MCFD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCFD2_HUMAN
• UniProt AC: Q8NI22
• Protein Name: Multiple coagulation factor deficiency protein 2
• Gene Name: MCFD2
• Organism: Homo sapiens (Human).
• Sequence Length: 146
• Subcellular Localization: Endoplasmic reticulum-Golgi intermediate compartment . Endoplasmic reticulum . Golgi apparatus .
• Protein Description: The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors..
• Protein Sequence: MTMRSLLRTPFLCGLLWAFCAPGARAEEPAASFSQPGSMGLDKNTVHDQEHIMEHLEGVINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLELSTAITHVHKEEGSEQAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKSLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	O-linked_Glycosylation	RAEEPAASFSQPGSM CCCCCCCCCCCCCCC	27.77	OGP
34	O-linked_Glycosylation	EEPAASFSQPGSMGL CCCCCCCCCCCCCCC	32.73	OGP
62	Ubiquitination	HLEGVINKPEAEMSP HHHHHHCCCCHHCCH	32.86	-
68	Phosphorylation	NKPEAEMSPQELQLH CCCCHHCCHHHHHHE	18.22	26091039
94	O-linked_Glycosylation	LLDGLELSTAITHVH HHCCHHHHHHHHHHH	13.35	55833649
95	O-linked_Glycosylation	LDGLELSTAITHVHK HCCHHHHHHHHHHHH	34.40	55833655
98	O-linked_Glycosylation	LELSTAITHVHKEEG HHHHHHHHHHHHHCC	18.51	55833659
106	Phosphorylation	HVHKEEGSEQAPLMS HHHHHCCCCCCCCCC	29.80	29507054
113	Phosphorylation	SEQAPLMSEDELINI CCCCCCCCHHHHHHH	49.97	-
124	Ubiquitination	LINIIDGVLRDDDKN HHHHHHHHCCCCCCC	3.34	21890473
130	Ubiquitination	GVLRDDDKNNDGYID HHCCCCCCCCCCCCC	65.72	-
135	Phosphorylation	DDKNNDGYIDYAEFA CCCCCCCCCCHHHHH	8.09	22817900
138	Phosphorylation	NNDGYIDYAEFAKSL CCCCCCCHHHHHHHC	9.85	30622161
143	Ubiquitination	IDYAEFAKSLQ---- CCHHHHHHHCC----	57.95	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCFD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCFD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCFD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMAN1_HUMAN	LMAN1	physical	12717434
A4_HUMAN	APP	physical	21832049
GDE_HUMAN	AGL	physical	26344197
CAPZB_HUMAN	CAPZB	physical	26344197
IF6_HUMAN	EIF6	physical	26344197
ENOPH_HUMAN	ENOPH1	physical	26344197
SYLC_HUMAN	LARS	physical	26344197
PSD12_HUMAN	PSMD12	physical	26344197
PSMD6_HUMAN	PSMD6	physical	26344197
RUVB2_HUMAN	RUVBL2	physical	26344197
SYVC_HUMAN	VARS	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613625: Factor V and factor VIII combined deficiency 2 (F5F8D2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00025: Antihemophilic Factor