PSMD6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD6_HUMAN
• UniProt AC: Q15008
• Protein Name: 26S proteasome non-ATPase regulatory subunit 6
• Gene Name: PSMD6
• Organism: Homo sapiens (Human).
• Sequence Length: 389
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
• Protein Sequence: MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	LEEEGLPKNPDLRIA HHHCCCCCCCCCHHH	82.95	24816145
18	Methylation	LPKNPDLRIAQLRFL CCCCCCCHHHHHHHH	29.58	115489471
42	Sulfoxidation	AAVRDELMAAVRDNN HHHHHHHHHHHHCCC	1.80	21406390
43	Ubiquitination	AVRDELMAAVRDNNM HHHHHHHHHHHCCCC	18.54	29967540
44	Ubiquitination	VRDELMAAVRDNNMA HHHHHHHHHHCCCCH	5.28	22817900
48	Ubiquitination	LMAAVRDNNMAPYYE HHHHHHCCCCHHHHH	29.61	22817900
54	Ubiquitination	DNNMAPYYEALCKSL CCCCHHHHHHHHHHC	8.15	21906983
54	Ubiquitination	DNNMAPYYEALCKSL CCCCHHHHHHHHHHC	8.15	22817900
55	Ubiquitination	NNMAPYYEALCKSLD CCCHHHHHHHHHHCC	29.35	22817900
55	Ubiquitination	NNMAPYYEALCKSLD CCCHHHHHHHHHHCC	29.35	21890473
58	Ubiquitination	APYYEALCKSLDWQI HHHHHHHHHHCCCCC	3.47	21963094
59	Ubiquitination	PYYEALCKSLDWQID HHHHHHHHHCCCCCC	55.70	16196087
60	Phosphorylation	YYEALCKSLDWQIDV HHHHHHHHCCCCCCH	30.48	28555341
62	Ubiquitination	EALCKSLDWQIDVDL HHHHHHCCCCCCHHH	42.18	21963094
65 (in isoform 4)	Phosphorylation	-	4.93	25262027
66 (in isoform 4)	Phosphorylation	-	16.87	21815630
68	Ubiquitination	LDWQIDVDLLNKMKK CCCCCCHHHHHHHHH	41.51	21906983
68	Ubiquitination	LDWQIDVDLLNKMKK CCCCCCHHHHHHHHH	41.51	27667366
68 (in isoform 4)	Phosphorylation	-	41.51	25262027
69	Ubiquitination	DWQIDVDLLNKMKKA CCCCCHHHHHHHHHC	5.96	21963094
69	Ubiquitination	DWQIDVDLLNKMKKA CCCCCHHHHHHHHHC	5.96	21890473
72	Ubiquitination	IDVDLLNKMKKANED CCHHHHHHHHHCCHH	52.66	24816145
77	Ubiquitination	LNKMKKANEDELKRL HHHHHHCCHHHHHHH	67.16	22817900
78	Ubiquitination	NKMKKANEDELKRLD HHHHHCCHHHHHHHH	58.69	33845483
78 (in isoform 4)	Phosphorylation	-	58.69	22210691
79	Ubiquitination	KMKKANEDELKRLDE HHHHCCHHHHHHHHH	67.35	33845483
81	Ubiquitination	KKANEDELKRLDEEL HHCCHHHHHHHHHHH	6.39	22817900
82	Ubiquitination	KANEDELKRLDEELE HCCHHHHHHHHHHHH	49.20	29967540
85	Ubiquitination	EDELKRLDEELEDAE HHHHHHHHHHHHHHH	51.89	22817900
87	Ubiquitination	ELKRLDEELEDAEKN HHHHHHHHHHHHHHH	58.06	29967540
88	Ubiquitination	LKRLDEELEDAEKNL HHHHHHHHHHHHHHC	7.31	29967540
91	Ubiquitination	LDEELEDAEKNLGES HHHHHHHHHHHCCHH	21.93	21906983
91	Ubiquitination	LDEELEDAEKNLGES HHHHHHHHHHHCCHH	21.93	22817900
92	Ubiquitination	DEELEDAEKNLGESE HHHHHHHHHHCCHHH	55.59	22817900
93	Ubiquitination	EELEDAEKNLGESEI HHHHHHHHHCCHHHH	60.23	21906983
107	Acetylation	IRDAMMAKAEYLCRI HHHHHHHHHHHHHHH	24.69	27452117
107	Ubiquitination	IRDAMMAKAEYLCRI HHHHHHHHHHHHHHH	24.69	21906983
