dbPTM

FANCG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FANCG_HUMAN
UniProt AC	O15287
Protein Name	Fanconi anemia group G protein
Gene Name	FANCG
Organism	Homo sapiens (Human).
Sequence Length	622
Subcellular Localization	Nucleus . Cytoplasm . The major form is nuclear. The minor form is cytoplasmic.
Protein Description	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene..
Protein Sequence	MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLSWIRPSDRDAFLEEFRTSLPKSCDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRQTTSVG ------CCCCCCCCC	32.85	22210691
5	Phosphorylation	---MSRQTTSVGSSC ---CCCCCCCCCHHH	21.67	22210691
7	Phosphorylation	-MSRQTTSVGSSCLD -CCCCCCCCCHHHHH	28.06	15299017
28	Ubiquitination	DRLVRQAKVAQNSGL HHHHHHHHHHHHCCC	29.75	-
182	Ubiquitination	KDLLLLLKTWSPPAE HHHHHHHHHCCCCHH	48.17	-
258	Ubiquitination	ALGSCHRKMGNPQRA HHHHHHHHCCCHHHH	27.74	-
347	Ubiquitination	CGTQSQTKHILASRC CCCHHHHHHHHHHHH	22.47	-
357	Phosphorylation	LASRCLQTGRAGDAA HHHHHHHCCCCCHHH	18.71	22210691
383	Phosphorylation	DSSEPRFSPPPSPPG CCCCCCCCCCCCCCC	37.46	22817900
387	Phosphorylation	PRFSPPPSPPGPCMP CCCCCCCCCCCCCCH	49.88	22817900
422	Phosphorylation	TLCEELLSRTSSLLP HHHHHHHHHHHHHHH	46.25	24719451
430	Ubiquitination	RTSSLLPKMSRLWED HHHHHHHHHHHHHHH	49.86	-
491	Ubiquitination	FRATPEEKEQGAAFN HHCCHHHHHCCCCCC	54.39	-
504	Ubiquitination	FNCEQGCKSDAALQQ CCCCCCCCCHHHHHH	59.19	-
557	Phosphorylation	TYFHLLQTLKRLDRR HHHHHHHHHHHHCCH	33.93	-
559	Ubiquitination	FHLLQTLKRLDRRDE HHHHHHHHHHCCHHH	55.06	21890473
615	Phosphorylation	FLEEFRTSLPKSCDL HHHHHHHHCCCCCCC	38.12	24719451
618	Ubiquitination	EFRTSLPKSCDL--- HHHHHCCCCCCC---	69.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
387	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FANCG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FANCG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GABP1_HUMAN	GABPB1	physical	16189514
ZBED1_HUMAN	ZBED1	physical	16189514
SAMD3_HUMAN	SAMD3	physical	16189514
USBP1_HUMAN	USHBP1	physical	16189514
K1C19_HUMAN	KRT19	physical	16189514
SPTN1_HUMAN	SPTAN1	physical	11401546
CP2E1_HUMAN	CYP2E1	physical	14499622
FANCA_HUMAN	FANCA	physical	10373536
FANCA_HUMAN	FANCA	physical	11739169
FANCA_HUMAN	FANCA	physical	12649160
FANCC_HUMAN	FANCC	physical	10373536
FANCF_HUMAN	FANCF	physical	11063725
FANCF_HUMAN	FANCF	physical	12649160
FANCG_HUMAN	FANCG	physical	15138265
FANCG_HUMAN	FANCG	physical	10652215
RTN2_HUMAN	RTN2	physical	14499622
PSB1_HUMAN	PSMB1	physical	14499622
FANCE_HUMAN	FANCE	physical	12239156
FANCA_HUMAN	FANCA	physical	12239156
FANCA_HUMAN	FANCA	physical	11157805
FANCF_HUMAN	FANCF	physical	11157805
FANCE_HUMAN	FANCE	physical	11157805
FANCG_HUMAN	FANCG	physical	11157805
XPF_HUMAN	ERCC4	physical	20518486
ERCC1_HUMAN	ERCC1	physical	20518486
FANCA_HUMAN	FANCA	physical	20450923
