dbPTM

TPM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TPM2_HUMAN
UniProt AC	P07951
Protein Name	Tropomyosin beta chain
Gene Name	TPM2
Organism	Homo sapiens (Human).
Sequence Length	284
Subcellular Localization	Cytoplasm, cytoskeleton . Associates with F-actin stress fibers.
Protein Description	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization..
Protein Sequence	MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDAIKKKM -------CHHHHHHH	7.68	-
12	Acetylation	KKKMQMLKLDKENAI HHHHHHHHCCHHHHH	49.66	22632943
12	Ubiquitination	KKKMQMLKLDKENAI HHHHHHHHCCHHHHH	49.66	-
29	Acetylation	AEQAEADKKQAEDRC HHHHHHHHHHHHHHH	54.56	7671341
30	Ubiquitination	EQAEADKKQAEDRCK HHHHHHHHHHHHHHH	56.11	21906983
30 (in isoform 1)	Ubiquitination	-	56.11	21890473
30 (in isoform 2)	Ubiquitination	-	56.11	21890473
36	Glutathionylation	KKQAEDRCKQLEEEQ HHHHHHHHHHHHHHH	5.22	22555962
37	Ubiquitination	KQAEDRCKQLEEEQQ HHHHHHHHHHHHHHH	59.83	-
37 (in isoform 2)	Ubiquitination	-	59.83	-
48	Acetylation	EEQQALQKKLKGTED HHHHHHHHHHCCCHH	62.01	7668171
48	Ubiquitination	EEQQALQKKLKGTED HHHHHHHHHHCCCHH	62.01	21906983
48 (in isoform 1)	Ubiquitination	-	62.01	21890473
48 (in isoform 2)	Ubiquitination	-	62.01	21890473
51	Ubiquitination	QALQKKLKGTEDEVE HHHHHHHCCCHHHHH	73.07	21906983
51 (in isoform 1)	Ubiquitination	-	73.07	21890473
51 (in isoform 2)	Ubiquitination	-	73.07	21890473
53	Phosphorylation	LQKKLKGTEDEVEKY HHHHHCCCHHHHHHH	38.38	24692096
59	Ubiquitination	GTEDEVEKYSESVKE CCHHHHHHHHHHHHH	60.29	-
60	Phosphorylation	TEDEVEKYSESVKEA CHHHHHHHHHHHHHH	12.26	26437602
61	Phosphorylation	EDEVEKYSESVKEAQ HHHHHHHHHHHHHHH	34.17	26437602
63	Phosphorylation	EVEKYSESVKEAQEK HHHHHHHHHHHHHHH	32.33	26437602
65	Ubiquitination	EKYSESVKEAQEKLE HHHHHHHHHHHHHHH	57.52	21906983
65 (in isoform 1)	Ubiquitination	-	57.52	21890473
65 (in isoform 2)	Ubiquitination	-	57.52	21890473
76	Acetylation	EKLEQAEKKATDAEA HHHHHHHHHHHHHHH	51.20	7668181
77	Ubiquitination	KLEQAEKKATDAEAD HHHHHHHHHHHHHHH	48.28	-
79	Phosphorylation	EQAEKKATDAEADVA HHHHHHHHHHHHHHH	44.62	23403867
82 (in isoform 3)	Ubiquitination	-	48.49	21890473
87	Phosphorylation	DAEADVASLNRRIQL HHHHHHHHHHHHHHH	26.48	19664994
108	Phosphorylation	RAQERLATALQKLEE HHHHHHHHHHHHHHH	32.28	24692096
112	Acetylation	RLATALQKLEEAEKA HHHHHHHHHHHHHHH	59.73	22632937
112	Ubiquitination	RLATALQKLEEAEKA HHHHHHHHHHHHHHH	59.73	-
112 (in isoform 2)	Ubiquitination	-	59.73	-
113 (in isoform 3)	Ubiquitination	-	4.66	21890473
118	Acetylation	QKLEEAEKAADESER HHHHHHHHHHHHHHH	56.79	88209
118	Ubiquitination	QKLEEAEKAADESER HHHHHHHHHHHHHHH	56.79	21906983
118 (in isoform 1)	Ubiquitination	-	56.79	21890473
118 (in isoform 2)	Ubiquitination	-	56.79	21890473
123	Phosphorylation	AEKAADESERGMKVI HHHHHHHHHHHHHHH	32.89	26437602
128	Sumoylation	DESERGMKVIENRAM HHHHHHHHHHHHHHC	42.77	-
128	Sumoylation	DESERGMKVIENRAM HHHHHHHHHHHHHHC	42.77	-
128	Ubiquitination	DESERGMKVIENRAM HHHHHHHHHHHHHHC	42.77	-
128 (in isoform 2)	Ubiquitination	-	42.77	-
132 (in isoform 3)	Ubiquitination	-	26.36	21890473
136	Ubiquitination	VIENRAMKDEEKMEL HHHHHHCCHHHHHHH	62.09	-
140	Acetylation	RAMKDEEKMELQEMQ HHCCHHHHHHHHHHH	35.31	7684549
149	Acetylation	ELQEMQLKEAKHIAE HHHHHHHHHHHHHHC	38.44	23236377
149	Ubiquitination	ELQEMQLKEAKHIAE HHHHHHHHHHHHHHC	38.44	21890473
149 (in isoform 1)	Ubiquitination	-	38.44	21890473
149 (in isoform 2)	Ubiquitination	-	38.44	21890473
152	Acetylation	EMQLKEAKHIAEDSD HHHHHHHHHHHCCCC	36.31	26210075
