dbPTM

BCL10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BCL10_HUMAN
UniProt AC	O95999
Protein Name	B-cell lymphoma/leukemia 10
Gene Name	BCL10
Organism	Homo sapiens (Human).
Sequence Length	233
Subcellular Localization	Cytoplasm, perinuclear region . Membrane raft . Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Protein Description	Involved in adaptive immune response. [PubMed: 25365219 Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1]
Protein Sequence	MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGESSTTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANSSEMFLPLRSRTVSRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPTAPSL -------CCCCCCCC	14.54	19413330
4	Phosphorylation	----MEPTAPSLTEE ----CCCCCCCCCHH	37.58	23663014
7	Phosphorylation	-MEPTAPSLTEEDLT -CCCCCCCCCHHHHH	45.52	23663014
9	Phosphorylation	EPTAPSLTEEDLTEV CCCCCCCCHHHHHHH	41.48	23663014
14	Phosphorylation	SLTEEDLTEVKKDAL CCCHHHHHHHHHHHH	51.56	23663014
17	Ubiquitination	EEDLTEVKKDALENL HHHHHHHHHHHHHHH	38.41	-
18	Ubiquitination	EDLTEVKKDALENLR HHHHHHHHHHHHHHH	54.10	-
29	S-palmitoylation	ENLRVYLCEKIIAER HHHHHHHHHHHHHHH	2.47	29575903
31	Ubiquitination	LRVYLCEKIIAERHF HHHHHHHHHHHHHHH	38.11	18287044
52	Phosphorylation	KILSREDTEEISCRT HHCCCCCCCCCCCCH	30.66	27273156
59	Phosphorylation	TEEISCRTSSRKRAG CCCCCCCHHHHHHHH	35.07	25627689
63	Ubiquitination	SCRTSSRKRAGKLLD CCCHHHHHHHHHHHH	48.85	1828704
67	Acetylation	SSRKRAGKLLDYLQE HHHHHHHHHHHHHHH	44.91	25953088
67	Ubiquitination	SSRKRAGKLLDYLQE HHHHHHHHHHHHHHH	44.91	-
77	Ubiquitination	DYLQENPKGLDTLVE HHHHHCCCCHHHHHH	81.39	-
81	Phosphorylation	ENPKGLDTLVESIRR HCCCCHHHHHHHHHH	37.43	21406692
85	Phosphorylation	GLDTLVESIRREKTQ CHHHHHHHHHHHHHH	17.57	21406692
90	Ubiquitination	VESIRREKTQNFLIQ HHHHHHHHHHCHHHH	54.31	-
98	Ubiquitination	TQNFLIQKITDEVLK HHCHHHHHHHHHHHH	40.35	-
100	Phosphorylation	NFLIQKITDEVLKLR CHHHHHHHHHHHHHC	32.89	-
105	Ubiquitination	KITDEVLKLRNIKLE HHHHHHHHHCCCCHH	51.05	-
110	Ubiquitination	VLKLRNIKLEHLKGL HHHHCCCCHHHCCCC	51.91	-
115	Ubiquitination	NIKLEHLKGLKCSSC CCCHHHCCCCCCCCC	65.19	-
118	Ubiquitination	LEHLKGLKCSSCEPF HHHCCCCCCCCCCCC	40.51	-
120	Phosphorylation	HLKGLKCSSCEPFPD HCCCCCCCCCCCCCC	36.11	29255136
121	Phosphorylation	LKGLKCSSCEPFPDG CCCCCCCCCCCCCCC	31.78	29255136
130	Phosphorylation	EPFPDGATNNLSRSN CCCCCCCCCCCCCCC	30.12	29255136
134	Phosphorylation	DGATNNLSRSNSDES CCCCCCCCCCCCCCC	35.47	29255136
136	Phosphorylation	ATNNLSRSNSDESNF CCCCCCCCCCCCCCH	36.99	25159151
138	Phosphorylation	NNLSRSNSDESNFSE CCCCCCCCCCCCHHH	43.96	23927012
141	Phosphorylation	SRSNSDESNFSEKLR CCCCCCCCCHHHHHH	48.44	23927012
144	Phosphorylation	NSDESNFSEKLRAST CCCCCCHHHHHHHHE	37.76	28450419
146	Ubiquitination	DESNFSEKLRASTVM CCCCHHHHHHHHEEE	41.91	-
163	Phosphorylation	PEGESSTTPFFSTNS CCCCCCCCCCEECCC	21.75	-
167	Phosphorylation	SSTTPFFSTNSSLNL CCCCCCEECCCCCCC	27.36	28348404
168	Phosphorylation	STTPFFSTNSSLNLP CCCCCEECCCCCCCC	33.68	22468782
170	Phosphorylation	TPFFSTNSSLNLPVL CCCEECCCCCCCCEE	35.97	17371994
171	Phosphorylation	PFFSTNSSLNLPVLE CCEECCCCCCCCEEE	24.28	17371994
218	Phosphorylation	EEGTCANSSEMFLPL CCCCCCCCCCCEEEE	14.78	20466000
227	Phosphorylation	EMFLPLRSRTVSRQ- CCEEEECCCCCCCC-	39.73	-
229	Phosphorylation	FLPLRSRTVSRQ--- EEEECCCCCCCC---	24.87	-
231	Phosphorylation	PLRSRTVSRQ----- EECCCCCCCC-----	25.09	16280327

