dbPTM

BRCA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BRCA2_HUMAN
UniProt AC	P51587
Protein Name	Breast cancer type 2 susceptibility protein
Gene Name	BRCA2
Organism	Homo sapiens (Human).
Sequence Length	3418
Subcellular Localization	Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Protein Description	Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination. [PubMed: 24896180]
Protein Sequence	MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVVDTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEPNDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGLEIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSYKGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLTSSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCENDPKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLSNLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYMRVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNNLALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVKQHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLSEHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSDCKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKSTFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDCNKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENEDNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQIKEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAKESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTGNQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFSHQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNLCRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTSVSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYLSNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAYPQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIKKVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKVFADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFSTASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLISQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQNVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQDKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKERQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKNNSNQAAAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPKEFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANISETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLIAASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSVSTPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQPPRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	SEHKNNNYEPNLFKT CCCCCCCCCCCCCCC	34.58	29978859
63	Ubiquitination	NYEPNLFKTPQRKPS CCCCCCCCCCCCCCC	63.56	29967540
64	Phosphorylation	YEPNLFKTPQRKPSY CCCCCCCCCCCCCCH	19.81	23882029
68	Ubiquitination	LFKTPQRKPSYNQLA CCCCCCCCCCHHHHC	32.82	29967540
70	Phosphorylation	KTPQRKPSYNQLAST CCCCCCCCHHHHCCC	39.49	26074081
71	Phosphorylation	TPQRKPSYNQLASTP CCCCCCCHHHHCCCC	18.56	26074081
76	Phosphorylation	PSYNQLASTPIIFKE CCHHHHCCCCEEEEC	43.22	25159151
77	Phosphorylation	SYNQLASTPIIFKEQ CHHHHCCCCEEEECC	16.95	25159151
87	Phosphorylation	IFKEQGLTLPLYQSP EEECCCCCCCCCCCC	32.90	29255136
91	Phosphorylation	QGLTLPLYQSPVKEL CCCCCCCCCCCCCHH	12.66	29255136
93	Phosphorylation	LTLPLYQSPVKELDK CCCCCCCCCCCHHHH	20.36	30266825
96	Ubiquitination	PLYQSPVKELDKFKL CCCCCCCCHHHHCCC	56.81	29967540
112	Phosphorylation	LGRNVPNSRHKSLRT CCCCCCCCCCHHHHH	29.68	25599653
119	Phosphorylation	SRHKSLRTVKTKMDQ CCCHHHHHHCHHCHH	31.48	24719451
158	Phosphorylation	VTPQRDKSVVCGSLF CCCCCCCCEEECCCC	24.87	28555341
167	Phosphorylation	VCGSLFHTPKFVKGR EECCCCCCCCCCCCC	22.34	23898821
193	Phosphorylation	AEVDPDMSWSSSLAT CCCCCCCCCCCCCCC	31.05	22817900
203	Phosphorylation	SSLATPPTLSSTVLI CCCCCCCCCCCEEEE	40.24	22817900
205	Phosphorylation	LATPPTLSSTVLIVR CCCCCCCCCEEEEEE	26.83	22817900