152	Ubiquitination	EMQLKEAKHIAEDSD HHHHHHHHHHHCCCC	36.31	-
152 (in isoform 2)	Ubiquitination	-	36.31	-
158	Phosphorylation	AKHIAEDSDRKYEEV HHHHHCCCCHHHHHH	30.71	24692096
162	Phosphorylation	AEDSDRKYEEVARKL HCCCCHHHHHHHHHH	20.44	28796482
163 (in isoform 3)	Phosphorylation	-	49.37	20068231
168	Ubiquitination	KYEEVARKLVILEGE HHHHHHHHHHHHHCH	37.05	-
168 (in isoform 1)	Ubiquitination	-	37.05	21890473
168 (in isoform 2)	Ubiquitination	-	37.05	21890473
170 (in isoform 3)	Phosphorylation	-	5.42	27499020
174 (in isoform 3)	Phosphorylation	-	41.15	27499020
178 (in isoform 3)	Phosphorylation	-	63.09	26657352
179	Phosphorylation	LEGELERSEERAEVA HHCHHHCHHHHHHHH	34.14	26437602
179 (in isoform 3)	Phosphorylation	-	34.14	26657352
188	Phosphorylation	ERAEVAESKCGDLEE HHHHHHHHHCCCHHH	24.41	26437602
190	Glutathionylation	AEVAESKCGDLEEEL HHHHHHHCCCHHHHH	7.74	22555962
198	Ubiquitination	GDLEEELKIVTNNLK CCHHHHHHHHHHHHH	38.11	-
199 (in isoform 2)	Phosphorylation	-	7.84	20068231
201	Phosphorylation	EEELKIVTNNLKSLE HHHHHHHHHHHHHHH	23.12	26437602
205	Ubiquitination	KIVTNNLKSLEAQAD HHHHHHHHHHHHHHH	55.93	2190698
205 (in isoform 1)	Ubiquitination	-	55.93	21890473
205 (in isoform 2)	Ubiquitination	-	55.93	-
206	Phosphorylation	IVTNNLKSLEAQADK HHHHHHHHHHHHHHH	34.31	24692096
206 (in isoform 2)	Phosphorylation	-	34.31	27499020
210 (in isoform 2)	Phosphorylation	-	40.49	27499020
213	Acetylation	SLEAQADKYSTKEDK HHHHHHHHCCCHHHH	44.08	23236377
213	Ubiquitination	SLEAQADKYSTKEDK HHHHHHHHCCCHHHH	44.08	-
214	Phosphorylation	LEAQADKYSTKEDKY HHHHHHHCCCHHHHH	23.32	26437602
214 (in isoform 2)	Phosphorylation	-	23.32	26657352
215	Phosphorylation	EAQADKYSTKEDKYE HHHHHHCCCHHHHHH	38.45	25159151
215 (in isoform 2)	Phosphorylation	-	38.45	26657352
215 (in isoform 3)	Ubiquitination	-	38.45	21890473
216	Phosphorylation	AQADKYSTKEDKYEE HHHHHCCCHHHHHHH	35.05	26437602
216 (in isoform 3)	Phosphorylation	-	35.05	30266825
220	Acetylation	KYSTKEDKYEEEIKL HCCCHHHHHHHHHHH	56.50	22632931
220	Methylation	KYSTKEDKYEEEIKL HCCCHHHHHHHHHHH	56.50	22632931
220	Ubiquitination	KYSTKEDKYEEEIKL HCCCHHHHHHHHHHH	56.50	-
221	Phosphorylation	YSTKEDKYEEEIKLL CCCHHHHHHHHHHHH	40.68	26437602
223 (in isoform 3)	Phosphorylation	-	63.03	30266825
226	Ubiquitination	DKYEEEIKLLEEKLK HHHHHHHHHHHHHHH	50.75	-
226 (in isoform 3)	Phosphorylation	-	50.75	30266825
231	Ubiquitination	EIKLLEEKLKEAETR HHHHHHHHHHHHHHH	56.32	-
233	Ubiquitination	KLLEEKLKEAETRAE HHHHHHHHHHHHHHH	66.98	-
237	Phosphorylation	EKLKEAETRAEFAER HHHHHHHHHHHHHHH	42.08	26437602
245	Phosphorylation	RAEFAERSVAKLEKT HHHHHHHHHHHHHHH	20.24	26437602
248	Acetylation	FAERSVAKLEKTIDD HHHHHHHHHHHHHHH	55.83	30996315
248	Ubiquitination	FAERSVAKLEKTIDD HHHHHHHHHHHHHHH	55.83	-
251	Ubiquitination	RSVAKLEKTIDDLED HHHHHHHHHHHHHHH	62.31	-
251 (in isoform 2)	Ubiquitination	-	62.31	21890473
252	Phosphorylation	SVAKLEKTIDDLEDE HHHHHHHHHHHHHHH	21.91	24692096
252 (in isoform 2)	Phosphorylation	-	21.91	30266825
259 (in isoform 2)	Phosphorylation	-	28.22	30266825
261	Phosphorylation	DDLEDEVYAQKMKYK HHHHHHHHHHHHHHH	10.98	19764811
262 (in isoform 2)	Phosphorylation	-	14.00	30266825
267	Phosphorylation	VYAQKMKYKAISEEL HHHHHHHHHHHHHHH	11.36	-
268	Ubiquitination	YAQKMKYKAISEELD HHHHHHHHHHHHHHH	33.45	-
271	Phosphorylation	KMKYKAISEELDNAL HHHHHHHHHHHHHHH	29.85	26437602
282	Phosphorylation	DNALNDITSL----- HHHHHHHHCC-----	27.17	29632367
283	Phosphorylation	NALNDITSL------ HHHHHHHCC------	32.20	24692096

