dbPTM

ACTN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACTN4_HUMAN
UniProt AC	O43707
Protein Name	Alpha-actinin-4 {ECO:0000305}
Gene Name	ACTN4 {ECO:0000312\|HGNC:HGNC:166}
Organism	Homo sapiens (Human).
Sequence Length	911
Subcellular Localization	Nucleus . Cytoplasm . Cell junction . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclus
Protein Description	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. [PubMed: 15772161 Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA]
Protein Sequence	MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVDYHAANQSY ----CCCCCCCCCCC	5.07	22996817
10	Phosphorylation	DYHAANQSYQYGPSS CCCCCCCCCCCCCCC	17.63	24043423
11	Phosphorylation	YHAANQSYQYGPSSA CCCCCCCCCCCCCCC	8.94	26552605
13	Phosphorylation	AANQSYQYGPSSAGN CCCCCCCCCCCCCCC	23.83	26552605
16	Phosphorylation	QSYQYGPSSAGNGAG CCCCCCCCCCCCCCC	28.58	26552605
17	Phosphorylation	SYQYGPSSAGNGAGG CCCCCCCCCCCCCCC	43.24	27251275
27	Phosphorylation	NGAGGGGSMGDYMAQ CCCCCCCCHHHHHCC	23.90	27251275
31	Phosphorylation	GGGSMGDYMAQEDDW CCCCHHHHHCCCCCC	6.66	26552605
50	Malonylation	LLDPAWEKQQRKTFT CCCHHHHHHHHHHHH	40.82	26320211
50	Ubiquitination	LLDPAWEKQQRKTFT CCCHHHHHHHHHHHH	40.82	-
54	Ubiquitination	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	21890473
54	Acetylation	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	26051181
54	Malonylation	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	26320211
54	Ubiquitination	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	-
55	Phosphorylation	WEKQQRKTFTAWCNS HHHHHHHHHHHHHHH	28.54	26437602
57	Phosphorylation	KQQRKTFTAWCNSHL HHHHHHHHHHHHHHH	25.20	26437602
62	Phosphorylation	TFTAWCNSHLRKAGT HHHHHHHHHHHHHCC	22.29	26437602
66	Acetylation	WCNSHLRKAGTQIEN HHHHHHHHHCCCCCC	58.49	26051181
66	Malonylation	WCNSHLRKAGTQIEN HHHHHHHHHCCCCCC	58.49	26320211
66	Ubiquitination	WCNSHLRKAGTQIEN HHHHHHHHHCCCCCC	58.49	-
69	Phosphorylation	SHLRKAGTQIENIDE HHHHHHCCCCCCCCH	31.10	25849741
83	Ubiquitination	EDFRDGLKLMLLLEV HHHHHHHHHHHHHHH	37.06	-
85	Sulfoxidation	FRDGLKLMLLLEVIS HHHHHHHHHHHHHHC	2.07	30846556
92	Phosphorylation	MLLLEVISGERLPKP HHHHHHHCCCCCCCC	39.51	-
95 (in isoform 3)	Phosphorylation	-	60.87	24905233
96 (in isoform 3)	Phosphorylation	-	5.79	24905233
98 (in isoform 3)	Phosphorylation	-	65.19	24905233
103 (in isoform 3)	Phosphorylation	-	29.74	24905233