117	Acetylation	YLCRIGDKEGALTAF HHHHHCCCCCCCHHH	53.48	25953088
117	Ubiquitination	YLCRIGDKEGALTAF HHHHHCCCCCCCHHH	53.48	27667366
126	Ubiquitination	GALTAFRKTYDKTVA CCCHHHHHCCCCHHH	45.01	29967540
127	Ubiquitination	ALTAFRKTYDKTVAL CCHHHHHCCCCHHHH	32.47	29967540
130	Acetylation	AFRKTYDKTVALGHR HHHHCCCCHHHHHHH	34.19	27452117
130	Ubiquitination	AFRKTYDKTVALGHR HHHHCCCCHHHHHHH	34.19	22817900
135	Ubiquitination	YDKTVALGHRLDIVF CCCHHHHHHHHHHHH	8.30	29967540
146	Ubiquitination	DIVFYLLRIGLFYMD HHHHHHHHHHHHHCC	20.52	22817900
152	Sulfoxidation	LRIGLFYMDNDLITR HHHHHHHCCCCCCCC	2.80	21406390
160	Ubiquitination	DNDLITRNTEKAKSL CCCCCCCCHHHHHHH	43.89	21963094
165	2-Hydroxyisobutyrylation	TRNTEKAKSLIEEGG CCCHHHHHHHHHCCC	57.79	-
165	Acetylation	TRNTEKAKSLIEEGG CCCHHHHHHHHHCCC	57.79	27452117
165	Ubiquitination	TRNTEKAKSLIEEGG CCCHHHHHHHHHCCC	57.79	29967540
166	Phosphorylation	RNTEKAKSLIEEGGD CCHHHHHHHHHCCCC	39.16	23312004
170	Ubiquitination	KAKSLIEEGGDWDRR HHHHHHHCCCCCCHH	62.58	33845483
179	Ubiquitination	GDWDRRNRLKVYQGL CCCCHHHHHHHHCCH	33.79	29967540
181	Ubiquitination	WDRRNRLKVYQGLYC CCHHHHHHHHCCHHH	35.34	-
183	Ubiquitination	RRNRLKVYQGLYCVA HHHHHHHHCCHHHEE	8.69	22817900
187	Phosphorylation	LKVYQGLYCVAIRDF HHHHCCHHHEEHHCH	7.54	28152594
190	Ubiquitination	YQGLYCVAIRDFKQA HCCHHHEEHHCHHHH	6.37	22817900
193	Ubiquitination	LYCVAIRDFKQAAEL HHHEEHHCHHHHHHH	49.32	21963094
194	Ubiquitination	YCVAIRDFKQAAELF HHEEHHCHHHHHHHH	4.54	22817900
197	Ubiquitination	AIRDFKQAAELFLDT EHHCHHHHHHHHHHH	11.95	21963094
200	Ubiquitination	DFKQAAELFLDTVST CHHHHHHHHHHHHHH	4.41	22817900
201	Ubiquitination	FKQAAELFLDTVSTF HHHHHHHHHHHHHHC	4.34	22817900
203	Ubiquitination	QAAELFLDTVSTFTS HHHHHHHHHHHHCCC	37.41	21906983
203	Ubiquitination	QAAELFLDTVSTFTS HHHHHHHHHHHHCCC	37.41	21963094
204	Ubiquitination	AAELFLDTVSTFTSY HHHHHHHHHHHCCCH	20.64	21963094
216	Phosphorylation	TSYELMDYKTFVTYT CCHHCCCCCHHEEEH	9.65	20860994
218	Ubiquitination	YELMDYKTFVTYTVY HHCCCCCHHEEEHHH	19.67	29967540
222	Phosphorylation	DYKTFVTYTVYVSMI CCCHHEEEHHHHHHH	6.73	20860994
225	Phosphorylation	TFVTYTVYVSMIALE HHEEEHHHHHHHHHC	4.49	23911959
227	Phosphorylation	VTYTVYVSMIALERP EEEHHHHHHHHHCCC	6.18	23911959
234	Ubiquitination	SMIALERPDLREKVI HHHHHCCCCHHHHHH	35.30	16196087
235	Ubiquitination	MIALERPDLREKVIK HHHHCCCCHHHHHHC	65.66	16196087
238	Ubiquitination	LERPDLREKVIKGAE HCCCCHHHHHHCHHH	60.00	16196087
239	Ubiquitination	ERPDLREKVIKGAEI CCCCHHHHHHCHHHH	42.71	22817900
242	Ubiquitination	DLREKVIKGAEILEV CHHHHHHCHHHHHHH	55.87	21906983
244	Ubiquitination	REKVIKGAEILEVLH HHHHHCHHHHHHHHH	8.82	16196087
245	Ubiquitination	EKVIKGAEILEVLHS HHHHCHHHHHHHHHC	57.69	16196087
246	Ubiquitination	KVIKGAEILEVLHSL HHHCHHHHHHHHHCC	3.84	16196087
