	DSNNLDQSLPRNLPV CCCCCCHHCCCCCCE	39.75	23401153
456	Phosphorylation	LPRNLPVTIISQDFG CCCCCCEEEEECCCC	15.62	23403867
459	Phosphorylation	NLPVTIISQDFGDAS CCCEEEEECCCCCCC	21.61	23403867
466	Phosphorylation	SQDFGDASPRTNGQE ECCCCCCCCCCCCCC	21.47	22617229
487	Phosphorylation	SEESPEDSKYFLPYH CCCCCCCCCCCCCCC	27.82	-
489	Phosphorylation	ESPEDSKYFLPYHPP CCCCCCCCCCCCCCC	17.82	27642862
493	Phosphorylation	DSKYFLPYHPPQRRM CCCCCCCCCCCCCCC	29.16	-
512	Phosphorylation	IQLQRAKSPISLKRT CCCEECCCCCCCEEC	26.87	23401153
515	Phosphorylation	QRAKSPISLKRTSDF EECCCCCCCEECCCC	31.08	23403867
519	Phosphorylation	SPISLKRTSDFQAKG CCCCCEECCCCCCCC	30.94	27251275
520	Phosphorylation	PISLKRTSDFQAKGH CCCCEECCCCCCCCC	40.22	27251275
532	Phosphorylation	KGHEEEGTDASPSSC CCCCCCCCCCCCCCC	31.50	23403867
535	Phosphorylation	EEEGTDASPSSCGSL CCCCCCCCCCCCCCC	28.29	23403867
537	Phosphorylation	EGTDASPSSCGSLPI CCCCCCCCCCCCCCC	35.45	23401153
538	Phosphorylation	GTDASPSSCGSLPIT CCCCCCCCCCCCCCC	26.36	23403867
541	Phosphorylation	ASPSSCGSLPITNSF CCCCCCCCCCCCCCC	34.99	23403867
545	Phosphorylation	SCGSLPITNSFTKMQ CCCCCCCCCCCCCCC	23.91	23186163
547	Phosphorylation	GSLPITNSFTKMQPP CCCCCCCCCCCCCCC	26.16	23403867
549	Phosphorylation	LPITNSFTKMQPPRS CCCCCCCCCCCCCCC	25.98	-
556	Phosphorylation	TKMQPPRSRSSIMSI CCCCCCCCCCCCEEE	42.14	19706536
558	Phosphorylation	MQPPRSRSSIMSITA CCCCCCCCCCEEEEE	26.01	19706536
559	Phosphorylation	QPPRSRSSIMSITAE CCCCCCCCCEEEEEC	22.62	19706536
562	Phosphorylation	RSRSSIMSITAEPPG CCCCCCEEEEECCCC	18.34	16356856
564	Phosphorylation	RSSIMSITAEPPGND CCCCEEEEECCCCCC	20.05	27251275
572	Phosphorylation	AEPPGNDSIVRRYKE ECCCCCCHHHHHCCC	27.30	16356856
585	Phosphorylation	KEDAPHRSTVEEDND CCCCCCCCCCCCCCC	33.50	23312004
586	Phosphorylation	EDAPHRSTVEEDNDS CCCCCCCCCCCCCCC	31.71	23917254
593	Phosphorylation	TVEEDNDSGGFDALD CCCCCCCCCCCCCCC	47.25	23401153
609	Phosphorylation	DDDSHERYSFGPSSI CCCCCCCCCCCCCCC	12.84	25072903
610	Phosphorylation	DDSHERYSFGPSSIH CCCCCCCCCCCCCCC	29.92	25072903
614	Phosphorylation	ERYSFGPSSIHSSSS CCCCCCCCCCCCCCC	42.16	25072903
615	Phosphorylation	RYSFGPSSIHSSSSS CCCCCCCCCCCCCCC	27.70	25072903
618	Phosphorylation	FGPSSIHSSSSSHQS CCCCCCCCCCCCCCC	30.19	25072903
619	Phosphorylation	GPSSIHSSSSSHQSE CCCCCCCCCCCCCCC	21.78	25072903
620	Phosphorylation	PSSIHSSSSSHQSEG CCCCCCCCCCCCCCC	38.58	25072903
621	Phosphorylation	SSIHSSSSSHQSEGL CCCCCCCCCCCCCCC	33.51	25072903
622	Phosphorylation	SIHSSSSSHQSEGLD CCCCCCCCCCCCCCC	27.74	25072903
625	Phosphorylation	SSSSSHQSEGLDAYD CCCCCCCCCCCCCCC	28.36	25072903
631	Phosphorylation	QSEGLDAYDLEQVNL CCCCCCCCCHHHHHH	22.26	25072903
644	Phosphorylation	NLMFRKFSLERPFRP HHHHHHHCCCCCCCC	32.15	28464451
652	Phosphorylation	LERPFRPSVTSVGHV CCCCCCCCCCEECCC	33.50	30576142
654	Phosphorylation	RPFRPSVTSVGHVRG CCCCCCCCEECCCCC	23.25	23312004
655	Phosphorylation	PFRPSVTSVGHVRGP CCCCCCCEECCCCCC	24.76	23312004
696	Ubiquitination	GSFVHSVKPGSLAEK CCCEEECCCCCHHHH	46.83	-
703	Ubiquitination	KPGSLAEKAGLREGH CCCCHHHHHCCCCCC	41.99	-
854	Phosphorylation	QRLMHRGSREEVDGT HHHHHCCCHHHCCCH	36.15	22985185
861	Phosphorylation	SREEVDGTHHTLRAL CHHHCCCHHHHHHHH	13.16	22985185
864	Phosphorylation	EVDGTHHTLRALRNT HCCCHHHHHHHHHHC	15.44	22985185
871	O-linked_Glycosylation	TLRALRNTLQPEEAL HHHHHHHCCCHHHHH	21.97	30379171
871	Phosphorylation	TLRALRNTLQPEEAL HHHHHHHCCCHHHHH	21.97	23403867
879	Phosphorylation	LQPEEALSTSDPRVS CCHHHHHCCCCCCCC	32.67	23403867
880	Phosphorylation	QPEEALSTSDPRVSP CHHHHHCCCCCCCCH	37.69	23401153
881	Phosphorylation	PEEALSTSDPRVSPR HHHHHCCCCCCCCHH	42.09	23403867