108	Ubiquitination	RGKMRVHKINNVNKA CCCCCEEECCCHHHH	44.25	-
112	Ubiquitination	RVHKINNVNKALDFI CEEECCCHHHHHHHH	7.22	-
114	Acetylation	HKINNVNKALDFIAS EECCCHHHHHHHHHH	46.15	19608861
121	Phosphorylation	KALDFIASKGVKLVS HHHHHHHHCCCEEEE	25.73	63745159
122	Acetylation	ALDFIASKGVKLVSI HHHHHHHCCCEEEEE	59.71	27452117
122	Succinylation	ALDFIASKGVKLVSI HHHHHHHCCCEEEEE	59.71	23954790
122	Ubiquitination	ALDFIASKGVKLVSI HHHHHHHCCCEEEEE	59.71	-
125	Acetylation	FIASKGVKLVSIGAE HHHHCCCEEEEECCH	52.41	26051181
125	Ubiquitination	FIASKGVKLVSIGAE HHHHCCCEEEEECCH	52.41	-
128	Phosphorylation	SKGVKLVSIGAEEIV HCCCEEEEECCHHEE	26.24	28348404
131	Ubiquitination	VKLVSIGAEEIVDGN CEEEEECCHHEECCC	15.02	21906983
142	Phosphorylation	VDGNAKMTLGMIWTI ECCCCHHHHHHHHHH	21.32	-
159	Phosphorylation	RFAIQDISVEETSAK HHHHHCCCCCCCCHH	31.59	19664994
163	Phosphorylation	QDISVEETSAKEGLL HCCCCCCCCHHHCCH	22.07	23927012
164	Phosphorylation	DISVEETSAKEGLLL CCCCCCCCHHHCCHH	40.39	23927012
173	Glutathionylation	KEGLLLWCQRKTAPY HHCCHHHHCCCCCCC	2.57	22555962
173	S-palmitoylation	KEGLLLWCQRKTAPY HHCCHHHHCCCCCCC	2.57	29575903
181	Malonylation	QRKTAPYKNVNVQNF CCCCCCCCCCCCCEE	54.05	26320211
181	Ubiquitination	QRKTAPYKNVNVQNF CCCCCCCCCCCCCEE	54.05	21890473
191	Phosphorylation	NVQNFHISWKDGLAF CCCEEEEECCCCHHH	21.36	28857561
202	Ubiquitination	GLAFNALIHRHRPEL CHHHHHHHHHCCHHH	2.20	21906983
212	Phosphorylation	HRPELIEYDKLRKDD CCHHHHCHHHCCCCC	16.04	119481
214	Acetylation	PELIEYDKLRKDDPV HHHHCHHHCCCCCCC	49.65	25825284
214	Malonylation	PELIEYDKLRKDDPV HHHHCHHHCCCCCCC	49.65	26320211
214	Ubiquitination	PELIEYDKLRKDDPV HHHHCHHHCCCCCCC	49.65	19608861
217	Acetylation	IEYDKLRKDDPVTNL HCHHHCCCCCCCCCC	76.54	26051181
217	Malonylation	IEYDKLRKDDPVTNL HCHHHCCCCCCCCCC	76.54	26320211
217	Succinylation	IEYDKLRKDDPVTNL HCHHHCCCCCCCCCC	76.54	23954790
217	Ubiquitination	IEYDKLRKDDPVTNL HCHHHCCCCCCCCCC	76.54	-
233	Acetylation	NAFEVAEKYLDIPKM HHHHHHHHHCCCCCC	41.18	25825284
233	Ubiquitination	NAFEVAEKYLDIPKM HHHHHHHHHCCCCCC	41.18	21906983
234	Phosphorylation	AFEVAEKYLDIPKML HHHHHHHHCCCCCCC	10.91	23403867
235	Ubiquitination	FEVAEKYLDIPKMLD HHHHHHHCCCCCCCC	7.73	21890473
239	Ubiquitination	EKYLDIPKMLDAEDI HHHCCCCCCCCHHHH	53.05	-
240	Sulfoxidation	KYLDIPKMLDAEDIV HHCCCCCCCCHHHHH	3.25	30846556
242	Ubiquitination	LDIPKMLDAEDIVNT CCCCCCCCHHHHHHC	44.40	21890473
249	Phosphorylation	DAEDIVNTARPDEKA CHHHHHHCCCCCHHH	17.10	28857561