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
61	S	Phosphorylation	Kinase	PIK3CG	P48736	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
61	S	Phosphorylation	-
Phosphorylated on Ser-61 by PIK3CG.
61	S	Phosphorylation	-
Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TPM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPM2_HUMAN	TPM2	physical	7568216
RAD_HUMAN	RRAD	physical	8557685
TPM1_HUMAN	TPM1	physical	3857586
TPM2_HUMAN	TPM2	physical	3857586
ACTS_HUMAN	ACTA1	physical	17194691
TPM4_HUMAN	TPM4	physical	22939629
TPM3_HUMAN	TPM3	physical	22939629
HECD1_HUMAN	HECTD1	physical	22863883
ACTN1_HUMAN	ACTN1	physical	26344197
ACTN4_HUMAN	ACTN4	physical	26344197
KCRU_HUMAN	CKMT1B	physical	26344197
PSMD5_HUMAN	PSMD5	physical	26344197

Drug and Disease Associations

Kegg Disease
OMIM Disease
609285	Nemaline myopathy 4 (NEM4)
108120	Arthrogryposis, distal, 1A (DA1A)
609285	Cap myopathy 2 (CAPM2)
601680	Arthrogryposis, distal, 2B (DA2B)
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TPM2_HUMAN

Related Literatures of Post-Translational Modification

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