MALT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MALT1_MOUSE
• UniProt AC: Q2TBA3
• Protein Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog
• Gene Name: Malt1 {ECO:0000312|MGI:MGI:2445027}
• Organism: Mus musculus (Mouse).
• Sequence Length: 832
• Subcellular Localization: Cytoplasm, perinuclear region. Nucleus . Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10 (By similarity).
• Protein Description: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity (By similarity). MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. [PubMed: 25282160]
• Protein Sequence: MSLWGQPLQASPPLAVRQPPTASSGPSTSPPAGATLNRLPEPLLRRLSESLDRAPEGRGWRQLAELAGSRGRLRLSGLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQALEHTEVLPLLNPPGLKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPYGNSSELVFNTVHVKDAGFYVCRVNNSSTFEFSQWSQLDVCDVAEVTDSFQGSMDGISESRLQICVEPRSQRLVPGSMLLLQCVAIGSPMPHYQWFKDESPLTHETKKHYTVPYVDIEHEGTYWCHVYNDRDSQDSKKAEVTIGRTDEAVECTEDELNNLGHPDNKEQTGQPLAKDKVALLIGNMSYWEHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMCNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGRQALEIRSSLSEKRALTDPVQGAPCSAEALVRNLQWAKAHELPESMCLKFQCGVHIQLGFAAEFSNVMIIYTSIVHKPPEIIMCDAYVTDFPLDLDIDPKHANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLIFTVCLSYQYSGLEDTVEEKQEVNVGKPLIAKLDMHRGLGRKTCFQACRMPDEPYHSSTSTSAGAGHFHSSQDSFHDVYHSHLGNADSGMPPDRCHCSRTPHTFISNYPPHHYCQFGRSNVPVETTDEMPFSFSDRLMISEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSLWGQPLQ ------CCCCCCCCC	32.59	-
2	Phosphorylation	------MSLWGQPLQ ------CCCCCCCCC	32.59	25367039
11	Phosphorylation	WGQPLQASPPLAVRQ CCCCCCCCCCCEECC	17.68	20469934
23	Phosphorylation	VRQPPTASSGPSTSP ECCCCCCCCCCCCCC	38.00	28285833
27	Phosphorylation	PTASSGPSTSPPAGA CCCCCCCCCCCCCCC	45.07	28285833
29	Phosphorylation	ASSGPSTSPPAGATL CCCCCCCCCCCCCCH	32.97	27566939
48	Phosphorylation	EPLLRRLSESLDRAP HHHHHHHHHHHHCCC	24.27	29176673
76	Phosphorylation	SRGRLRLSGLDLEQC CCCCEEECCCCHHHC	30.76	23984901
141	Phosphorylation	KITVNPESKAVLAGQ EEEECHHHHHHHHHH	27.46	20415495
310	Phosphorylation	NDRDSQDSKKAEVTI CCCCCCCCCEEEEEE	28.55	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Hectd3	Q3U487	PMID:30741923

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MALT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MALT1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF6_MOUSE	Traf6	physical	16831874
MALT1_MOUSE	Malt1	physical	22366302

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.