255	Ubiquitination	NTARPDEKAIMTYVS HCCCCCHHHHHHHHH	51.06	-
258	Sulfoxidation	RPDEKAIMTYVSSFY CCCHHHHHHHHHHHH	2.36	30846556
259	Phosphorylation	PDEKAIMTYVSSFYH CCHHHHHHHHHHHHH	18.04	28152594
260	Phosphorylation	DEKAIMTYVSSFYHA CHHHHHHHHHHHHHH	4.87	28152594
262	Phosphorylation	KAIMTYVSSFYHAFS HHHHHHHHHHHHHHH	12.33	26657352
263	Phosphorylation	AIMTYVSSFYHAFSG HHHHHHHHHHHHHHC	21.56	28152594
265	Phosphorylation	MTYVSSFYHAFSGAQ HHHHHHHHHHHHCHH	8.32	22617229
269	Phosphorylation	SSFYHAFSGAQKAET HHHHHHHHCHHHHHH	33.72	22617229
276	Phosphorylation	SGAQKAETAANRICK HCHHHHHHHHHHHHH	35.61	25348954
280	Methylation	KAETAANRICKVLAV HHHHHHHHHHHHHHH	30.84	-
283	Acetylation	TAANRICKVLAVNQE HHHHHHHHHHHHCCC	37.60	25825284
295	Sulfoxidation	NQENEHLMEDYEKLA CCCCHHHHHHHHHHH	3.87	30846556
298	Phosphorylation	NEHLMEDYEKLASDL CHHHHHHHHHHHHHH	11.14	110736575
303	Phosphorylation	EDYEKLASDLLEWIR HHHHHHHHHHHHHHH	38.95	23403867
310	Methylation	SDLLEWIRRTIPWLE HHHHHHHHHHCHHHH	30.66	-
312	Phosphorylation	LLEWIRRTIPWLEDR HHHHHHHHCHHHHHC	22.88	21406692
319	Methylation	TIPWLEDRVPQKTIQ HCHHHHHCCCHHHHH	32.42	-
323	Acetylation	LEDRVPQKTIQEMQQ HHHCCCHHHHHHHHH	41.34	26051181
323	Malonylation	LEDRVPQKTIQEMQQ HHHCCCHHHHHHHHH	41.34	26320211
323	Ubiquitination	LEDRVPQKTIQEMQQ HHHCCCHHHHHHHHH	41.34	-
324	Phosphorylation	EDRVPQKTIQEMQQK HHCCCHHHHHHHHHH	23.73	62150667
328	Sulfoxidation	PQKTIQEMQQKLEDF CHHHHHHHHHHHHHH	2.68	30846556
331	Acetylation	TIQEMQQKLEDFRDY HHHHHHHHHHHHHHH	36.63	25825284
331	Ubiquitination	TIQEMQQKLEDFRDY HHHHHHHHHHHHHHH	36.63	-
338	Phosphorylation	KLEDFRDYRRVHKPP HHHHHHHHHHHCCCC	8.96	28152594
346	Ubiquitination	RRVHKPPKVQEKCQL HHHCCCCCHHHCEEE	66.14	-
350	Acetylation	KPPKVQEKCQLEINF CCCCHHHCEEEEEEC	15.36	26051181
350	Ubiquitination	KPPKVQEKCQLEINF CCCCHHHCEEEEEEC	15.36	21906983
351	Glutathionylation	PPKVQEKCQLEINFN CCCHHHCEEEEEECC	5.70	22555962
351	S-nitrosylation	PPKVQEKCQLEINFN CCCHHHCEEEEEECC	5.70	22178444
351	S-palmitoylation	PPKVQEKCQLEINFN CCCHHHCEEEEEECC	5.70	29575903
359	Phosphorylation	QLEINFNTLQTKLRL EEEEECCHHHHHHHH	18.99	26657352
362	Phosphorylation	INFNTLQTKLRLSNR EECCHHHHHHHHHCC	34.85	21712546
367	Phosphorylation	LQTKLRLSNRPAFMP HHHHHHHHCCCCCCC	25.10	54885953
375	Phosphorylation	NRPAFMPSEGKMVSD CCCCCCCCCCCCCCC	47.39	26437602
378	Ubiquitination	AFMPSEGKMVSDINN CCCCCCCCCCCCCCC	31.88	21906983
379	Sulfoxidation	FMPSEGKMVSDINNG CCCCCCCCCCCCCCC	5.26	30846556