206	Phosphorylation	ATPPTLSSTVLIVRN CCCCCCCCEEEEEEC	26.16	22817900
207	Phosphorylation	TPPTLSSTVLIVRNE CCCCCCCEEEEEECC	18.89	22817900
230	Ubiquitination	HDTTANVKSYFSNHD CCCHHHHHHHHHCCC	38.97	29967540
231	Phosphorylation	DTTANVKSYFSNHDE CCHHHHHHHHHCCCH	27.42	29978859
232	Phosphorylation	TTANVKSYFSNHDES CHHHHHHHHHCCCHH	12.81	29978859
234	Phosphorylation	ANVKSYFSNHDESLK HHHHHHHHCCCHHHH	25.64	26425664
239	Phosphorylation	YFSNHDESLKKNDRF HHHCCCHHHHCCCEE	52.09	23401153
241	Ubiquitination	SNHDESLKKNDRFIA HCCCHHHHCCCEEEE	59.83	29967540
242	Ubiquitination	NHDESLKKNDRFIAS CCCHHHHCCCEEEEE	70.18	-
253	Phosphorylation	FIASVTDSENTNQRE EEEECCCCCCCCHHH	24.31	21815630
268	Methylation	AASHGFGKTSGNSFK HHHCCCCCCCCCCEE	36.94	-
268	Ubiquitination	AASHGFGKTSGNSFK HHHCCCCCCCCCCEE	36.94	-
273	Phosphorylation	FGKTSGNSFKVNSCK CCCCCCCCEECCCCH	29.94	-
275	Methylation	KTSGNSFKVNSCKDH CCCCCCEECCCCHHC	40.09	-
343	Ubiquitination	ANADECEKSKNQVKE CCHHHHHHHHHHHHH	77.66	-
363	Phosphorylation	SEVEPNDTDPLDSNV ECCCCCCCCCCCCCC	46.27	25159151
382	Ubiquitination	PFESGSDKISKEVVP CCCCCCCCCCCCHHH	51.05	29967540
384	Phosphorylation	ESGSDKISKEVVPSL CCCCCCCCCCHHHHH	28.62	20068231
417	Phosphorylation	KIPLLHISSCDQNIS CCCEEEECCCCCCCC	17.73	25627689
426	Ubiquitination	CDQNISEKDLLDTEN CCCCCCHHHHCCCCC	47.05	29967540
431	Phosphorylation	SEKDLLDTENKRKKD CHHHHCCCCCHHHHH	41.23	-
445	Phosphorylation	DFLTSENSLPRISSL HCCCCCCCCCCCCCC	35.38	21815630
450	Phosphorylation	ENSLPRISSLPKSEK CCCCCCCCCCCCCCC	27.40	24719451
451	Phosphorylation	NSLPRISSLPKSEKP CCCCCCCCCCCCCCC	46.44	23403867
454	Acetylation	PRISSLPKSEKPLNE CCCCCCCCCCCCCCC	76.24	20167786
454	Ubiquitination	PRISSLPKSEKPLNE CCCCCCCCCCCCCCC	76.24	29967540
455	Phosphorylation	RISSLPKSEKPLNEE CCCCCCCCCCCCCCC	49.24	28122231
457	Ubiquitination	SSLPKSEKPLNEETV CCCCCCCCCCCCCCC	62.99	29967540
485	Ubiquitination	TDCILAVKQAISGTS HHHHHHHHHHHCCCC	28.53	29967540
489	Phosphorylation	LAVKQAISGTSPVAS HHHHHHHCCCCCCHH	38.75	25159151
491	Phosphorylation	VKQAISGTSPVASSF HHHHHCCCCCCHHHC	24.06	29978859
492	Phosphorylation	KQAISGTSPVASSFQ HHHHCCCCCCHHHCC	22.39	27050516
496	Phosphorylation	SGTSPVASSFQGIKK CCCCCCHHHCCCHHH	31.74	26074081
497	Phosphorylation	GTSPVASSFQGIKKS CCCCCHHHCCCHHHH	16.32	26074081
502	Ubiquitination	ASSFQGIKKSIFRIR HHHCCCHHHHHEEEC	47.49	29967540
511	Phosphorylation	SIFRIRESPKETFNA HHEEECCCCCHHCCC	31.27	21406692
519	Phosphorylation	PKETFNASFSGHMTD CCHHCCCHHCCCCCC	22.50	28555341
547	Phosphorylation	LEIHTVCSQKEDSLC CEEEEEECCCCCCCC	39.69	-
581	Phosphorylation	LKNAGLISTLKKKTN HHHCCHHHHHHHHCC	32.50	25159151
582	Phosphorylation	KNAGLISTLKKKTNK HHCCHHHHHHHHCCC	35.29	25159151
592	Phosphorylation	KKTNKFIYAIHDETS HHCCCEEEEECCCCC	11.57	25159151
601	Acetylation	IHDETSYKGKKIPKD ECCCCCCCCCCCCCC	65.11	25953088
601	Ubiquitination	IHDETSYKGKKIPKD ECCCCCCCCCCCCCC	65.11	29967540
610	Ubiquitination	KKIPKDQKSELINCS CCCCCCHHCCCCCCC	56.91	29967540
641	Phosphorylation	ADSGLLHSSVKRSCS CCCCCCCHHHHHCCC	36.47	26074081
642	Phosphorylation	DSGLLHSSVKRSCSQ CCCCCCHHHHHCCCC	22.40	26074081
646	Phosphorylation	LHSSVKRSCSQNDSE CCHHHHHCCCCCCCC	16.65	28450419
648	Phosphorylation	SSVKRSCSQNDSEEP HHHHHCCCCCCCCCC	33.01	28450419
652	Phosphorylation	RSCSQNDSEEPTLSL HCCCCCCCCCCEEEE	51.95	28450419
656	Phosphorylation	QNDSEEPTLSLTSSF CCCCCCCEEEEEHHH	32.05	28102081
660	Phosphorylation	EEPTLSLTSSFGTIL CCCEEEEEHHHHHHH	20.96	20860994
662	Phosphorylation	PTLSLTSSFGTILRK CEEEEEHHHHHHHHH	23.59	20860994
665	Phosphorylation	SLTSSFGTILRKCSR EEEHHHHHHHHHHCC	18.15	20860994
675	Phosphorylation	RKCSRNETCSNNTVI HHHCCCCCCCCCCEE	25.45	-
677	Phosphorylation	CSRNETCSNNTVISQ HCCCCCCCCCCEECC	40.30	-
680	Phosphorylation	NETCSNNTVISQDLD CCCCCCCCEECCCCC	24.38	-
683	Phosphorylation	CSNNTVISQDLDYKE CCCCCEECCCCCCCC	17.19	17525332
688	Phosphorylation	VISQDLDYKEAKCNK EECCCCCCCCCCCCH	20.30	29759185
703	Phosphorylation	EKLQLFITPEADSLS HHEEEEECCCCCCCH	14.03	26074081