886	Phosphorylation	STSDPRVSPRLSRAS CCCCCCCCHHHHHHH	12.94	23401153
890	Phosphorylation	PRVSPRLSRASFLFG CCCCHHHHHHHHHHH	27.38	28111955
923	Phosphorylation	NERVRIISGSPLGSL CCCEEEEECCCCHHH	30.74	23403867
925	Phosphorylation	RVRIISGSPLGSLAR CEEEEECCCCHHHHH	15.34	23561803
929	Phosphorylation	ISGSPLGSLARSSLD EECCCCHHHHHHHCH	26.92	23403867
939	Ubiquitination	RSSLDATKLLTEKQE HHHCHHHHHHHHHHH	43.13	-
944	Ubiquitination	ATKLLTEKQEELDPE HHHHHHHHHHHCCCC	58.75	-
952	Phosphorylation	QEELDPESELGKNLS HHHCCCCCHHCCCCC	43.43	27251275
963	Phosphorylation	KNLSLIPYSLVRAFY CCCCCCCHHHHHHHH	13.98	28176486
964	Phosphorylation	NLSLIPYSLVRAFYC CCCCCCHHHHHHHHC	18.29	28176486
970	Phosphorylation	YSLVRAFYCERRRPV HHHHHHHHCCCCCCC	7.75	-
995	Phosphorylation	LVQRLLNSGGAMEFT HHHHHHHCCCCEEEE	38.28	-
1002	Phosphorylation	SGGAMEFTICKSDIV CCCCEEEEEEHHHCC	16.50	-
1019	Ubiquitination	DEFLRRQKTETIIYS HHHHHHCCCCEEEEE	46.66	-
1020	Phosphorylation	EFLRRQKTETIIYSR HHHHHCCCCEEEEEC	29.98	28674151
1026	Phosphorylation	KTETIIYSREKNPNA CCCEEEEECCCCCCC	24.45	24719451
1029	Ubiquitination	TIIYSREKNPNAFEC EEEEECCCCCCCEEC	76.28	-
1081	Acetylation	LFIRVCEKNIKRFRK HHHHHHHHHHHHHHH	59.87	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
116	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
556	S	Phosphorylation	Kinase	MAP4K1	Q92918	GPS
558	S	Phosphorylation	Kinase	AKT1	P31749	PSP
558	S	Phosphorylation	Kinase	MAP4K1	Q92918	GPS
559	S	Phosphorylation	Kinase	PRKCB	P05771	Uniprot
559	S	Phosphorylation	Kinase	PKCT	Q04759	PSP
615	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
644	S	Phosphorylation	Kinase	AKT1	P31749	PSP
644	S	Phosphorylation	Kinase	PRKCB	P05771	Uniprot
644	S	Phosphorylation	Kinase	PRKCQ	Q04759	Uniprot
652	S	Phosphorylation	Kinase	AKT1	P31749	PSP
652	S	Phosphorylation	Kinase	PRKCB	P05771	Uniprot
652	S	Phosphorylation	Kinase	PRKCQ	Q04759	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
559	S	Phosphorylation	-
Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.
644	S	Phosphorylation	-
Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.
652	S	Phosphorylation	-
Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CAR11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL10_HUMAN	BCL10	physical	11278692
PDPK1_HUMAN	PDPK1	physical	15802604
CBLB_HUMAN	CBLB	physical	19815501
CSN5_HUMAN	COPS5	physical	19444310
BCL10_HUMAN	BCL10	physical	18806265
DPP4_HUMAN	DPP4	physical	17287217
CAR11_HUMAN	CARD11	physical	18625728
KPCB_HUMAN	PRKCB	physical	16356855
IKKA_HUMAN	CHUK	physical	16356855
BCL10_HUMAN	BCL10	physical	16356855
CHIP_HUMAN	STUB1	physical	23322406
CCND1_HUMAN	CCND1	physical	23322406
MALT1_HUMAN	MALT1	physical	23322406
UBP2_HUMAN	USP2	physical	23264041
RN181_HUMAN	RNF181	physical	26711259
BCL10_HUMAN	BCL10	physical	24074955
2AAA_HUMAN	PPP2R1A	physical	21157432
KPCT_HUMAN	PRKCQ	physical	21157432
RNF31_HUMAN	RNF31	physical	27777308
KPCD_HUMAN	PRKCD	physical	22528498
KPCT_HUMAN	PRKCQ	physical	22528498
BCL10_HUMAN	BCL10	physical	22528498
MALT1_HUMAN	MALT1	physical	22528498
M3K7_HUMAN	MAP3K7	physical	27497262
KC1A_HUMAN	CSNK1A1	physical	19118383
M4K1_HUMAN	MAP4K1	physical	19706536

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616452	B-cell expansion with NFKB and T-cell anergy (BENTA)
615206	Immunodeficiency 11 (IMD11)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CAR11_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; SER-593 ANDSER-925, AND MASS SPECTROMETRY.	19690332 [Abstract]

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