381	Phosphorylation	PSEGKMVSDINNGWQ CCCCCCCCCCCCCHH	29.31	28857561
385	Ubiquitination	KMVSDINNGWQHLEQ CCCCCCCCCHHHHHH	54.11	-
397	Phosphorylation	LEQAEKGYEEWLLNE HHHHHHHHHHHHHHH	23.03	110736583
403	Ubiquitination	GYEEWLLNEIRRLER HHHHHHHHHHHHHHH	40.24	-
406	Acetylation	EWLLNEIRRLERLDH HHHHHHHHHHHHHHH	30.84	-
406	Ubiquitination	EWLLNEIRRLERLDH HHHHHHHHHHHHHHH	30.84	-
413	Ubiquitination	RRLERLDHLAEKFRQ HHHHHHHHHHHHHHH	31.37	-
417	Acetylation	RLDHLAEKFRQKASI HHHHHHHHHHHHHHH	39.99	25825284
417	Malonylation	RLDHLAEKFRQKASI HHHHHHHHHHHHHHH	39.99	26320211
417	Ubiquitination	RLDHLAEKFRQKASI HHHHHHHHHHHHHHH	39.99	19608861
421	Ubiquitination	LAEKFRQKASIHEAW HHHHHHHHHHHHHHH	39.58	21890473
423	Phosphorylation	EKFRQKASIHEAWTD HHHHHHHHHHHHHCC	31.36	28355574
429	Phosphorylation	ASIHEAWTDGKEAML HHHHHHHCCHHHHHH	41.75	26074081
432	Acetylation	HEAWTDGKEAMLKHR HHHHCCHHHHHHHCC	45.14	26051181
432	Ubiquitination	HEAWTDGKEAMLKHR HHHHCCHHHHHHHCC	45.14	-
437	Acetylation	DGKEAMLKHRDYETA CHHHHHHHCCCCCCC	24.41	25953088
441	Phosphorylation	AMLKHRDYETATLSD HHHHCCCCCCCCHHH	18.35	28152594
443	Phosphorylation	LKHRDYETATLSDIK HHCCCCCCCCHHHHH	20.79	28152594
445	Phosphorylation	HRDYETATLSDIKAL CCCCCCCCHHHHHHH	33.93	28152594
447	Phosphorylation	DYETATLSDIKALIR CCCCCCHHHHHHHHH	32.70	7303209
450	Acetylation	TATLSDIKALIRKHE CCCHHHHHHHHHHHH	41.97	27452117
450	Ubiquitination	TATLSDIKALIRKHE CCCHHHHHHHHHHHH	41.97	-
455	Acetylation	DIKALIRKHEAFESD HHHHHHHHHHHHHHH	38.51	25825284
455	Ubiquitination	DIKALIRKHEAFESD HHHHHHHHHHHHHHH	38.51	-
461	Phosphorylation	RKHEAFESDLAAHQD HHHHHHHHHHHHCHH	31.32	26657352
469	Ubiquitination	DLAAHQDRVEQIAAI HHHHCHHHHHHHHHH	27.57	21890473
469	Methylation	DLAAHQDRVEQIAAI HHHHCHHHHHHHHHH	27.57	-
485	Phosphorylation	QELNELDYYDSHNVN HHHHHCCCCCCCCCC	23.07	37817035
486	Phosphorylation	ELNELDYYDSHNVNT HHHHCCCCCCCCCCH	15.61	21406692
488	Phosphorylation	NELDYYDSHNVNTRC HHCCCCCCCCCCHHH	10.80	37817047
493	Phosphorylation	YDSHNVNTRCQKICD CCCCCCCHHHHHHHH	28.65	37817053
497	Acetylation	NVNTRCQKICDQWDA CCCHHHHHHHHHHHH	49.26	25953088
497	Ubiquitination	NVNTRCQKICDQWDA CCCHHHHHHHHHHHH	49.26	-
499	S-nitrosocysteine	NTRCQKICDQWDALG CHHHHHHHHHHHHHH	4.02	-
499	Glutathionylation	NTRCQKICDQWDALG CHHHHHHHHHHHHHH	4.02	22555962
499	S-nitrosylation	NTRCQKICDQWDALG CHHHHHHHHHHHHHH	4.02	22178444
499	S-palmitoylation	NTRCQKICDQWDALG CHHHHHHHHHHHHHH	4.02	29575903