727	Phosphorylation	DPKSKKVSDIKEEVL CCCCCCHHHHHHHHH	42.36	29970186
730	Ubiquitination	SKKVSDIKEEVLAAA CCCHHHHHHHHHHHH	53.46	29967540
745	Ubiquitination	CHPVQHSKVEYSDTD CCCCCCCCCCCCCCC	36.64	29967540
755	Phosphorylation	YSDTDFQSQKSLLYD CCCCCHHHHHHHEEC	39.30	17525332
757	Ubiquitination	DTDFQSQKSLLYDHE CCCHHHHHHHEECCC	48.60	29967540
768	Phosphorylation	YDHENASTLILTPTS ECCCCCCEEEECCCC	18.53	28348404
772	Phosphorylation	NASTLILTPTSKDVL CCCEEEECCCCHHHH	19.95	28348404
774	Phosphorylation	STLILTPTSKDVLSN CEEEECCCCHHHHHH	43.08	28122231
775	Phosphorylation	TLILTPTSKDVLSNL EEEECCCCHHHHHHH	28.23	28122231
786	Phosphorylation	LSNLVMISRGKESYK HHHHEEEECCCCHHC	19.51	28509920
791	Phosphorylation	MISRGKESYKMSDKL EEECCCCHHCCCHHC	33.27	28509920
792	Phosphorylation	ISRGKESYKMSDKLK EECCCCHHCCCHHCC	16.29	28509920
799	Ubiquitination	YKMSDKLKGNNYESD HCCCHHCCCCCCCCC	66.39	29967540
805	Phosphorylation	LKGNNYESDVELTKN CCCCCCCCCCCHHCC	36.27	30576142
811	Ubiquitination	ESDVELTKNIPMEKN CCCCCHHCCCCCCCC	66.56	-
817	Ubiquitination	TKNIPMEKNQDVCAL HCCCCCCCCCCEEEE	54.37	29967540
829	Ubiquitination	CALNENYKNVELLPP EEECCCCCCCCCCCH	67.13	29967540
838	Ubiquitination	VELLPPEKYMRVASP CCCCCHHHHCCCCCC	50.55	29967540
848	Ubiquitination	RVASPSRKVQFNQNT CCCCCCCCEEECCCC	44.73	29967540
862	Ubiquitination	TNLRVIQKNQEETTS CCEEEEECCHHCCCC	49.85	29967540
874	Phosphorylation	TTSISKITVNPDSEE CCCEEEEEECCCHHH	20.26	29523821
879	Phosphorylation	KITVNPDSEELFSDN EEEECCCHHHHCCCC	33.94	28464451
884	Phosphorylation	PDSEELFSDNENNFV CCHHHHCCCCCCCEE	52.75	29523821
907	Ubiquitination	NLALGNTKELHETDL CEECCCCCCCCCCCC	63.38	29967540
925	Phosphorylation	NEPIFKNSTMVLYGD CCCCCCCCEEEEEEC	20.62	29083192
926	Phosphorylation	EPIFKNSTMVLYGDT CCCCCCCEEEEEECC	22.23	29083192
930	Phosphorylation	KNSTMVLYGDTGDKQ CCCEEEEEECCCCCC	11.09	29978859
933	Phosphorylation	TMVLYGDTGDKQATQ EEEEEECCCCCCCEE	42.81	29978859
945	Ubiquitination	ATQVSIKKDLVYVLA CEEEEECHHHEEEEE	55.41	29967540
949	Phosphorylation	SIKKDLVYVLAEENK EECHHHEEEEECCCC	9.31	27642862
964	Ubiquitination	NSVKQHIKMTLGQDL HHHHHHHHHHHCCCH	24.57	29967540
973	Phosphorylation	TLGQDLKSDISLNID HHCCCHHCCCEEECC	47.69	-
976	Phosphorylation	QDLKSDISLNIDKIP CCHHCCCEEECCCCC	21.98	-
981	Ubiquitination	DISLNIDKIPEKNND CCEEECCCCCCCCCC	57.26	29967540
985	Ubiquitination	NIDKIPEKNNDYMNK ECCCCCCCCCCHHHH	56.55	-
992	Ubiquitination	KNNDYMNKWAGLLGP CCCCHHHHHHHHHCC	23.14	29967540
1020	Phosphorylation	SNKEIKLSEHNIKKS CCCEEECCHHCCCHH	31.63	30266825
1093	Phosphorylation	ITPQMLFSKQDFNSN CCHHHEEECCCCCCC	25.99	24719451
1094	Ubiquitination	TPQMLFSKQDFNSNH CHHHEEECCCCCCCC	46.69	29967540
1104	Phosphorylation	FNSNHNLTPSQKAEI CCCCCCCCHHHHHHH	26.64	25159151
1108	Ubiquitination	HNLTPSQKAEITELS CCCCHHHHHHHHHHH	52.93	29967540
1132	Ubiquitination	FEFTQFRKPSYILQK EEEEECCCCCEEEEC	39.34	29967540
1135	Phosphorylation	TQFRKPSYILQKSTF EECCCCCEEEECCEE	17.74	-
1139	Ubiquitination	KPSYILQKSTFEVPE CCCEEEECCEEECCH	48.28	29967540
1141	Phosphorylation	SYILQKSTFEVPENQ CEEEECCEEECCHHH	30.74	28555341
1153	Ubiquitination	ENQMTILKTTSEECR HHHEEEEECCCHHHH	46.00	29967540
1197	Ubiquitination	RKFAGLLKNDCNKSA HHHHHHHHCCCCCCC	56.64	29967540
1202	Ubiquitination	LLKNDCNKSASGYLT HHHCCCCCCCCCCCC	54.45	29967540
1226	Ubiquitination	FYSAHGTKLNVSTEA EEECCCCCCCCCHHH	42.53	29967540
1236	Ubiquitination	VSTEALQKAVKLFSD CCHHHHHHHHHHHHC	56.87	-
1239	Ubiquitination	EALQKAVKLFSDIEN HHHHHHHHHHHCCCC	48.99	29967540
1264	Ubiquitination	PISLSSSKCHDSVVS CCCCCCCCCCCCHHH	37.22	29967540
1282	Phosphorylation	IENHNDKTVSEKNNK EECCCCCCCCCCCCC	31.93	24706070
1284	Phosphorylation	NHNDKTVSEKNNKCQ CCCCCCCCCCCCCEE	48.35	24706070
1323	Ubiquitination	NTENEDNKYTAASRN CCCCCCCCCCCCCCC	57.19	-
1324	Phosphorylation	TENEDNKYTAASRNS CCCCCCCCCCCCCCC	14.10	27642862
1331	Phosphorylation	YTAASRNSHNLEFDG CCCCCCCCCCCEECC	16.79	21712546