252	Phosphorylation	EILEVLHSLPAVRQY HHHHHHHCCHHHHHH	31.71	21601212
283	Ubiquitination	AVVEQEMKKDWLFAP HHHHHHHCCCCCCCC	46.99	16196087
284	Acetylation	VVEQEMKKDWLFAPH HHHHHHCCCCCCCCH	53.48	26051181
284	Ubiquitination	VVEQEMKKDWLFAPH HHHHHHCCCCCCCCH	53.48	16196087
292	Ubiquitination	DWLFAPHYRYYVREM CCCCCCHHHHHHHHH	10.15	22817900
295	Ubiquitination	FAPHYRYYVREMRIH CCCHHHHHHHHHHHH	5.52	21963094
297	Ubiquitination	PHYRYYVREMRIHAY CHHHHHHHHHHHHHH	18.84	21963094
300	Ubiquitination	RYYVREMRIHAYSQL HHHHHHHHHHHHHHH	16.88	22817900
301	Ubiquitination	YYVREMRIHAYSQLL HHHHHHHHHHHHHHH	1.79	21963094
304	Ubiquitination	REMRIHAYSQLLESY HHHHHHHHHHHHHHH	5.25	22817900
307	Ubiquitination	RIHAYSQLLESYRSL HHHHHHHHHHHHHHC	4.75	21963094
308	Ubiquitination	IHAYSQLLESYRSLT HHHHHHHHHHHHHCH	2.97	21963094
310	Ubiquitination	AYSQLLESYRSLTLG HHHHHHHHHHHCHHH	26.30	21906983
310	Ubiquitination	AYSQLLESYRSLTLG HHHHHHHHHHHCHHH	26.30	22817900
311	Ubiquitination	YSQLLESYRSLTLGY HHHHHHHHHHCHHHH	8.54	22817900
313	Ubiquitination	QLLESYRSLTLGYMA HHHHHHHHCHHHHHH	19.92	27667366
317	Ubiquitination	SYRSLTLGYMAEAFG HHHHCHHHHHHHHHC	12.63	27667366
322	Ubiquitination	TLGYMAEAFGVGVEF HHHHHHHHHCCCHHH	9.28	22817900
323	Ubiquitination	LGYMAEAFGVGVEFI HHHHHHHHCCCHHHH	6.49	21906983
323	Ubiquitination	LGYMAEAFGVGVEFI HHHHHHHHCCCHHHH	6.49	27667366
324	Ubiquitination	GYMAEAFGVGVEFID HHHHHHHCCCHHHHC	23.47	27667366
324	Ubiquitination	GYMAEAFGVGVEFID HHHHHHHCCCHHHHC	23.47	21890473
326	Ubiquitination	MAEAFGVGVEFIDQE HHHHHCCCHHHHCHH	17.39	22817900
327	Ubiquitination	AEAFGVGVEFIDQEL HHHHCCCHHHHCHHH	5.15	22817900
332	Ubiquitination	VGVEFIDQELSRFIA CCHHHHCHHHHHHHH	49.03	21906983
332	Ubiquitination	VGVEFIDQELSRFIA CCHHHHCHHHHHHHH	49.03	27667366
333	Ubiquitination	GVEFIDQELSRFIAA CHHHHCHHHHHHHHH	44.99	21906983
333	Ubiquitination	GVEFIDQELSRFIAA CHHHHCHHHHHHHHH	44.99	27667366
334	Ubiquitination	VEFIDQELSRFIAAG HHHHCHHHHHHHHHC	3.56	27667366
336	Ubiquitination	FIDQELSRFIAAGRL HHCHHHHHHHHHCCC	39.35	16196087
337	Ubiquitination	IDQELSRFIAAGRLH HCHHHHHHHHHCCCC	3.91	16196087
343	Ubiquitination	RFIAAGRLHCKIDKV HHHHHCCCCCCHHHH	5.64	27667366
344	Ubiquitination	FIAAGRLHCKIDKVN HHHHCCCCCCHHHHH	14.95	27667366
346	Ubiquitination	AAGRLHCKIDKVNEI HHCCCCCCHHHHHHH	43.10	21963094
349	Acetylation	RLHCKIDKVNEIVET CCCCCHHHHHHHHHH	50.89	25953088
349	Ubiquitination	RLHCKIDKVNEIVET CCCCCHHHHHHHHHH	50.89	21906983
356	Phosphorylation	KVNEIVETNRPDSKN HHHHHHHHCCCCCCC	26.15	27732954
361	Phosphorylation	VETNRPDSKNWQYQE HHHCCCCCCCCCHHH	30.48	25849741
362	Ubiquitination	ETNRPDSKNWQYQET HHCCCCCCCCCHHHH	70.37	21890473
362	Ubiquitination	ETNRPDSKNWQYQET HHCCCCCCCCCHHHH	70.37	27667366
366	Phosphorylation	PDSKNWQYQETIKKG CCCCCCCHHHHHHHC	10.42	28796482
