dbPTM

KCC2G_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCC2G_HUMAN
UniProt AC	Q13555
Protein Name	Calcium/calmodulin-dependent protein kinase type II subunit gamma
Gene Name	CAMK2G
Organism	Homo sapiens (Human).
Sequence Length	558
Subcellular Localization	Sarcoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side .
Protein Description	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning..
Protein Sequence	MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKGRVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	CTRFTDDYQLFEELG CCCCCCCHHHHHHHC	15.21	28796482
22	Ubiquitination	QLFEELGKGAFSVVR HHHHHHCCCHHHHHH	60.74	-
26	Phosphorylation	ELGKGAFSVVRRCVK HHCCCHHHHHHHHCC	21.11	28857561
34	Ubiquitination	VVRRCVKKTSTQEYA HHHHHCCCCCCHHHH	27.58	-
35	Phosphorylation	VRRCVKKTSTQEYAA HHHHCCCCCCHHHHH	31.15	26437602
36	Phosphorylation	RRCVKKTSTQEYAAK HHHCCCCCCHHHHHH	36.65	26437602
37	Phosphorylation	RCVKKTSTQEYAAKI HHCCCCCCHHHHHHH	30.56	26437602
43	Ubiquitination	STQEYAAKIINTKKL CCHHHHHHHHHCCCC	35.63	-
57	Ubiquitination	LSARDHQKLEREARI CCHHHHHHHHHHHHH	49.23	-
69	Acetylation	ARICRLLKHPNIVRL HHHHHHHCCCCEEEE	62.70	26051181
69	Malonylation	ARICRLLKHPNIVRL HHHHHHHCCCCEEEE	62.70	26320211
69	Ubiquitination	ARICRLLKHPNIVRL HHHHHHHCCCCEEEE	62.70	-
69 (in isoform 6)	Ubiquitination	-	62.70	-
79	Phosphorylation	NIVRLHDSISEEGFH CEEEECCCCCCCCCE	19.78	24275569
114	Phosphorylation	YYSEADASHCIHQIL HHCHHHHHHHHHHHH	21.31	-
138	Ubiquitination	DIVHRDLKPENLLLA CCCCCCCCHHHHHHH	55.35	-
138 (in isoform 6)	Ubiquitination	-	55.35	-
146	Phosphorylation	PENLLLASKCKGAAV HHHHHHHHHCCCCCC	38.26	28857561
147 (in isoform 6)	Ubiquitination	-	34.07	-
182	Phosphorylation	AGTPGYLSPEVLRKD CCCCCCCCHHHHHCC	15.55	21815630
227	Acetylation	HKLYQQIKAGAYDFP HHHHHHHHHCCCCCC	36.11	132797
227	Ubiquitination	HKLYQQIKAGAYDFP HHHHHHHHHCCCCCC	36.11	21906983
227 (in isoform 1)	Ubiquitination	-	36.11	21906983
227 (in isoform 2)	Ubiquitination	-	36.11	21906983
227 (in isoform 3)	Ubiquitination	-	36.11	21906983
227 (in isoform 4)	Ubiquitination	-	36.11	21906983
227 (in isoform 5)	Ubiquitination	-	36.11	21906983
227 (in isoform 6)	Ubiquitination	-	36.11	21906983
227 (in isoform 7)	Ubiquitination	-	36.11	21906983
227 (in isoform 8)	Ubiquitination	-	36.11	21906983
227 (in isoform 9)	Ubiquitination	-	36.11	21906983
231	Phosphorylation	QQIKAGAYDFPSPEW HHHHHCCCCCCCCCH	19.73	28857561
235	Phosphorylation	AGAYDFPSPEWDTVT HCCCCCCCCCHHCCC	35.13	28857561
240	Phosphorylation	FPSPEWDTVTPEAKN CCCCCHHCCCHHHHH	27.61	28857561
246	Ubiquitination	DTVTPEAKNLINQML HCCCHHHHHHHHHHH	51.10	-
254	Phosphorylation	NLINQMLTINPAKRI HHHHHHHCCCHHHCC	17.23	29396449