1339	Phosphorylation	HNLEFDGSDSSKNDT CCCEECCCCCCCCCE	35.84	25627689
1343	Ubiquitination	FDGSDSSKNDTVCIH ECCCCCCCCCEEEEE	63.90	29967540
1374	Ubiquitination	KLSGQFMKEGNTQIK HHCCCHHHCCCCCCC	64.85	29967540
1381	Ubiquitination	KEGNTQIKEDLSDLT HCCCCCCCHHHHHCC	35.04	29967540
1394	Ubiquitination	LTFLEVAKAQEACHG CCHHHHHHHHHHHCC	56.64	29967540
1406	Ubiquitination	CHGNTSNKEQLTATK HCCCCCCHHHHCCCC	46.75	29967540
1413	Sumoylation	KEQLTATKTEQNIKD HHHHCCCCCHHHHHH	47.83	-
1413	Sumoylation	KEQLTATKTEQNIKD HHHHCCCCCHHHHHH	47.83	-
1413	Ubiquitination	KEQLTATKTEQNIKD HHHHCCCCCHHHHHH	47.83	29967540
1419	Ubiquitination	TKTEQNIKDFETSDT CCCHHHHHHHHHCCC	65.01	29967540
1434	Ubiquitination	FFQTASGKNISVAKE EEECCCCCCCEECHH	48.92	29967540
1440	Ubiquitination	GKNISVAKESFNKIV CCCCEECHHHHHHHH	52.30	29967540
1453	Ubiquitination	IVNFFDQKPEELHNF HHHHHCCCHHHHHCC	57.13	29967540
1474	Acetylation	HSDIRKNKMDILSYE CHHHHHCCCCCCCCC	40.77	19809589
1474	Ubiquitination	HSDIRKNKMDILSYE CHHHHHCCCCCCCCC	40.77	-
1480	Phosphorylation	NKMDILSYEETDIVK CCCCCCCCCCCHHHH	17.84	26657352
1492	Ubiquitination	IVKHKILKESVPVGT HHHHHHCCCCCCCCC	51.95	29967540
1515	Ubiquitination	GQPERDEKIKEPTLL CCCCCCCCCCCCEEE	64.47	29967540
1517	Ubiquitination	PERDEKIKEPTLLGF CCCCCCCCCCEEEEE	69.57	29967540
1526	Phosphorylation	PTLLGFHTASGKKVK CEEEEEECCCCCEEE	21.91	25627689
1528	Phosphorylation	LLGFHTASGKKVKIA EEEEECCCCCEEEEE	52.91	25159151
1533	Acetylation	TASGKKVKIAKESLD CCCCCEEEEEHHHHH	45.91	19820125
1536	Acetylation	GKKVKIAKESLDKVK CCEEEEEHHHHHHHH	51.84	19820133
1543	Ubiquitination	KESLDKVKNLFDEKE HHHHHHHHHHCCHHH	54.39	29967540
1549	Ubiquitination	VKNLFDEKEQGTSEI HHHHCCHHHCCCCCC	58.12	29967540
1565	Ubiquitination	SFSHQWAKTLKYREA HHHHHHHHHHHHHHH	51.97	29967540
1568	Ubiquitination	HQWAKTLKYREACKD HHHHHHHHHHHHHHC	47.71	-
1614	Ubiquitination	IETVVPPKLLSDNLC EEEECCHHHHCCCCC	56.86	29967540
1624	Phosphorylation	SDNLCRQTENLKTSK CCCCCCCCCCCCCCC	13.90	24719451
1631	Ubiquitination	TENLKTSKSIFLKVK CCCCCCCCEEEEEEE	53.45	-
1632	Phosphorylation	ENLKTSKSIFLKVKV CCCCCCCEEEEEEEE	20.52	24719451
1650	Phosphorylation	VEKETAKSPATCYTN HHHHCCCCCCCCCCC	19.80	22468782
1655	Phosphorylation	AKSPATCYTNQSPYS CCCCCCCCCCCCCCC	12.36	22468782
1659	Phosphorylation	ATCYTNQSPYSVIEN CCCCCCCCCCCEEEC	28.07	22468782
1661	Phosphorylation	CYTNQSPYSVIENSA CCCCCCCCCEEECCH	22.33	22468782
1662	Phosphorylation	YTNQSPYSVIENSAL CCCCCCCCEEECCHH	21.72	22468782
1678	Ubiquitination	FYTSCSRKTSVSQTS HHHCCCCCCCCCHHH	28.94	29967540
1679	Phosphorylation	YTSCSRKTSVSQTSL HHCCCCCCCCCHHHH	33.00	28348404
1680	Phosphorylation	TSCSRKTSVSQTSLL HCCCCCCCCCHHHHH	23.86	23911959
1682	Phosphorylation	CSRKTSVSQTSLLEA CCCCCCCCHHHHHHH	27.75	28348404
1690	Ubiquitination	QTSLLEAKKWLREGI HHHHHHHHHHHHHCC	34.80	29967540
1729	Ubiquitination	STIAENDKNHLSEKQ CCCCCCCCCCCCCCC	58.82	29967540
1765	Ubiquitination	NDSGYLSKNKLDSGI CCCCCCCCCCCCCCC	56.35	29967540
1767	Ubiquitination	SGYLSKNKLDSGIEP CCCCCCCCCCCCCHH	58.36	29967540
1770	Phosphorylation	LSKNKLDSGIEPVLK CCCCCCCCCCHHHHH	52.70	28122231
1777	Ubiquitination	SGIEPVLKNVEDQKN CCCHHHHHCHHHHCC	60.21	29967540
1783	Ubiquitination	LKNVEDQKNTSFSKV HHCHHHHCCCCHHHH	74.62	29967540
1786	Phosphorylation	VEDQKNTSFSKVISN HHHHCCCCHHHHHHC	36.60	24719451
1789	Ubiquitination	QKNTSFSKVISNVKD HCCCCHHHHHHCCCC	41.39	29967540
1815	Phosphorylation	ICVEELVTSSSPCKN CCHHHHHCCCCCCCC	35.20	30266825
1816	Phosphorylation	CVEELVTSSSPCKNK CHHHHHCCCCCCCCC	22.72	30266825
1817	Phosphorylation	VEELVTSSSPCKNKN HHHHHCCCCCCCCCC	29.00	30266825
1818	Phosphorylation	EELVTSSSPCKNKNA HHHHCCCCCCCCCCC	33.80	30266825
1860	Ubiquitination	CVSHETIKKVKDIFT EEEHHHHHHHHHHHC	59.96	29967540
1863	Ubiquitination	HETIKKVKDIFTDSF HHHHHHHHHHHCHHH	54.72	29967540
1869	Phosphorylation	VKDIFTDSFSKVIKE HHHHHCHHHHHHHHH	28.50	21815630
1872	Ubiquitination	IFTDSFSKVIKENNE HHCHHHHHHHHHCCC	46.07	22817900