369	Phosphorylation	KNWQYQETIKKGDLL CCCCHHHHHHHCHHH	23.67	28796482
371	Ubiquitination	WQYQETIKKGDLLLN CCHHHHHHHCHHHHH	59.11	21906983
372	Ubiquitination	QYQETIKKGDLLLNR CHHHHHHHCHHHHHH	54.53	21906983
379	Methylation	KGDLLLNRVQKLSRV HCHHHHHHHHHHHHH	32.01	115489465
382	Ubiquitination	LLLNRVQKLSRVINM HHHHHHHHHHHHHCC	45.64	27667366
384	Phosphorylation	LNRVQKLSRVINM-- HHHHHHHHHHHCC--	31.38	24719451
399	Ubiquitination	----------------- -----------------		21963094
402	Ubiquitination	-------------------- --------------------		22817900
415	Ubiquitination	--------------------------------- ---------------------------------		27667366
424	Ubiquitination	------------------------------------------ ------------------------------------------		27667366
425	Ubiquitination	------------------------------------------- -------------------------------------------		27667366
435	Ubiquitination	----------------------------------------------------- -----------------------------------------------------		27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMD6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSMD1_HUMAN	PSMD1	physical	17353931
PSMD2_HUMAN	PSMD2	physical	17353931
PSD12_HUMAN	PSMD12	physical	17353931
PSD13_HUMAN	PSMD13	physical	17353931
PSD11_HUMAN	PSMD11	physical	17353931
PSMD3_HUMAN	PSMD3	physical	17353931
PRS4_HUMAN	PSMC1	physical	17353931
PRS7_HUMAN	PSMC2	physical	17353931
PRS6A_HUMAN	PSMC3	physical	17353931
PRS8_HUMAN	PSMC5	physical	17353931
PSMD8_HUMAN	PSMD8	physical	17353931
PSDE_HUMAN	PSMD14	physical	17353931
PSMD7_HUMAN	PSMD7	physical	17353931
PRS10_HUMAN	PSMC6	physical	17353931
PRS6B_HUMAN	PSMC4	physical	17353931
PSA2_HUMAN	PSMA2	physical	17353931
TELO2_HUMAN	TELO2	physical	17353931
PSB5_HUMAN	PSMB5	physical	17353931
PSMD4_HUMAN	PSMD4	physical	17353931
UBE3C_HUMAN	UBE3C	physical	12692129
BRCA2_HUMAN	BRCA2	physical	17563742
PSMD8_HUMAN	PSMD8	physical	22939629
PRS8_HUMAN	PSMC5	physical	22863883
PSD12_HUMAN	PSMD12	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
UBQL1_HUMAN	UBQLN1	physical	25416956
SAHH2_HUMAN	AHCYL1	physical	26344197
PSA3_HUMAN	PSMA3	physical	26344197
PSA4_HUMAN	PSMA4	physical	26344197
PSB3_HUMAN	PSMB3	physical	26344197
PSB5_HUMAN	PSMB5	physical	26344197
PSB6_HUMAN	PSMB6	physical	26344197
PSB8_HUMAN	PSMB8	physical	26344197
PRS6A_HUMAN	PSMC3	physical	26344197
PSD10_HUMAN	PSMD10	physical	26344197
PSD11_HUMAN	PSMD11	physical	26344197
PSD13_HUMAN	PSMD13	physical	26344197
PSDE_HUMAN	PSMD14	physical	26344197
PSMD2_HUMAN	PSMD2	physical	26344197
PSMD7_HUMAN	PSMD7	physical	26344197
PSMD8_HUMAN	PSMD8	physical	26344197
SYAP1_HUMAN	SYAP1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.