259	Ubiquitination	MLTINPAKRITADQA HHCCCHHHCCCHHHH	45.66	-
259 (in isoform 6)	Ubiquitination	-	45.66	-
268	Acetylation	ITADQALKHPWVCQR CCHHHHHCCCCHHCH	51.11	25953088
268	Ubiquitination	ITADQALKHPWVCQR CCHHHHHCCCCHHCH	51.11	-
268 (in isoform 6)	Ubiquitination	-	51.11	-
276	Phosphorylation	HPWVCQRSTVASMMH CCCHHCHHHHHHHHH	11.01	19369195
277	Phosphorylation	PWVCQRSTVASMMHR CCHHCHHHHHHHHHH	23.45	23663014
280	Phosphorylation	CQRSTVASMMHRQET HCHHHHHHHHHHHHH	16.59	30183078
287	Phosphorylation	SMMHRQETVECLRKF HHHHHHHHHHHHHHH	17.17	29255136
299	Methylation	RKFNARRKLKGAILT HHHHHHHHHHHHHHH	49.34	-
301	Methylation	FNARRKLKGAILTTM HHHHHHHHHHHHHHH	49.70	-
306	Phosphorylation	KLKGAILTTMLVSRN HHHHHHHHHHHHHCC	12.21	25954137
306	Phosphorylation	KLKGAILTTMLVSRN HHHHHHHHHHHHHCC	12.21	23403867
306 (in isoform 5)	Phosphorylation	-	12.21	25954137
306 (in isoform 6)	Phosphorylation	-	12.21	25954137
307	Phosphorylation	LKGAILTTMLVSRNF HHHHHHHHHHHHCCH	12.69	22673903
307	Phosphorylation	LKGAILTTMLVSRNF HHHHHHHHHHHHCCH	12.69	23403867
307 (in isoform 5)	Phosphorylation	-	12.69	22673903
307 (in isoform 6)	Phosphorylation	-	12.69	22673903
311	Phosphorylation	ILTTMLVSRNFSAAK HHHHHHHHCCHHHHH	19.97	18691976
311	Phosphorylation	ILTTMLVSRNFSAAK HHHHHHHHCCHHHHH	19.97	22617229
311 (in isoform 5)	Phosphorylation	-	19.97	18691976
311 (in isoform 6)	Phosphorylation	-	19.97	18691976
315	Phosphorylation	MLVSRNFSAAKSLLN HHHHCCHHHHHHHHH	30.76	18691976
315	Phosphorylation	MLVSRNFSAAKSLLN HHHHCCHHHHHHHHH	30.76	28176443
315 (in isoform 5)	Phosphorylation	-	30.76	18691976
315 (in isoform 6)	Phosphorylation	-	30.76	18691976
318	Acetylation	SRNFSAAKSLLNKKS HCCHHHHHHHHHHCC	41.16	25953088
319	Phosphorylation	RNFSAAKSLLNKKSD CCHHHHHHHHHHCCC	33.10	23401153
320	Phosphorylation	NFSAAKSLLNKKSDG CHHHHHHHHHHCCCC	6.35	30266825
320 (in isoform 5)	Phosphorylation	-	6.35	30266825
320 (in isoform 6)	Phosphorylation	-	6.35	30266825
321	Phosphorylation	FSAAKSLLNKKSDGG HHHHHHHHHHCCCCC	13.09	30266825
321	Phosphorylation	FSAAKSLLNKKSDGG HHHHHHHHHHCCCCC	13.09	24719451
321 (in isoform 5)	Phosphorylation	-	13.09	30266825
321 (in isoform 6)	Phosphorylation	-	13.09	30266825
325	Phosphorylation	KSLLNKKSDGGVKKR HHHHHHCCCCCCCCC	43.00	30266825
325	Phosphorylation	KSLLNKKSDGGVKKR HHHHHHCCCCCCCCC	43.00	23663014
325 (in isoform 10)	Phosphorylation	-	43.00	23663014
325 (in isoform 11)	Phosphorylation	-	43.00	18691976
325 (in isoform 2)	Phosphorylation	-	43.00	23663014
325 (in isoform 3)	Phosphorylation	-	43.00	23663014
325 (in isoform 5)	Phosphorylation	-	43.00	30266825
325 (in isoform 6)	Phosphorylation	-	43.00	30266825