1872	Ubiquitination	IFTDSFSKVIKENNE HHCHHHHHHHHHCCC	46.07	21890473
1875	Ubiquitination	DSFSKVIKENNENKS HHHHHHHHHCCCCCH	58.33	22817900
1926	Phosphorylation	KVFADIQSEEILQHN CHHCCCCHHHHHHHC	37.21	20044836
1937	Phosphorylation	LQHNQNMSGLEKVSK HHHCCCCCHHHCCCC	48.02	28555341
1941	Ubiquitination	QNMSGLEKVSKISPC CCCCHHHCCCCCCCC	57.77	29967540
1943	Phosphorylation	MSGLEKVSKISPCDV CCHHHCCCCCCCCCE	35.03	20044836
1944	Ubiquitination	SGLEKVSKISPCDVS CHHHCCCCCCCCCEE	50.63	29967540
1946	Phosphorylation	LEKVSKISPCDVSLE HHCCCCCCCCCEECC	24.18	25159151
1951	Phosphorylation	KISPCDVSLETSDIC CCCCCCEECCCCCCC	13.77	25159151
1954	Phosphorylation	PCDVSLETSDICKCS CCCEECCCCCCCCCC	36.67	27732954
1955	Phosphorylation	CDVSLETSDICKCSI CCEECCCCCCCCCCH	18.66	27732954
1959	Ubiquitination	LETSDICKCSIGKLH CCCCCCCCCCHHCCC	31.20	29967540
1967	Ubiquitination	CSIGKLHKSVSSANT CCHHCCCCCCCCCCC	64.09	29967540
1968	Phosphorylation	SIGKLHKSVSSANTC CHHCCCCCCCCCCCC	19.24	28450419
1970	Phosphorylation	GKLHKSVSSANTCGI HCCCCCCCCCCCCEE	30.72	28450419
1971	Phosphorylation	KLHKSVSSANTCGIF CCCCCCCCCCCCEEE	24.31	28450419
1974	Phosphorylation	KSVSSANTCGIFSTA CCCCCCCCCEEEECC	16.30	26074081
1979	Phosphorylation	ANTCGIFSTASGKSV CCCCEEEECCCCCEE	22.57	26074081
1982	Phosphorylation	CGIFSTASGKSVQVS CEEEECCCCCEEECC	47.01	25627689
1984	Ubiquitination	IFSTASGKSVQVSDA EEECCCCCEEECCHH	44.98	29967540
2008	Ubiquitination	SEIEDSTKQVFSKVL HHCHHHHHHHHHHHH	48.71	29967540
2013	Ubiquitination	STKQVFSKVLFKSNE HHHHHHHHHHHCCCC	31.34	-
2017	Methylation	VFSKVLFKSNEHSDQ HHHHHHHCCCCCHHH	48.49	-
2017	Ubiquitination	VFSKVLFKSNEHSDQ HHHHHHHCCCCCHHH	48.49	29967540
2031	Phosphorylation	QLTREENTAIRTPEH HCCHHHHHCCCCHHH	27.09	30108239
2035	Phosphorylation	EENTAIRTPEHLISQ HHHHCCCCHHHHHHC	27.24	25849741
2041	Phosphorylation	RTPEHLISQKGFSYN CCHHHHHHCCCCCEE	32.00	25159151
2071	Phosphorylation	KQVSILESSLHKVKG CEEEEHHHHHHHHHH	34.45	23403867
2072	Phosphorylation	QVSILESSLHKVKGV EEEEHHHHHHHHHHH	25.72	23403867
2075	Ubiquitination	ILESSLHKVKGVLEE EHHHHHHHHHHHHHH	51.43	29967540
2077	Ubiquitination	ESSLHKVKGVLEEFD HHHHHHHHHHHHHHH	48.37	29967540
2088	Phosphorylation	EEFDLIRTEHSLHYS HHHHHHCCCCCCCCC	30.93	27080861
2091	Phosphorylation	DLIRTEHSLHYSPTS HHHCCCCCCCCCCCC	15.60	28450419
2094	Phosphorylation	RTEHSLHYSPTSRQN CCCCCCCCCCCCCCC	22.95	28450419
2095	Phosphorylation	TEHSLHYSPTSRQNV CCCCCCCCCCCCCCH	15.79	25159151
2097	Phosphorylation	HSLHYSPTSRQNVSK CCCCCCCCCCCCHHH	30.51	28450419
2098	Phosphorylation	SLHYSPTSRQNVSKI CCCCCCCCCCCHHHH	34.94	28450419
2104	Ubiquitination	TSRQNVSKILPRVDK CCCCCHHHHHHCCCC	43.93	29967540
2124	Ubiquitination	CVNSEMEKTCSKEFK HCCHHHHHHHCCCEE	54.22	29967540
2150	Ubiquitination	SENNHSIKVSPYLSQ CCCCCCCEECCHHHH	39.41	29967540
2152	Phosphorylation	NNHSIKVSPYLSQFQ CCCCCEECCHHHHHH	11.65	25159151
2162	Ubiquitination	LSQFQQDKQQLVLGT HHHHHHHHHHHHHCC	35.29	29967540
2186	Phosphorylation	VLGKEQASPKNVKME ECCCCCCCCCCEEEE	35.78	27422710
2191	Ubiquitination	QASPKNVKMEIGKTE CCCCCCEEEEECCCC	39.96	29967540
2196	Ubiquitination	NVKMEIGKTETFSDV CEEEEECCCCCCCCC	49.18	-
2206	Ubiquitination	TFSDVPVKTNIEVCS CCCCCCCCCCEEEEC	29.77	29967540
2244	Ubiquitination	DDELTDSKLPSHATH CCCCCCCCCCCCCCC	68.19	-
2286	Ubiquitination	LVGEPSIKRNLLNEF EECCHHHHHHHHHHH	39.30	29967540
2302	Ubiquitination	RIIENQEKSLKASKS HHHHHHHHHHHHCCC	51.85	29967540
2308	Ubiquitination	EKSLKASKSTPDGTI HHHHHHCCCCCCCCC	64.31	-
2359	Ubiquitination	PGQEFLSKSHLYEHL CCCHHCCHHHHHHEE	44.00	29967540
2363	Phosphorylation	FLSKSHLYEHLTLEK HCCHHHHHHEEEECC	8.90	25159151
2404	Ubiquitination	ITTGRPTKVFVPPFK HHCCCCCEEECCCCC	36.04	-
2411	Methylation	KVFVPPFKTKSHFHR EEECCCCCCCCHHHH	61.90	-
2411	Ubiquitination	KVFVPPFKTKSHFHR EEECCCCCCCCHHHH	61.90	29967540
2413	Methylation	FVPPFKTKSHFHRVE ECCCCCCCCHHHHHH	42.39	-
2448	Ubiquitination	GSDDSKNKINDNEIH CCCCCCCCCCHHHHH	46.77	29967540
