RAD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAD_HUMAN
• UniProt AC: P55042
• Protein Name: GTP-binding protein RAD
• Gene Name: RRAD
• Organism: Homo sapiens (Human).
• Sequence Length: 308
• Subcellular Localization: Cell membrane.
• Protein Description: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D..
• Protein Sequence: MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAAAGTGTQGPRLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTLNGGGSG ------CCCCCCCCC	29.00	29396449
14	Methylation	GSGAGGSRGGGQERE CCCCCCCCCCCCCCC	51.56	115385907
24	Methylation	GQERERRRGSTPWGP CCCCCCCCCCCCCCC	50.03	-
26	Phosphorylation	ERERRRGSTPWGPAP CCCCCCCCCCCCCCC	29.50	27966365
27	Phosphorylation	RERRRGSTPWGPAPP CCCCCCCCCCCCCCC	26.36	27966365
39	Phosphorylation	APPLHRRSMPVDERD CCCCCCCCCCCCHHH	27.65	28355574
52	Phosphorylation	RDLQAALTPGALTAA HHHHHHCCHHHHHHH	18.23	28450419
57	Phosphorylation	ALTPGALTAAAAGTG HCCHHHHHHHHCCCC	17.45	28857561
63	Phosphorylation	LTAAAAGTGTQGPRL HHHHHCCCCCCCCCC	32.12	28857561
65	Phosphorylation	AAAAGTGTQGPRLDW HHHCCCCCCCCCCCC	30.14	28857561
76	Phosphorylation	RLDWPEDSEDSLSSG CCCCCCCCCCHHHCC	41.46	23090842
79	Phosphorylation	WPEDSEDSLSSGGSD CCCCCCCHHHCCCCC	26.54	23090842
81	Phosphorylation	EDSEDSLSSGGSDSD CCCCCHHHCCCCCCH	30.78	23090842
82	Phosphorylation	DSEDSLSSGGSDSDE CCCCHHHCCCCCCHH	53.09	26657352
85	Phosphorylation	DSLSSGGSDSDESVY CHHHCCCCCCHHHHH	37.15	23090842
87	Phosphorylation	LSSGGSDSDESVYKV HHCCCCCCHHHHHHH	45.00	23090842
90	Phosphorylation	GGSDSDESVYKVLLL CCCCCHHHHHHHHHH	35.42	23090842
92	Phosphorylation	SDSDESVYKVLLLGA CCCHHHHHHHHHHCC	12.50	23090842
204	Ubiquitination	PIILVGNKSDLVRSR CEEEECCHHHHHHCE	39.14	-
205	Phosphorylation	IILVGNKSDLVRSRE EEEECCHHHHHHCEE	39.93	22199227
214	Phosphorylation	LVRSREVSVDEGRAC HHHCEEEECCCCCEE	21.06	22817900
257	Phosphorylation	QIRLRRDSKEANARR HHHHHCCCHHHHHHH	30.50	7876254
273	Phosphorylation	AGTRRRESLGKKAKR HHHHHHHHHHHHHHH	40.38	7876254
290	Phosphorylation	GRIVARNSRKMAFRA HHHHHHCHHHHHHHC	27.94	22817900
299	Phosphorylation	KMAFRAKSKSCHDLS HHHHHCCCCCCCCCC	28.90	22617229
301	Phosphorylation	AFRAKSKSCHDLSVL HHHCCCCCCCCCCCC	24.63	30266825
306	Phosphorylation	SKSCHDLSVL----- CCCCCCCCCC-----	27.68	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
214	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
214	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
214	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
214	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
214	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
257	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
257	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
257	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
257	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
273	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
273	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
273	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
273	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
273	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
273	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
273	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
273	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
290	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
290	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
290	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
290	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
299	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
299	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
299	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
299	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPM2_HUMAN	TPM2	physical	8557685
TPM2_MOUSE	Tpm2	physical	8557685
NDKA_HUMAN	NME1	physical	10611312
EGFR_HUMAN	EGFR	physical	25313011
STAT3_HUMAN	STAT3	physical	25313011
EEA1_HUMAN	EEA1	physical	25313011

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.