325 (in isoform 7)	Phosphorylation	-	43.00	23663014
325 (in isoform 8)	Phosphorylation	-	43.00	23663014
325 (in isoform 9)	Phosphorylation	-	43.00	23663014
329	Phosphorylation	NKKSDGGVKKRKSSS HHCCCCCCCCCCCCC	8.92	30266825
329 (in isoform 5)	Phosphorylation	-	8.92	30266825
329 (in isoform 6)	Phosphorylation	-	8.92	30266825
333	Phosphorylation	DGGVKKRKSSSSVHL CCCCCCCCCCCCEEE	64.67	-
333 (in isoform 2)	Phosphorylation	-	64.67	23663014
333 (in isoform 8)	Phosphorylation	-	64.67	23663014
333 (in isoform 9)	Phosphorylation	-	64.67	23663014
334	Phosphorylation	GGVKKRKSSSSVHLM CCCCCCCCCCCEEEC	39.21	27732954
334 (in isoform 10)	Phosphorylation	-	39.21	25627689
334 (in isoform 3)	Phosphorylation	-	39.21	25627689
334 (in isoform 7)	Phosphorylation	-	39.21	25627689
335	Phosphorylation	GVKKRKSSSSVHLMP CCCCCCCCCCEEECC	29.66	27732954
335 (in isoform 10)	Phosphorylation	-	29.66	25849741
335 (in isoform 3)	Phosphorylation	-	29.66	25849741
335 (in isoform 7)	Phosphorylation	-	29.66	25849741
336	Phosphorylation	VKKRKSSSSVHLMPQ CCCCCCCCCEEECCC	43.39	27732954
337	Phosphorylation	KKRKSSSSVHLMPQS CCCCCCCCEEECCCC	18.59	27732954
338	Phosphorylation	KRKSSSSVHLMPQSN CCCCCCCEEECCCCC	4.31	-
338 (in isoform 2)	Phosphorylation	-	4.31	18691976
338 (in isoform 8)	Phosphorylation	-	4.31	18691976
338 (in isoform 9)	Phosphorylation	-	4.31	23663014
341 (in isoform 10)	Phosphorylation	-	1.39	19369195
343	Phosphorylation	SSVHLMPQSNNKNSL CCEEECCCCCCCCCC	44.84	-
343 (in isoform 9)	Phosphorylation	-	44.84	23663014
344	Phosphorylation	SVHLMPQSNNKNSLV CEEECCCCCCCCCCC	36.18	27732954
344 (in isoform 9)	Phosphorylation	-	36.18	23663014
346	Phosphorylation	HLMPQSNNKNSLVSP EECCCCCCCCCCCCC	50.57	26055452
346	Phosphorylation	HLMPQSNNKNSLVSP EECCCCCCCCCCCCC	50.57	18691976
346 (in isoform 11)	Phosphorylation	-	50.57	19369195
346 (in isoform 5)	Phosphorylation	-	50.57	20068231
346 (in isoform 6)	Phosphorylation	-	50.57	20068231
347 (in isoform 10)	Phosphorylation	-	52.76	25159151
347 (in isoform 3)	Phosphorylation	-	52.76	22468782
347 (in isoform 7)	Phosphorylation	-	52.76	19369195
348 (in isoform 10)	Phosphorylation	-	42.57	25159151
348 (in isoform 7)	Phosphorylation	-	42.57	25849741
349	Phosphorylation	PQSNNKNSLVSPAQE CCCCCCCCCCCCCCC	31.58	19369195
350	Phosphorylation	QSNNKNSLVSPAQEP CCCCCCCCCCCCCCC	6.55	-
350 (in isoform 10)	Phosphorylation	-	6.55	25159151
350 (in isoform 7)	Phosphorylation	-	6.55	19369195
350 (in isoform 9)	Phosphorylation	-	6.55	29514088
352	Phosphorylation	NNKNSLVSPAQEPAP CCCCCCCCCCCCCCC	21.58	25159151
353 (in isoform 10)	Phosphorylation	-	30.40	30108239
353 (in isoform 7)	Phosphorylation	-	30.40	19369195