2459	Ubiquitination	NEIHQFNKNNSNQAA HHHHHCCCCCCCCCE	59.81	29967540
2472	Ubiquitination	AAAVTFTKCEEEPLD CEEEEEEECCCCCHH	35.14	29967540
2498	Acetylation	QDMRIKKKQRQRVFP HHHCCCHHHHHCCCC	45.79	18586591
2514	Ubiquitination	PGSLYLAKTSTLPRI CCCEEEEECCCCCCE	40.17	-
2524	Methylation	TLPRISLKAAVGGQV CCCCEEEEHHHCCCC	27.75	-
2538	Ubiquitination	VPSACSHKQLYTYGV CCCCCCCCHHHHCCC	26.21	29967540
2541	Phosphorylation	ACSHKQLYTYGVSKH CCCCCHHHHCCCCCC	8.74	23312004
2542	Phosphorylation	CSHKQLYTYGVSKHC CCCCHHHHCCCCCCE	23.53	23312004
2543	Phosphorylation	SHKQLYTYGVSKHCI CCCHHHHCCCCCCEE	11.28	23312004
2546	Phosphorylation	QLYTYGVSKHCIKIN HHHHCCCCCCEEEEC	16.60	23312004
2570	Ubiquitination	HTEDYFGKESLWTGK ECCCCCCCCEECCCC	33.94	29967540
2577	Ubiquitination	KESLWTGKGIQLADG CCEECCCCCEEECCC	45.53	29967540
2594	Ubiquitination	LIPSNDGKAGKEEFY EECCCCCCCCHHHHH	57.75	29967540
2597	Ubiquitination	SNDGKAGKEEFYRAL CCCCCCCHHHHHHHH	59.95	29967540
2616	Phosphorylation	GVDPKLISRIWVYNH CCCHHHHHHHHHHHH	28.31	25003641
2621	Phosphorylation	LISRIWVYNHYRWII HHHHHHHHHHHHHHH	4.92	25003641
2640	Ubiquitination	AMECAFPKEFANRCL HHHHCCCHHHHHHCC	60.04	29967540
2648	Phosphorylation	EFANRCLSPERVLLQ HHHHHCCCHHHHHHH	28.48	24719451
2657	Ubiquitination	ERVLLQLKYRYDTEI HHHHHHHHHHHCCCC	18.09	-
2681	Phosphorylation	KIMERDDTAAKTLVL HHHHCCCHHHHHHHH	32.57	26074081
2685	Phosphorylation	RDDTAAKTLVLCVSD CCCHHHHHHHHHHHH	19.85	26074081
2691	Phosphorylation	KTLVLCVSDIISLSA HHHHHHHHHHHHHHC	23.30	26074081
2695	Phosphorylation	LCVSDIISLSANISE HHHHHHHHHHCCCCC	19.33	26074081
2697	Phosphorylation	VSDIISLSANISETS HHHHHHHHCCCCCCC	16.69	26074081
2701	Phosphorylation	ISLSANISETSSNKT HHHHCCCCCCCCCCC	34.33	26074081
2741	Ubiquitination	PPLLAVLKNGRLTVG CCCEEEEECCCCCCC	51.24	-
2854	Phosphorylation	EEKEAAKYVEAQQKR HHHHHHHHHHHHHHH	9.97	23403867
2882	Acetylation	EHEENTTKPYLPSRA HHHHCCCCCCCCCHH	29.62	26051181
2882	Ubiquitination	EHEENTTKPYLPSRA HHHHCCCCCCCCCHH	29.62	29967540
2905	Phosphorylation	LQDGAELYEAVKNAA HHCHHHHHHHHHHCC	8.05	29978859
2950	"N6,N6-dimethyllysine"	QIQLEIRKAMESAEQ HHHHHHHHHHHHHHH	58.72	-
2950	Methylation	QIQLEIRKAMESAEQ HHHHHHHHHHHHHHH	58.72	-
2954	Phosphorylation	EIRKAMESAEQKEQG HHHHHHHHHHHHHCC	24.83	24719451
2958	Ubiquitination	AMESAEQKEQGLSRD HHHHHHHHHCCCCCC	43.43	-
2967	Phosphorylation	QGLSRDVTTVWKLRI CCCCCCHHHHEEEEE	21.66	-
2968	Phosphorylation	GLSRDVTTVWKLRIV CCCCCHHHHEEEEEE	24.98	-
2988	Phosphorylation	EKDSVILSIWRPSSD CCCEEEEEEECCCHH	14.69	24719451
2993	Phosphorylation	ILSIWRPSSDLYSLL EEEEECCCHHHHHHH	28.10	30206219
2994	Phosphorylation	LSIWRPSSDLYSLLT EEEECCCHHHHHHHH	34.03	30206219
2997	Phosphorylation	WRPSSDLYSLLTEGK ECCCHHHHHHHHCCC	11.41	30206219
2998	Phosphorylation	RPSSDLYSLLTEGKR CCCHHHHHHHHCCCC	24.97	30206219
3001	Phosphorylation	SDLYSLLTEGKRYRI HHHHHHHHCCCCEEE	48.24	30206219
3009	Phosphorylation	EGKRYRIYHLATSKS CCCCEEEEEEEECCC	5.04	22817900
3031	Ubiquitination	NIQLAATKKTQYQQL HHEEEECCCCCCCCC	49.44	29967540
3032	Ubiquitination	IQLAATKKTQYQQLP HEEEECCCCCCCCCC	36.18	-
3179	Ubiquitination	LCNEAENKLMHILHA HCHHHHHHHHHHHHC	38.40	29967540
3193	Phosphorylation	ANDPKWSTPTKDCTS CCCCCCCCCCCCCCC	33.59	22817900
3196	Ubiquitination	PKWSTPTKDCTSGPY CCCCCCCCCCCCCCC	52.59	29967540
3199	Phosphorylation	STPTKDCTSGPYTAQ CCCCCCCCCCCCEEE	47.02	25693802
3200	Phosphorylation	TPTKDCTSGPYTAQI CCCCCCCCCCCEEEE	44.07	25693802
3203	Phosphorylation	KDCTSGPYTAQIIPG CCCCCCCCEEEECCC	20.45	25693802
3204	Phosphorylation	DCTSGPYTAQIIPGT CCCCCCCEEEECCCC	18.41	25693802
3211	Phosphorylation	TAQIIPGTGNKLLMS EEEECCCCCCCEECC	32.02	25159151
3218	Phosphorylation	TGNKLLMSSPNCEIY CCCCEECCCCCCEEE	42.48	24850871
3219	Phosphorylation	GNKLLMSSPNCEIYY CCCEECCCCCCEEEE	13.23	26552605
3225	Phosphorylation	SSPNCEIYYQSPLSL CCCCCEEEECCHHHH	3.52	26552605
3226	Phosphorylation	SPNCEIYYQSPLSLC CCCCEEEECCHHHHH	14.26	22199227
3228	Phosphorylation	NCEIYYQSPLSLCMA CCEEEECCHHHHHHH	16.22	26552605