507	Phosphorylation	DQWDALGSLTHSRRE HHHHHHHHCHHHHHH	30.83	9418949
509	Phosphorylation	WDALGSLTHSRREAL HHHHHHCHHHHHHHH	21.36	23403867
511	Phosphorylation	ALGSLTHSRREALEK HHHHCHHHHHHHHHH	28.00	23403867
518	Acetylation	SRREALEKTEKQLEA HHHHHHHHHHHHHHH	63.93	25953088
521	Acetylation	EALEKTEKQLEAIDQ HHHHHHHHHHHHHHH	66.47	25953088
521	Ubiquitination	EALEKTEKQLEAIDQ HHHHHHHHHHHHHHH	66.47	-
533	Phosphorylation	IDQLHLEYAKRAAPF HHHHHHHHHHHHCCC	24.63	28258704
592	Acetylation	EAILAIHKEAQRIAE HHHHHHHHHHHHHHH	48.94	19608861
592	Malonylation	EAILAIHKEAQRIAE HHHHHHHHHHHHHHH	48.94	26320211
592	Ubiquitination	EAILAIHKEAQRIAE HHHHHHHHHHHHHHH	48.94	19608861
604	Acetylation	IAESNHIKLSGSNPY HHHHCCCCCCCCCCC	29.11	25953088
604	Malonylation	IAESNHIKLSGSNPY HHHHCCCCCCCCCCC	29.11	26320211
604	Ubiquitination	IAESNHIKLSGSNPY HHHHCCCCCCCCCCC	29.11	-
606	Phosphorylation	ESNHIKLSGSNPYTT HHCCCCCCCCCCCCC	34.86	26657352
608	Phosphorylation	NHIKLSGSNPYTTVT CCCCCCCCCCCCCCC	31.12	28152594
611	Phosphorylation	KLSGSNPYTTVTPQI CCCCCCCCCCCCHHH	21.20	110736599
612	Phosphorylation	LSGSNPYTTVTPQII CCCCCCCCCCCHHHH	18.95	28152594
613	Phosphorylation	SGSNPYTTVTPQIIN CCCCCCCCCCHHHHH	19.28	28152594
615	Phosphorylation	SNPYTTVTPQIINSK CCCCCCCCHHHHHHC	13.84	72246255
621	Phosphorylation	VTPQIINSKWEKVQQ CCHHHHHHCHHHHHH	28.83	22817900
622	Acetylation	TPQIINSKWEKVQQL CHHHHHHCHHHHHHH	55.68	25825284
622	Ubiquitination	TPQIINSKWEKVQQL CHHHHHHCHHHHHHH	55.68	-
625	Acetylation	IINSKWEKVQQLVPK HHHHCHHHHHHHCCC	44.20	19608861
625	Malonylation	IINSKWEKVQQLVPK HHHHCHHHHHHHCCC	44.20	26320211
625	Ubiquitination	IINSKWEKVQQLVPK HHHHCHHHHHHHCCC	44.20	21890473
632	Malonylation	KVQQLVPKRDHALLE HHHHHCCCCHHHHHH	64.08	26320211
632	Ubiquitination	KVQQLVPKRDHALLE HHHHHCCCCHHHHHH	64.08	21890473
640	Ubiquitination	RDHALLEEQSKQQSN CHHHHHHHHHHHHCH	61.19	-
642	Phosphorylation	HALLEEQSKQQSNEH HHHHHHHHHHHCHHH	35.39	108826509
643	Ubiquitination	ALLEEQSKQQSNEHL HHHHHHHHHHCHHHH	52.64	-
656	Phosphorylation	HLRRQFASQANVVGP HHHHHHHHHCCCCCH	30.98	26657352
667	Phosphorylation	VVGPWIQTKMEEIGR CCCHHHHHHHHHHCC	24.19	22817900
668	Ubiquitination	VGPWIQTKMEEIGRI CCHHHHHHHHHHCCE	28.12	-
679	Sulfoxidation	IGRISIEMNGTLEDQ HCCEEEEECCCHHHH	5.52	28183972
682	Phosphorylation	ISIEMNGTLEDQLSH EEEEECCCHHHHHHH	23.21	22817900
693	Phosphorylation	QLSHLKQYERSIVDY HHHHHHHHHHHHCCC	16.24	28064214