354	Phosphorylation	KNSLVSPAQEPAPLQ CCCCCCCCCCCCCCC	20.89	23663014
354	Phosphorylation	KNSLVSPAQEPAPLQ CCCCCCCCCCCCCCC	20.89	23663014
354 (in isoform 10)	Phosphorylation	-	20.89	26657352
354 (in isoform 7)	Phosphorylation	-	20.89	25627689
355 (in isoform 10)	Phosphorylation	-	61.67	25159151
355 (in isoform 5)	Phosphorylation	-	61.67	26437602
355 (in isoform 7)	Phosphorylation	-	61.67	25627689
356	Phosphorylation	SLVSPAQEPAPLQTA CCCCCCCCCCCCCCC	45.60	27251275
356 (in isoform 5)	Phosphorylation	-	45.60	22673903
356 (in isoform 9)	Phosphorylation	-	45.60	19369195
357	Phosphorylation	LVSPAQEPAPLQTAM CCCCCCCCCCCCCCC	27.39	-
357 (in isoform 5)	Phosphorylation	-	27.39	24076635
357 (in isoform 9)	Phosphorylation	-	27.39	25849741
358 (in isoform 5)	Phosphorylation	-	19.38	26437602
359	Phosphorylation	SPAQEPAPLQTAMEP CCCCCCCCCCCCCCC	35.40	18691976
359	Phosphorylation	SPAQEPAPLQTAMEP CCCCCCCCCCCCCCC	35.40	18691976
359 (in isoform 9)	Phosphorylation	-	35.40	25849741
362	Phosphorylation	QEPAPLQTAMEPQTT CCCCCCCCCCCCCEE	35.34	17192257
362 (in isoform 9)	Phosphorylation	-	35.34	25159151
363 (in isoform 9)	Phosphorylation	-	6.33	25159151
364 (in isoform 9)	Phosphorylation	-	9.79	25627689
366 (in isoform 5)	Phosphorylation	-	24.59	22673903
367 (in isoform 5)	Phosphorylation	-	36.18	22673903
367 (in isoform 7)	Phosphorylation	-	36.18	28102081
368	Phosphorylation	QTAMEPQTTVVHNAT CCCCCCCEEEEECCC	32.07	30576142
368 (in isoform 4)	Phosphorylation	-	32.07	22210691
369	Phosphorylation	TAMEPQTTVVHNATD CCCCCCEEEEECCCC	18.45	27050516
370 (in isoform 8)	Phosphorylation	-	4.72	19369195
371 (in isoform 7)	Phosphorylation	-	2.43	28102081
371 (in isoform 8)	Phosphorylation	-	2.43	25849741
372 (in isoform 7)	Phosphorylation	-	17.55	28102081
373 (in isoform 5)	Phosphorylation	-	32.69	19369195
373 (in isoform 8)	Phosphorylation	-	32.69	19369195
375	Phosphorylation	TTVVHNATDGIKGST EEEEECCCCCCCCCC	39.82	26657352
375 (in isoform 4)	Phosphorylation	-	39.82	19369195
376 (in isoform 8)	Phosphorylation	-	55.18	19369195
376 (in isoform 9)	Phosphorylation	-	55.18	28102081
377 (in isoform 8)	Phosphorylation	-	21.10	25627689
378	Phosphorylation	VHNATDGIKGSTESC EECCCCCCCCCCCCC	5.20	22210691
378 (in isoform 7)	Phosphorylation	-	5.20	24247654
378 (in isoform 8)	Phosphorylation	-	5.20	25627689
379 (in isoform 5)	Phosphorylation	-	52.95	25159151
380 (in isoform 5)	Phosphorylation	-	37.57	25159151
380 (in isoform 9)	Phosphorylation	-	37.57	28102081
381	Phosphorylation	ATDGIKGSTESCNTT CCCCCCCCCCCCCCC	24.81	25159151
381 (in isoform 4)	Phosphorylation	-	24.81	25159151
381 (in isoform 9)	Phosphorylation	-	24.81	28102081