3231	Phosphorylation	IYYQSPLSLCMAKRK EEECCHHHHHHHCCC	23.94	22199227
3238	Ubiquitination	SLCMAKRKSVSTPVS HHHHHCCCCCCCCCC	55.28	29967540
3239	Phosphorylation	LCMAKRKSVSTPVSA HHHHCCCCCCCCCCH	25.90	25599653
3241	Phosphorylation	MAKRKSVSTPVSAQM HHCCCCCCCCCCHHC	33.80	25599653
3242	Phosphorylation	AKRKSVSTPVSAQMT HCCCCCCCCCCHHCC	26.08	25159151
3245	Phosphorylation	KSVSTPVSAQMTSKS CCCCCCCCHHCCCCC	17.62	25599653
3249	Phosphorylation	TPVSAQMTSKSCKGE CCCCHHCCCCCCCCC	22.41	25599653
3250	Phosphorylation	PVSAQMTSKSCKGEK CCCHHCCCCCCCCCC	19.75	25599653
3284	Phosphorylation	LPLPPPVSPICTFVS CCCCCCCCCCEEEEC	17.83	22199227
3288	Phosphorylation	PPVSPICTFVSPAAQ CCCCCCEEEECHHHH	28.00	28122231
3291	Phosphorylation	SPICTFVSPAAQKAF CCCEEEECHHHHHHH	12.48	22199227
3306	Phosphorylation	QPPRSCGTKYETPIK CCCCCCCCCCCCCCC	34.48	-
3308	Phosphorylation	PRSCGTKYETPIKKK CCCCCCCCCCCCCHH	25.52	27642862
3310	Phosphorylation	SCGTKYETPIKKKEL CCCCCCCCCCCHHHC	27.50	23898821
3319	Phosphorylation	IKKKELNSPQMTPFK CCHHHCCCCCCCCCH	29.18	29978859
3323	Phosphorylation	ELNSPQMTPFKKFNE HCCCCCCCCCHHHCH	21.96	25159151
3374	Phosphorylation	ESTRTAPTSSEDYLR CCCCCCCCCCHHHHH	42.28	26074081
3375	Phosphorylation	STRTAPTSSEDYLRL CCCCCCCCCHHHHHH	30.58	21815630
3376	Phosphorylation	TRTAPTSSEDYLRLK CCCCCCCCHHHHHHH	36.64	26074081
3379	Phosphorylation	APTSSEDYLRLKRRC CCCCCHHHHHHHHHH	6.94	26074081
3387	Phosphorylation	LRLKRRCTTSLIKEQ HHHHHHHHHHHHHHH	20.01	16825431
3389	Phosphorylation	LKRRCTTSLIKEQES HHHHHHHHHHHHHHH	15.22	24719451
3397	Phosphorylation	LIKEQESSQASTEEC HHHHHHHCCCCHHHH	29.07	-
3414	Phosphorylation	NKQDTITTKKYI--- HHCCCCCCCCCC---	22.99	25599653

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
77	T	Phosphorylation	Kinase	CDK2	P24941	PSP
193	S	Phosphorylation	Kinase	PLK1	P53350	PSP
203	T	Phosphorylation	Kinase	PLK1	P53350	PSP
205	S	Phosphorylation	Kinase	PLK1	P53350	PSP
206	S	Phosphorylation	Kinase	PLK1	P53350	PSP
207	T	Phosphorylation	Kinase	PLK1	P53350	PSP
3291	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot
3291	S	Phosphorylation	Kinase	CDK2	P24941	Uniprot
3387	T	Phosphorylation	Kinase	CHEK1	O14757	Uniprot
3387	T	Phosphorylation	Kinase	CHEK2	O96017	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:24658274

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
3291	S	Phosphorylation		15800615
Phosphorylation at Ser-3291 by CDK1 and CDK2 is low in S phase when recombination is active, but increases as cells progress towards mitosis; this phosphorylation prevents homologous recombination-dependent repair during S phase and G2 by inhibiting RAD51 binding.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
3319	Phosphorylation	3326 (7)	K ⇒ *	rs11571833	Breast cancer Lung cancer Cancer Breast cancer (estrogen-receptor negative)	23535729 23535733 24880342 27197191 27117709 25751625 28604730 29059683 29058716
3323	Phosphorylation	3326 (3)	K ⇒ *	rs11571833	Breast cancer Lung cancer Cancer Breast cancer (estrogen-receptor negative)	23535729 23535733 24880342 27197191 27117709 25751625 28604730 29059683 29058716

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD51_HUMAN	RAD51	physical	9126738
HM20B_HUMAN	HMG20B	physical	11207365
BRCA1_HUMAN	BRCA1	physical	11477095
RAD51_HUMAN	RAD51	physical	12815053
RAD51_HUMAN	RAD51	physical	14580352
FANCG_HUMAN	FANCG	physical	12915460
HM20B_HUMAN	HMG20B	physical	12032298
SEM1_HUMAN	SHFM1	physical	10373512
RAD51_HUMAN	RAD51	physical	9560268
BARD1_HUMAN	BARD1	physical	14636569
BABA2_HUMAN	BRE	physical	14636569
BRCC3_HUMAN	BRCC3	physical	14636569
RAD51_HUMAN	RAD51	physical	14636569
RAD51_HUMAN	RAD51	physical	11477095
P53_HUMAN	TP53	physical	14636569
BCCIP_HUMAN	BCCIP	physical	11313963
KAT2B_HUMAN	KAT2B	physical	12815053
KAT2B_HUMAN	KAT2B	physical	9824164
SMAD2_HUMAN	SMAD2	physical	12165866
SMAD3_HUMAN	SMAD3	physical	12165866