696	Phosphorylation	HLKQYERSIVDYKPN HHHHHHHHHCCCCCC	18.28	101545089
700	Phosphorylation	YERSIVDYKPNLDLL HHHHHCCCCCCHHHH	19.90	119485
701	Acetylation	ERSIVDYKPNLDLLE HHHHCCCCCCHHHHH	23.98	26051181
701	Ubiquitination	ERSIVDYKPNLDLLE HHHHCCCCCCHHHHH	23.98	-
725	Phosphorylation	LIFDNKHTNYTMEHI HHHCCCCCCCCHHHH	31.37	28152594
727	Phosphorylation	FDNKHTNYTMEHIRV HCCCCCCCCHHHHHH	14.49	28152594
728	Phosphorylation	DNKHTNYTMEHIRVG CCCCCCCCHHHHHHC	20.39	26437602
729	Sulfoxidation	NKHTNYTMEHIRVGW CCCCCCCHHHHHHCH	2.20	30846556
741	Phosphorylation	VGWEQLLTTIARTIN HCHHHHHHHHHHHHH	25.42	21712546
746	Phosphorylation	LLTTIARTINEVENQ HHHHHHHHHHHHHHH	21.09	20860994
756	Phosphorylation	EVENQILTRDAKGIS HHHHHHHCCCCCCCC	28.29	7303829
760	Ubiquitination	QILTRDAKGISQEQM HHHCCCCCCCCHHHH	62.15	-
763	Phosphorylation	TRDAKGISQEQMQEF CCCCCCCCHHHHHHH	36.01	21712546
767	Sulfoxidation	KGISQEQMQEFRASF CCCCHHHHHHHHHHC	3.97	28465586
773	Phosphorylation	QMQEFRASFNHFDKD HHHHHHHHCCCCCCC	23.48	113301157
779	Acetylation	ASFNHFDKDHGGALG HHCCCCCCCCCCCCC	51.16	25825284
779	Malonylation	ASFNHFDKDHGGALG HHCCCCCCCCCCCCC	51.16	26320211
779	Methylation	ASFNHFDKDHGGALG HHCCCCCCCCCCCCC	51.16	-
779	Ubiquitination	ASFNHFDKDHGGALG HHCCCCCCCCCCCCC	51.16	-
793	S-nitrosocysteine	GPEEFKACLISLGYD CHHHHHHHHHHCCCC	3.41	-
793	S-nitrosylation	GPEEFKACLISLGYD CHHHHHHHHHHCCCC	3.41	22178444
793	S-palmitoylation	GPEEFKACLISLGYD CHHHHHHHHHHCCCC	3.41	29575903
796	Phosphorylation	EFKACLISLGYDVEN HHHHHHHHCCCCCCC	11.64	63750705
799	Phosphorylation	ACLISLGYDVENDRQ HHHHHCCCCCCCCCC	23.31	29496963
805	Methylation	GYDVENDRQGEAEFN CCCCCCCCCCHHHHH	58.97	-
839	Phosphorylation	IDFMSRETTDTDTAD HHHHCCCCCCCCCHH	28.94	21712546
840	Phosphorylation	DFMSRETTDTDTADQ HHHCCCCCCCCCHHH	31.95	110736607
842	Phosphorylation	MSRETTDTDTADQVI HCCCCCCCCCHHHHH	32.91	110736615
844	Phosphorylation	RETTDTDTADQVIAS CCCCCCCCHHHHHHH	33.94	27251275
851	Phosphorylation	TADQVIASFKVLAGD CHHHHHHHHHHHHCC	17.93	24719451
853	Acetylation	DQVIASFKVLAGDKN HHHHHHHHHHHCCCC	33.57	24846083
859	Acetylation	FKVLAGDKNFITAEE HHHHHCCCCEECHHH	53.49	25825284
859	Ubiquitination	FKVLAGDKNFITAEE HHHHHCCCCEECHHH	53.49	21906983
868	Methylation	FITAEELRRELPPDQ EECHHHHHHHCCCCH	33.05	-
878	Phosphorylation	LPPDQAEYCIARMAP CCCCHHHHHHHHCCC	7.68	28152594
883	Sulfoxidation	AEYCIARMAPYQGPD HHHHHHHCCCCCCCC	3.05	30846556
886	Phosphorylation	CIARMAPYQGPDAVP HHHHCCCCCCCCCCC	19.30	21406692