382	Phosphorylation	TDGIKGSTESCNTTT CCCCCCCCCCCCCCC	40.35	30278072
382 (in isoform 4)	Phosphorylation	-	40.35	25159151
382 (in isoform 5)	Phosphorylation	-	40.35	25159151
384	Phosphorylation	GIKGSTESCNTTTED CCCCCCCCCCCCCCC	16.86	23401153
384 (in isoform 4)	Phosphorylation	-	16.86	25159151
385	Phosphorylation	IKGSTESCNTTTEDE CCCCCCCCCCCCCCH	4.22	19369195
385	Phosphorylation	IKGSTESCNTTTEDE CCCCCCCCCCCCCCH	4.22	18691976
385 (in isoform 5)	Phosphorylation	-	4.22	30108239
386 (in isoform 5)	Phosphorylation	-	50.14	26657352
387	Phosphorylation	GSTESCNTTTEDEDL CCCCCCCCCCCCHHH	39.15	23927012
387 (in isoform 4)	Phosphorylation	-	39.15	30108239
387 (in isoform 5)	Phosphorylation	-	39.15	25159151
387 (in isoform 9)	Phosphorylation	-	39.15	24247654
388	Phosphorylation	STESCNTTTEDEDLK CCCCCCCCCCCHHHC	17.75	19060867
388	Phosphorylation	STESCNTTTEDEDLK CCCCCCCCCCCHHHC	17.75	25159151
388 (in isoform 4)	Phosphorylation	-	17.75	26657352
389	Phosphorylation	TESCNTTTEDEDLKG CCCCCCCCCCHHHCC	39.13	25262027
389 (in isoform 4)	Phosphorylation	-	39.13	25159151
390 (in isoform 8)	Phosphorylation	-	58.26	28102081
391	Phosphorylation	SCNTTTEDEDLKGRV CCCCCCCCHHHCCCC	53.25	25159151
391	Phosphorylation	SCNTTTEDEDLKGRV CCCCCCCCHHHCCCC	53.25	18691976
392	Phosphorylation	CNTTTEDEDLKGRVP CCCCCCCHHHCCCCC	60.04	25159151
392	Phosphorylation	CNTTTEDEDLKGRVP CCCCCCCHHHCCCCC	60.04	-
394	Phosphorylation	TTTEDEDLKGRVPEG CCCCCHHHCCCCCCC	4.38	25159151
394	Phosphorylation	TTTEDEDLKGRVPEG CCCCCHHHCCCCCCC	4.38	18691976
394 (in isoform 8)	Phosphorylation	-	4.38	28102081
395 (in isoform 8)	Phosphorylation	-	54.82	28102081
397	Phosphorylation	EDEDLKGRVPEGRSS CCHHHCCCCCCCCCC	51.67	30108239
398	Phosphorylation	DEDLKGRVPEGRSSR CHHHCCCCCCCCCCC	31.96	26657352
398	Phosphorylation	DEDLKGRVPEGRSSR CHHHCCCCCCCCCCC	31.96	-
399	Phosphorylation	EDLKGRVPEGRSSRD HHHCCCCCCCCCCCC	42.37	25159151
401 (in isoform 8)	Phosphorylation	-	37.85	24247654
402 (in isoform 6)	Phosphorylation	-	29.78	19369195
403 (in isoform 6)	Phosphorylation	-	40.35	25849741
405 (in isoform 6)	Phosphorylation	-	38.38	19369195
408	Phosphorylation	GRSSRDRTAPSAGMQ CCCCCCCCCCCCCCC	47.40	27080861
408 (in isoform 6)	Phosphorylation	-	47.40	19369195
409 (in isoform 6)	Phosphorylation	-	9.28	25627689
410 (in isoform 6)	Phosphorylation	-	24.89	25627689
419	Phosphorylation	AGMQPQPSLCSSAMR CCCCCCHHHCCHHHH	36.44	21082442
422	Phosphorylation	QPQPSLCSSAMRKQE CCCHHHCCHHHHHHH	26.82	29978859
422 (in isoform 6)	Phosphorylation	-	26.82	28102081
423	Phosphorylation	PQPSLCSSAMRKQEI CCHHHCCHHHHHHHH	25.70	29978859
426 (in isoform 6)	Phosphorylation	-	36.90	28102081