BRCA2_HUMAN	BRCA2	physical	20450923
FANCF_HUMAN	FANCF	physical	20450923
FANCM_HUMAN	FANCM	physical	20347429
FANCA_HUMAN	FANCA	physical	20347429
FP100_HUMAN	C17orf70	physical	20347429
FANCL_HUMAN	FANCL	physical	20347429
CENPS_HUMAN	APITD1	physical	20347429
CENPX_HUMAN	STRA13	physical	20347429
SPTN1_HUMAN	SPTAN1	physical	19102630
XRCC3_HUMAN	XRCC3	physical	18212739
FANCF_HUMAN	FANCF	physical	18212739
PRDX3_HUMAN	PRDX3	physical	17060495
FANCA_HUMAN	FANCA	physical	16720839
FANCL_HUMAN	FANCL	physical	16720839
FANCB_HUMAN	FANCB	physical	16720839
XRCC3_HUMAN	XRCC3	physical	16621732
FANCA_HUMAN	FANCA	physical	16621732
FANCF_HUMAN	FANCF	physical	16621732
BRCA2_HUMAN	BRCA2	physical	16621732
FANCA_HUMAN	FANCA	physical	15367677
FANCA_HUMAN	FANCA	physical	15299017
FANCC_HUMAN	FANCC	physical	15299017
FANCF_HUMAN	FANCF	physical	15262960
FANCA_HUMAN	FANCA	physical	15192709
TOP3A_HUMAN	TOP3A	physical	12724401
FANCA_HUMAN	FANCA	physical	12724401
BLM_HUMAN	BLM	physical	12724401
RFA1_HUMAN	RPA1	physical	12724401
FANCA_HUMAN	FANCA	physical	11438206
FANCC_HUMAN	FANCC	physical	11438206
FANCA_HUMAN	FANCA	physical	11181053
FANCA_HUMAN	FANCA	physical	11167740
FANCA_HUMAN	FANCA	physical	11063725
FANCA_HUMAN	FANCA	physical	10961856
FANCA_HUMAN	FANCA	physical	22705371
FAP20_HUMAN	C1orf86	physical	22705371
SPB1_HUMAN	FTSJ3	physical	19447967
ZBED1_HUMAN	ZBED1	physical	19447967
USBP1_HUMAN	USHBP1	physical	19447967
CP2E1_HUMAN	CYP2E1	physical	11756225
FANCL_HUMAN	FANCL	physical	24910428
FANCA_HUMAN	FANCA	physical	24910428
UIMC1_HUMAN	UIMC1	physical	25132264
BRCC3_HUMAN	BRCC3	physical	25132264
ABRX1_HUMAN	FAM175A	physical	25132264
FANCA_HUMAN	FANCA	physical	25132264
CTNB1_HUMAN	CTNNB1	physical	22653977
FANCA_HUMAN	FANCA	physical	22343915
FANCM_HUMAN	FANCM	physical	22343915
FANCL_HUMAN	FANCL	physical	22343915
FAP20_HUMAN	C1orf86	physical	22343915
FP100_HUMAN	C17orf70	physical	22343915
FANCA_HUMAN	FANCA	physical	28514442
UBB_HUMAN	UBB	physical	28514442
PAPS1_HUMAN	PAPSS1	physical	28514442
CSTFT_HUMAN	CSTF2T	physical	28514442
FANCA_HUMAN	FANCA	physical	28215707
SPTA1_HUMAN	SPTA1	physical	16889989
AAPK1_HUMAN	PRKAA1	physical	27449087

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614082	Fanconi anemia complementation group G (FANCG)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FANCG_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"FANCG promotes formation of a newly identified protein complexcontaining BRCA2, FANCD2 and XRCC3."; Wilson J.B., Yamamoto K., Marriott A.S., Hussain S., Sung P.,Hoatlin M.E., Mathew C.G., Takata M., Thompson L.H., Kupfer G.M.,Jones N.J.; Oncogene 27:3641-3652(2008). Cited for: INTERACTION WITH BRCA2; FANCD2 AND XRCC3, PHOSPHORYLATION AT SER-7,AND MUTAGENESIS OF SER-7; SER-383 AND SER-387.	18212739 [Abstract]