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
134	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
136	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
138	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
138	S	Phosphorylation	Kinase	CAMK2B	Q13554	GPS
141	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
144	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
218	S	Phosphorylation	Kinase	AKT1	P31749	PSP
231	S	Phosphorylation	Kinase	AKT1	P31749	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	BIRC3	Q13489	PMID:16775419
-	K	Ubiquitination	E3 ubiquitin ligase	ITCH	Q96J02	PMID:15082780
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:15082780

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BCL10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BCL10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KT33B_HUMAN	KRT33B	physical	17353931
MALT1_HUMAN	MALT1	physical	11090634
TRADD_HUMAN	TRADD	physical	10400625
CAR10_HUMAN	CARD10	physical	11259443
CARD9_HUMAN	CARD9	physical	11053425
CAR11_HUMAN	CARD11	physical	11278692
CAR14_HUMAN	CARD14	physical	11278692
TRAF2_HUMAN	TRAF2	physical	10753917
BCL10_HUMAN	BCL10	physical	16775419
IKBA_HUMAN	NFKBIA	physical	20551178
MALT1_HUMAN	MALT1	physical	20551178
MIB2_MOUSE	Mib2	physical	21896478
BCL10_HUMAN	BCL10	physical	21896478
MALT1_MOUSE	Malt1	physical	21896478
MIB2_HUMAN	MIB2	physical	21896478
CAR11_HUMAN	CARD11	physical	19815501
MALT1_HUMAN	MALT1	physical	19444310
CAR11_HUMAN	CARD11	physical	19444310
KCC2G_HUMAN	CAMK2G	physical	21513986
CAR11_HUMAN	CARD11	physical	21513986
IKKB_HUMAN	IKBKB	physical	17213322
FBW1A_HUMAN	BTRC	physical	17213322
MALT1_HUMAN	MALT1	physical	11262391
IKKA_HUMAN	CHUK	physical	11113112
IKKB_HUMAN	IKBKB	physical	11113112
NEMO_HUMAN	IKBKG	physical	11113112
TRAF2_HUMAN	TRAF2	physical	11466612
BIRC3_HUMAN	BIRC3	physical	11466612
CAR11_HUMAN	CARD11	physical	18625728
MK09_HUMAN	MAPK9	physical	17189706
MALT1_HUMAN	MALT1	physical	17948050
AKT1_HUMAN	AKT1	physical	16280327
BCL3_HUMAN	BCL3	physical	16280327
USP9X_HUMAN	USP9X	physical	23690623
NEMO_HUMAN	IKBKG	physical	23690623
MALT1_HUMAN	MALT1	physical	23690623
CAR11_HUMAN	CARD11	physical	23690623
I15RA_HUMAN	IL15RA	physical	21988832
CDK9_HUMAN	CDK9	physical	21988832
SRSF1_HUMAN	SRSF1	physical	21988832
S20A1_HUMAN	SLC20A1	physical	21988832
NHRF1_HUMAN	SLC9A3R1	physical	21988832
TMG4_HUMAN	PRRG4	physical	21988832
USBP1_HUMAN	USHBP1	physical	21988832
MALT1_HUMAN	MALT1	physical	24130731
BIRC3_HUMAN	BIRC3	physical	16395405
MALT1_HUMAN	MALT1	physical	14695475
UB2V2_HUMAN	UBE2V2	physical	14695475
NEMO_HUMAN	IKBKG	physical	14695475
IKKA_HUMAN	CHUK	physical	14695475
IKKB_HUMAN	IKBKB	physical	14695475
UBE2N_HUMAN	UBE2N	physical	14695475
BCL10_HUMAN	BCL10	physical	25416956
CAR11_HUMAN	CARD11	physical	25548215
MALT1_HUMAN	MALT1	physical	25548215
BCL10_HUMAN	BCL10	physical	24074955
CAR11_HUMAN	CARD11	physical	21157432
2AAA_HUMAN	PPP2R1A	physical	21157432
MALT1_HUMAN	MALT1	physical	21157432
PP2AA_HUMAN	PPP2CA	physical	21157432
SQSTM_HUMAN	SQSTM1	physical	22658522
MALT1_HUMAN	MALT1	physical	22658522
ATG5_HUMAN	ATG5	physical	22658522
MLP3A_HUMAN	MAP1LC3A	physical	22658522
RNF31_HUMAN	RNF31	physical	27777308
CAR11_HUMAN	CARD11	physical	27777308
MALT1_HUMAN	MALT1	physical	27777308
MALT1_HUMAN	MALT1	physical	22528498
MALT1_HUMAN	MALT1	physical	19118383
CAR11_HUMAN	CARD11	physical	19118383
IKKB_HUMAN	IKBKB	physical	19118383
CAR14_HUMAN	CARD14	physical	27071417

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
	Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1
	14)(p22
	q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
616098
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BCL10_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]