427 (in isoform 6)	Phosphorylation	-	38.92	28102081
433 (in isoform 6)	Phosphorylation	-	3.45	24247654
484	Phosphorylation	FYFENLLSKNSKPIH HHHHHHHCCCCCCCE	32.72	-
515	Phosphorylation	CIAYIRLTQYIDGQG HHHHHHHHHEECCCC	14.96	28152594
517	Phosphorylation	AYIRLTQYIDGQGRP HHHHHHHEECCCCCC	8.85	28152594
547	Phosphorylation	GKWLNVHYHCSGAPA CCEEEEEEEECCCCC	10.55	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
280	S	Phosphorylation	Kinase	CAMK2G	Q13555	PSP
287	T	Phosphorylation	Kinase	CAMK2B	Q13554	PSP
319	S	Phosphorylation	Kinase	CAMK2G	Q13555	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
287	T	Phosphorylation	16690701
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin.
287	T	Phosphorylation	16690701
Phosphorylation of Thr-287 locks the kinase into an activated state.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCC2G_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD_HUMAN	RRAD	physical	9115241
SMAD2_HUMAN	SMAD2	physical	11027280
SMAD4_HUMAN	SMAD4	physical	11027280
ZN363_HUMAN	RCHY1	physical	17568776
NMDZ1_HUMAN	GRIN1	physical	9670010
NMDE2_HUMAN	GRIN2B	physical	9670010
RAD_HUMAN	RRAD	physical	9677319
STMN1_HUMAN	STMN1	physical	21768358
DDX11_HUMAN	DDX11	physical	26344197
PDLI5_HUMAN	PDLIM5	physical	26344197
SBDS_HUMAN	SBDS	physical	26344197
FLNA_HUMAN	FLNA	physical	25241761
SMAD3_HUMAN	SMAD3	physical	25241761

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
DB06616	Bosutinib

Regulatory Network of KCC2G_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287; THR-307; SER-311;SER-315; SER-319; SER-325; SER-349; SER-352; THR-375; SER-381;THR-382; SER-384; THR-387; THR-388 AND SER-419, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325 AND SER-349, ANDMASS SPECTROMETRY.	18691976 [Abstract]
"Proteomics analysis of protein kinases by target class-selectiveprefractionation and tandem mass spectrometry."; Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R.,Keri G., Wehland J., Daub H.; Mol. Cell. Proteomics 6:537-547(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315 AND SER-319, ANDMASS SPECTROMETRY.	17192257 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Ca2+-calmodulin-dependent protein kinase expression and signalling inskeletal muscle during exercise."; Rose A.J., Kiens B., Richter E.A.; J. Physiol. (Lond.) 574:889-903(2006). Cited for: FUNCTION IN SKELETAL MUSCLE, PHOSPHORYLATION AT THR-287, FUNCTION INPHOSPHORYLATION OF PLN, TISSUE SPECIFICITY, AND INDUCTION.	16690701 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287, AND MASSSPECTROMETRY.	17081983 [Abstract]

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