RFA1_HUMAN	RPA1	physical	12527904
BUB1B_HUMAN	BUB1B	physical	10749118
RAD51_HUMAN	RAD51	physical	9405383
RAD51_HUMAN	RAD51	physical	9523196
FACD2_HUMAN	FANCD2	physical	15115758
RAD51_HUMAN	RAD51	physical	12442171
RAD51_HUMAN	RAD51	physical	15065660
FLNA_HUMAN	FLNA	physical	11602572
BRCA1_HUMAN	BRCA1	physical	14499622
FANCE_HUMAN	FANCE	physical	15199141
RAD51_HUMAN	RAD51	physical	11313963
EMSY_HUMAN	C11orf30	physical	14651845
RAD51_HUMAN	RAD51	physical	9774970
STA5A_HUMAN	STAT5A	physical	12459499
RAD51_HUMAN	RAD51	physical	9811893
SEM1_HUMAN	SHFM1	physical	12228710
BARD1_HUMAN	BARD1	physical	19176389
AURKB_HUMAN	AURKB	physical	19176389
MCPH1_HUMAN	MCPH1	physical	20107607
MCPH1_HUMAN	MCPH1	physical	19549900
RAD51_HUMAN	RAD51	physical	15671039
RAD51_HUMAN	RAD51	physical	16914443
UBP11_HUMAN	USP11	physical	15314155
FANCG_HUMAN	FANCG	physical	20450923
XRCC3_HUMAN	XRCC3	physical	20450923
FACD2_HUMAN	FANCD2	physical	20450923
FACD2_HUMAN	FANCD2	physical	18212739
FANCG_HUMAN	FANCG	physical	18212739
XRCC3_HUMAN	XRCC3	physical	18212739
RAD51_HUMAN	RAD51	physical	16793542
PALB2_HUMAN	PALB2	physical	16793542
FANCG_HUMAN	FANCG	physical	16621732
XRCC3_HUMAN	XRCC3	physical	16621732
FACD2_HUMAN	FANCD2	physical	15199141
RAD51_HUMAN	RAD51	physical	21076401
RAD51_HUMAN	RAD51	physical	20729859
SEM1_HUMAN	SHFM1	physical	16205630
BRCA1_HUMAN	BRCA1	physical	19369211
PALB2_HUMAN	PALB2	physical	19369211
RAD51_HUMAN	RAD51	physical	21670257
MAGD1_HUMAN	MAGED1	physical	15930293
RAD51_HUMAN	RAD51	physical	10551859
HM20B_HUMAN	HMG20B	physical	21399666
RAD51_HUMAN	RAD51	physical	21399666
RAD51_HUMAN	RAD51	physical	15800615
DMC1_HUMAN	DMC1	physical	17541404
RAD51_HUMAN	RAD51	physical	17541404
RAD51_HUMAN	RAD51	physical	17515904
PALB2_HUMAN	PALB2	physical	19609323
POLH_HUMAN	POLH	physical	24485656
PDS5B_HUMAN	PDS5B	physical	22293751
RAD51_HUMAN	RAD51	physical	22293751
PALB2_HUMAN	PALB2	physical	22293751
CDC45_HUMAN	CDC45	physical	22293751
PCNA_HUMAN	PCNA	physical	22293751
RAD21_HUMAN	RAD21	physical	22293751
SMC3_HUMAN	SMC3	physical	22293751
SEM1_HUMAN	SHFM1	physical	26145171
FACD2_HUMAN	FANCD2	physical	19861535
ERCC5_HUMAN	ERCC5	physical	26833090
PALB2_HUMAN	PALB2	physical	26833090
RAD51_HUMAN	RAD51	physical	26833090
SEM1_HUMAN	SHFM1	physical	26833090
CDK9_HUMAN	CDK9	genetic	28319113
KDM5C_HUMAN	KDM5C	genetic	28319113
HDAC6_HUMAN	HDAC6	genetic	28319113
SNF5_HUMAN	SMARCB1	genetic	28319113
PARP1_HUMAN	PARP1	genetic	28628639
PARP2_HUMAN	PARP2	genetic	28628639
RA51B_XENLA	rad51-b	physical	21719678
BUB1B_HUMAN	BUB1B	physical	28985013
KAT2B_HUMAN	KAT2B	physical	28985013
PLK1_HUMAN	PLK1	physical	28985013
PP2AA_HUMAN	PPP2CA	physical	28985013

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
114480	Breast cancer (BC)
613347	Pancreatic cancer 2 (PNCA2)
612555	Breast-ovarian cancer, familial, 2 (BROVCA2)
605724	Fanconi anemia complementation group D1 (FANCD1)
613029	Glioma 3 (GLM3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BRCA2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683 AND SER-755, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism forrecombinational repair."; Esashi F., Christ N., Gannon J., Liu Y., Hunt T., Jasin M., West S.C.; Nature 434:598-604(2005). Cited for: PHOSPHORYLATION AT SER-3291 BY CDK2, INTERACTION WITH RAD51, ANDMUTAGENESIS OF SER-3291.	15800615 [Abstract]
"The checkpoint kinases Chk1 and Chk2 regulate the functionalassociations between hBRCA2 and Rad51 in response to DNA damage."; Bahassi E.M., Ovesen J.L., Riesenberg A.L., Bernstein W.Z.,Hasty P.E., Stambrook P.J.; Oncogene 27:3977-3985(2008). Cited for: FUNCTION IN RAD51-DEPENDENT DNA REPAIR, PHOSPHORYLATION AT THR-3387 BYCHEK1 AND CHEK2, MUTAGENESIS OF THR-3387, AND INTERACTION WITH RAD51.	18317453 [Abstract]

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