898	Phosphorylation	AVPGALDYKSFSTAL CCCCCCCCCHHHHHH	14.91	21406692
899	Acetylation	VPGALDYKSFSTALY CCCCCCCCHHHHHHC	44.70	70505
900	Phosphorylation	PGALDYKSFSTALYG CCCCCCCHHHHHHCC	20.42	27251275
902	Phosphorylation	ALDYKSFSTALYGES CCCCCHHHHHHCCCC	21.62	27251275
903	Phosphorylation	LDYKSFSTALYGESD CCCCHHHHHHCCCCC	20.76	28152594
906	Phosphorylation	KSFSTALYGESDL-- CHHHHHHCCCCCC--	19.18	28152594
909	Phosphorylation	STALYGESDL----- HHHHCCCCCC-----	39.59	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACTN4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACTN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACTN4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYOZ2_HUMAN	MYOZ2	physical	16189514
MYOZ1_HUMAN	MYOZ1	physical	16189514
PDLI1_HUMAN	PDLIM1	physical	16189514
KCC2A_HUMAN	CAMK2A	physical	11160423
KCC2B_HUMAN	CAMK2B	physical	11160423
LRRC7_RAT	Lrrc7	physical	11160423
INO80_HUMAN	INO80	physical	20197409
MEF2A_HUMAN	MEF2A	physical	16980305
ESR1_HUMAN	ESR1	physical	21078666
VDR_HUMAN	VDR	physical	21078666
THIO_HUMAN	TXN	physical	21988832
RS27_HUMAN	RPS27	physical	21988832
POTE1_HUMAN	POT1	physical	21988832
IMA1_HUMAN	KPNA2	physical	21988832
MK07_HUMAN	MAPK7	physical	21988832
ACTN1_HUMAN	ACTN1	physical	22863883
HGS_HUMAN	HGS	physical	22863883
SF3A3_HUMAN	SF3A3	physical	22863883
ACTN3_HUMAN	ACTN3	physical	25416956
BMP7_HUMAN	BMP7	physical	25416956
MYOZ2_HUMAN	MYOZ2	physical	25416956
RARA_HUMAN	RARA	physical	22351778
KCRB_HUMAN	CKB	physical	26344197
CY1_HUMAN	CYC1	physical	26344197
ECSIT_HUMAN	ECSIT	physical	26344197
MCFD2_HUMAN	MCFD2	physical	26344197
PSB8_HUMAN	PSMB8	physical	26344197
TPM1_HUMAN	TPM1	physical	26344197
TPM3_HUMAN	TPM3	physical	26344197
TPM4_HUMAN	TPM4	physical	26344197
CTNB1_HUMAN	CTNNB1	physical	25241761
HGS_HUMAN	HGS	physical	26819309
NFYA_HUMAN	NFYA	physical	15364540
ACT_SCHPO	act1	physical	27075176

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
603278	Focal segmental glomerulosclerosis 1 (FSGS1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACTN4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-114; LYS-214; LYS-417;LYS-592 AND LYS-625, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-265, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-265, AND MASSSPECTROMETRY.	15592455 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-378, AND MASSSPECTROMETRY.	17370265 [Abstract]